| alpha-Tocopherol-succinate | hsa00030 | Pentose phosphate pathway | 4.23E-02 | 2 | P51854, P37837 | TKTL1, TALDO1 | More | |
| alpha-Tocopherol-succinate | hsa00100 | Steroid biosynthesis | 3.94E-02 | 1 | P35610 | SOAT1 | More | |
| alpha-Tocopherol-succinate | hsa00190 | Oxidative phosphorylation | 8.71E-03 | 3 | Q16718, Q13488, O14521 | NDUFA5, TCIRG1, SDHD | More | |
| alpha-Tocopherol-succinate | hsa00220 | Arginine biosynthesis | 2.64E-04 | 2 | P15104, P49448 | GLUL, GLUD2 | More | |
| alpha-Tocopherol-succinate | hsa00250 | Alanine, aspartate and glutamate metabolism | 4.40E-03 | 2 | P49448, P15104 | GLUD2, GLUL | More | |
| alpha-Tocopherol-succinate | hsa00310 | Lysine degradation | 3.23E-02 | 2 | Q9NVH6, O15047 | TMLHE, SETD1A | More | |
| alpha-Tocopherol-succinate | hsa00471 | D-Glutamine and D-glutamate metabolism | 3.94E-02 | 1 | P49448 | GLUD2 | More | |
| alpha-Tocopherol-succinate | hsa00512 | Mucin type O-glycan biosynthesis | 3.78E-02 | 2 | O95395, Q8N4A0 | GCNT3, GALNT4 | More | |
| alpha-Tocopherol-succinate | hsa00531 | Glycosaminoglycan degradation | 3.78E-02 | 1 | P15586 | GNS | More | |
| alpha-Tocopherol-succinate | hsa00533 | Glycosaminoglycan biosynthesis - keratan sulfate | 3.43E-02 | 1 | Q9NY97 | B3GNT2 | More | |
| alpha-Tocopherol-succinate | hsa00561 | Glycerolipid metabolism | 4.62E-02 | 2 | P51648, P23743 | ALDH3A2, DGKA | More | |
| alpha-Tocopherol-succinate | hsa00562 | Inositol phosphate metabolism | 4.55E-02 | 2 | P27987, P42338 | ITPKB, PIK3CB | More | |
| alpha-Tocopherol-succinate | hsa00564 | Glycerophospholipid metabolism | 6.20E-04 | 5 | Q6P1A2, Q9Y259, P23743, P49619, Q3LIE5 | MBOAT5, CHKB, DGKA, DGKG, ADPRM | More | |
| alpha-Tocopherol-succinate | hsa00600 | Sphingolipid metabolism | 4.50E-02 | 1 | P15289 | ARSA | More | |
| alpha-Tocopherol-succinate | hsa00620 | Pyruvate metabolism | 2.88E-03 | 4 | P40925, P40926, P51648, P14550 | MDH1, MDH2, ALDH3A2, AKR1A1 | More | |
| alpha-Tocopherol-succinate | hsa00910 | Nitrogen metabolism | 4.40E-03 | 2 | P15104, P49448 | GLUL, GLUD2 | More | |
| alpha-Tocopherol-succinate | hsa00920 | Sulfur metabolism | 3.18E-02 | 1 | Q16762 | TST | More | |
| alpha-Tocopherol-succinate | hsa00970 | Aminoacyl-tRNA biosynthesis | 3.78E-02 | 2 | O95363, Q15046 | FARS2, KARS | More | |
| alpha-Tocopherol-succinate | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 3.10E-02 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | |
| alpha-Tocopherol-succinate | hsa00982 | Drug metabolism - cytochrome P450 | 3.10E-02 | 2 | P11712, P78417 | CYP2C9, GSTO1 | More | |
| alpha-Tocopherol-succinate | hsa00983 | Drug metabolism - other enzymes | 2.83E-02 | 3 | P20839, P32320, P05164 | IMPDH1, CDA, MPO | More | |
| alpha-Tocopherol-succinate | hsa01100 | Metabolic pathways | 4.40E-04 | 26 | P21953, Q9UJ14, P15104, P42338, P27987, Q96DU7, Q02153, P40926, O94777, P53004, Q86XP1, P14550, Q9UHK6, Q86VZ5, Q96G23, P09917, Q9UNP4, P32321, P49448, Q9BPW9, P46976, P05496, Q99437, O15239, O15047, Q9NVH6 | BCKDHB, GGTL3, GLUL, PIK3CB, ITPKB, ITPKC, GUCY1B3, MDH2, DPM2, BLVRA, DGKH, AKR1A1, AMACR, SGMS1, LASS2, ALOX5, ST3GAL5, DCTD, GLUD2, DHRS9, GYG1, ATP5G1, ATP6V0B, NDUFA1, SETD1A, TMLHE | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P51817 | PRKX | cAMP-dependent protein kinase catalytic subunit PRKX | P21953 | BCKDHB | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 0.765 | | Q86XP1 | DGKH | Diacylglycerol kinase eta | Q9UJ14 | GGTL3 | Glutathione hydrolase 7 | -0.722 | | P51817 | PRKX | cAMP-dependent protein kinase catalytic subunit PRKX | P15104 | GLUL | Glutamine synthetase | -0.819 | | P51817 | PRKX | cAMP-dependent protein kinase catalytic subunit PRKX | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.733 | | P51817 | PRKX | cAMP-dependent protein kinase catalytic subunit PRKX | P27987 | ITPKB | Inositol-trisphosphate 3-kinase B | 0.745 | | Q86XP1 | DGKH | Diacylglycerol kinase eta | Q96DU7 | ITPKC | Inositol-trisphosphate 3-kinase C | 0.85 | | Q86XP1 | DGKH | Diacylglycerol kinase eta | Q02153 | GUCY1B3 | Guanylate cyclase soluble subunit beta-1 | 0.761 | | Q86XP1 | DGKH | Diacylglycerol kinase eta | P40926 | MDH2 | Malate dehydrogenase, mitochondrial | -0.734 | | Q86XP1 | DGKH | Diacylglycerol kinase eta | O94777 | DPM2 | Dolichol phosphate-mannose biosynthesis regulatory protein | -0.715 | | P51817 | PRKX | cAMP-dependent protein kinase catalytic subunit PRKX | P53004 | BLVRA | Biliverdin reductase A | 0.901 | | Q86XP1 | DGKH | Diacylglycerol kinase eta | Q86XP1 | DGKH | Diacylglycerol kinase eta | 1 | | Q86XP1 | DGKH | Diacylglycerol kinase eta | P14550 | AKR1A1 | Aldo-keto reductase family 1 member A1 | -0.778 | | Q86XP1 | DGKH | Diacylglycerol kinase eta | Q9UHK6 | AMACR | Alpha-methylacyl-CoA racemase | 0.908 | | Q86XP1 | DGKH | Diacylglycerol kinase eta | Q86VZ5 | SGMS1 | Phosphatidylcholine:ceramide cholinephosphotransferase 1 | 0.834 | | Q86XP1 | DGKH | Diacylglycerol kinase eta | Q96G23 | LASS2 | Ceramide synthase 2 | 0.756 | | P51817 | PRKX | cAMP-dependent protein kinase catalytic subunit PRKX | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | -0.705 | | P51817 | PRKX | cAMP-dependent protein kinase catalytic subunit PRKX | Q9UNP4 | ST3GAL5 | Lactosylceramide alpha-2,3-sialyltransferase | 0.743 | | P51817 | PRKX | cAMP-dependent protein kinase catalytic subunit PRKX | P32321 | DCTD | Deoxycytidylate deaminase | 0.79 | | P51817 | PRKX | cAMP-dependent protein kinase catalytic subunit PRKX | P49448 | GLUD2 | Glutamate dehydrogenase 2, mitochondrial | 0.74 | | P51817 | PRKX | cAMP-dependent protein kinase catalytic subunit PRKX | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | -0.798 | | P51817 | PRKX | cAMP-dependent protein kinase catalytic subunit PRKX | P46976 | GYG1 | Glycogenin-1 | -0.82 | | Q86XP1 | DGKH | Diacylglycerol kinase eta | P05496 | ATP5G1 | ATP synthase F(0) complex subunit C1, mitochondrial | -0.721 | | Q86XP1 | DGKH | Diacylglycerol kinase eta | Q99437 | ATP6V0B | V-type proton ATPase 21 kDa proteolipid subunit c'' | -0.703 | | Q86XP1 | DGKH | Diacylglycerol kinase eta | O15239 | NDUFA1 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | -0.754 | | Q86XP1 | DGKH | Diacylglycerol kinase eta | O15047 | SETD1A | Histone-lysine N-methyltransferase SETD1A | -0.709 | | Q86XP1 | DGKH | Diacylglycerol kinase eta | Q9NVH6 | TMLHE | Trimethyllysine dioxygenase, mitochondrial | 0.858 |
|
| alpha-Tocopherol-succinate | hsa01521 | EGFR tyrosine kinase inhibitor resistance | 2.32E-02 | 3 | P17252, P19174, Q9NRA1 | PRKCA, PLCG1, PDGFC | More | |
| alpha-Tocopherol-succinate | hsa01524 | Platinum drug resistance | 3.69E-03 | 3 | Q14790, P48023, P31751 | CASP8, FASLG, AKT2 | More | |
| alpha-Tocopherol-succinate | hsa03010 | Ribosome | 7.34E-03 | 6 | P62753, P62829, P62888, P61927, P61513, P36578 | RPS6, RPL23, RPL30, RPL37, RPL37A, RPL4 | More | |
| alpha-Tocopherol-succinate | hsa03015 | mRNA surveillance pathway | 3.86E-02 | 3 | Q13362, Q14738, Q9UBU9 | PPP2R5C, PPP2R5D, NXF1 | More | |
| alpha-Tocopherol-succinate | hsa03020 | RNA polymerase | 2.51E-02 | 2 | P24928, P62487 | POLR2A, POLR2G | More | |
| alpha-Tocopherol-succinate | hsa03040 | Spliceosome | 1.42E-07 | 14 | Q14562, O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643 | DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P23743 | DGKA | Diacylglycerol kinase alpha | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | 0.85 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | -0.76 | | P23743 | DGKA | Diacylglycerol kinase alpha | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | 0.866 | | P78417 | GSTO1 | Glutathione S-transferase omega-1 | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | -0.794 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O60508 | CDC40 | Pre-mRNA-processing factor 17 | -0.812 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | -0.822 | | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | -0.741 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P26368 | U2AF2 | Splicing factor U2AF 65 kDa subunit | -0.751 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13595 | TRA2A | Transformer-2 protein homolog alpha | -0.74 | | P78417 | GSTO1 | Glutathione S-transferase omega-1 | Q13595 | TRA2A | Transformer-2 protein homolog alpha | -0.87 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | -0.749 | | P23743 | DGKA | Diacylglycerol kinase alpha | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.796 | | P78417 | GSTO1 | Glutathione S-transferase omega-1 | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | -0.735 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.798 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84103 | SFRS3 | Serine/arginine-rich splicing factor 3 | -0.773 | | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P84103 | SFRS3 | Serine/arginine-rich splicing factor 3 | -0.763 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | -0.822 | | P23743 | DGKA | Diacylglycerol kinase alpha | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.89 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | -0.802 | | P23743 | DGKA | Diacylglycerol kinase alpha | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 0.861 | | P78417 | GSTO1 | Glutathione S-transferase omega-1 | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | -0.715 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q9Y2W2 | WBP11 | WW domain-binding protein 11 | -0.743 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O43447 | PPIH | Peptidyl-prolyl cis-trans isomerase H | -0.766 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O75643 | ASCC3L1 | U5 small nuclear ribonucleoprotein 200 kDa helicase | -0.745 |
|
| alpha-Tocopherol-succinate | hsa03320 | PPAR signaling pathway | 4.02E-02 | 2 | Q13133, Q02318 | NR1H3, CYP27A1 | More | |
| alpha-Tocopherol-succinate | hsa04010 | MAPK signaling pathway | 1.53E-02 | 2 | Q9H2K8, Q12933 | TAOK3, TRAF2 | More | |
| alpha-Tocopherol-succinate | hsa04012 | ErbB signaling pathway | 2.32E-02 | 3 | P16333, P17252, P19174 | NCK1, PRKCA, PLCG1 | More | |
| alpha-Tocopherol-succinate | hsa04014 | Ras signaling pathway | 2.05E-05 | 14 | P31751, P42338, P20827, Q9NRA1, P49767, Q13009, P17252, Q7LDG7, Q14644, P0DP23, P62873, P63218, P50151, P19174 | AKT2, PIK3CB, EFNA1, PDGFC, VEGFC, TIAM1, PRKCA, RASGRP2, RASA3, CALM1, GNB1, GNG5, GNG10, PLCG1 | More | |
