PharmaCoNets of Alectinib (SPCN: 205.98 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Alectinibhsa00030Pentose phosphate pathway3.74E-022P60891, P52209PRPS1, PGDMore
Alectinibhsa00071Fatty acid degradation3.50E-024O75521, P00325, P11766, P33121ECI2, ADH1B, ADH5, ACSL1More
Alectinibhsa00120Primary bile acid biosynthesis3.72E-022P22680, P22307CYP7A1, SCP2More
Alectinibhsa00190Oxidative phosphorylation4.38E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Alectinibhsa00240Pyrimidine metabolism4.29E-022P21589, P04183NT5E, TK1More
Alectinibhsa00500Starch and sucrose metabolism1.34E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Alectinibhsa00513Various types of N-glycan biosynthesis4.96E-021Q9NR34MAN1C1More
Alectinibhsa00564Glycerophospholipid metabolism4.29E-022Q6P1A2, P23743MBOAT5, DGKAMore
Alectinibhsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Alectinibhsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Alectinibhsa00600Sphingolipid metabolism3.76E-021P15289ARSAMore
Alectinibhsa00630Glyoxylate and dicarboxylate metabolism3.68E-052P40925, P15104MDH1, GLULMore
Alectinibhsa00670One carbon pool by folate1.33E-022P04818, Q99707TYMS, MTRMore
Alectinibhsa00730Thiamine metabolism3.83E-022P05186, P24666ALPL, ACP1More
Alectinibhsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Alectinibhsa00830Retinol metabolism2.20E-024P00325, P11766, Q9BPW9, O75911ADH1B, ADH5, DHRS9, DHRS3More
Alectinibhsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Alectinibhsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Alectinibhsa01521EGFR tyrosine kinase inhibitor resistance3.18E-042P04049, P08069RAF1, IGF1RMore
Alectinibhsa01522Endocrine resistance4.47E-042P04049, P08069RAF1, IGF1RMore
Alectinibhsa01523Antifolate resistance1.68E-022Q92820, P04818GGH, TYMSMore
Alectinibhsa01524Platinum drug resistance4.67E-024Q13489, P98170, P78417, P43246BIRC3, BIRC4, GSTO1, MSH2More
Alectinibhsa02010ABC transporters1.98E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Alectinibhsa03020RNA polymerase3.00E-023P30876, P24928, P62487POLR2B, POLR2A, POLR2GMore
Alectinibhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Alectinibhsa03040Spliceosome6.61E-0411Q14562, O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, O43447DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, PPIHMore
Alectinibhsa03060Protein export4.42E-022P37108, Q15005SRP14, SPCS2More
Alectinibhsa03410Base excision repair7.59E-031P27695APEX1More
Alectinibhsa03430Mismatch repair4.38E-021P20585MSH3More
Alectinibhsa03450Non-homologous end-joining4.48E-031P78527PRKDCMore
Alectinibhsa04010MAPK signaling pathway1.69E-032P04049, P08069RAF1, IGF1RMore
Alectinibhsa04012ErbB signaling pathway6.63E-034P16333, P19174, P01106, P04049NCK1, PLCG1, MYC, RAF1More
Alectinibhsa04014Ras signaling pathway1.30E-032P04049, P08069RAF1, IGF1RMore
Alectinibhsa04015Rap1 signaling pathway6.04E-058P04049, P08069, P06213, P25116, Q8TEU7, O00522, P08514, P17252RAF1, IGF1R, INSR, F2R, RAPGEF6, KRIT1, ITGA2B, PRKCAMore
