PharmaCoNets of Alogliptin (SPCN: 46.74 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Alogliptinhsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Alogliptinhsa00270Cysteine and methionine metabolism1.92E-022Q96RQ9, P40926IL4I1, MDH2More
Alogliptinhsa00500Starch and sucrose metabolism6.17E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Alogliptinhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Alogliptinhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Alogliptinhsa00730Thiamine metabolism2.27E-022P05186, P24666ALPL, ACP1More
Alogliptinhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Alogliptinhsa00970Aminoacyl-tRNA biosynthesis2.12E-021P14868DARSMore
Alogliptinhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Alogliptinhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Alogliptinhsa012102-Oxocarboxylic acid metabolism3.43E-021P50213IDH3AMore
Alogliptinhsa03020RNA polymerase3.00E-023P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Alogliptinhsa03060Protein export4.42E-022P37108, Q15005SRP14, SPCS2More
Alogliptinhsa03450Non-homologous end-joining4.21E-021P13010XRCC5More
Alogliptinhsa04010MAPK signaling pathway4.76E-025Q15283, P21860, Q12933, P01584, O14944RASA2, ERBB3, TRAF2, IL1B, EREGMore
Alogliptinhsa04020Calcium signaling pathway3.61E-024Q96DU7, Q08828, Q13557, P21860ITPKC, ADCY1, CAMK2D, ERBB3More
Alogliptinhsa04064NF-kappa B signaling pathway2.35E-024P01584, P63279, Q8NHW4, Q9NQC7IL1B, UBE2I, CCL4L2, CYLDMore
Alogliptinhsa04070Phosphatidylinositol signaling system1.53E-022Q86XP1, Q96DU7DGKH, ITPKCMore
Alogliptinhsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Alogliptinhsa04141Protein processing in endoplasmic reticulum2.78E-023P07384, O95487, O95816CAPN1, SEC24B, BAG2More
Alogliptinhsa04142Lysosome1.46E-027P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2More
Alogliptinhsa04144Endocytosis1.67E-028P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q14161, Q9UMY4HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, GIT2, SNX12More
Alogliptinhsa04213Longevity regulating pathway - multiple species2.82E-023Q08828, P51828, P0DMV8ADCY1, ADCY7, HSPA1AMore
Alogliptinhsa04217Necroptosis2.34E-024P01375, P48023, Q14765, Q99878TNF, FASLG, STAT4, H2AC14More
Alogliptinhsa04270Vascular smooth muscle contraction9.46E-046P0DP23, Q08828, P51828, P35579, P35749, P35318CALM1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Alogliptinhsa04310Wnt signaling pathway1.79E-022P17612, P67870PRKACA, CSNK2BMore
Alogliptinhsa04340Hedgehog signaling pathway3.91E-021P17612PRKACAMore
Alogliptinhsa04360Axon guidance1.50E-023P20827, P23528, Q06124EFNA1, CFL1, PTPN11More
Alogliptinhsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Alogliptinhsa04530Tight junction1.74E-036P63261, P16989, P56750, Q9Y478, Q92974, Q14247ACTG1, CSDA, CLDN17, PRKAB1, ARHGEF2, CTTNMore
Alogliptinhsa04611Platelet activation2.12E-022Q9Y490, P17612TLN1, PRKACAMore
Alogliptinhsa04613Neutrophil extracellular trap formation1.73E-024Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Alogliptinhsa04623Cytosolic DNA-sensing pathway1.65E-022P01584, Q8NHW4IL1B, CCL4L2More
Alogliptinhsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Alogliptinhsa04657IL-17 signaling pathway1.36E-025O00463, Q16539, P49841, P14780, P01375TRAF5, MAPK14, GSK3B, MMP9, TNFMore
Alogliptinhsa04664Fc epsilon RI signaling pathway1.74E-034P01375, Q16539, Q9UQC2, P20292TNF, MAPK14, GAB2, ALOX5APMore
Alogliptinhsa04668TNF signaling pathway8.30E-049P01375, Q12933, O00463, Q16539, Q99941, P01584, P20749, P14780, O95429TNF, TRAF2, TRAF5, MAPK14, CREBL1, IL1B, BCL3, MMP9, BAG4More
Alogliptinhsa04713Circadian entrainment4.25E-023Q13557, Q02153, Q08828CAMK2D, GUCY1B3, ADCY1More
Alogliptinhsa04714Thermogenesis1.25E-023P15336, P63261, Q9Y478ATF2, ACTG1, PRKAB1More
Alogliptinhsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Alogliptinhsa04742Taste transduction3.91E-021P17612PRKACAMore
Alogliptinhsa04750Inflammatory mediator regulation of TRP channels4.23E-035P01584, Q08828, P51828, Q13557, P0DP23IL1B, ADCY1, ADCY7, CAMK2D, CALM1More