| alpha-Tocopherol-succinate | hsa04015 | Rap1 signaling pathway | 2.56E-06 | 15 | P20827, Q9NRA1, P49767, Q96FS4, P11215, P25116, Q8TEU7, Q13009, Q7LDG7, P42338, P31751, P0DP23, P08514, P17252, P19174 | EFNA1, PDGFC, VEGFC, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, RASGRP2, PIK3CB, AKT2, CALM1, ITGA2B, PRKCA, PLCG1 | More | |
| alpha-Tocopherol-succinate | hsa04020 | Calcium signaling pathway | 2.91E-05 | 10 | Q16566, P17252, P30679, O15399, P19174, P25116, P0DP23, P23634, Q9NRA1, P49767 | CAMK4, PRKCA, GNA15, GRIN2D, PLCG1, F2R, CALM1, ATP2B4, PDGFC, VEGFC | More | |
| alpha-Tocopherol-succinate | hsa04022 | cGMP-PKG signaling pathway | 5.07E-03 | 2 | P31751, P0DP23 | AKT2, CALM1 | More | |
| alpha-Tocopherol-succinate | hsa04024 | cAMP signaling pathway | 3.23E-03 | 2 | P31751, P0DP23 | AKT2, CALM1 | More | |
| alpha-Tocopherol-succinate | hsa04062 | Chemokine signaling pathway | 9.71E-04 | 11 | P09769, P07948, P42338, P19174, P63218, P50151, P43250, P49407, Q7LDG7, Q13009, Q8WYR1 | FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ARRB1, RASGRP2, TIAM1, PIK3R5 | More | |
| alpha-Tocopherol-succinate | hsa04064 | NF-kappa B signaling pathway | 3.99E-02 | 6 | P10415, Q13489, P29965, Q9UDY8, Q8WV28, Q13315 | BCL2, BIRC3, CD40LG, MALT1, BLNK, ATM | More | |
| alpha-Tocopherol-succinate | hsa04068 | FoxO signaling pathway | 1.25E-02 | 2 | P48023, Q96BR1 | FASLG, SGK3 | More | |
| alpha-Tocopherol-succinate | hsa04070 | Phosphatidylinositol signaling system | 1.14E-03 | 5 | P19174, P0DP23, Q14643, P23743, P17252 | PLCG1, CALM1, ITPR1, DGKA, PRKCA | More | |
| alpha-Tocopherol-succinate | hsa04071 | Sphingolipid signaling pathway | 3.68E-04 | 9 | P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415, Q12933, Q02156 | PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2, TRAF2, PRKCE | More | |
| alpha-Tocopherol-succinate | hsa04072 | Phospholipase D signaling pathway | 7.45E-03 | 5 | P25116, P19174, P17252, P23743, Q9NRA1 | F2R, PLCG1, PRKCA, DGKA, PDGFC | More | |
| alpha-Tocopherol-succinate | hsa04080 | Neuroactive ligand-receptor interaction | 2.16E-02 | 7 | P08311, Q15722, P21453, Q9H228, P21462, P21730, P07550 | CTSG, LTB4R, S1PR1, EDG8, FPR1, C5AR1, ADRB2 | More | |
| alpha-Tocopherol-succinate | hsa04110 | Cell cycle | 2.90E-02 | 4 | Q9UBD5, P06493, P30304, P33981 | ORC3, CDK1, CDC25A, TTK | More | |
| alpha-Tocopherol-succinate | hsa04120 | Ubiquitin mediated proteolysis | 1.68E-02 | 2 | O00762, Q14139 | UBE2C, UBE4A | More | |
| alpha-Tocopherol-succinate | hsa04122 | Sulfur relay system | 3.18E-02 | 1 | Q16762 | TST | More | |
| alpha-Tocopherol-succinate | hsa04141 | Protein processing in endoplasmic reticulum | 6.31E-04 | 9 | P27824, P30101, Q15437, P0DMV8, P11142, Q8IXB1, P08238, Q9NR31, Q9UNL2 | CANX, PDIA3, SEC23B, HSPA1A, HSPA8, DNAJC10, HSP90AB1, SAR1A, SSR3 | More | |
| alpha-Tocopherol-succinate | hsa04145 | Phagosome | 9.65E-07 | 14 | O75015, P11215, Q15080, P14598, Q71U36, Q13509, P68371, Q13488, P05164, P78380, O60603, P35443, P27824, P13765 | FCGR3B, ITGAM, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1, MPO, OLR1, TLR2, THBS4, CANX, HLA-DOB | More | |
| alpha-Tocopherol-succinate | hsa04151 | PI3K-Akt signaling pathway | 4.31E-04 | 21 | P42338, P43657, P25116, P20827, Q9NRA1, P49767, Q13362, P08238, Q8WYR1, P62873, P63218, P50151, P16144, O15335, Q13751, O60603, P14784, P01568, P10415, P17252, P30281 | PIK3CB, P2RY5, F2R, EFNA1, PDGFC, VEGFC, PPP2R5C, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, ITGB4, CHAD, LAMB3, TLR2, IL2RB, IFNA21, BCL2, PRKCA, CCND3 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | -0.735 | | P17252 | PRKCA | Protein kinase C alpha type | P25116 | F2R | Proteinase-activated receptor 1 | 0.857 | | P23743 | DGKA | Diacylglycerol kinase alpha | P25116 | F2R | Proteinase-activated receptor 1 | -0.73 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P20827 | EFNA1 | Ephrin-A1 | 0.715 | | P23743 | DGKA | Diacylglycerol kinase alpha | Q9NRA1 | PDGFC | Platelet-derived growth factor C | -0.759 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P49767 | VEGFC | Vascular endothelial growth factor C | 0.743 | | P17252 | PRKCA | Protein kinase C alpha type | P49767 | VEGFC | Vascular endothelial growth factor C | 0.719 | | P23743 | DGKA | Diacylglycerol kinase alpha | P49767 | VEGFC | Vascular endothelial growth factor C | -0.774 | | P17252 | PRKCA | Protein kinase C alpha type | Q13362 | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | 0.745 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | | P23743 | DGKA | Diacylglycerol kinase alpha | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.927 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q8WYR1 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | 0.752 | | P17252 | PRKCA | Protein kinase C alpha type | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.852 | | P23743 | DGKA | Diacylglycerol kinase alpha | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.815 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | | P17252 | PRKCA | Protein kinase C alpha type | P16144 | ITGB4 | Integrin beta-4 | 0.755 | | P23743 | DGKA | Diacylglycerol kinase alpha | P16144 | ITGB4 | Integrin beta-4 | -0.847 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O15335 | CHAD | Chondroadherin | 0.795 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13751 | LAMB3 | Laminin subunit beta-3 | 0.844 | | P17252 | PRKCA | Protein kinase C alpha type | O60603 | TLR2 | Toll-like receptor 2 | -0.716 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | | P17252 | PRKCA | Protein kinase C alpha type | P01568 | IFNA21 | Interferon alpha-21 | 0.733 | | P23743 | DGKA | Diacylglycerol kinase alpha | P01568 | IFNA21 | Interferon alpha-21 | -0.772 | | P17252 | PRKCA | Protein kinase C alpha type | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.844 | | P17252 | PRKCA | Protein kinase C alpha type | P17252 | PRKCA | Protein kinase C alpha type | 1 | | P23743 | DGKA | Diacylglycerol kinase alpha | P17252 | PRKCA | Protein kinase C alpha type | -0.707 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P30281 | CCND3 | G1/S-specific cyclin-D3 | 0.743 |
|
| alpha-Tocopherol-succinate | hsa04210 | Apoptosis | 1.67E-02 | 3 | Q14790, P48023, P42575 | CASP8, FASLG, CASP2 | More | |
| alpha-Tocopherol-succinate | hsa04215 | Apoptosis - multiple species | 1.56E-02 | 2 | Q13489, P10415 | BIRC3, BCL2 | More | |
| alpha-Tocopherol-succinate | hsa04217 | Necroptosis | 2.06E-06 | 13 | P01568, Q13489, Q9NQC7, P42224, P07900, P08238, P15104, P01584, Q6FI13, P10415, Q9H444, O43633, Q08752 | IFNA21, BIRC3, CYLD, STAT1, HSP90AA1, HSP90AB1, GLUL, IL1B, H2AC18; H2AC19, BCL2, CHMP4B, CHMP2A, PPID | More | |
| alpha-Tocopherol-succinate | hsa04218 | Cellular senescence | 3.65E-03 | 2 | P31751, P0DP23 | AKT2, CALM1 | More | |
| alpha-Tocopherol-succinate | hsa04261 | Adrenergic signaling in cardiomyocytes | 4.86E-05 | 10 | P09493, P67936, P63092, P31751, Q13362, Q14738, P0DP23, P17252, P10415, P23634 | TPM1, TPM4, GNAS, AKT2, PPP2R5C, PPP2R5D, CALM1, PRKCA, BCL2, ATP2B4 | More | |
| alpha-Tocopherol-succinate | hsa04310 | Wnt signaling pathway | 1.79E-02 | 2 | P17612, P67870 | PRKACA, CSNK2B | More | |
| alpha-Tocopherol-succinate | hsa04330 | Notch signaling pathway | 3.98E-03 | 3 | Q92542, P49768, P46531 | NCSTN, PSEN1, NOTCH1 | More | |
| alpha-Tocopherol-succinate | hsa04340 | Hedgehog signaling pathway | 3.91E-02 | 1 | P17612 | PRKACA | More | |
| alpha-Tocopherol-succinate | hsa04360 | Axon guidance | 3.34E-03 | 8 | P16333, P20827, O95631, P42338, P07332, P19174, O14639, P24844 | NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1, ABLIM1, MYL9 | More | |
| alpha-Tocopherol-succinate | hsa04370 | VEGF signaling pathway | 7.26E-03 | 3 | P19174, P31751, P17252 | PLCG1, AKT2, PRKCA | More | |
| alpha-Tocopherol-succinate | hsa04371 | Apelin signaling pathway | 1.27E-04 | 10 | P63218, P50151, Q8WYR1, P31751, Q14814, Q14344, Q13485, P84022, Q16566, P0DP23 | GNG5, GNG10, PIK3R5, AKT2, MEF2D, GNA13, SMAD4, SMAD3, CAMK4, CALM1 | More | |
| alpha-Tocopherol-succinate | hsa04380 | Osteoclast differentiation | 2.11E-03 | 2 | Q9NQC7, P31751 | CYLD, AKT2 | More | |
| alpha-Tocopherol-succinate | hsa04390 | Hippo signaling pathway | 2.08E-02 | 3 | P84022, Q13485, Q13489 | SMAD3, SMAD4, BIRC3 | More | |
| alpha-Tocopherol-succinate | hsa04512 | ECM-receptor interaction | 3.73E-02 | 2 | P07359, P08514 | GP1BA, ITGA2B | More | |
| alpha-Tocopherol-succinate | hsa04514 | Cell adhesion molecules | 8.19E-03 | 3 | P16109, P56750, O00501 | SELP, CLDN17, CLDN5 | More | |
| alpha-Tocopherol-succinate | hsa04530 | Tight junction | 1.38E-04 | 5 | Q8TEU7, P16989, P56750, O00501, Q14247 | RAPGEF6, CSDA, CLDN17, CLDN5, CTTN | More | |
| alpha-Tocopherol-succinate | hsa04540 | Gap junction | 1.73E-05 | 6 | P17252, Q13509, P68371, Q71U36, Q9NRA1, Q14643 | PRKCA, TUBB3, TUBB2C, TUBA1A, PDGFC, ITPR1 | More | |
| alpha-Tocopherol-succinate | hsa04610 | Complement and coagulation cascades | 5.66E-04 | 4 | P25116, P01042, P09871, P11215 | F2R, KNG1, C1S, ITGAM | More | |
| alpha-Tocopherol-succinate | hsa04611 | Platelet activation | 4.98E-07 | 9 | P25116, Q7LDG7, Q9Y490, P08514, Q15746, Q8WYR1, P63092, P17612, P07359 | F2R, RASGRP2, TLN1, ITGA2B, MYLK, PIK3R5, GNAS, PRKACA, GP1BA | More | |
| alpha-Tocopherol-succinate | hsa04612 | Antigen processing and presentation | 7.18E-04 | 11 | P13765, P48382, P26715, P26717, Q13241, P01732, P30101, P27824, P08238, P11142, P01375 | HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A, PDIA3, CANX, HSP90AB1, HSPA8, TNF | More | |
| alpha-Tocopherol-succinate | hsa04613 | Neutrophil extracellular trap formation | 2.60E-04 | 19 | P17252, P16109, O60603, P05164, P08246, Q9UM07, Q6FI13, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P08514, P21462, P07359 | PRKCA, SELP, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA | More | |
| alpha-Tocopherol-succinate | hsa04620 | Toll-like receptor signaling pathway | 4.78E-02 | 1 | P31751 | AKT2 | More | |
| alpha-Tocopherol-succinate | hsa04621 | NOD-like receptor signaling pathway | 2.92E-02 | 3 | P01584, P07900, P43490 | IL1B, HSP90AA1, PBEF1 | More | |
| alpha-Tocopherol-succinate | hsa04622 | RIG-I-like receptor signaling pathway | 8.23E-05 | 3 | Q9NQC7, Q12933, P10145 | CYLD, TRAF2, IL8 | More | |
| alpha-Tocopherol-succinate | hsa04625 | C-type lectin receptor signaling pathway | 1.38E-05 | 3 | Q9NQC7, P31751, P0DP23 | CYLD, AKT2, CALM1 | More | |