Alectinibhsa04022cGMP-PKG signaling pathway3.15E-021P04049RAF1More
Alectinibhsa04024cAMP signaling pathway2.49E-021P04049RAF1More
Alectinibhsa04062Chemokine signaling pathway1.41E-027P07948, P62873, P63218, P50151, P43250, Q13009, P04049LYN, GNB1, GNG5, GNG10, GRK6, TIAM1, RAF1More
Alectinibhsa04064NF-kappa B signaling pathway1.26E-0419P10415, Q13489, O00463, P14778, P01584, P01375, P29965, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, Q9NQC7BCL2, BIRC3, TRAF5, IL1R1, IL1B, TNF, CD40LG, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CYLDMore
Alectinibhsa04066HIF-1 signaling pathway2.16E-021P08069IGF1RMore
Alectinibhsa04068FoxO signaling pathway3.80E-042P04049, P08069RAF1, IGF1RMore
Alectinibhsa04070Phosphatidylinositol signaling system3.47E-024P0DP23, Q14643, P23743, P17252CALM1, ITPR1, DGKA, PRKCAMore
Alectinibhsa04071Sphingolipid signaling pathway1.74E-025P04049, P17252, Q13362, Q9BX95, P10415RAF1, PRKCA, PPP2R5C, SGPP1, BCL2More
Alectinibhsa04072Phospholipase D signaling pathway2.82E-021P04049RAF1More
Alectinibhsa04110Cell cycle3.67E-069Q9UBD5, P06493, O60566, P78527, Q14683, P30304, P33981, P42773, P01106ORC3, CDK1, BUB1B, PRKDC, SMC1A, CDC25A, TTK, CDKN2C, MYCMore
Alectinibhsa04114Oocyte meiosis2.99E-021P08069IGF1RMore
Alectinibhsa04120Ubiquitin mediated proteolysis1.08E-036Q9UBT2, Q14145, Q13042, P62837, Q15751, Q14669SAE2, KEAP1, CDC16, UBE2D2, HERC1, TRIP12More
Alectinibhsa04140Autophagy - animal7.72E-042P08069, P04049IGF1R, RAF1More
Alectinibhsa04142Lysosome7.47E-059P06865, P22304, P38571, Q13510, Q9UJJ9, P07602, Q9NRA2, P49279, P61916HEXA, IDS, LIPA, ASAH1, GNPTG, PSAP, SLC17A5, SLC11A1, NPC2More
Alectinibhsa04144Endocytosis2.00E-049P0DMV8, Q9H444, O75351, P62491, Q96B97, Q15438, Q8WU79, Q14161, Q9UMY4HSPA1A, CHMP4B, VPS4B, RAB11A, SH3KBP1, PSCD1, SMAP1L, GIT2, SNX12More
Alectinibhsa04145Phagosome1.59E-037Q15080, P14598, Q13509, P68371, Q13488, O60603, P13765NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, TLR2, HLA-DOBMore
Alectinibhsa04150mTOR signaling pathway5.20E-042P08069, P04049IGF1R, RAF1More
Alectinibhsa04151PI3K-Akt signaling pathway4.50E-029P25116, P49767, Q13362, P62873, P16144, O60603, P01568, P10415, P17252F2R, VEGFC, PPP2R5C, GNB1, ITGB4, TLR2, IFNA21, BCL2, PRKCAMore
Alectinibhsa04152AMPK signaling pathway1.99E-021P08069IGF1RMore
Alectinibhsa04210Apoptosis2.16E-021P04049RAF1More
Alectinibhsa04211Longevity regulating pathway2.16E-021P08069IGF1RMore
Alectinibhsa04213Longevity regulating pathway - multiple species1.11E-034P08069, Q08828, P51828, P0DMV8IGF1R, ADCY1, ADCY7, HSPA1AMore
Alectinibhsa04217Necroptosis3.17E-0515P01375, P01568, P48023, Q13489, P98170, P42224, Q14765, P08238, P15104, Q6FI13, Q99878, P10415, O43633, P21796, Q08752TNF, IFNA21, FASLG, BIRC3, BIRC4, STAT1, STAT4, HSP90AB1, GLUL, H2AC18; H2AC19, H2AC14, BCL2, CHMP2A, VDAC1, PPIDMore
Alectinibhsa04218Cellular senescence2.49E-021P04049RAF1More
Alectinibhsa04261Adrenergic signaling in cardiomyocytes2.84E-025P09493, Q13362, P0DP23, P17252, P10415TPM1, PPP2R5C, CALM1, PRKCA, BCL2More
