PharmaCoNets

PharmaCoNets of Alcaftadine (S_PCN: 204.91 )

Alcaftadine regulated-network (S_DN: 24.87)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Alcaftadine

hsa00030

Pentose phosphate pathway

3.06E-04

P60891, P51854, P37837

PRPS1, TKTL1, TALDO1

Alcaftadine

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Alcaftadine

hsa00071

Fatty acid degradation

3.50E-02

O75521, P00325, P11766, P33121

ECI2, ADH1B, ADH5, ACSL1

Alcaftadine

hsa00190

Oxidative phosphorylation

5.12E-04

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Alcaftadine

hsa00220

Arginine biosynthesis

3.83E-02

P05089, P49448

ARG1, GLUD2

Alcaftadine

hsa00310

Lysine degradation

4.14E-02

Q02809

PLOD1

Alcaftadine

hsa00500

Starch and sucrose metabolism

5.14E-04

O43451, P46976, P06737

MGAM, GYG1, PYGL

Alcaftadine

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Alcaftadine

hsa00520

Amino sugar and nucleotide sugar metabolism

2.11E-02

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Alcaftadine

hsa00565

Ether lipid metabolism

4.93E-02

Q8N661

TMEM86B

Alcaftadine

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Alcaftadine

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Alcaftadine

hsa00603

Glycosphingolipid biosynthesis - globo and isoglobo series

8.72E-03

P06865, O75752

HEXA, B3GALNT1

Alcaftadine

hsa00604

Glycosphingolipid biosynthesis - ganglio series

2.46E-02

P06865, Q9H4F1

HEXA, ST6GALNAC4

Alcaftadine

hsa00730

Thiamine metabolism

3.03E-03

P05186, P24666

ALPL, ACP1

Alcaftadine

hsa00770

Pantothenate and CoA biosynthesis

2.26E-04

O95498, O95497, Q9NRN7

VNN2, VNN1, AASDHPPT

Alcaftadine

hsa00830

Retinol metabolism

2.27E-03

P00325, P11766, P00352, Q9BPW9, O75911

ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3

Alcaftadine

hsa00970

Aminoacyl-tRNA biosynthesis

2.02E-05

O95363, P54136, P14868, Q15046

FARS2, RARS1, DARS, KARS

Alcaftadine

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-03

P78417, P11712

GSTO1, CYP2C9

Alcaftadine

hsa00982

Drug metabolism - cytochrome P450

9.14E-03

P11712, P78417

CYP2C9, GSTO1

Alcaftadine

hsa01100

Metabolic pathways

4.43E-02

Q9NR34, P05089, P32320, P22748, P55809, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737

MAN1C1, ARG1, CDA, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9NR34	MAN1C1	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC	-0.716
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32320	CDA	Cytidine deaminase	0.701
Q16539	MAPK14	Mitogen-activated protein kinase 14	P22748	CA4	Carbonic anhydrase 4	0.767
Q16539	MAPK14	Mitogen-activated protein kinase 14	P55809	OXCT1	Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	-0.746
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06280	GLA	Alpha-galactosidase A	0.714
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16875	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3	0.849
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43286	B4GALT5	Beta-1,4-galactosyltransferase 5	0.917
Q16539	MAPK14	Mitogen-activated protein kinase 14	O43451	MGAM	Maltase-glucoamylase	0.871
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05186	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	0.901
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24666	ACP1	Low molecular weight phosphotyrosine protein phosphatase	-0.832
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9HCC0	MCCC2	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	-0.782
Q16539	MAPK14	Mitogen-activated protein kinase 14	P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	0.886
Q16539	MAPK14	Mitogen-activated protein kinase 14	P57054	PIGP	Phosphatidylinositol N-acetylglucosaminyltransferase subunit P	-0.881
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UNP4	ST3GAL5	Lactosylceramide alpha-2,3-sialyltransferase	-0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.743
Q16539	MAPK14	Mitogen-activated protein kinase 14	P32321	DCTD	Deoxycytidylate deaminase	-0.748
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75911	DHRS3	Short-chain dehydrogenase/reductase 3	-0.81
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q9UHY7	ENOPH1	Enolase-phosphatase E1	-0.737
Q16539	MAPK14	Mitogen-activated protein kinase 14	P43490	PBEF1	Nicotinamide phosphoribosyltransferase	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	P46976	GYG1	Glycogenin-1	0.817
Q16539	MAPK14	Mitogen-activated protein kinase 14	P06737	PYGL	Glycogen phosphorylase, liver form	0.863

Alcaftadine

hsa01200

Carbon metabolism

4.32E-02

P51854, P37837, P60891

TKTL1, TALDO1, PRPS1

Alcaftadine

hsa01210

2-Oxocarboxylic acid metabolism

1.40E-02

P50213

IDH3A

Alcaftadine

hsa01230

Biosynthesis of amino acids

2.60E-02

P51854, P60891, P37837

TKTL1, PRPS1, TALDO1

Alcaftadine

hsa01521

EGFR tyrosine kinase inhibitor resistance

1.82E-02

P04049

RAF1

Alcaftadine

hsa01522

Endocrine resistance

2.16E-02

P04049

RAF1

Alcaftadine

hsa01523

Antifolate resistance

1.43E-03

Q92820, P04818

GGH, TYMS

Alcaftadine

hsa01524

Platinum drug resistance

4.78E-02

P31751

AKT2

Alcaftadine

hsa02010

ABC transporters

2.17E-03

P45844, P08183, Q8IZY2

ABCG1, ABCB1, ABCA7

Alcaftadine

hsa03013

RNA transport

4.09E-02

P52298, Q09161, O14893, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5

NCBP2, NCBP1, GEMIN2, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3

Alcaftadine

hsa03020

RNA polymerase

4.40E-02

P24928, P62487

POLR2A, POLR2G

Alcaftadine

hsa03022

Basal transcription factors

3.32E-02

O00268, Q15544

TAF4, TAF11

Alcaftadine

hsa03040

Spliceosome

1.28E-05

O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Alcaftadine

hsa03320

PPAR signaling pathway

4.33E-02

Q6PCB7, Q9UNU6

SLC27A1, CYP8B1

Alcaftadine

hsa03450

Non-homologous end-joining

4.21E-02

P13010

XRCC5

Alcaftadine

hsa04010

MAPK signaling pathway

4.15E-02

P04049

RAF1

Alcaftadine

hsa04012

ErbB signaling pathway

1.82E-02

P04049

RAF1

Alcaftadine

hsa04014

Ras signaling pathway

1.71E-03

P04049, P31751, P42338, P20827, P49767, Q13009, Q7LDG7, P0DP23, P63218, P50151, P19174

RAF1, AKT2, PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, CALM1, GNG5, GNG10, PLCG1

Alcaftadine

hsa04015

Rap1 signaling pathway

7.70E-04

P04049, P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P31751, P0DP23, P19174

