PharmaCoNets of Alitretinoin (SPCN: 18.24 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Alitretinoinhsa00310Lysine degradation4.97E-022Q9NVH6, O15047TMLHE, SETD1AMore
Alitretinoinhsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Alitretinoinhsa00520Amino sugar and nucleotide sugar metabolism7.87E-033Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Alitretinoinhsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate2.03E-021Q9Y2C2USTMore
Alitretinoinhsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Alitretinoinhsa00561Glycerolipid metabolism7.73E-033Q8NEB5, P14550, Q86XP1PPAPDC1B, AKR1A1, DGKHMore
Alitretinoinhsa00591Linoleic acid metabolism4.96E-021P11712CYP2C9More
Alitretinoinhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series4.30E-032P06865, O75752HEXA, B3GALNT1More
Alitretinoinhsa00620Pyruvate metabolism4.97E-022P40926, P14550MDH2, AKR1A1More
Alitretinoinhsa00900Terpenoid backbone biosynthesis3.03E-031Q9UHG3PCYOX1More
Alitretinoinhsa00970Aminoacyl-tRNA biosynthesis3.78E-022O95363, Q15046FARS2, KARSMore
Alitretinoinhsa00980Metabolism of xenobiotics by cytochrome P4503.03E-031Q16772GSTA3More
Alitretinoinhsa00982Drug metabolism - cytochrome P4503.03E-031Q16772GSTA3More
Alitretinoinhsa00983Drug metabolism - other enzymes2.64E-035P04183, P20839, P32320, P05164, Q16772TK1, IMPDH1, CDA, MPO, GSTA3More
Alitretinoinhsa01240Biosynthesis of cofactors3.29E-022P13716, P14618ALAD, PKM2More
Alitretinoinhsa01522Endocrine resistance5.97E-034P14780, P22694, P10415, Q13323MMP9, PRKACB, BCL2, BIKMore
Alitretinoinhsa01524Platinum drug resistance1.79E-022O15392, P11388BIRC5, TOP2AMore
Alitretinoinhsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Alitretinoinhsa03040Spliceosome1.28E-0513O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Alitretinoinhsa03320PPAR signaling pathway3.78E-022Q6PCB7, Q9UNU6SLC27A1, CYP8B1More
Alitretinoinhsa04014Ras signaling pathway2.36E-028P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1More
Alitretinoinhsa04015Rap1 signaling pathway1.79E-028P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1More
Alitretinoinhsa04061Viral protein interaction with cytokine and cytokine receptor1.65E-025P09341, P19875, Q13651, P14784, P01375CXCL1, CXCL2, IL10RA, IL2RB, TNFMore
Alitretinoinhsa04062Chemokine signaling pathway9.23E-0310P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5More
Alitretinoinhsa04064NF-kappa B signaling pathway5.05E-0410P10415, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q13315, P24522, P09341BCL2, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, ATM, GADD45A, CXCL1More
Alitretinoinhsa04080Neuroactive ligand-receptor interaction4.90E-036P08311, Q15722, P21453, Q9H228, O00398, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, ADRB2More
Alitretinoinhsa04114Oocyte meiosis4.51E-035Q9Y6D9, P51812, Q02750, P16298, Q17RY0MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Alitretinoinhsa04120Ubiquitin mediated proteolysis3.92E-024Q969M7, Q86TM6, Q16763, O95071UBE2F, SYVN1, UBE2S, UBR5More
Alitretinoinhsa04130SNARE interactions in vesicular transport4.96E-021O15155BET1More
Alitretinoinhsa04137Mitophagy - animal2.73E-023Q96CV9, Q14596, P18848OPTN, NBR1, ATF4More