Alectinibhsa04270Vascular smooth muscle contraction8.53E-057P0DP23, P04049, Q08828, P51828, P35579, P35749, P35318CALM1, RAF1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Alectinibhsa04360Axon guidance2.49E-021P04049RAF1More
Alectinibhsa04370VEGF signaling pathway8.29E-031P04049RAF1More
Alectinibhsa04371Apelin signaling pathway1.28E-048P62873, P63218, P50151, P04049, Q13485, P84022, Q16566, P0DP23GNB1, GNG5, GNG10, RAF1, SMAD4, SMAD3, CAMK4, CALM1More
Alectinibhsa04380Osteoclast differentiation2.05E-0312Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, P78324CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, SIRPAMore
Alectinibhsa04392Hippo signaling pathway - multiple species3.01E-021Q6V0I7FAT4More
Alectinibhsa04510Focal adhesion1.18E-032P04049, P08069RAF1, IGF1RMore
Alectinibhsa04520Adherens junction8.29E-031P08069IGF1RMore
Alectinibhsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Alectinibhsa04540Gap junction2.79E-035P17252, Q13509, P68371, P04049, Q14643PRKCA, TUBB3, TUBB2C, RAF1, ITPR1More
Alectinibhsa04550Signaling pathways regulating pluripotency of stem cells3.80E-042P04049, P08069RAF1, IGF1RMore
Alectinibhsa04610Complement and coagulation cascades1.91E-031P0C0L4C4AMore
Alectinibhsa04611Platelet activation3.39E-023P25116, P08514, P07359F2R, ITGA2B, GP1BAMore
Alectinibhsa04612Antigen processing and presentation1.64E-028P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Alectinibhsa04613Neutrophil extracellular trap formation9.64E-0723P17252, P04049, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P08311, O75015, P21730, P21462, O43315, Q16539PRKCA, RAF1, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Alectinibhsa04614Renin-angiotensin system2.74E-023P15144, P08311, O75787ANPEP, CTSG, ATP6AP2More
Alectinibhsa04623Cytosolic DNA-sensing pathway1.65E-022P01584, Q8NHW4IL1B, CCL4L2More
Alectinibhsa04625C-type lectin receptor signaling pathway2.72E-0410Q9ULY5, P04049, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539CLEC4E, RAF1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14More
Alectinibhsa04630JAK-STAT signaling pathway1.49E-021P04049RAF1More
Alectinibhsa04640Hematopoietic cell lineage9.73E-0413P13612, P14778, P27930, P15144, P11836, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P01584ITGA4, IL1R1, IL1R2, ANPEP, MS4A1, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, IL1BMore
Alectinibhsa04650Natural killer cell mediated cytotoxicity4.51E-0511P01375, P78314, P06239, O60880, P20963, P04049, Q13241, P26718, O75015, P26717, P26715TNF, SH3BP2, LCK, SH2D1A, CD247, RAF1, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Alectinibhsa04657IL-17 signaling pathway1.11E-038O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1BMore
Alectinibhsa04658Th1 and Th2 cell differentiation1.33E-0510Q04759, P20963, P09693, Q16539, P06239, Q14765, P23771, Q9UL17, P13765, P23458PRKCQ, CD247, CD3G, MAPK14, LCK, STAT4, GATA3, TBX21, HLA-DOB, JAK1More
Alectinibhsa04659Th17 cell differentiation4.72E-0511Q04759, Q16539, P06239, P13765, P14778, Q9UL17, P23771, P01584, P09693, P20963, P23458PRKCQ, MAPK14, LCK, HLA-DOB, IL1R1, TBX21, GATA3, IL1B, CD3G, CD247, JAK1More