Alogliptinhsa04911Insulin secretion2.23E-023Q08828, Q99941, Q13557ADCY1, CREBL1, CAMK2DMore
Alogliptinhsa04915Estrogen signaling pathway3.17E-025Q08828, P51828, P0DMV8, P0DP23, Q15788ADCY1, ADCY7, HSPA1A, CALM1, NCOA1More
Alogliptinhsa04920Adipocytokine signaling pathway2.80E-022Q06124, Q9Y478PTPN11, PRKAB1More
Alogliptinhsa04932Non-alcoholic fatty liver disease1.04E-0411P01375, P49841, O43521, P48023, O75460, Q12933, P01584, P13073, P12074, O15239, O95298TNF, GSK3B, BCL2L11, FASLG, ERN1, TRAF2, IL1B, COX4I1, COX6A1, NDUFA1, NDUFC2More
Alogliptinhsa04934Cushing syndrome6.07E-034Q99941, Q08828, O15169, Q13557CREBL1, ADCY1, AXIN1, CAMK2DMore
Alogliptinhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Alogliptinhsa04962Vasopressin-regulated water reabsorption7.22E-032P52566, P62491ARHGDIB, RAB11AMore
Alogliptinhsa04970Salivary secretion4.78E-023Q08828, P51828, P0DP23ADCY1, ADCY7, CALM1More
Alogliptinhsa04976Bile secretion4.78E-023Q08828, P51828, Q14032ADCY1, ADCY7, BAATMore
Alogliptinhsa05010Alzheimer disease1.23E-028Q92542, O15239, P05496, P12074, P01584, Q12933, O15169, P43686NCSTN, NDUFA1, ATP5G1, COX6A1, IL1B, TRAF2, AXIN1, PSMC4More
Alogliptinhsa05012Parkinson disease3.53E-026P62987, O15239, P12074, P05496, P43686, Q13557UBA52, NDUFA1, COX6A1, ATP5G1, PSMC4, CAMK2DMore
Alogliptinhsa05014Amyotrophic lateral sclerosis2.99E-027O15239, P12074, P05496, Q12933, P43686, P37198, P35658NDUFA1, COX6A1, ATP5G1, TRAF2, PSMC4, NUP62, NUP214More
Alogliptinhsa05016Huntington disease2.46E-029O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12More
Alogliptinhsa05020Prion disease2.99E-027P01584, P46531, O15239, P05496, P12074, P43686, Q99941IL1B, NOTCH1, NDUFA1, ATP5G1, COX6A1, PSMC4, CREBL1More
Alogliptinhsa05022Pathways of neurodegeneration - multiple diseases9.10E-039O15239, P12074, P05496, Q12933, O15169, P01584, Q13557, P62987, P43686NDUFA1, COX6A1, ATP5G1, TRAF2, AXIN1, IL1B, CAMK2D, UBA52, PSMC4More
Alogliptinhsa05034Alcoholism1.96E-046Q96RR4, Q93077, P62807, O60814, P84243, P68431CAMKK2, HIST1H2AC, HIST1H2BC, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Alogliptinhsa05110Vibrio cholerae infection2.11E-032Q99437, P17612ATP6V0B, PRKACAMore
Alogliptinhsa05130Pathogenic Escherichia coli infection9.80E-034Q92974, P63261, Q06124, O95487ARHGEF2, ACTG1, PTPN11, SEC24BMore
Alogliptinhsa05134Legionellosis2.82E-023P01584, Q9NR31, P0DMV8IL1B, SAR1A, HSPA1AMore
Alogliptinhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Alogliptinhsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Alogliptinhsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Alogliptinhsa05163Human cytomegalovirus infection2.22E-0313P01375, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, O00463TNF, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, TRAF5More
Alogliptinhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Alogliptinhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Alogliptinhsa05211Renal cell carcinoma1.06E-022Q06124, Q99814PTPN11, EPAS1More
Alogliptinhsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Alogliptinhsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Alogliptinhsa05332Graft-versus-host disease3.70E-022P48023, P01375FASLG, TNFMore
Alogliptinhsa05418Fluid shear stress and atherosclerosis1.08E-037Q16539, Q14145, P10599, P14780, P01375, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Alogliptin (SDC: 5.50)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P09874PARP1Poly [ADPNoneribose] polymerase 1Predicted10.553610.44822.725
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
Q06124PTPN11TyrosineNoneprotein phosphatase nonNonereceptor type 11Predicted10.15130.45660.6131.6017
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
Q6V1X1DPP8Dipeptidyl peptidase 8Predicted00.28410.125900.3939
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P20292ALOX5APArachidonate 5NonelipoxygenaseNoneactivating proteinPredicted00.13030.24180.09070.6395
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)