Alitretinoinhsa04140Autophagy - animal5.97E-034P22694, Q14643, P10415, Q04759PRKACB, ITPR1, BCL2, PRKCQMore
Alitretinoinhsa04142Lysosome4.41E-022P10619, P49281CTSA, SLC11A2More
Alitretinoinhsa04150mTOR signaling pathway1.59E-022P23588, P04628EIF4B, WNT1More
Alitretinoinhsa04151PI3K-Akt signaling pathway3.70E-0212P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3More
Alitretinoinhsa04210Apoptosis2.31E-028Q13315, P10415, P01375, P24522, Q16548, Q13077, P18848, Q14643ATM, BCL2, TNF, GADD45A, BCL2A1, TRAF1, ATF4, ITPR1More
Alitretinoinhsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Alitretinoinhsa04330Notch signaling pathway7.73E-033Q92542, P49768, P46531NCSTN, PSEN1, NOTCH1More
Alitretinoinhsa04340Hedgehog signaling pathway1.19E-033P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Alitretinoinhsa04360Axon guidance4.04E-026P16333, P20827, O95631, P42338, P07332, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1More
Alitretinoinhsa04370VEGF signaling pathway2.47E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Alitretinoinhsa04371Apelin signaling pathway1.00E-027P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3More
Alitretinoinhsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Alitretinoinhsa04540Gap junction2.86E-023P22694, P68371, Q14643PRKACB, TUBB2C, ITPR1More
Alitretinoinhsa04550Signaling pathways regulating pluripotency of stem cells4.41E-022P04628, Q02535WNT1, ID3More
Alitretinoinhsa04612Antigen processing and presentation5.03E-037P13765, P48382, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Alitretinoinhsa04613Neutrophil extracellular trap formation4.02E-029P05164, P08246, Q9UM07, Q15080, P20160, P08311, P49913, P21730, P21462MPO, ELA2, PADI4, NCF4, AZU1, CTSG, CAMP, C5AR1, FPR1More
Alitretinoinhsa04621NOD-like receptor signaling pathway2.31E-028Q14643, P43490, O00463, P10415, P01375, P09341, P49913, P12838ITPR1, PBEF1, TRAF5, BCL2, TNF, CXCL1, CAMP, DEFA4More
Alitretinoinhsa04622RIG-I-like receptor signaling pathway2.65E-022Q12933, P10145TRAF2, IL8More
Alitretinoinhsa04625C-type lectin receptor signaling pathway2.81E-025P20749, Q9UDY8, Q14643, P01375, Q13191BCL3, MALT1, ITPR1, TNF, CBLBMore
Alitretinoinhsa04650Natural killer cell mediated cytotoxicity2.12E-0613P16298, P50591, P01375, P06239, O60880, P20963, Q02750, Q13241, P26718, O14931, P26717, Q07444, P26715PPP3CB, TNFSF10, TNF, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, NCR3, KLRC2, KLRC3, KLRC1More
Alitretinoinhsa04657IL-17 signaling pathway4.73E-025O00463, P09341, P14780, P80188, P01375TRAF5, CXCL1, MMP9, LCN2, TNFMore
Alitretinoinhsa04658Th1 and Th2 cell differentiation2.82E-0610Q04759, P07766, P20963, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Alitretinoinhsa04659Th17 cell differentiation1.91E-0615P25963, Q04759, P19174, P06239, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P20963NFKBIA, PRKCQ, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD247More
Alitretinoinhsa04660T cell receptor signaling pathway6.24E-0510P01375, Q9UDY8, Q04759, O95267, Q08881, P07766, P20963, P01732, Q13191, P06239TNF, MALT1, PRKCQ, RASGRP1, ITK, CD3E, CD247, CD8A, CBLB, LCKMore