| alpha-Tocopherol-succinate | hsa04650 | Natural killer cell mediated cytotoxicity | 3.02E-04 | 13 | P19174, P04141, P01375, P17252, O60880, P20963, P29350, P01568, Q13241, P26718, O75015, P26717, P26715 | PLCG1, CSF2, TNF, PRKCA, SH2D1A, CD247, PTPN6, IFNA21, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1 | More | |
| alpha-Tocopherol-succinate | hsa04657 | IL-17 signaling pathway | 3.33E-03 | 7 | P07900, O00463, P09341, P14780, P80188, P01375, P01584 | HSP90AA1, TRAF5, CXCL1, MMP9, LCN2, TNF, IL1B | More | |
| alpha-Tocopherol-succinate | hsa04658 | Th1 and Th2 cell differentiation | 1.26E-02 | 6 | Q04759, P20963, Q14765, P23771, Q9UL17, P13765 | PRKCQ, CD247, STAT4, GATA3, TBX21, HLA-DOB | More | |
| alpha-Tocopherol-succinate | hsa04659 | Th17 cell differentiation | 2.08E-03 | 8 | P25963, P19174, P14784, P14778, P84022, Q13485, P08238, P07766 | NFKBIA, PLCG1, IL2RB, IL1R1, SMAD3, SMAD4, HSP90AB1, CD3E | More | |
| alpha-Tocopherol-succinate | hsa04660 | T cell receptor signaling pathway | 5.84E-03 | 8 | P01375, Q04759, P10747, O95267, Q08881, P20963, P01732, Q13191 | TNF, PRKCQ, CD28, RASGRP1, ITK, CD247, CD8A, CBLB | More | |
| alpha-Tocopherol-succinate | hsa04662 | B cell receptor signaling pathway | 1.65E-04 | 6 | P31751, P42338, P60033, P07948, P21854, Q8N149 | AKT2, PIK3CB, CD81, LYN, CD72, LILRA2 | More | |
| alpha-Tocopherol-succinate | hsa04664 | Fc epsilon RI signaling pathway | 9.01E-06 | 7 | P31751, P04141, P42338, P17252, P07948, P19174, P09917 | AKT2, CSF2, PIK3CB, PRKCA, LYN, PLCG1, ALOX5 | More | |
| alpha-Tocopherol-succinate | hsa04666 | Fc gamma R-mediated phagocytosis | 4.10E-02 | 3 | P19174, P14598, P17252 | PLCG1, NCF1, PRKCA | More | |
| alpha-Tocopherol-succinate | hsa04672 | Intestinal immune network for IgA production | 3.76E-03 | 3 | P29965, P10747, P13765 | CD40LG, CD28, HLA-DOB | More | |
| alpha-Tocopherol-succinate | hsa04710 | Circadian rhythm | 1.44E-03 | 3 | O15516, Q16526, Q9Y478 | CLOCK, CRY1, PRKAB1 | More | |
| alpha-Tocopherol-succinate | hsa04713 | Circadian entrainment | 2.60E-02 | 4 | P0DP23, P17252, P62873, Q14643 | CALM1, PRKCA, GNB1, ITPR1 | More | |
| alpha-Tocopherol-succinate | hsa04720 | Long-term potentiation | 1.69E-03 | 5 | P17252, Q16566, P0DP23, O15399, Q14643 | PRKCA, CAMK4, CALM1, GRIN2D, ITPR1 | More | |
| alpha-Tocopherol-succinate | hsa04722 | Neurotrophin signaling pathway | 2.83E-03 | 2 | P31751, P0DP23 | AKT2, CALM1 | More | |
| alpha-Tocopherol-succinate | hsa04723 | Retrograde endocannabinoid signaling | 1.88E-02 | 4 | Q14643, P17252, P62873, Q16718 | ITPR1, PRKCA, GNB1, NDUFA5 | More | |
| alpha-Tocopherol-succinate | hsa04724 | Glutamatergic synapse | 4.31E-03 | 5 | O15399, P17252, P62873, P63218, Q9NSB8 | GRIN2D, PRKCA, GNB1, GNG5, HOMER2 | More | |
| alpha-Tocopherol-succinate | hsa04725 | Cholinergic synapse | 1.88E-02 | 4 | Q14643, P17252, P62873, P10415 | ITPR1, PRKCA, GNB1, BCL2 | More | |
| alpha-Tocopherol-succinate | hsa04727 | GABAergic synapse | 3.63E-02 | 2 | P50151, P15104 | GNG10, GLUL | More | |
| alpha-Tocopherol-succinate | hsa04728 | Dopaminergic synapse | 9.61E-05 | 8 | P63092, Q14643, P17252, P62873, P31751, Q13362, Q14738, P0DP23 | GNAS, ITPR1, PRKCA, GNB1, AKT2, PPP2R5C, PPP2R5D, CALM1 | More | |
| alpha-Tocopherol-succinate | hsa04740 | Olfactory transduction | 5.24E-03 | 2 | P62873, P0DP23 | GNB1, CALM1 | More | |
| alpha-Tocopherol-succinate | hsa04742 | Taste transduction | 3.91E-02 | 1 | P17612 | PRKACA | More | |
| alpha-Tocopherol-succinate | hsa04744 | Phototransduction | 1.84E-05 | 2 | P62873, P0DP23 | GNB1, CALM1 | More | |
| alpha-Tocopherol-succinate | hsa04750 | Inflammatory mediator regulation of TRP channels | 8.43E-03 | 4 | P19174, P17252, P0DP23, P01042 | PLCG1, PRKCA, CALM1, KNG1 | More | |
| alpha-Tocopherol-succinate | hsa04810 | Regulation of actin cytoskeleton | 1.16E-03 | 7 | Q15746, P08514, P11215, P16144, Q9NRA1, P25116, P01042 | MYLK, ITGA2B, ITGAM, ITGB4, PDGFC, F2R, KNG1 | More | |
| alpha-Tocopherol-succinate | hsa04910 | Insulin signaling pathway | 9.82E-04 | 2 | P0DP23, P31751 | CALM1, AKT2 | More | |
| alpha-Tocopherol-succinate | hsa04912 | GnRH signaling pathway | 3.89E-02 | 3 | P17252, Q14643, P0DP23 | PRKCA, ITPR1, CALM1 | More | |
| alpha-Tocopherol-succinate | hsa04915 | Estrogen signaling pathway | 5.07E-03 | 2 | P31751, P0DP23 | AKT2, CALM1 | More | |
| alpha-Tocopherol-succinate | hsa04916 | Melanogenesis | 4.78E-02 | 1 | P0DP23 | CALM1 | More | |
| alpha-Tocopherol-succinate | hsa04917 | Prolactin signaling pathway | 2.41E-02 | 1 | P31751 | AKT2 | More | |
| alpha-Tocopherol-succinate | hsa04920 | Adipocytokine signaling pathway | 6.13E-03 | 3 | Q9Y478, Q96RR4, P31751 | PRKAB1, CAMKK2, AKT2 | More | |
| alpha-Tocopherol-succinate | hsa04922 | Glucagon signaling pathway | 2.33E-03 | 5 | Q12778, P31751, Q13370, P0DP23, Q14643 | FOXO1, AKT2, PDE3B, CALM1, ITPR1 | More | |
| alpha-Tocopherol-succinate | hsa04923 | Regulation of lipolysis in adipocytes | 3.01E-02 | 1 | P31751 | AKT2 | More | |
| alpha-Tocopherol-succinate | hsa04924 | Renin secretion | 8.42E-06 | 5 | P22694, P07550, Q14643, Q13370, P0DP23 | PRKACB, ADRB2, ITPR1, PDE3B, CALM1 | More | |