RAF1, EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, AKT2, CALM1, PLCG1

Alcaftadine

hsa04022

cGMP-PKG signaling pathway

2.83E-04

P04049, P18848, Q8WYR1, P31751, P05141, P0DP24, P0DP23

RAF1, ATF4, PIK3R5, AKT2, SLC25A5, CALM2, CALM1

Alcaftadine

hsa04024

cAMP signaling pathway

1.30E-04

P31751, P0DP23, P04049

AKT2, CALM1, RAF1

Alcaftadine

hsa04060

Cytokine-cytokine receptor interaction

5.34E-03

P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730

IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4

Alcaftadine

hsa04061

Viral protein interaction with cytokine and cytokine receptor

1.32E-02

P09341, P25024, P47992, Q9UBD3, Q13651, P14784

CXCL1, CXCR1, XCL1, XCL2, IL10RA, IL2RB

Alcaftadine

hsa04062

Chemokine signaling pathway

1.76E-06

P25024, P25025, P09341, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P63218, P50151, P43250, P49407, Q08881, Q7LDG7, Q13009, P04049, P49841, Q8WYR1

CXCR1, CXCR2, CXCL1, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ARRB1, ITK, RASGRP2, TIAM1, RAF1, GSK3B, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P25024	CXCR1	C-X-C chemokine receptor type 1	P25024	CXCR1	C-X-C chemokine receptor type 1	1
P25024	CXCR1	C-X-C chemokine receptor type 1	P25025	CXCR2	C-X-C chemokine receptor type 2	0.929
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	P47992	XCL1	Lymphotactin	-0.706
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P25024	CXCR1	C-X-C chemokine receptor type 1	Q9UBD3	XCL2	Cytokine SCM-1 beta	-0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P25024	CXCR1	C-X-C chemokine receptor type 1	P07948	LYN	Tyrosine-protein kinase Lyn	0.707
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
P25024	CXCR1	C-X-C chemokine receptor type 1	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
P25024	CXCR1	C-X-C chemokine receptor type 1	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P25024	CXCR1	C-X-C chemokine receptor type 1	P49407	ARRB1	Beta-arrestin-1	-0.721
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Alcaftadine

hsa04064

NF-kappa B signaling pathway

4.37E-08

P10415, Q13489, P25963, P51617, O00463, P14778, P01584, P01375, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P24522, P09341, Q06643, Q9NQC7

BCL2, BIRC3, NFKBIA, IRAK1, TRAF5, IL1R1, IL1B, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, GADD45A, CXCL1, LTB, CYLD

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P10415	BCL2	Apoptosis regulator Bcl-2	-0.942
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O00463	TRAF5	TNF receptor-associated factor 5	-0.932
Q16539	MAPK14	Mitogen-activated protein kinase 14	O00463	TRAF5	TNF receptor-associated factor 5	-0.837
P06239	LCK	Tyrosine-protein kinase Lck	O00463	TRAF5	TNF receptor-associated factor 5	0.718
P08246	ELA2	Neutrophil elastase	O00463	TRAF5	TNF receptor-associated factor 5	-0.814
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q13077	TRAF1	TNF receptor-associated factor 1	-0.73
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16548	BCL2A1	Bcl-2-related protein A1	0.875
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q8WV28	BLNK	B-cell linker protein	-0.704
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q8WV28	BLNK	B-cell linker protein	-0.816
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
Q16539	MAPK14	Mitogen-activated protein kinase 14	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.724
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	Q06643	LTB	Lymphotoxin-beta	0.846
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9NQC7	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD	0.799

Alcaftadine

hsa04068

FoxO signaling pathway

1.99E-02

P04049

RAF1

Alcaftadine

hsa04071

Sphingolipid signaling pathway

1.54E-04

P04049, P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415

RAF1, PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2

Alcaftadine

hsa04072

Phospholipase D signaling pathway

2.82E-02

P04049

RAF1

Alcaftadine

hsa04080

Neuroactive ligand-receptor interaction

1.02E-03

P08311, P28472, Q15722, P21453, Q9H228, O00398, P21462, P21730, P07550

CTSG, GABRB3, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, ADRB2

Alcaftadine

hsa04110

Cell cycle

1.97E-05

P06493, O60566, O75293, P30304, P33981, P42773, P01106

CDK1, BUB1B, GADD45B, CDC25A, TTK, CDKN2C, MYC

Alcaftadine

hsa04114

Oocyte meiosis

4.19E-04

Q9Y6D9, P51812, Q02750, P16298, Q17RY0

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4

Alcaftadine

hsa04115

p53 signaling pathway

3.57E-02

P24522, Q13315, Q53FA7, O95067, P10415

GADD45A, ATM, TP53I3, CCNB2, BCL2

Alcaftadine

hsa04120

Ubiquitin mediated proteolysis

3.44E-02

Q14145, Q13042, P62837, Q15751

KEAP1, CDC16, UBE2D2, HERC1

Alcaftadine

hsa04140

Autophagy - animal

2.82E-02

P04049

RAF1

Alcaftadine

hsa04145

Phagosome

1.98E-02

Q15080, P14598, Q13509, Q13488, P05164, O60603, P35443, P13765

NCF4, NCF1, TUBB3, TCIRG1, MPO, TLR2, THBS4, HLA-DOB

Alcaftadine

hsa04150

mTOR signaling pathway

2.32E-02

P04049

RAF1

Alcaftadine

hsa04151

PI3K-Akt signaling pathway

1.67E-03

P62753, P42338, P43657, O43521, P27348, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P18848, O00141, Q6ZUJ8, P30281

RPS6, PIK3CB, P2RY5, BCL2L11, YWHAQ, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, ATF4, SGK, PIK3AP1, CCND3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P61073	CXCR4	C-X-C chemokine receptor type 4	P62753	RPS6	40S ribosomal protein S6	0.709
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P61073	CXCR4	C-X-C chemokine receptor type 4	O43521	BCL2L11	Bcl-2-like protein 11	0.724
P61073	CXCR4	C-X-C chemokine receptor type 4	P27348	YWHAQ	14-3-3 protein theta	0.708
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P61073	CXCR4	C-X-C chemokine receptor type 4	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P61073	CXCR4	C-X-C chemokine receptor type 4	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.723
P61073	CXCR4	C-X-C chemokine receptor type 4	O00141	SGK	Serine/threonine-protein kinase Sgk1	0.755
P61073	CXCR4	C-X-C chemokine receptor type 4	Q6ZUJ8	PIK3AP1	Phosphoinositide 3-kinase adapter protein 1	0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743

Alcaftadine

hsa04210

Apoptosis

3.11E-04

Q13315, P10415, Q13489, P25963, P01375, O75460, P24522, Q16548, Q13077, O43521, P18848, Q14643, P04049

ATM, BCL2, BIRC3, NFKBIA, TNF, ERN1, GADD45A, BCL2A1, TRAF1, BCL2L11, ATF4, ITPR1, RAF1

Alcaftadine

hsa04217

Necroptosis

4.76E-06

P01375, P01568, P48023, Q13489, P42224, Q14765, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q99878, Q93077, Q9H444, O43633, Q08752

TNF, IFNA21, FASLG, BIRC3, STAT1, STAT4, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, H2AC14, HIST1H2AC, CHMP4B, CHMP2A, PPID