Alitretinoinhsa04662B cell receptor signaling pathway1.74E-025P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Alitretinoinhsa04664Fc epsilon RI signaling pathway2.47E-024P42338, P07948, P19174, P09917PIK3CB, LYN, PLCG1, ALOX5More
Alitretinoinhsa04668TNF signaling pathway5.03E-037P01375, O00463, P18848, P09341, P20749, Q13077, P14780TNF, TRAF5, ATF4, CXCL1, BCL3, TRAF1, MMP9More
Alitretinoinhsa04710Circadian rhythm1.67E-022Q16526, Q9Y478CRY1, PRKAB1More
Alitretinoinhsa04720Long-term potentiation2.35E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Alitretinoinhsa04725Cholinergic synapse3.47E-034P22694, Q14643, P18848, P10415PRKACB, ITPR1, ATF4, BCL2More
Alitretinoinhsa04727GABAergic synapse2.73E-023P63218, P50151, P28472GNG5, GNG10, GABRB3More
Alitretinoinhsa04913Ovarian steroidogenesis2.72E-022P42330, P22694AKR1C3, PRKACBMore
Alitretinoinhsa04914Progesterone-mediated oocyte maturation7.70E-034Q17RY0, Q9Y6D9, P51812, Q02750CPEB4, MAD1L1, RPS6KA3, MAP2K1More
Alitretinoinhsa04915Estrogen signaling pathway2.07E-025P14780, P22694, P18848, Q14643, P10415MMP9, PRKACB, ATF4, ITPR1, BCL2More
Alitretinoinhsa04918Thyroid hormone synthesis2.75E-023P22694, P18848, Q14643PRKACB, ATF4, ITPR1More
Alitretinoinhsa04920Adipocytokine signaling pathway4.31E-022Q9Y478, Q96RR4PRKAB1, CAMKK2More
Alitretinoinhsa04922Glucagon signaling pathway4.66E-022P14618, P06737PKM2, PYGLMore
Alitretinoinhsa04924Renin secretion3.09E-033P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Alitretinoinhsa04927Cortisol synthesis and secretion3.58E-043Q14643, P18848, P22694ITPR1, ATF4, PRKACBMore
Alitretinoinhsa04928Parathyroid hormone synthesis, secretion and action4.51E-045Q14643, P22694, P23771, P18848, P10415ITPR1, PRKACB, GATA3, ATF4, BCL2More
Alitretinoinhsa04933AGE-RAGE signaling pathway in diabetic complications2.11E-036P84022, Q13485, P10415, P42338, P49767, P19174SMAD3, SMAD4, BCL2, PIK3CB, VEGFC, PLCG1More
Alitretinoinhsa04934Cushing syndrome4.74E-023Q14643, P22694, P04628ITPR1, PRKACB, WNT1More
Alitretinoinhsa04970Salivary secretion2.11E-023P07550, P22694, Q14643ADRB2, PRKACB, ITPR1More
Alitretinoinhsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Alitretinoinhsa05034Alcoholism3.50E-024P62873, Q93077, O60814, P68431GNB1, HIST1H2AC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Alitretinoinhsa05132Salmonella infection2.04E-024P25963, Q13489, P10415, Q9BQS8NFKBIA, BIRC3, BCL2, FYCO1More
Alitretinoinhsa05134Legionellosis3.83E-023P01375, P09341, P19875TNF, CXCL1, CXCL2More
Alitretinoinhsa05135Yersinia infection2.58E-024Q05397, P51812, Q02750, Q96JJ3PTK2, RPS6KA3, MAP2K1, ELMO2More
Alitretinoinhsa05140Leishmaniasis3.39E-023P11215, P42224, P29350ITGAM, STAT1, PTPN6More
Alitretinoinhsa05142Chagas disease2.90E-024P01375, P30679, P07766, P20963TNF, GNA15, CD3E, CD247More
Alitretinoinhsa05144Malaria3.83E-023P60033, P01375, P26718CD81, TNF, KLRK1More
Alitretinoinhsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Alitretinoinhsa05146Amoebiasis9.40E-058P09341, P19875, P01375, P05089, P30679, P22694, P12814, P08311CXCL1, CXCL2, TNF, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Alitretinoinhsa05150Staphylococcus aureus infection1.47E-025P21730, P21462, P13765, P12838, P49913C5AR1, FPR1, HLA-DOB, DEFA4, CAMPMore