Alectinibhsa04660T cell receptor signaling pathway2.97E-0512P01375, Q04759, O95267, Q08881, P20963, P09693, P01732, Q13191, P06239, P04049, Q16539, P49841TNF, PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3BMore
Alectinibhsa04662B cell receptor signaling pathway8.00E-056P42338, P60033, P07948, P21854, Q8N149, P04049PIK3CB, CD81, LYN, CD72, LILRA2, RAF1More
Alectinibhsa04664Fc epsilon RI signaling pathway3.64E-034P42338, P07948, P04049, P09917PIK3CB, LYN, RAF1, ALOX5More
Alectinibhsa04666Fc gamma R-mediated phagocytosis2.32E-021P04049RAF1More
Alectinibhsa04672Intestinal immune network for IgA production1.06E-043P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Alectinibhsa04713Circadian entrainment1.55E-047O15399, P0DP23, P17252, P62873, P63218, P50151, Q14643GRIN2D, CALM1, PRKCA, GNB1, GNG5, GNG10, ITPR1More
Alectinibhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Alectinibhsa04720Long-term potentiation1.23E-036P17252, Q16566, P0DP23, O15399, P04049, Q14643PRKCA, CAMK4, CALM1, GRIN2D, RAF1, ITPR1More
Alectinibhsa04722Neurotrophin signaling pathway7.10E-034P04049, P49841, O43524, P48023RAF1, GSK3B, FOXO3, FASLGMore
Alectinibhsa04723Retrograde endocannabinoid signaling1.88E-024Q14643, P17252, P62873, Q16718ITPR1, PRKCA, GNB1, NDUFA5More
Alectinibhsa04724Glutamatergic synapse1.82E-055O15399, P62873, P63218, P50151, P15104GRIN2D, GNB1, GNG5, GNG10, GLULMore
Alectinibhsa04725Cholinergic synapse5.42E-058Q14643, P17252, P62873, P63218, P50151, Q16566, P42338, P10415ITPR1, PRKCA, GNB1, GNG5, GNG10, CAMK4, PIK3CB, BCL2More
Alectinibhsa04726Serotonergic synapse3.11E-035P62873, P63218, P50151, P09917, P04049GNB1, GNG5, GNG10, ALOX5, RAF1More
Alectinibhsa04727GABAergic synapse1.00E-044P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Alectinibhsa04728Dopaminergic synapse3.55E-025Q14643, P17252, P62873, Q13362, P0DP23ITPR1, PRKCA, GNB1, PPP2R5C, CALM1More
Alectinibhsa04730Long-term depression1.25E-042P08069, P04049IGF1R, RAF1More
Alectinibhsa04744Phototransduction7.13E-052P62873, P0DP23GNB1, CALM1More
Alectinibhsa04750Inflammatory mediator regulation of TRP channels1.32E-0310P14778, P01584, Q08828, P51828, P22694, Q16539, Q14643, Q04759, P0DP24, P0DP23IL1R1, IL1B, ADCY1, ADCY7, PRKACB, MAPK14, ITPR1, PRKCQ, CALM2, CALM1More
Alectinibhsa04810Regulation of actin cytoskeleton3.81E-021P04049RAF1More
Alectinibhsa04910Insulin signaling pathway1.49E-021P04049RAF1More
Alectinibhsa04912GnRH signaling pathway1.03E-0410P17252, Q08828, P51828, Q16539, Q9Y6R4, Q14643, P0DP23, P0DP24, P22694, P04049PRKCA, ADCY1, ADCY7, MAPK14, MAP3K4, ITPR1, CALM1, CALM2, PRKACB, RAF1More
Alectinibhsa04913Ovarian steroidogenesis8.40E-042P06213, P08069INSR, IGF1RMore
Alectinibhsa04914Progesterone-mediated oocyte maturation4.47E-042P08069, P04049IGF1R, RAF1More
Alectinibhsa04915Estrogen signaling pathway2.02E-046P04049, Q08828, P51828, P0DMV8, P0DP23, Q15788RAF1, ADCY1, ADCY7, HSPA1A, CALM1, NCOA1More