Alcaftadine

hsa04218

Cellular senescence

3.00E-04

P01106, P31751, P04049, O75293, P30304, P06493, P0DP23

MYC, AKT2, RAF1, GADD45B, CDC25A, CDK1, CALM1

Alcaftadine

hsa04261

Adrenergic signaling in cardiomyocytes

2.83E-03

P07550, P22694, P31751, P18848, Q13362, P0DP23

ADRB2, PRKACB, AKT2, ATF4, PPP2R5C, CALM1

Alcaftadine

hsa04270

Vascular smooth muscle contraction

2.32E-02

P04049

RAF1

Alcaftadine

hsa04360

Axon guidance

1.51E-02

P16333, P20827, O95631, P42338, P07332, P04049, P19174

NCK1, EFNA1, NTN1, PIK3CB, FES, RAF1, PLCG1

Alcaftadine

hsa04370

VEGF signaling pathway

1.94E-06

P16298, P31751, Q05397, Q02750, P04049

PPP3CB, AKT2, PTK2, MAP2K1, RAF1

Alcaftadine

hsa04371

Apelin signaling pathway

3.31E-04

P63218, P50151, Q8WYR1, P31751, P04049, Q14814, Q14344, Q13485, P84022, P0DP23

GNG5, GNG10, PIK3R5, AKT2, RAF1, MEF2D, GNA13, SMAD4, SMAD3, CALM1

Alcaftadine

hsa04380

Osteoclast differentiation

1.35E-04

Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P31751, P01584, P14778, O75015, Q8WV28, P01375, Q15080, P78324

CYLD, GAB2, MAPK14, JAK1, LCK, AKT2, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, SIRPA

Alcaftadine

hsa04510

Focal adhesion

3.48E-02

P04049

RAF1

Alcaftadine

hsa04530

Tight junction

3.29E-02

P16989, P56750, Q14247

CSDA, CLDN17, CTTN

Alcaftadine

hsa04540

Gap junction

1.33E-02

P04049

RAF1

Alcaftadine

hsa04550

Signaling pathways regulating pluripotency of stem cells

1.58E-03

P04628, P40189, P04049

WNT1, IL6ST, RAF1

Alcaftadine

hsa04610

Complement and coagulation cascades

2.33E-03

P0C0L4

C4A

Alcaftadine

hsa04612

Antigen processing and presentation

9.02E-05

P13765, P01730, Q14953, P26715, P26717, Q13241, P01732, P01375

HLA-DOB, CD4, KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNF

Alcaftadine

hsa04613

Neutrophil extracellular trap formation

9.62E-07

P17252, P04049, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539

PRKCA, RAF1, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	P17252	PRKCA	Protein kinase C alpha type	-0.735
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
P08246	ELA2	Neutrophil elastase	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.889
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P31645	SLC6A4	Sodium-dependent serotonin transporter	P04908	H2AC4; H2AC8	Histone H2A type 1-B/E	0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P0C0S5	H2AFZ	Histone H2A.Z	0.785
P08246	ELA2	Neutrophil elastase	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.907
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q93077	HIST1H2AC	Histone H2A type 1-C	0.737
P11712	CYP2C9	Cytochrome P450 2C9	Q93077	HIST1H2AC	Histone H2A type 1-C	0.754
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728
P31645	SLC6A4	Sodium-dependent serotonin transporter	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.913
P11712	CYP2C9	Cytochrome P450 2C9	P68431	H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12	Histone H3.1	0.845
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945
P08246	ELA2	Neutrophil elastase	P20160	AZU1	Azurocidin	0.842
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P08246	ELA2	Neutrophil elastase	P08311	CTSG	Cathepsin G	0.792
P08246	ELA2	Neutrophil elastase	P49913	CAMP	Cathelicidin antimicrobial peptide	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.983
P08246	ELA2	Neutrophil elastase	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.703
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P21462	FPR1	fMet-Leu-Phe receptor	0.839
P08246	ELA2	Neutrophil elastase	P21462	FPR1	fMet-Leu-Phe receptor	0.85
P31645	SLC6A4	Sodium-dependent serotonin transporter	O43315	AQP9	Aquaporin-9	-0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O43315	AQP9	Aquaporin-9	0.934
P31645	SLC6A4	Sodium-dependent serotonin transporter	Q16539	MAPK14	Mitogen-activated protein kinase 14	-0.744
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883

Alcaftadine

hsa04614

Renin-angiotensin system

2.74E-02

P15144, P08311, O75787

ANPEP, CTSG, ATP6AP2

Alcaftadine

hsa04620

Toll-like receptor signaling pathway

4.78E-02

P31751

AKT2

Alcaftadine

hsa04621

NOD-like receptor signaling pathway

3.10E-03

Q14643, P25963, Q13489, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P49913, P12838

ITPR1, NFKBIA, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CAMP, DEFA4

Alcaftadine

hsa04622

RIG-I-like receptor signaling pathway

1.81E-02

Q9NQC7

CYLD

Alcaftadine

hsa04623

Cytosolic DNA-sensing pathway

3.15E-02

P01568, P25963

IFNA21, NFKBIA

Alcaftadine

hsa04625

C-type lectin receptor signaling pathway

3.02E-05

Q9ULY5, P04049, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P31751, P0DP24, P0DP23, Q16539

CLEC4E, RAF1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, AKT2, CALM2, CALM1, MAPK14

Alcaftadine

hsa04630

JAK-STAT signaling pathway

1.01E-04

O75925, P40189, Q06124, P04049

PIAS1, IL6ST, PTPN11, RAF1

Alcaftadine

hsa04640

Hematopoietic cell lineage

4.50E-06

P13612, P21926, P14778, P27930, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P01584

ITGA4, CD9, IL1R1, IL1R2, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, IL1B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P06239	LCK	Tyrosine-protein kinase Lck	P13612	ITGA4	Integrin alpha-4	0.732
P52732	KIF11	Kinesin-like protein KIF11	P21926	CD9	CD9 antigen	-0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P15144	ANPEP	Aminopeptidase N	0.851
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P11836	MS4A1	B-lymphocyte antigen CD20	-0.71
P06239	LCK	Tyrosine-protein kinase Lck	P25063	CD24	Signal transducer CD24	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719
P06493	CDK1	Cyclin-dependent kinase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.732
P06493	CDK1	Cyclin-dependent kinase 1	P06127	CD5	T-cell surface glycoprotein CD5	-0.739
P06239	LCK	Tyrosine-protein kinase Lck	P09564	CD7	T-cell antigen CD7	0.84
P52732	KIF11	Kinesin-like protein KIF11	P09564	CD7	T-cell antigen CD7	-0.886
P06493	CDK1	Cyclin-dependent kinase 1	P09564	CD7	T-cell antigen CD7	-0.735
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807

Alcaftadine

hsa04650

Natural killer cell mediated cytotoxicity

2.33E-10

P16298, P50591, P01375, P78314, P06239, O60880, P20963, Q02750, P04049, Q13241, P26718, O14931, O75015, P26717, Q14953, P26715