| alpha-Tocopherol-succinate | hsa04925 | Aldosterone synthesis and secretion | 3.44E-02 | 3 | P0DP23, Q16566, P23634 | CALM1, CAMK4, ATP2B4 | More | |
| alpha-Tocopherol-succinate | hsa04926 | Relaxin signaling pathway | 2.59E-02 | 3 | P42338, P50151, P49407 | PIK3CB, GNG10, ARRB1 | More | |
| alpha-Tocopherol-succinate | hsa04929 | GnRH secretion | 6.70E-04 | 3 | P42338, P31751, P49407 | PIK3CB, AKT2, ARRB1 | More | |
| alpha-Tocopherol-succinate | hsa04930 | Type II diabetes mellitus | 2.47E-02 | 1 | Q02156 | PRKCE | More | |
| alpha-Tocopherol-succinate | hsa04932 | Non-alcoholic fatty liver disease | 2.26E-03 | 5 | Q14790, P48023, P01584, P12074, O15239 | CASP8, FASLG, IL1B, COX6A1, NDUFA1 | More | |
| alpha-Tocopherol-succinate | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 5.04E-06 | 9 | P84022, Q13485, P42224, P10415, P42338, Q12778, P49767, P17252, P19174 | SMAD3, SMAD4, STAT1, BCL2, PIK3CB, FOXO1, VEGFC, PRKCA, PLCG1 | More | |
| alpha-Tocopherol-succinate | hsa04940 | Type I diabetes mellitus | 1.55E-02 | 3 | P10747, P13765, P01375 | CD28, HLA-DOB, TNF | More | |
| alpha-Tocopherol-succinate | hsa04960 | Aldosterone-regulated sodium reabsorption | 4.40E-02 | 1 | O00141 | SGK | More | |
| alpha-Tocopherol-succinate | hsa04961 | Endocrine and other factor-regulated calcium reabsorption | 2.76E-02 | 2 | P23634, P63092 | ATP2B4, GNAS | More | |
| alpha-Tocopherol-succinate | hsa04966 | Collecting duct acid secretion | 2.86E-02 | 2 | Q13488, Q9Y666 | TCIRG1, SLC12A7 | More | |
| alpha-Tocopherol-succinate | hsa04970 | Salivary secretion | 3.70E-03 | 5 | P07550, P22694, Q14643, P0DP23, P49913 | ADRB2, PRKACB, ITPR1, CALM1, CAMP | More | |
| alpha-Tocopherol-succinate | hsa04971 | Gastric acid secretion | 4.78E-02 | 1 | P0DP23 | CALM1 | More | |
| alpha-Tocopherol-succinate | hsa04973 | Carbohydrate digestion and absorption | 2.41E-02 | 1 | P31751 | AKT2 | More | |
| alpha-Tocopherol-succinate | hsa04974 | Protein digestion and absorption | 2.47E-02 | 1 | Q7Z2H8 | SLC36A1 | More | |
| alpha-Tocopherol-succinate | hsa04975 | Fat digestion and absorption | 3.43E-02 | 1 | O14494 | PLPP1 | More | |
| alpha-Tocopherol-succinate | hsa04976 | Bile secretion | 4.50E-02 | 1 | Q9BY07 | SLC4A5 | More | |
| alpha-Tocopherol-succinate | hsa05010 | Alzheimer disease | 5.74E-04 | 16 | P49768, Q92542, O15239, Q16718, O14521, P05496, Q14643, Q00535, P0DP23, Q12933, Q13509, P68371, O15169, P31751, Q08752, P43686 | PSEN1, NCSTN, NDUFA1, NDUFA5, SDHD, ATP5G1, ITPR1, CDK5, CALM1, TRAF2, TUBB3, TUBB2C, AXIN1, AKT2, PPID, PSMC4 | More | |
| alpha-Tocopherol-succinate | hsa05012 | Parkinson disease | 1.44E-03 | 8 | Q16718, O14521, Q14643, P19174, P0DP23, Q71U36, Q13509, P68371 | NDUFA5, SDHD, ITPR1, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2C | More | |
| alpha-Tocopherol-succinate | hsa05020 | Prion disease | 1.23E-03 | 9 | P11142, Q16718, O14521, Q14643, Q71U36, Q13509, P68371, P14598, Q15080 | HSPA8, NDUFA5, SDHD, ITPR1, TUBA1A, TUBB3, TUBB2C, NCF1, NCF4 | More | |
| alpha-Tocopherol-succinate | hsa05022 | Pathways of neurodegeneration - multiple diseases | 3.42E-04 | 13 | Q14643, Q71U36, Q13509, P68371, P10415, Q16718, O14521, Q13561, P19174, P17252, Q00535, Q08752, P0DP23 | ITPR1, TUBA1A, TUBB3, TUBB2C, BCL2, NDUFA5, SDHD, DCTN2, PLCG1, PRKCA, CDK5, PPID, CALM1 | More | |
| alpha-Tocopherol-succinate | hsa05030 | Cocaine addiction | 4.19E-02 | 1 | Q00535 | CDK5 | More | |
| alpha-Tocopherol-succinate | hsa05031 | Amphetamine addiction | 4.78E-02 | 1 | P0DP23 | CALM1 | More | |
| alpha-Tocopherol-succinate | hsa05034 | Alcoholism | 1.05E-02 | 6 | O15399, Q16566, P0DP23, P63218, O60814, P68431 | GRIN2D, CAMK4, CALM1, GNG5, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | |
| alpha-Tocopherol-succinate | hsa05110 | Vibrio cholerae infection | 2.81E-04 | 3 | Q99437, P63092, P17612 | ATP6V0B, GNAS, PRKACA | More | |
| alpha-Tocopherol-succinate | hsa05130 | Pathogenic Escherichia coli infection | 2.48E-04 | 9 | Q71U36, Q14247, P56750, O00501, P16333, Q13509, P68371, P25116, P29350 | TUBA1A, CTTN, CLDN17, CLDN5, NCK1, TUBB3, TUBB2C, F2R, PTPN6 | More | |
| alpha-Tocopherol-succinate | hsa05131 | Shigellosis | 3.33E-03 | 10 | Q12933, P68431, Q02156, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752 | TRAF2, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, PRKCE, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPID | More | |
| alpha-Tocopherol-succinate | hsa05132 | Salmonella infection | 8.60E-04 | 9 | P25963, Q9UJU2, Q13489, P10415, O60603, Q9BQS8, Q13561, Q13509, P68371 | NFKBIA, LEF1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C | More | |
| alpha-Tocopherol-succinate | hsa05133 | Pertussis | 1.08E-04 | 5 | P11215, P0DP23, P23528, P09871, Q02556 | ITGAM, CALM1, CFL1, C1S, IRF8 | More | |
| alpha-Tocopherol-succinate | hsa05134 | Legionellosis | 1.49E-02 | 2 | Q9NR31, P0DMV8 | SAR1A, HSPA1A | More | |
| alpha-Tocopherol-succinate | hsa05140 | Leishmaniasis | 1.27E-04 | 7 | P14598, P11215, P42224, P13765, O60603, P29350, Q15080 | NCF1, ITGAM, STAT1, HLA-DOB, TLR2, PTPN6, NCF4 | More | |
| alpha-Tocopherol-succinate | hsa05142 | Chagas disease | 2.70E-02 | 2 | P48023, Q14790 | FASLG, CASP8 | More | |