Alectinibhsa04916Melanogenesis1.33E-021P04049RAF1More
Alectinibhsa04917Prolactin signaling pathway6.63E-031P04049RAF1More
Alectinibhsa04918Thyroid hormone synthesis3.16E-022P17252, P27824PRKCA, CANXMore
Alectinibhsa04919Thyroid hormone signaling pathway1.82E-021P04049RAF1More
Alectinibhsa04920Adipocytokine signaling pathway4.72E-024P33121, Q04759, Q9Y4H2, P01375ACSL1, PRKCQ, IRS2, TNFMore
Alectinibhsa04921Oxytocin signaling pathway2.32E-021P04049RAF1More
Alectinibhsa04922Glucagon signaling pathway3.47E-024Q12778, Q13370, P0DP23, Q14643FOXO1, PDE3B, CALM1, ITPR1More
Alectinibhsa04923Regulation of lipolysis in adipocytes3.76E-021P06213INSRMore
Alectinibhsa04924Renin secretion1.13E-034P07550, Q14643, Q13370, P0DP23ADRB2, ITPR1, PDE3B, CALM1More
Alectinibhsa04926Relaxin signaling pathway1.46E-036P42338, P63218, P50151, P49767, P04049, P49407PIK3CB, GNG5, GNG10, VEGFC, RAF1, ARRB1More
Alectinibhsa04928Parathyroid hormone synthesis, secretion and action1.99E-021P04049RAF1More
Alectinibhsa04929GnRH secretion3.50E-033P42338, P49407, P04049PIK3CB, ARRB1, RAF1More
Alectinibhsa04930Type II diabetes mellitus3.14E-021P06213INSRMore
Alectinibhsa04932Non-alcoholic fatty liver disease7.01E-0511P01375, P49841, O43521, P48023, O75460, P01584, P13073, P12074, Q16718, O95298, O14521TNF, GSK3B, BCL2L11, FASLG, ERN1, IL1B, COX4I1, COX6A1, NDUFA5, NDUFC2, SDHDMore
Alectinibhsa04933AGE-RAGE signaling pathway in diabetic complications1.27E-025P42224, P10415, Q12778, P49767, P17252STAT1, BCL2, FOXO1, VEGFC, PRKCAMore
Alectinibhsa04935Growth hormone synthesis, secretion and action2.16E-021P04049RAF1More
Alectinibhsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Alectinibhsa04960Aldosterone-regulated sodium reabsorption3.14E-021P06213INSRMore
Alectinibhsa04964Proximal tubule bicarbonate reclamation4.48E-021P00918CA2More
Alectinibhsa04966Collecting duct acid secretion1.95E-033Q13488, P00918, Q9Y666TCIRG1, CA2, SLC12A7More
Alectinibhsa04970Salivary secretion2.14E-034P07550, Q08828, P51828, P0DP23ADRB2, ADCY1, ADCY7, CALM1More
Alectinibhsa04976Bile secretion3.14E-035O43315, Q08828, P51828, P08183, Q14032AQP9, ADCY1, ADCY7, ABCB1, BAATMore
Alectinibhsa05010Alzheimer disease3.55E-027Q16718, O14521, Q14643, P0DP23, Q13509, P68371, Q08752NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2C, PPIDMore
Alectinibhsa05012Parkinson disease2.25E-026Q16718, O14521, Q14643, P0DP23, Q13509, P68371NDUFA5, SDHD, ITPR1, CALM1, TUBB3, TUBB2CMore
Alectinibhsa05016Huntington disease2.46E-029O95298, P13073, P12074, P24928, P30876, P62487, O75460, P28070, O00232NDUFC2, COX4I1, COX6A1, POLR2A, POLR2B, POLR2G, ERN1, PSMB4, PSMD12More
Alectinibhsa05020Prion disease1.31E-039Q16718, O14521, Q14643, Q13509, P68371, P49841, P14598, Q15080, Q16539NDUFA5, SDHD, ITPR1, TUBB3, TUBB2C, GSK3B, NCF1, NCF4, MAPK14More
Alectinibhsa05022Pathways of neurodegeneration - multiple diseases1.75E-0414Q14643, Q13509, P68371, P49841, P10415, Q16718, O14521, Q06055, Q13561, P17252, Q16539, Q08752, O15020, P0DP23ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, SDHD, ATP5G2, DCTN2, PRKCA, MAPK14, PPID, SPTBN2, CALM1More