PPP3CB, TNFSF10, TNF, SH3BP2, LCK, SH2D1A, CD247, MAP2K1, RAF1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KIR2DS5, KLRC1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q6PCB7	SLC27A1	Long-chain fatty acid transport protein 1	P16298	PPP3CB	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform	0.774
Q6PCB7	SLC27A1	Long-chain fatty acid transport protein 1	P50591	TNFSF10	Tumor necrosis factor ligand superfamily member 10	0.9
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P78314	SH3BP2	SH3 domain-binding protein 2	0.761
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.823
P06239	LCK	Tyrosine-protein kinase Lck	O60880	SH2D1A	SH2 domain-containing protein 1A	0.906
P25024	CXCR1	C-X-C chemokine receptor type 1	O60880	SH2D1A	SH2 domain-containing protein 1A	-0.788
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P07550	ADRB2	Beta-2 adrenergic receptor	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.727
Q6PCB7	SLC27A1	Long-chain fatty acid transport protein 1	Q02750	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	0.799
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13241	KLRD1	Natural killer cells antigen CD94	-0.82
P06239	LCK	Tyrosine-protein kinase Lck	Q13241	KLRD1	Natural killer cells antigen CD94	0.758
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13241	KLRD1	Natural killer cells antigen CD94	-0.701
P07550	ADRB2	Beta-2 adrenergic receptor	Q13241	KLRD1	Natural killer cells antigen CD94	0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.91
P06239	LCK	Tyrosine-protein kinase Lck	P26718	KLRK1	NKG2-D type II integral membrane protein	0.886
P25024	CXCR1	C-X-C chemokine receptor type 1	P26718	KLRK1	NKG2-D type II integral membrane protein	-0.81
P07550	ADRB2	Beta-2 adrenergic receptor	P26718	KLRK1	NKG2-D type II integral membrane protein	0.701
P06239	LCK	Tyrosine-protein kinase Lck	O14931	NCR3	Natural cytotoxicity triggering receptor 3	0.732
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
P25024	CXCR1	C-X-C chemokine receptor type 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.846
P06239	LCK	Tyrosine-protein kinase Lck	P26717	KLRC2	NKG2-C type II integral membrane protein	0.756
P25024	CXCR1	C-X-C chemokine receptor type 1	P26717	KLRC2	NKG2-C type II integral membrane protein	-0.721
P07550	ADRB2	Beta-2 adrenergic receptor	P26717	KLRC2	NKG2-C type II integral membrane protein	0.72
P07550	ADRB2	Beta-2 adrenergic receptor	Q14953	KIR2DS5	Killer cell immunoglobulin-like receptor 2DS5	0.815
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.846
P06239	LCK	Tyrosine-protein kinase Lck	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.756
P25024	CXCR1	C-X-C chemokine receptor type 1	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	-0.721
P07550	ADRB2	Beta-2 adrenergic receptor	P26715	KLRC1	NKG2-A/NKG2-B type II integral membrane protein	0.72

Alcaftadine

hsa04657

IL-17 signaling pathway

2.63E-04

O00463, Q16539, P49841, P09341, P19875, P14780, P80188, P01375, P01584

TRAF5, MAPK14, GSK3B, CXCL1, CXCL2, MMP9, LCN2, TNF, IL1B

Alcaftadine

hsa04658

Th1 and Th2 cell differentiation

3.56E-07

Q04759, P07766, P20963, P09693, Q16539, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85

Alcaftadine

hsa04659

Th17 cell differentiation

1.83E-07

Q04759, Q16539, P19174, P01730, P06239, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P01584, P08238, P07766, P09693, P20963, P23458

PRKCQ, MAPK14, PLCG1, CD4, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9UL17	TBX21	T-box transcription factor TBX21	-0.872
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.763
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757

Alcaftadine

hsa04660

T cell receptor signaling pathway

1.22E-07

P01375, P25963, Q9UDY8, Q04759, P10747, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841

TNF, NFKBIA, MALT1, PRKCQ, CD28, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P25024	CXCR1	C-X-C chemokine receptor type 1	P01375	TNF	Tumor necrosis factor	0.718
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P08246	ELA2	Neutrophil elastase	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	-0.896
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P08246	ELA2	Neutrophil elastase	Q04759	PRKCQ	Protein kinase C theta type	-0.748
P08246	ELA2	Neutrophil elastase	P10747	CD28	T-cell-specific surface glycoprotein CD28	-0.854
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
P08246	ELA2	Neutrophil elastase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.724
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.866
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P08246	ELA2	Neutrophil elastase	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.782
P25024	CXCR1	C-X-C chemokine receptor type 1	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.736
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P25024	CXCR1	C-X-C chemokine receptor type 1	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.771
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.781
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.803
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
P25024	CXCR1	C-X-C chemokine receptor type 1	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P25024	CXCR1	C-X-C chemokine receptor type 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.779
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
P25024	CXCR1	C-X-C chemokine receptor type 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.795
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P25024	CXCR1	C-X-C chemokine receptor type 1	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.823