Alitretinoinhsa05152Tuberculosis4.32E-026P48382, P01375, P10415, P13765, P49913, Q9UDY8RFX5, TNF, BCL2, HLA-DOB, CAMP, MALT1More
Alitretinoinhsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Alitretinoinhsa05170Human immunodeficiency virus 1 infection4.37E-024Q02750, P62879, P16298, Q05397MAP2K1, GNB2, PPP3CB, PTK2More
Alitretinoinhsa05200Pathways in cancer9.46E-0317Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RBMore
Alitretinoinhsa05202Transcriptional misregulation in cancer2.51E-0210Q13315, P14780, Q15744, Q16548, Q13077, P05164, P12838, P08246, Q9C0K0, P24522ATM, MMP9, CEBPE, BCL2A1, TRAF1, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Alitretinoinhsa05204Chemical carcinogenesis3.03E-031Q16772GSTA3More
Alitretinoinhsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Alitretinoinhsa05212Pancreatic cancer4.45E-034P42338, P84022, Q13485, O75293PIK3CB, SMAD3, SMAD4, GADD45BMore
Alitretinoinhsa05220Chronic myeloid leukemia1.44E-036Q13547, Q13485, P25963, P84022, P42338, O75293HDAC1, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45BMore
Alitretinoinhsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Alitretinoinhsa05225Hepatocellular carcinoma1.21E-023P04628, Q92922, Q9NPI1WNT1, SMARCC1, BRD7More
Alitretinoinhsa05226Gastric cancer2.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Alitretinoinhsa05310Asthma5.45E-043P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Alitretinoinhsa05321Inflammatory bowel disease2.88E-066P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Alitretinoinhsa05322Systemic lupus erythematosus1.98E-024P29965, Q93077, O60814, P68431CD40LG, HIST1H2AC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Alitretinoinhsa05332Graft-versus-host disease5.67E-034P13765, P01375, P26715, Q13241HLA-DOB, TNF, KLRC1, KLRD1More
Alitretinoinhsa05418Fluid shear stress and atherosclerosis4.21E-032Q16772, P51636GSTA3, CAV2More

Community members of Alitretinoin (SDC: 1.61)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P10826RARBRetinoic acid receptor betaReported00.00940.34660.30050.9983
P21453S1PR1Sphingosine 1Nonephosphate receptor 1Predicted10.14340.38470.2211.0621
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P31997CEACAM8Carcinoembryonic antigenNonerelated cell adhesion molecule 8Predicted00.44580.003900.2307
P40199CEACAM6Carcinoembryonic antigenNonerelated cell adhesion molecule 6Predicted00.52180.003900.2687
Q13046PSG7Putative pregnancyNonespecific betaNone1Noneglycoprotein 7Predicted00.00110.00400.0086
Q16557PSG3PregnancyNonespecific betaNone1Noneglycoprotein 3Predicted00.15040.00400.0832
Q9UQ74PSG8PregnancyNonespecific betaNone1Noneglycoprotein 8Predicted00.10920.003900.0625
P11464PSG1PregnancyNonespecific betaNone1Noneglycoprotein 1Predicted00.17730.00400.0965
Q00887PSG9PregnancyNonespecific betaNone1Noneglycoprotein 9Predicted00.14390.003800.0796
P10588NR2F6Nuclear receptor subfamily 2 group F member 6Predicted00.39230.06800.3321
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
P18065IGFBP2InsulinNonelike growth factorNonebinding protein 2Predicted00.18190.002200.0953
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
RARBP10826IC507
RARBP10826Ki0.5
RARBP10826Ki0.7
RARBP10826Ki11
RARBP10826Kd7
RARBP10826Kd97
RARBP10826Kd100