Alectinibhsa05032Morphine addiction1.34E-024P62873, P63218, P50151, P43250GNB1, GNG5, GNG10, GRK6More
Alectinibhsa05034Alcoholism5.33E-0612O15399, Q16566, P0DP23, P62873, P63218, P50151, P04049, Q93077, P62807, Q93079, O60814, P68431GRIN2D, CAMK4, CALM1, GNB1, GNG5, GNG10, RAF1, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Alectinibhsa05131Shigellosis2.27E-028P68431, Q9UDY8, Q14247, Q14643, Q12778, Q13315, P10415, Q08752H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, MALT1, CTTN, ITPR1, FOXO1, ATM, BCL2, PPIDMore
Alectinibhsa05132Salmonella infection7.93E-039P04049, Q9UJU2, Q13489, P10415, O60603, Q9BQS8, Q13561, Q13509, P68371RAF1, LEF1, BIRC3, BCL2, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Alectinibhsa05133Pertussis3.51E-021P0C0L4C4AMore
Alectinibhsa05134Legionellosis2.82E-023P01584, Q9NR31, P0DMV8IL1B, SAR1A, HSPA1AMore
Alectinibhsa05140Leishmaniasis1.59E-0512P13612, O75015, P14598, P23458, P42224, P13765, O60603, P01375, P01584, P29350, Q16539, Q15080ITGA4, FCGR3B, NCF1, JAK1, STAT1, HLA-DOB, TLR2, TNF, IL1B, PTPN6, MAPK14, NCF4More
Alectinibhsa05143African trypanosomiasis2.72E-022P01375, P48023TNF, FASLGMore
Alectinibhsa05144Malaria5.35E-056P60033, O60603, P01375, P35443, P01584, P26718CD81, TLR2, TNF, THBS4, IL1B, KLRK1More
Alectinibhsa05145Toxoplasmosis1.11E-026P10415, Q13489, P42224, P13765, O60603, P29965BCL2, BIRC3, STAT1, HLA-DOB, TLR2, CD40LGMore
Alectinibhsa05146Amoebiasis1.45E-039P01584, P09341, P14778, P27930, P01375, O60603, P05089, P22694, P08311IL1B, CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, CTSGMore
Alectinibhsa05150Staphylococcus aureus infection1.31E-022P0C0L4, P13646C4A, KRT13More
Alectinibhsa05152Tuberculosis9.31E-049P04049, Q13488, P0DP23, P42224, O60603, P10415, P13765, P01568, Q9UDY8RAF1, TCIRG1, CALM1, STAT1, TLR2, BCL2, HLA-DOB, IFNA21, MALT1More
Alectinibhsa05160Hepatitis C1.40E-035P60033, P04049, P49841, P01375, P48023CD81, RAF1, GSK3B, TNF, FASLGMore
Alectinibhsa05161Hepatitis B1.99E-021P04049RAF1More
Alectinibhsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Alectinibhsa05163Human cytomegalovirus infection1.45E-0313P04049, P62873, P63218, P50151, P0DP23, Q8NHW4, Q08828, P51828, P23458, P01584, Q13651, P30101, P01568RAF1, GNB1, GNG5, GNG10, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, IL1B, IL10RA, PDIA3, IFNA21More
Alectinibhsa05164Influenza A3.65E-021P04049RAF1More
Alectinibhsa05165Human papillomavirus infection3.10E-028P16144, Q05086, P01568, P42224, Q13488, Q13362, Q12778, Q13315ITGB4, UBE3A, IFNA21, STAT1, TCIRG1, PPP2R5C, FOXO1, ATMMore
Alectinibhsa05167Kaposi sarcoma-associated herpesvirus infection8.94E-0410P01568, P42224, P62873, P63218, P50151, Q14643, P04049, P07948, P0DP23, Q9UJU2IFNA21, STAT1, GNB1, GNG5, GNG10, ITPR1, RAF1, LYN, CALM1, LEF1More
Alectinibhsa05168Herpes simplex virus 1 infection4.43E-028P01568, Q07955, P84103, Q13243, Q13489, P30101, Q13398, Q9NZL3IFNA21, SFRS1, SFRS3, SFRS5, BIRC3, PDIA3, ZNF211, ZNF224More