Alcaftadine

hsa04662

B cell receptor signaling pathway

4.90E-04

P31751, P42338, P60033, P07948, P21854, Q8N149, P04049

AKT2, PIK3CB, CD81, LYN, CD72, LILRA2, RAF1

Alcaftadine

hsa04664

Fc epsilon RI signaling pathway

1.45E-03

P31751, P42338, P07948, P19174, P04049, P09917

AKT2, PIK3CB, LYN, PLCG1, RAF1, ALOX5

Alcaftadine

hsa04666

Fc gamma R-mediated phagocytosis

2.32E-02

P04049

RAF1

Alcaftadine

hsa04668

TNF signaling pathway

2.79E-04

P01375, O00463, Q13489, P25963, P18848, P19875, P01584, P20749, Q13077, P14780, P20333

TNF, TRAF5, BIRC3, NFKBIA, ATF4, CXCL2, IL1B, BCL3, TRAF1, MMP9, TNFRSF1B

Alcaftadine

hsa04670

Leukocyte transendothelial migration

4.20E-02

P14780, Q96A32, P17252, P14598, Q15080, Q08881, P42681

MMP9, MYLPF, PRKCA, NCF1, NCF4, ITK, TXK

Alcaftadine

hsa04714

Thermogenesis

5.21E-03

Q16539, P33121, Q16718, O14521

MAPK14, ACSL1, NDUFA5, SDHD

Alcaftadine

hsa04720

Long-term potentiation

4.88E-03

P16298, P51812, Q02750, P04049

PPP3CB, RPS6KA3, MAP2K1, RAF1

Alcaftadine

hsa04721

Synaptic vesicle cycle

3.15E-02

Q13488, P31645

TCIRG1, SLC6A4

Alcaftadine

hsa04722

Neurotrophin signaling pathway

2.01E-04

P31751, P04049, P49841, O43524, P48023, P0DP23

AKT2, RAF1, GSK3B, FOXO3, FASLG, CALM1

Alcaftadine

hsa04726

Serotonergic synapse

1.33E-02

P04049

RAF1

Alcaftadine

hsa04728

Dopaminergic synapse

3.02E-03

P14416, P63218, P50151, P31751, P49841, Q16539, P49407, P0DP23

DRD2, GNG5, GNG10, AKT2, GSK3B, MAPK14, ARRB1, CALM1

Alcaftadine

hsa04730

Long-term depression

1.16E-02

P04049

RAF1

Alcaftadine

hsa04740

Olfactory transduction

9.46E-04

Q9H255, P0DP23

OR51E2, CALM1

Alcaftadine

hsa04742

Taste transduction

1.01E-02

P30939

HTR1F

Alcaftadine

hsa04744

Phototransduction

1.81E-02

P0DP23

CALM1

Alcaftadine

hsa04750

Inflammatory mediator regulation of TRP channels

1.17E-02

P14778, P01584, P51828, P22694, Q16539, Q14643, Q04759, P0DP24

IL1R1, IL1B, ADCY7, PRKACB, MAPK14, ITPR1, PRKCQ, CALM2

Alcaftadine

hsa04810

Regulation of actin cytoskeleton

3.81E-02

P04049

RAF1

Alcaftadine

hsa04910

Insulin signaling pathway

2.40E-05

P0DP23, P04049, P31751

CALM1, RAF1, AKT2

Alcaftadine

hsa04912

GnRH signaling pathway

2.74E-02

P51828, Q16539, Q9Y6R4, Q14643, P0DP24, P22694, P04049

ADCY7, MAPK14, MAP3K4, ITPR1, CALM2, PRKACB, RAF1

Alcaftadine

hsa04913

Ovarian steroidogenesis

2.54E-02

P42330, P22694

AKR1C3, PRKACB

Alcaftadine

hsa04914

Progesterone-mediated oocyte maturation

2.23E-04

Q17RY0, Q9Y6D9, P51812, Q02750, P04049

CPEB4, MAD1L1, RPS6KA3, MAP2K1, RAF1

Alcaftadine

hsa04915

Estrogen signaling pathway

2.42E-04

P04049, P31751, P0DP23

RAF1, AKT2, CALM1

Alcaftadine

hsa04916

Melanogenesis

1.47E-03

P0DP23, P04049

CALM1, RAF1

Alcaftadine

hsa04917

Prolactin signaling pathway

3.49E-04

P31751, P04049

AKT2, RAF1

Alcaftadine

hsa04919

Thyroid hormone signaling pathway

1.82E-02

P04049

RAF1

Alcaftadine

hsa04920

Adipocytokine signaling pathway

6.24E-04

P25963, Q06124, P33121, Q9Y478, Q04759, P31751, P01375

NFKBIA, PTPN11, ACSL1, PRKAB1, PRKCQ, AKT2, TNF

Alcaftadine

hsa04921

Oxytocin signaling pathway

2.32E-02

P04049

RAF1

Alcaftadine

hsa04922

Glucagon signaling pathway

1.79E-03

P31751, P0DP23

AKT2, CALM1

Alcaftadine

hsa04923

Regulation of lipolysis in adipocytes

3.01E-02

P31751

AKT2

Alcaftadine

hsa04924

Renin secretion

6.02E-03

P22694, P07550, P0DP23

PRKACB, ADRB2, CALM1

Alcaftadine

hsa04926

Relaxin signaling pathway

6.24E-03

P18848, P22694, P14780, P04049, P30679

ATF4, PRKACB, MMP9, RAF1, GNA15

Alcaftadine

hsa04927

Cortisol synthesis and secretion

2.54E-02

P18848, P22694

ATF4, PRKACB

Alcaftadine

hsa04928

Parathyroid hormone synthesis, secretion and action

1.99E-02

P04049

RAF1

Alcaftadine

hsa04929

GnRH secretion

1.87E-04

P31751, P04049

AKT2, RAF1

Alcaftadine

hsa04931

Insulin resistance

1.48E-02

Q06124, Q9Y478

PTPN11, PRKAB1

Alcaftadine

hsa04932

Non-alcoholic fatty liver disease

1.52E-05

P01375, P49841, O43521, P18848, P48023, O75460, P01584, P13073, Q16718, O14521

TNF, GSK3B, BCL2L11, ATF4, FASLG, ERN1, IL1B, COX4I1, NDUFA5, SDHD

Alcaftadine

hsa04933

AGE-RAGE signaling pathway in diabetic complications

3.21E-02

P84022, Q13485, P42338, P49767, P19174

SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1

Alcaftadine

hsa04935

Growth hormone synthesis, secretion and action

2.16E-02

P04049

RAF1

Alcaftadine

hsa04940

Type I diabetes mellitus

1.87E-02

P48023, P01375

FASLG, TNF

Alcaftadine

hsa04964

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Alcaftadine

hsa04966

Collecting duct acid secretion

4.93E-02

P00918

CA2

Alcaftadine

hsa04970

Salivary secretion

6.99E-04

P07550, P22694, Q14643, P17252, P0DP23, P49913

ADRB2, PRKACB, ITPR1, PRKCA, CALM1, CAMP

Alcaftadine

hsa04971

Gastric acid secretion

4.78E-02

P0DP23

CALM1

Alcaftadine

hsa04973

Carbohydrate digestion and absorption

2.41E-02

P31751

AKT2

Alcaftadine

hsa04976

Bile secretion

3.32E-02

O43315, P08183

AQP9, ABCB1

Alcaftadine

hsa05010

Alzheimer disease

8.89E-04

P13073, Q00535, O75460, P0DP24, P0DP23, P01584, P18848, P31751, P05141

COX4I1, CDK5, ERN1, CALM2, CALM1, IL1B, ATF4, AKT2, SLC25A5

Alcaftadine

hsa05012

Parkinson disease

3.89E-02

P13073, P05141, O75460, P18848, P0DP24

COX4I1, SLC25A5, ERN1, ATF4, CALM2

Alcaftadine

hsa05016

Huntington disease

4.87E-02

P13073, P24928, P62487, P05141, O75460

COX4I1, POLR2A, POLR2G, SLC25A5, ERN1

Alcaftadine

hsa05020

Prion disease

3.80E-02

Q16718, O14521, P49841, Q16539

NDUFA5, SDHD, GSK3B, MAPK14

Alcaftadine

hsa05022

Pathways of neurodegeneration - multiple diseases

2.12E-04

P49841, Q16718, O14521, P13073, O75460, P18848, Q13561, P05141, P20333, Q16539, Q00535, P01584, Q08752, P0DP24, P0DP23

