PharmaCoNets of Alclofenac (SPCN: 10.24 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Alclofenachsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Alclofenachsa00190Oxidative phosphorylation3.56E-023Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Alclofenachsa00230Purine metabolism1.81E-022P20839, Q02153IMPDH1, GUCY1B3More
Alclofenachsa00260Glycine, serine and threonine metabolism1.99E-021P22557ALAS2More
Alclofenachsa00330Arginine and proline metabolism4.86E-021P17707AMD1More
Alclofenachsa00565Ether lipid metabolism3.00E-031Q8N661TMEM86BMore
Alclofenachsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Alclofenachsa03013RNA transport3.98E-029P52298, Q09161, O14893, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, NCBP1, GEMIN2, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Alclofenachsa04020Calcium signaling pathway4.45E-023P0DP24, P51828, P23634CALM2, ADCY7, ATP2B4More
Alclofenachsa04024cAMP signaling pathway3.79E-023P51828, P0DP24, P23634ADCY7, CALM2, ATP2B4More
Alclofenachsa04071Sphingolipid signaling pathway2.14E-023Q13510, Q13362, Q9UQC2ASAH1, PPP2R5C, GAB2More
Alclofenachsa04114Oocyte meiosis8.69E-034P0DP24, P51828, P27348, Q13362CALM2, ADCY7, YWHAQ, PPP2R5CMore
Alclofenachsa04120Ubiquitin mediated proteolysis2.89E-022O95071, P0CG47UBR5, UBBMore
Alclofenachsa04137Mitophagy - animal9.52E-032Q07817, P0CG47BCL2L1, UBBMore
Alclofenachsa04145Phagosome1.66E-039Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Alclofenachsa04261Adrenergic signaling in cardiomyocytes1.06E-024P51828, Q13362, P0DP24, P23634ADCY7, PPP2R5C, CALM2, ATP2B4More
Alclofenachsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Alclofenachsa04666Fc gamma R-mediated phagocytosis2.42E-025P23528, P06396, O14494, P14598, P17252CFL1, GSN, PLPP1, NCF1, PRKCAMore
Alclofenachsa04672Intestinal immune network for IgA production1.62E-023P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Alclofenachsa04744Phototransduction2.80E-022P62873, P0DP23GNB1, CALM1More
Alclofenachsa04916Melanogenesis4.80E-024P0DP23, Q9UJU2, P17252, P04628CALM1, LEF1, PRKCA, WNT1More
Alclofenachsa04925Aldosterone synthesis and secretion1.32E-023P51828, P0DP24, P23634ADCY7, CALM2, ATP2B4More
Alclofenachsa04961Endocrine and other factor-regulated calcium reabsorption2.09E-022P23634, P62491ATP2B4, RAB11AMore
Alclofenachsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Alclofenachsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Alclofenachsa04970Salivary secretion3.20E-033P51828, P23634, P0DP24ADCY7, ATP2B4, CALM2More
Alclofenachsa04972Pancreatic secretion4.94E-033P23634, P51828, P62491ATP2B4, ADCY7, RAB11AMore
Alclofenachsa05132Salmonella infection2.93E-0210P51617, Q9UJU2, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, Q13509, P68371IRAK1, LEF1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, TUBB3, TUBB2CMore
Alclofenachsa05133Pertussis4.20E-021P0C0L4C4AMore
Alclofenachsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Alclofenachsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Alclofenachsa05152Tuberculosis5.68E-039Q13488, P0DP23, P48382, O60603, P10415, P13765, P01568, Q9UDY8, P51617TCIRG1, CALM1, RFX5, TLR2, BCL2, HLA-DOB, IFNA21, MALT1, IRAK1More
Alclofenachsa05170Human immunodeficiency virus 1 infection5.94E-0312P62873, P0DP23, P17252, O00463, Q14643, P01568, P51617, O60603, P23528, P10415, Q93034, Q9Y6Q5GNB1, CALM1, PRKCA, TRAF5, ITPR1, IFNA21, IRAK1, TLR2, CFL1, BCL2, CUL5, AP1M2More
Alclofenachsa05202Transcriptional misregulation in cancer3.51E-0211Q12778, Q15532, P14780, P14923, Q16548, Q13489, Q13077, P35226, P05164, P08246, Q9C0K0FOXO1, SS18, MMP9, JUP, BCL2A1, BIRC3, TRAF1, BMI1, MPO, ELA2, BCL11BMore
Alclofenachsa05205Proteoglycans in cancer1.09E-0210Q13009, Q12955, Q14643, O75369, P14780, P17252, O60603, P04628, Q13635, P08962TIAM1, ANK3, ITPR1, FLNB, MMP9, PRKCA, TLR2, WNT1, PTCH1, CD63More
Alclofenachsa05320Autoimmune thyroid disease8.64E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Alclofenachsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More

Community members of Alclofenac (SDC: 2.88)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P10415BCL2Apoptosis regulator BclNone2Predicted10.03410.527112.0714
Q07817BCL2L1BclNone2Nonelike protein 1Predicted10.08720.434911.9134
O95551TTRAPTyrosylNoneDNA phosphodiesterase 2Predicted00.20920.256900.6184
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)