Alectinibhsa05169Epstein-Barr virus infection5.05E-0313P13765, Q13547, O00463, Q16539, P42338, P07948, Q13761, P24522, O75293, O60603, P07766, P09693, P20963HLA-DOB, HDAC1, TRAF5, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, TLR2, CD3E, CD3G, CD247More
Alectinibhsa05170Human immunodeficiency virus 1 infection5.56E-0514P04049, P62873, P63218, P50151, P0DP23, P17252, P30101, Q14643, P01568, O60603, Q13315, P23528, P10415, Q9Y6Q5RAF1, GNB1, GNG5, GNG10, CALM1, PRKCA, PDIA3, ITPR1, IFNA21, TLR2, ATM, CFL1, BCL2, AP1M2More
Alectinibhsa05200Pathways in cancer1.50E-0423Q13751, P08238, P42224, Q9UJU2, P17252, P43246, P84022, Q13485, P14923, P10415, Q13489, P98170, P49767, Q12778, P25116, P62873, P63218, P50151, P78417, O75293, P0DP23, P01568, P01042LAMB3, HSP90AB1, STAT1, LEF1, PRKCA, MSH2, SMAD3, SMAD4, JUP, BCL2, BIRC3, BIRC4, VEGFC, FOXO1, F2R, GNB1, GNG5, GNG10, GSTO1, GADD45B, CALM1, IFNA21, KNG1More
Alectinibhsa05202Transcriptional misregulation in cancer4.06E-0617P41732, P17844, P14780, P27930, Q16548, Q13077, P08069, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522TSPAN7, DDX5, MMP9, IL1R2, BCL2A1, TRAF1, IGF1R, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Alectinibhsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Alectinibhsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Alectinibhsa05205Proteoglycans in cancer2.57E-036Q12955, P04049, Q14247, P17252, P08069, P08962ANK3, RAF1, CTTN, PRKCA, IGF1R, CD63More
Alectinibhsa05206MicroRNAs in cancer3.15E-021P04049RAF1More
Alectinibhsa05210Colorectal cancer7.91E-035P84022, Q13485, P43246, P04049, O75293SMAD3, SMAD4, MSH2, RAF1, GADD45BMore
Alectinibhsa05211Renal cell carcinoma1.16E-021P04049RAF1More
Alectinibhsa05212Pancreatic cancer5.79E-034P04049, P84022, Q13485, O75293RAF1, SMAD3, SMAD4, GADD45BMore
Alectinibhsa05213Endometrial cancer9.95E-031P04049RAF1More
Alectinibhsa05214Glioma5.31E-045P08069, P0DP23, Q16566, P04049, O75293IGF1R, CALM1, CAMK4, RAF1, GADD45BMore
Alectinibhsa05215Prostate cancer1.65E-042P08069, P04049IGF1R, RAF1More
Alectinibhsa05217Basal cell carcinoma3.50E-024Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Alectinibhsa05218Melanoma3.85E-052P08069, P04049IGF1R, RAF1More
Alectinibhsa05219Bladder cancer4.98E-031P04049RAF1More
Alectinibhsa05220Chronic myeloid leukemia9.95E-031P04049RAF1More
Alectinibhsa05221Acute myeloid leukemia8.29E-031P04049RAF1More
Alectinibhsa05222Small cell lung cancer3.80E-024Q13751, Q13489, P98170, O75293LAMB3, BIRC3, BIRC4, GADD45BMore
Alectinibhsa05223Non-small cell lung cancer6.63E-031P04049RAF1More
Alectinibhsa05224Breast cancer2.11E-042P04049, P08069RAF1, IGF1RMore
Alectinibhsa05225Hepatocellular carcinoma1.65E-042P04049, P08069RAF1, IGF1RMore
Alectinibhsa05226Gastric cancer8.29E-031P04049RAF1More
Alectinibhsa05230Central carbon metabolism in cancer9.95E-031P04049RAF1More
Alectinibhsa05231Choline metabolism in cancer4.44E-034P04049, Q9Y259, P19174, P49619RAF1, CHKB, PLCG1, DGKGMore
Alectinibhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer1.43E-039O95267, P20963, P09693, P06239, P04049, P23458, O60603, Q04759, Q16539RASGRP1, CD247, CD3G, LCK, RAF1, JAK1, TLR2, PRKCQ, MAPK14More
Alectinibhsa05310Asthma1.35E-022P13765, P29965HLA-DOB, CD40LGMore
Alectinibhsa05320Autoimmune thyroid disease1.05E-044P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Alectinibhsa05321Inflammatory bowel disease1.28E-047O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1BMore
Alectinibhsa05322Systemic lupus erythematosus4.80E-0610P08246, P09871, P10747, P13765, P29965, Q6FI13, Q93077, P62807, O60814, P68431ELA2, C1S, CD28, HLA-DOB, CD40LG, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Alectinibhsa05323Rheumatoid arthritis1.29E-024P13765, Q13488, P10747, O60603HLA-DOB, TCIRG1, CD28, TLR2More
Alectinibhsa05330Allograft rejection7.91E-055P13765, P29965, P48023, P10747, P01375HLA-DOB, CD40LG, FASLG, CD28, TNFMore
Alectinibhsa05332Graft-versus-host disease3.34E-035P13765, P48023, P01375, P26715, Q13241HLA-DOB, FASLG, TNF, KLRC1, KLRD1More
Alectinibhsa05412Arrhythmogenic right ventricular cardiomyopathy2.45E-034P54284, P14923, P08514, Q9UJU2CACNB3, JUP, ITGA2B, LEF1More
Alectinibhsa05414Dilated cardiomyopathy4.55E-022P54284, P26678CACNB3, PLNMore
Alectinibhsa05415Diabetic cardiomyopathy1.58E-037P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3BMore
Alectinibhsa05416Viral myocarditis2.61E-033P13765, P29965, P10747HLA-DOB, CD40LG, CD28More

Community members of Alectinib (SDC: 7.33)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P17252PRKCAProtein kinase C alpha typePredicted00.14090.694812.4601
P04049RAF1RAF protoNoneoncogene serine/threonineNoneprotein kinasePredicted10.5570.757212.7929
P08069IGF1RInsulinNonelike growth factor 1 receptorPredicted10.20820.95610.98833.0047
P09619PDGFRBPlateletNonederived growth factor receptor betaPredicted00.04960.94440.74082.6543
P05186ALPLAlkaline phosphatase, tissueNonenonspecific isozymePredicted00.30640.41430.19921.181
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P25116F2RProteinaseNoneactivated receptor 1Predicted10.20380.31960.51361.2547
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P27695APEX1DNANone(apurinic or apyrimidinic site) endonucleasePredicted10.4020.2210.12170.7647
Q96RR4CAMKK2Calcium/calmodulinNonedependent protein kinase kinase 2Predicted00.36280.34060.46511.3277
P21730C5AR1C5a anaphylatoxin chemotactic receptor 1Predicted10.02580.21670.53960.986
Q96KQ7EHMT2HistoneNonelysine NNonemethyltransferase EHMT2Predicted00.07280.21650.29090.7603
P30530AXLTyrosineNoneprotein kinase receptor UFOPredicted10.37970.53650.16371.4264
Q15078CDK5R1CyclinNonedependent kinase 5 activator 1Predicted00.13580.50040.25751.3263
P43490PBEF1Nicotinamide phosphoribosyltransferasePredicted10.44230.70640.2381.872
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
P33981TTKDual specificity protein kinase TTKPredicted00.00390.58050.2591.422
P78527PRKDCDNANonedependent protein kinase catalytic subunitPredicted00.1780.19440.24960.7273
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)