GSK3B, NDUFA5, SDHD, COX4I1, ERN1, ATF4, DCTN2, SLC25A5, TNFRSF1B, MAPK14, CDK5, IL1B, PPID, CALM2, CALM1

Alcaftadine

hsa05030

Cocaine addiction

4.19E-02

Q00535

CDK5

Alcaftadine

hsa05031

Amphetamine addiction

6.98E-03

P0DP23, P22694, P18848, Q13547

CALM1, PRKACB, ATF4, HDAC1

Alcaftadine

hsa05034

Alcoholism

2.78E-04

P04049, Q93077, P62807, O60814, P68431

RAF1, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Alcaftadine

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

1.85E-03

Q16539, P09341, P25024, P25025, P07948

MAPK14, CXCL1, CXCR1, CXCR2, LYN

Alcaftadine

hsa05131

Shigellosis

3.34E-02

P01375, P25963, O00463, Q04759, Q9UDY8, Q9H1Y0, Q14643, Q12778, Q13315, P10415, Q96A32

TNF, NFKBIA, TRAF5, PRKCQ, MALT1, ATG5, ITPR1, FOXO1, ATM, BCL2, MYLPF

Alcaftadine

hsa05132

Salmonella infection

1.81E-02

P51617, P25963, P01375, P04049, Q9UJU2, Q13489, P10415, Q96A32, O60603, Q9BQS8, Q13561, Q13509

IRAK1, NFKBIA, TNF, RAF1, LEF1, BIRC3, BCL2, MYLPF, TLR2, FYCO1, DCTN2, TUBB3

Alcaftadine

hsa05133

Pertussis

4.20E-02

P0C0L4

C4A

Alcaftadine

hsa05135

Yersinia infection

6.38E-03

Q05397, P51812, P13612, P06239, Q16539, Q02750, P01375, P49841, Q96JJ3

PTK2, RPS6KA3, ITGA4, LCK, MAPK14, MAP2K1, TNF, GSK3B, ELMO2

Alcaftadine

hsa05140

Leishmaniasis

4.73E-06

P13612, O75015, P14598, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P29350, P49006, Q16539, P51617, Q15080

ITGA4, FCGR3B, NCF1, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13612	ITGA4	Integrin alpha-4	-0.797
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.92
Q16539	MAPK14	Mitogen-activated protein kinase 14	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.814
P09960	LTA4H	Leukotriene A-4 hydrolase	P14598	NCF1	Neutrophil cytosol factor 1	0.798
P08246	ELA2	Neutrophil elastase	P14598	NCF1	Neutrophil cytosol factor 1	0.762
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P09960	LTA4H	Leukotriene A-4 hydrolase	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	0.787
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.785
Q16539	MAPK14	Mitogen-activated protein kinase 14	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.754
P08246	ELA2	Neutrophil elastase	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.729
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P08246	ELA2	Neutrophil elastase	O60603	TLR2	Toll-like receptor 2	0.853
P09960	LTA4H	Leukotriene A-4 hydrolase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.768
P08246	ELA2	Neutrophil elastase	P25963	NFKBIA	NF-kappa-B inhibitor alpha	0.701
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P08246	ELA2	Neutrophil elastase	P01375	TNF	Tumor necrosis factor	0.751
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P09960	LTA4H	Leukotriene A-4 hydrolase	P29350	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	0.808
Q16539	MAPK14	Mitogen-activated protein kinase 14	P49006	MARCKSL1	MARCKS-related protein	-0.852
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P08246	ELA2	Neutrophil elastase	P51617	IRAK1	Interleukin-1 receptor-associated kinase 1	-0.734
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q15080	NCF4	Neutrophil cytosol factor 4	0.762
P09960	LTA4H	Leukotriene A-4 hydrolase	Q15080	NCF4	Neutrophil cytosol factor 4	0.758
P08246	ELA2	Neutrophil elastase	Q15080	NCF4	Neutrophil cytosol factor 4	0.945

Alcaftadine

hsa05143

African trypanosomiasis

7.50E-04

P01375, P69905, P68871, P48023

TNF, HBA2, HBB, FASLG

Alcaftadine

hsa05144

Malaria

1.50E-05

P60033, P69905, P68871, O60603, P01375, P35443, P01584, P26718

CD81, HBA2, HBB, TLR2, TNF, THBS4, IL1B, KLRK1

Alcaftadine

hsa05145

Toxoplasmosis

3.07E-02

P51617, P25963, P01375, P10415, Q13489, P13765, O60603

IRAK1, NFKBIA, TNF, BCL2, BIRC3, HLA-DOB, TLR2

Alcaftadine

hsa05146

Amoebiasis

2.47E-05

P01584, P09341, P19875, P14778, P27930, P01375, O60603, P05089, P30679, P22694, P12814, P08311

IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, ARG1, GNA15, PRKACB, ACTN1, CTSG

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01584	IL1B	Interleukin-1 beta	0.807
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09341	CXCL1	Growth-regulated alpha protein	0.788
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09341	CXCL1	Growth-regulated alpha protein	0.7
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P07550	ADRB2	Beta-2 adrenergic receptor	P19875	CXCL2	C-X-C motif chemokine 2	-0.83
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14778	IL1R1	Interleukin-1 receptor type 1	0.766
Q16539	MAPK14	Mitogen-activated protein kinase 14	P14778	IL1R1	Interleukin-1 receptor type 1	0.76
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
Q16539	MAPK14	Mitogen-activated protein kinase 14	P27930	IL1R2	Interleukin-1 receptor type 2	0.811
P06239	LCK	Tyrosine-protein kinase Lck	P27930	IL1R2	Interleukin-1 receptor type 2	-0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P01375	TNF	Tumor necrosis factor	0.78
P07550	ADRB2	Beta-2 adrenergic receptor	P01375	TNF	Tumor necrosis factor	-0.755
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05089	ARG1	Arginase-1	0.848
Q16539	MAPK14	Mitogen-activated protein kinase 14	P05089	ARG1	Arginase-1	0.702
P06239	LCK	Tyrosine-protein kinase Lck	P05089	ARG1	Arginase-1	-0.803
P07550	ADRB2	Beta-2 adrenergic receptor	P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	-0.8
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	-0.772
P07550	ADRB2	Beta-2 adrenergic receptor	P22694	PRKACB	cAMP-dependent protein kinase catalytic subunit beta	0.724
P06239	LCK	Tyrosine-protein kinase Lck	P12814	ACTN1	Alpha-actinin-1	-0.867
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08311	CTSG	Cathepsin G	0.744
P06239	LCK	Tyrosine-protein kinase Lck	P08311	CTSG	Cathepsin G	-0.816