| alpha-Tocopherol-succinate | hsa05145 | Toxoplasmosis | 1.02E-03 | 7 | P25963, P10415, Q13489, P42224, P13765, O60603, P29965 | NFKBIA, BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LG | More | |
| alpha-Tocopherol-succinate | hsa05146 | Amoebiasis | 4.92E-02 | 5 | P09341, P01375, P05089, P22694, P08311 | CXCL1, TNF, ARG1, PRKACB, CTSG | More | |
| alpha-Tocopherol-succinate | hsa05150 | Staphylococcus aureus infection | 2.66E-03 | 6 | P21730, P21462, O75015, P13765, P12838, P49913 | C5AR1, FPR1, FCGR3B, HLA-DOB, DEFA4, CAMP | More | |
| alpha-Tocopherol-succinate | hsa05152 | Tuberculosis | 3.87E-04 | 9 | Q13488, P0DP23, P42224, O60603, P31751, P10415, P13765, P01568, Q9UDY8 | TCIRG1, CALM1, STAT1, TLR2, AKT2, BCL2, HLA-DOB, IFNA21, MALT1 | More | |
| alpha-Tocopherol-succinate | hsa05161 | Hepatitis B | 8.49E-03 | 4 | P25963, Q13485, P10415, P84022 | NFKBIA, SMAD4, BCL2, SMAD3 | More | |
| alpha-Tocopherol-succinate | hsa05162 | Measles | 4.65E-02 | 2 | P23458, P0DMV8 | JAK1, HSPA1A | More | |
| alpha-Tocopherol-succinate | hsa05163 | Human cytomegalovirus infection | 1.01E-02 | 6 | P31751, P62873, P0DP23, P17252, P30101, P01568 | AKT2, GNB1, CALM1, PRKCA, PDIA3, IFNA21 | More | |
| alpha-Tocopherol-succinate | hsa05165 | Human papillomavirus infection | 3.56E-03 | 14 | P16144, P26012, Q05086, P46531, P49768, P01568, P42224, Q13488, Q99437, P63092, Q13362, Q12778, O15169, Q13315 | ITGB4, ITGB8, UBE3A, NOTCH1, PSEN1, IFNA21, STAT1, TCIRG1, ATP6V0B, GNAS, PPP2R5C, FOXO1, AXIN1, ATM | More | |
| alpha-Tocopherol-succinate | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 1.55E-04 | 9 | P01568, P31751, P42224, P62873, P19174, Q14643, P04141, P0DP23, Q9UJU2 | IFNA21, AKT2, STAT1, GNB1, PLCG1, ITPR1, CSF2, CALM1, LEF1 | More | |
| alpha-Tocopherol-succinate | hsa05170 | Human immunodeficiency virus 1 infection | 3.45E-05 | 12 | P31751, P62873, P0DP23, P17252, P30101, Q14643, P01568, O60603, Q13315, P19174, P10415, Q9Y6Q5 | AKT2, GNB1, CALM1, PRKCA, PDIA3, ITPR1, IFNA21, TLR2, ATM, PLCG1, BCL2, AP1M2 | More | |
| alpha-Tocopherol-succinate | hsa05171 | Coronavirus disease - COVID-19 | 9.31E-04 | 12 | P01584, P42224, P01568, P62753, P36578, P62888, P61927, P61513, P62829, P04141, P19174, P17252 | IL1B, STAT1, IFNA21, RPS6, RPL4, RPL30, RPL37, RPL37A, RPL23, CSF2, PLCG1, PRKCA | More | |
| alpha-Tocopherol-succinate | hsa05200 | Pathways in cancer | 9.61E-07 | 31 | Q13751, P42338, P08238, P42224, P19174, Q9UJU2, P17252, P43246, P84022, Q13485, Q13547, P14923, P30281, P10415, Q13489, P49767, Q12778, P31751, P43657, P25116, P62873, P63218, P50151, Q14344, Q7LDG7, P78417, O75293, P0DP23, P01568, P14784, P01042 | LAMB3, PIK3CB, HSP90AB1, STAT1, PLCG1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, HDAC1, JUP, CCND3, BCL2, BIRC3, VEGFC, FOXO1, AKT2, P2RY5, F2R, GNB1, GNG5, GNG10, GNA13, RASGRP2, GSTO1, GADD45B, CALM1, IFNA21, IL2RB, KNG1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13751 | LAMB3 | Laminin subunit beta-3 | 0.844 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | | P23743 | DGKA | Diacylglycerol kinase alpha | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.927 | | P17252 | PRKCA | Protein kinase C alpha type | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | -0.706 | | P23743 | DGKA | Diacylglycerol kinase alpha | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.78 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | | P23743 | DGKA | Diacylglycerol kinase alpha | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.851 | | P17252 | PRKCA | Protein kinase C alpha type | Q9UJU2 | LEF1 | Lymphoid enhancer-binding factor 1 | 0.881 | | P17252 | PRKCA | Protein kinase C alpha type | P17252 | PRKCA | Protein kinase C alpha type | 1 | | P23743 | DGKA | Diacylglycerol kinase alpha | P17252 | PRKCA | Protein kinase C alpha type | -0.707 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43246 | MSH2 | DNA mismatch repair protein Msh2 | -0.811 | | P23743 | DGKA | Diacylglycerol kinase alpha | P43246 | MSH2 | DNA mismatch repair protein Msh2 | 0.791 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.725 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.746 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.754 | | P17252 | PRKCA | Protein kinase C alpha type | P14923 | JUP | Junction plakoglobin | 0.761 | | P23743 | DGKA | Diacylglycerol kinase alpha | P14923 | JUP | Junction plakoglobin | -0.727 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P30281 | CCND3 | G1/S-specific cyclin-D3 | 0.743 | | P17252 | PRKCA | Protein kinase C alpha type | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.844 | | P17252 | PRKCA | Protein kinase C alpha type | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | 0.849 | | P23743 | DGKA | Diacylglycerol kinase alpha | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.725 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P49767 | VEGFC | Vascular endothelial growth factor C | 0.743 | | P17252 | PRKCA | Protein kinase C alpha type | P49767 | VEGFC | Vascular endothelial growth factor C | 0.719 | | P23743 | DGKA | Diacylglycerol kinase alpha | P49767 | VEGFC | Vascular endothelial growth factor C | -0.774 | | P17252 | PRKCA | Protein kinase C alpha type | Q12778 | FOXO1 | Forkhead box protein O1 | 0.863 | | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | 1 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | -0.735 | | P17252 | PRKCA | Protein kinase C alpha type | P25116 | F2R | Proteinase-activated receptor 1 | 0.857 | | P23743 | DGKA | Diacylglycerol kinase alpha | P25116 | F2R | Proteinase-activated receptor 1 | -0.73 | | P17252 | PRKCA | Protein kinase C alpha type | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.852 | | P23743 | DGKA | Diacylglycerol kinase alpha | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.815 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | 0.87 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | | P23743 | DGKA | Diacylglycerol kinase alpha | P78417 | GSTO1 | Glutathione S-transferase omega-1 | -0.784 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | 0.731 | | P17252 | PRKCA | Protein kinase C alpha type | P0DP23 | CALM1 | Calmodulin-1 | -0.776 | | P23743 | DGKA | Diacylglycerol kinase alpha | P0DP23 | CALM1 | Calmodulin-1 | 0.829 | | P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | P0DP23 | CALM1 | Calmodulin-1 | 0.761 | | P17252 | PRKCA | Protein kinase C alpha type | P01568 | IFNA21 | Interferon alpha-21 | 0.733 | | P23743 | DGKA | Diacylglycerol kinase alpha | P01568 | IFNA21 | Interferon alpha-21 | -0.772 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | | P23743 | DGKA | Diacylglycerol kinase alpha | P01042 | KNG1 | Kininogen-1 | -0.73 |
|
| alpha-Tocopherol-succinate | hsa05202 | Transcriptional misregulation in cancer | 3.18E-03 | 11 | Q12778, Q13315, P41732, P14780, Q15744, Q16548, P35226, P05164, P12838, P08246, Q9C0K0 | FOXO1, ATM, TSPAN7, MMP9, CEBPE, BCL2A1, BMI1, MPO, DEFA4, ELA2, BCL11B | More | |
| alpha-Tocopherol-succinate | hsa05204 | Chemical carcinogenesis | 4.92E-02 | 2 | P78417, P11712 | GSTO1, CYP2C9 | More | |
| alpha-Tocopherol-succinate | hsa05210 | Colorectal cancer | 1.78E-02 | 3 | P84022, Q13485, P10415 | SMAD3, SMAD4, BCL2 | More | |
| alpha-Tocopherol-succinate | hsa05211 | Renal cell carcinoma | 4.78E-02 | 1 | P31751 | AKT2 | More | |
| alpha-Tocopherol-succinate | hsa05212 | Pancreatic cancer | 1.11E-03 | 5 | P42338, P31751, P84022, Q13485, O75293 | PIK3CB, AKT2, SMAD3, SMAD4, GADD45B | More | |
| alpha-Tocopherol-succinate | hsa05213 | Endometrial cancer | 3.60E-02 | 1 | P31751 | AKT2 | More | |
| alpha-Tocopherol-succinate | hsa05214 | Glioma | 3.74E-04 | 4 | P0DP23, P17252, P31751, P19174 | CALM1, PRKCA, AKT2, PLCG1 | More | |
| alpha-Tocopherol-succinate | hsa05218 | Melanoma | 3.01E-02 | 1 | P31751 | AKT2 | More | |
| alpha-Tocopherol-succinate | hsa05220 | Chronic myeloid leukemia | 1.98E-04 | 7 | Q13547, Q13485, P25963, P84022, P31751, P42338, O75293 | HDAC1, SMAD4, NFKBIA, SMAD3, AKT2, PIK3CB, GADD45B | More | |
| alpha-Tocopherol-succinate | hsa05221 | Acute myeloid leukemia | 4.79E-03 | 4 | P14923, P31751, P11215, P04141 | JUP, AKT2, ITGAM, CSF2 | More | |
| alpha-Tocopherol-succinate | hsa05222 | Small cell lung cancer | 1.36E-03 | 4 | P31751, Q13489, P10415, P25963 | AKT2, BIRC3, BCL2, NFKBIA | More | |
| alpha-Tocopherol-succinate | hsa05223 | Non-small cell lung cancer | 2.41E-02 | 1 | P31751 | AKT2 | More | |
| alpha-Tocopherol-succinate | hsa05226 | Gastric cancer | 1.86E-03 | 4 | P31751, P84022, Q13485, P10415 | AKT2, SMAD3, SMAD4, BCL2 | More | |
| alpha-Tocopherol-succinate | hsa05230 | Central carbon metabolism in cancer | 4.78E-02 | 1 | P31751 | AKT2 | More | |
| alpha-Tocopherol-succinate | hsa05231 | Choline metabolism in cancer | 4.97E-04 | 6 | Q9NRA1, Q9Y259, P19174, P23743, P49619, P17252 | PDGFC, CHKB, PLCG1, DGKA, DGKG, PRKCA | More | |
| alpha-Tocopherol-succinate | hsa05310 | Asthma | 6.83E-03 | 3 | P13765, P12724, P01375 | HLA-DOB, RNASE3, TNF | More | |
| alpha-Tocopherol-succinate | hsa05320 | Autoimmune thyroid disease | 1.27E-03 | 4 | P13765, P29965, P01568, P10747 | HLA-DOB, CD40LG, IFNA21, CD28 | More | |
| alpha-Tocopherol-succinate | hsa05321 | Inflammatory bowel disease | 2.27E-03 | 5 | P01375, P13765, Q14765, Q9UL17, P23771 | TNF, HLA-DOB, STAT4, TBX21, GATA3 | More | |
| alpha-Tocopherol-succinate | hsa05322 | Systemic lupus erythematosus | 7.03E-04 | 10 | O75015, P08246, P08311, P09871, P01375, P10747, P13765, P29965, Q6FI13, P68431 | FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | |
| alpha-Tocopherol-succinate | hsa05323 | Rheumatoid arthritis | 8.71E-04 | 6 | P01375, P13765, Q13488, P10747, P09341, O60603 | TNF, HLA-DOB, TCIRG1, CD28, CXCL1, TLR2 | More | |
| alpha-Tocopherol-succinate | hsa05330 | Allograft rejection | 9.93E-04 | 4 | P13765, P29965, P10747, P01375 | HLA-DOB, CD40LG, CD28, TNF | More | |
| alpha-Tocopherol-succinate | hsa05332 | Graft-versus-host disease | 4.66E-04 | 5 | P13765, P10747, P01375, P26715, Q13241 | HLA-DOB, CD28, TNF, KLRC1, KLRD1 | More | |
| alpha-Tocopherol-succinate | hsa05415 | Diabetic cardiomyopathy | 3.55E-02 | 5 | P17252, P14598, Q15080, Q16718, O14521 | PRKCA, NCF1, NCF4, NDUFA5, SDHD | More | |
| alpha-Tocopherol-succinate | hsa05416 | Viral myocarditis | 2.62E-02 | 3 | P13765, P29965, P10747 | HLA-DOB, CD40LG, CD28 | More | |
| alpha-Tocopherol-succinate | hsa05418 | Fluid shear stress and atherosclerosis | 3.65E-03 | 2 | P31751, P0DP23 | AKT2, CALM1 | More | |
