PharmaCoNets of Alfentanil (SPCN: 19.67 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Alfentanilhsa00052Galactose metabolism1.06E-032P06280, O43451GLA, MGAMMore
Alfentanilhsa00071Fatty acid degradation4.66E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Alfentanilhsa00220Arginine biosynthesis1.43E-022P05089, P49448ARG1, GLUD2More
Alfentanilhsa00500Starch and sucrose metabolism8.89E-073O43451, P46976, P06737MGAM, GYG1, PYGLMore
Alfentanilhsa00730Thiamine metabolism2.92E-052P05186, P24666ALPL, ACP1More
Alfentanilhsa00770Pantothenate and CoA biosynthesis7.90E-033O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Alfentanilhsa00970Aminoacyl-tRNA biosynthesis1.58E-044O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Alfentanilhsa00983Drug metabolism - other enzymes2.44E-022P32320, P05164CDA, MPOMore
Alfentanilhsa03008Ribosome biogenesis in eukaryotes4.42E-023Q9NYH9, P78345, Q9BVP2UTP6, RPP38, GNL3More
Alfentanilhsa03013RNA transport2.29E-0413O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q14240, Q9Y6A5, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, EIF4A2, TACC3, FXR1More
Alfentanilhsa04062Chemokine signaling pathway3.93E-0310P25024, P25025, P47992, Q9UBD3, P07948, P63218, P50151, P49407, Q08881, P49841CXCR1, CXCR2, XCL1, XCL2, LYN, GNG5, GNG10, ARRB1, ITK, GSK3BMore
Alfentanilhsa04064NF-kappa B signaling pathway4.92E-026P10415, P51617, Q13546, Q9UDY8, Q13077, P24522BCL2, IRAK1, RIPK1, MALT1, TRAF1, GADD45AMore
Alfentanilhsa04070Phosphatidylinositol signaling system4.07E-024P0DP23, Q14643, O14732, P17252CALM1, ITPR1, IMPA2, PRKCAMore
Alfentanilhsa04071Sphingolipid signaling pathway1.82E-049P17252, Q9H228, P01375, Q13362, Q16537, Q9BX95, P04637, P10415, Q9UQC2PRKCA, EDG8, TNF, PPP2R5C, PPP2R5E, SGPP1, TP53, BCL2, GAB2More
Alfentanilhsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Alfentanilhsa04261Adrenergic signaling in cardiomyocytes3.44E-025Q16537, P0DP23, P17252, P10415, P20020PPP2R5E, CALM1, PRKCA, BCL2, ATP2B1More
Alfentanilhsa04340Hedgehog signaling pathway3.32E-022P49841, P22694GSK3B, PRKACBMore
Alfentanilhsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Alfentanilhsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Alfentanilhsa04612Antigen processing and presentation4.68E-048P13765, P48382, P26715, P26717, Q07444, Q13241, O43908, P01732HLA-DOB, RFX5, KLRC1, KLRC2, KLRC3, KLRD1, KLRC4, CD8AMore
Alfentanilhsa04613Neutrophil extracellular trap formation1.68E-029P17252, O60603, P08246, Q92769, Q6FI13, P33778, P14598, Q15080, P21462PRKCA, TLR2, ELA2, HDAC2, H2AC18; H2AC19, H2BC3, NCF1, NCF4, FPR1More
Alfentanilhsa04614Renin-angiotensin system1.52E-021P50052AGTR2More
Alfentanilhsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Alfentanilhsa04650Natural killer cell mediated cytotoxicity6.61E-0812P01375, P78314, P06239, O60880, P20963, Q13241, P26718, O14931, O75015, P26717, Q07444, P26715TNF, SH3BP2, LCK, SH2D1A, CD247, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC3, KLRC1More
Alfentanilhsa04657IL-17 signaling pathway1.27E-035O00463, Q16539, P49841, P14780, P01375TRAF5, MAPK14, GSK3B, MMP9, TNFMore
Alfentanilhsa04658Th1 and Th2 cell differentiation7.09E-057Q04759, P20963, P09693, P06239, P23771, Q9UL17, Q13761PRKCQ, CD247, CD3G, LCK, GATA3, TBX21, RUNX3More
Alfentanilhsa04659Th17 cell differentiation2.34E-036Q04759, P06239, Q9UL17, P23771, P09693, P20963PRKCQ, LCK, TBX21, GATA3, CD3G, CD247More
Alfentanilhsa04660T cell receptor signaling pathway1.12E-0511P01375, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Alfentanilhsa04664Fc epsilon RI signaling pathway3.98E-023P01375, Q16539, Q9UQC2TNF, MAPK14, GAB2More
Alfentanilhsa04666Fc gamma R-mediated phagocytosis2.22E-024P49006, P06396, P14598, P17252MARCKSL1, GSN, NCF1, PRKCAMore
Alfentanilhsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Alfentanilhsa04720Long-term potentiation4.42E-023P17252, P0DP23, Q14643PRKCA, CALM1, ITPR1More
Alfentanilhsa04728Dopaminergic synapse2.82E-026P14416, P63218, P50151, P49841, Q16539, P49407DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1More
Alfentanilhsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Alfentanilhsa04912GnRH signaling pathway4.42E-023P17252, Q14643, P0DP23PRKCA, ITPR1, CALM1More
Alfentanilhsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Alfentanilhsa04925Aldosterone synthesis and secretion1.54E-024Q14643, P0DP23, P17252, P20020ITPR1, CALM1, PRKCA, ATP2B1More
Alfentanilhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Alfentanilhsa04966Collecting duct acid secretion3.15E-022P02730, Q9Y666SLC4A1, SLC12A7More
Alfentanilhsa04970Salivary secretion1.00E-024Q14643, P20020, P17252, P0DP23ITPR1, ATP2B1, PRKCA, CALM1More
Alfentanilhsa04972Pancreatic secretion1.00E-023Q14643, P20020, P17252ITPR1, ATP2B1, PRKCAMore
Alfentanilhsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Alfentanilhsa05120Epithelial cell signaling in Helicobacter pylori infection3.11E-024Q16539, P25024, P25025, P07948MAPK14, CXCR1, CXCR2, LYNMore
Alfentanilhsa05132Salmonella infection1.02E-0310P51617, Q9UJU2, Q13546, P10415, O75369, O60603, Q9BQS8, P51808, Q13561, Q13509IRAK1, LEF1, RIPK1, BCL2, FLNB, TLR2, FYCO1, DYNLT3, DCTN2, TUBB3More
Alfentanilhsa05135Yersinia infection4.65E-025P13612, P06239, Q16539, P01375, P49841ITGA4, LCK, MAPK14, TNF, GSK3BMore
Alfentanilhsa05140Leishmaniasis1.56E-025P14598, O60603, P49006, P51617, Q15080NCF1, TLR2, MARCKSL1, IRAK1, NCF4More
Alfentanilhsa05144Malaria1.64E-035P60033, O60603, P01375, P35443, P26718CD81, TLR2, TNF, THBS4, KLRK1More
Alfentanilhsa05146Amoebiasis2.73E-024P09341, P05089, P12814, P08311CXCL1, ARG1, ACTN1, CTSGMore
Alfentanilhsa05163Human cytomegalovirus infection1.46E-038P01375, P63218, P50151, P49841, P14778, P25025, Q16539, O00463TNF, GNG5, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Alfentanilhsa05169Epstein-Barr virus infection2.54E-028Q92769, P04637, Q13546, P10415, P24522, O60603, P51617, P09693HDAC2, TP53, RIPK1, BCL2, GADD45A, TLR2, IRAK1, CD3GMore
Alfentanilhsa05170Human immunodeficiency virus 1 infection6.54E-039P0DP23, P17252, Q13546, Q14643, P51617, O60603, P09693, P10415, Q9Y6Q5CALM1, PRKCA, RIPK1, ITPR1, IRAK1, TLR2, CD3G, BCL2, AP1M2More
Alfentanilhsa05212Pancreatic cancer3.40E-021P37173TGFBR2More
Alfentanilhsa05214Glioma1.00E-024P0DP23, P17252, P04637, P24522CALM1, PRKCA, TP53, GADD45AMore
Alfentanilhsa05216Thyroid cancer1.85E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Alfentanilhsa05217Basal cell carcinoma4.42E-023Q9UJU2, P04637, P24522LEF1, TP53, GADD45AMore
Alfentanilhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.88E-035O95267, P20963, P09693, P06239, Q04759RASGRP1, CD247, CD3G, LCK, PRKCQMore
Alfentanilhsa05322Systemic lupus erythematosus1.57E-024P08311, P62807, Q16778, P12814CTSG, HIST1H2BC, HIST2H2BE, ACTN1More
Alfentanilhsa05418Fluid shear stress and atherosclerosis1.94E-047Q16539, Q14145, P10599, P14780, P01375, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Alfentanil (SDC: 2.51)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P00352ALDH1A1Aldehyde dehydrogenase 1A1Predicted00.32080.29250.15430.8998
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P21462FPR1fMetNoneLeuNonePhe receptorPredicted00.12050.34920.43781.1964
P25025CXCR2CNoneXNoneC chemokine receptor type 2Predicted10.02780.51890.44941.5011
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
P51684CCR6CNoneC chemokine receptor type 6Predicted00.0850.17410.33040.7212
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)