Alcaftadine

hsa05152

Tuberculosis

3.61E-03

P04049, Q13488, P0DP23, P48382, O60603, P01375, P31751, P10415, P13765, P49913, Q9UDY8, P51617

RAF1, TCIRG1, CALM1, RFX5, TLR2, TNF, AKT2, BCL2, HLA-DOB, CAMP, MALT1, IRAK1

Alcaftadine

hsa05160

Hepatitis C

1.40E-03

P60033, P04049, P49841, P01375, P48023

CD81, RAF1, GSK3B, TNF, FASLG

Alcaftadine

hsa05161

Hepatitis B

4.82E-03

P17252, P04049, P14780, P25963, P01375, P10415, P51617, O60603, Q14765

PRKCA, RAF1, MMP9, NFKBIA, TNF, BCL2, IRAK1, TLR2, STAT4

Alcaftadine

hsa05163

Human cytomegalovirus infection

1.14E-03

P31751, P04049, P01375, P63218, P50151, Q14643, P0DP23, P49841, P14778, P25025, Q16539, P04637, O00463

AKT2, RAF1, TNF, GNG5, GNG10, ITPR1, CALM1, GSK3B, IL1R1, CXCR2, MAPK14, TP53, TRAF5

Alcaftadine

hsa05164

Influenza A

3.65E-02

P04049

RAF1

Alcaftadine

hsa05167

Kaposi sarcoma-associated herpesvirus infection

5.30E-04

P31751, P62879, P16298, P04049, Q02750, P0DP23, P0CG47

AKT2, GNB2, PPP3CB, RAF1, MAP2K1, CALM1, UBB

Alcaftadine

hsa05168

Herpes simplex virus 1 infection

3.38E-03

P25963, P01568, Q05823, P42224, Q07955, Q13243, Q13489, Q13398, Q9HCX3, P52738, O75820, Q9UDV6

NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS5, BIRC3, ZNF211, ZNF304, ZNF140, ZNF189, ZNF212

Alcaftadine

hsa05169

Epstein-Barr virus infection

4.84E-03

P13765, P01106, Q13547, O00463, P07948, Q13761, P24522, P07766, P09693, P20963

HLA-DOB, MYC, HDAC1, TRAF5, LYN, RUNX3, GADD45A, CD3E, CD3G, CD247

Alcaftadine

hsa05170

Human immunodeficiency virus 1 infection

2.67E-05

P31751, P04049, P0DP23, P01375, P17252, O00463, Q14643, P51617, P25963, O60603, Q13315, O95067, P10415, Q13619, Q93034, Q9Y6Q5

AKT2, RAF1, CALM1, TNF, PRKCA, TRAF5, ITPR1, IRAK1, NFKBIA, TLR2, ATM, CCNB2, BCL2, CUL4A, CUL5, AP1M2

Alcaftadine

hsa05200

Pathways in cancer

1.81E-03

Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P31751, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P0DP23, P14784

LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, AKT2, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, CALM1, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P31751	AKT2	RAC-beta serine/threonine-protein kinase	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P31751	AKT2	RAC-beta serine/threonine-protein kinase	P0DP23	CALM1	Calmodulin-1	0.761
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835

Alcaftadine

hsa05202

Transcriptional misregulation in cancer

7.38E-06

Q12778, Q15532, Q13315, P17844, P14780, P27930, P14923, Q16548, Q13489, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522

FOXO1, SS18, ATM, DDX5, MMP9, IL1R2, JUP, BCL2A1, BIRC3, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P08246	ELA2	Neutrophil elastase	Q12778	FOXO1	Forkhead box protein O1	-0.75
P08246	ELA2	Neutrophil elastase	Q15532	SS18	Protein SSXT	-0.806
P08246	ELA2	Neutrophil elastase	Q13315	ATM	Serine-protein kinase ATM	-0.742
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.863
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P14780	MMP9	Matrix metalloproteinase-9	0.94
P08246	ELA2	Neutrophil elastase	P14780	MMP9	Matrix metalloproteinase-9	0.859
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P27930	IL1R2	Interleukin-1 receptor type 2	0.926
P08246	ELA2	Neutrophil elastase	P14923	JUP	Junction plakoglobin	-0.811
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16548	BCL2A1	Bcl-2-related protein A1	0.958
P08246	ELA2	Neutrophil elastase	Q16548	BCL2A1	Bcl-2-related protein A1	0.766
P08246	ELA2	Neutrophil elastase	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.716
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.796
P08246	ELA2	Neutrophil elastase	Q13077	TRAF1	TNF receptor-associated factor 1	-0.725
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P35226	BMI1	Polycomb complex protein BMI-1	-0.778
P08246	ELA2	Neutrophil elastase	P35226	BMI1	Polycomb complex protein BMI-1	-0.824
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P05164	MPO	Myeloperoxidase	0.719
P08246	ELA2	Neutrophil elastase	P05164	MPO	Myeloperoxidase	0.903
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12838	DEFA4	Neutrophil defensin 4	0.784
P08246	ELA2	Neutrophil elastase	P12838	DEFA4	Neutrophil defensin 4	0.709
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P08246	ELA2	Neutrophil elastase	0.702
P08246	ELA2	Neutrophil elastase	P08246	ELA2	Neutrophil elastase	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.783
P08246	ELA2	Neutrophil elastase	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.75
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P41182	BCL6	B-cell lymphoma 6 protein	0.919
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q13547	HDAC1	Histone deacetylase 1	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q92769	HDAC2	Histone deacetylase 2	-0.7
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P12980	LYL1	Protein lyl-1	0.784
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.819
P08246	ELA2	Neutrophil elastase	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.7

Alcaftadine

hsa05203

Viral carcinogenesis

4.85E-02

Q15283, P62807, O60814

RASA2, HIST1H2BC, H2BC12

Alcaftadine

hsa05204

Chemical carcinogenesis

1.48E-02

P78417, P11712

GSTO1, CYP2C9

Alcaftadine

hsa05205

Proteoglycans in cancer

1.09E-02

P04049, P14780, P01375, P23588, Q13635, P22694

RAF1, MMP9, TNF, EIF4B, PTCH1, PRKACB

Alcaftadine

hsa05206

MicroRNAs in cancer

3.15E-02

P04049

RAF1

Alcaftadine

hsa05210

Colorectal cancer

1.66E-02

P04049

RAF1

Alcaftadine

hsa05211

Renal cell carcinoma

1.29E-03

P31751, P04049

AKT2, RAF1

Alcaftadine

hsa05212

Pancreatic cancer

2.09E-03

P42338, P31751, P04049, P84022, Q13485, O75293

PIK3CB, AKT2, RAF1, SMAD3, SMAD4, GADD45B

Alcaftadine

hsa05213

Endometrial cancer

8.16E-04

P31751, P04049

AKT2, RAF1

Alcaftadine

hsa05214

Glioma

8.46E-06

P0DP23, P04049, P31751

CALM1, RAF1, AKT2

Alcaftadine

hsa05215

Prostate cancer

1.33E-02

P04049

RAF1

Alcaftadine

hsa05216

Thyroid cancer

3.80E-02

P01106, O75293

MYC, GADD45B

Alcaftadine

hsa05217

Basal cell carcinoma

3.50E-02

Q13635, P49841, Q9UJU2, P24522

PTCH1, GSK3B, LEF1, GADD45A

Alcaftadine

hsa05218

Melanoma

4.47E-04

P31751, P04049

AKT2, RAF1

Alcaftadine

hsa05219

Bladder cancer

5.65E-03

P14780, P04637, P04049

MMP9, TP53, RAF1

Alcaftadine

hsa05220

Chronic myeloid leukemia

4.90E-04

Q13547, Q13485, P84022, P31751, P42338, P04049, O75293

HDAC1, SMAD4, SMAD3, AKT2, PIK3CB, RAF1, GADD45B

Alcaftadine

hsa05221

Acute myeloid leukemia

8.16E-04

P31751, P04049

AKT2, RAF1

Alcaftadine

hsa05222

Small cell lung cancer

5.10E-03

P31751, Q13489, P10415, P25963, Q13077, O00463, P24522

AKT2, BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45A

Alcaftadine

hsa05223

Non-small cell lung cancer

3.89E-05

P31751, P10826, P04049, Q9HC35, O75293

AKT2, RARB, RAF1, EML4, GADD45B

Alcaftadine

hsa05224

Breast cancer

1.24E-02

P04049, P49841, Q92837, P04637, P24522

RAF1, GSK3B, FRAT1, TP53, GADD45A

Alcaftadine

hsa05225

Hepatocellular carcinoma

1.33E-02

P04049

RAF1

Alcaftadine

hsa05226

Gastric cancer

6.88E-05

P04049, P31751, P04628, P10826

RAF1, AKT2, WNT1, RARB

Alcaftadine

hsa05230

Central carbon metabolism in cancer

1.12E-03

P04049, P31751

RAF1, AKT2

Alcaftadine

hsa05231

Choline metabolism in cancer

1.33E-02

P04049

RAF1

Alcaftadine

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

3.84E-06

O95267, P07766, P20963, P09693, P06239, P04049, P23458, O60603, Q04759, Q16539, Q9HC35, P01730

RASGRP1, CD3E, CD247, CD3G, LCK, RAF1, JAK1, TLR2, PRKCQ, MAPK14, EML4, CD4

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.852
Q16539	MAPK14	Mitogen-activated protein kinase 14	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.716
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P52732	KIF11	Kinesin-like protein KIF11	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.724
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.786
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.835
Q16539	MAPK14	Mitogen-activated protein kinase 14	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.744
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P06239	LCK	Tyrosine-protein kinase Lck	-0.726
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P52732	KIF11	Kinesin-like protein KIF11	P06239	LCK	Tyrosine-protein kinase Lck	-0.721
P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	P04049	RAF1	RAF proto-oncogene serine/threonine-protein kinase	1
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	P23458	JAK1	Tyrosine-protein kinase JAK1	0.757
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	O60603	TLR2	Toll-like receptor 2	0.842
Q16539	MAPK14	Mitogen-activated protein kinase 14	O60603	TLR2	Toll-like receptor 2	0.73
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q04759	PRKCQ	Protein kinase C theta type	-0.767
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P43490	PBEF1	Nicotinamide phosphoribosyltransferase	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.883
Q16539	MAPK14	Mitogen-activated protein kinase 14	Q16539	MAPK14	Mitogen-activated protein kinase 14	1
P52732	KIF11	Kinesin-like protein KIF11	Q9HC35	EML4	Echinoderm microtubule-associated protein-like 4	0.794
Q16539	MAPK14	Mitogen-activated protein kinase 14	P01730	CD4	T-cell surface glycoprotein CD4	-0.707
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P52732	KIF11	Kinesin-like protein KIF11	P01730	CD4	T-cell surface glycoprotein CD4	-0.719

Alcaftadine

hsa05310

Asthma

3.88E-02

P13765, P12724, P01375

HLA-DOB, RNASE3, TNF

Alcaftadine

hsa05321

Inflammatory bowel disease

2.87E-05

O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584

TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B

Alcaftadine

hsa05322

Systemic lupus erythematosus

2.09E-04

P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455

ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSB

Alcaftadine

hsa05330

Allograft rejection

2.72E-02

P48023, P01375

FASLG, TNF

Alcaftadine

hsa05332

Graft-versus-host disease

2.84E-06

P13765, P48023, P10747, P01375, P26715, Q13241

HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1

Alcaftadine

hsa05340

Primary immunodeficiency

1.31E-04

P01730, P01732, P11912, P07766, P06239

CD4, CD8A, CD79A, CD3E, LCK

Alcaftadine

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Alcaftadine

hsa05415

Diabetic cardiomyopathy

4.54E-04

P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406

PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDH

Alcaftadine

hsa05418

Fluid shear stress and atherosclerosis

3.80E-04

Q16539, P31751, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23

MAPK14, AKT2, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1

Community members of Alcaftadine (S_DC: 8.24)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

DRD2

D(2) dopamine receptor

Predicted

0.0604

0.4779

2.5081

P09874

PARP1

Poly [ADPNoneribose] polymerase 1

Predicted

0.5536

0.4482

2.725

Q16539

MAPK14

MitogenNoneactivated protein kinase 14

Predicted

0.0149

3.0075

Q02750

MAP2K1

Dual specificity mitogenNoneactivated protein kinase kinase 1

Predicted

0.312

0.5129

2.1819

P04049

RAF1

RAF protoNoneoncogene serine/threonineNoneprotein kinase

Predicted

0.557

0.7572

2.7929

Q9Y478

PRKAB1

5'NoneAMPNoneactivated protein kinase subunit betaNone1

Predicted

0.1478

0.1088

0.5564

0.8479

P31751

AKT2

RACNonebeta serine/threonineNoneprotein kinase

Predicted

0.4662

0.4856

2.2044

P09960

LTA4H

Leukotriene ANone4 hydrolase

Predicted

0.277

0.9519

0.1565

2.1988

P30939

HTR1F

5Nonehydroxytryptamine receptor 1F

Predicted

0.0009

0.0198

2.0202

P00918

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

P31645

SLC6A4

SodiumNonedependent serotonin transporter

Predicted

0.0477

0.0203

2.0442

P06239

LCK

TyrosineNoneprotein kinase Lck

Predicted

0.0576

0.7287

2.7575

P43490

PBEF1

Nicotinamide phosphoribosyltransferase

Predicted

0.4423

0.7064

0.238

1.872

P25024

CXCR1

CNoneXNoneC chemokine receptor type 1

Predicted

0.1656

0.4232

0.4009

1.33

P61073

CXCR4

CNoneXNoneC chemokine receptor type 4

Predicted

0.2823

0.4018

0.648

1.5927

P06493

CDK1

CyclinNonedependent kinase 1

Predicted

0.013

0.604

2.6105

P09917

ALOX5

Polyunsaturated fatty acid 5Nonelipoxygenase

Predicted

0.3822

0.2701

2.4612

P52732

KIF11

KinesinNonelike protein KIF11

Predicted

0.0082

0.8281

1.6602

P08246

ELA2

Neutrophil elastase

Predicted

0.496

0.6844

0.7132

2.33

P07550

ADRB2

BetaNone2 adrenergic receptor

Predicted

0.0071

0.2205

2.224

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

Q6PCB7

SLC27A1

LongNonechain fatty acid transport protein 1

Predicted

0.2915

0.0768

0.0992

0.3985

PharmaCoNets of Alcaftadine (SPCN: 204.91 )

Alcaftadine regulated-network (SDN: 24.87)

Community members of Alcaftadine (SDC: 8.24)

PharmaCoNets of Alcaftadine (S_PCN: 204.91 )

Alcaftadine regulated-network (S_DN: 24.87)

Community members of Alcaftadine (S_DC: 8.24)