PharmaCoNets of Adenosine (SPCN: 178.76 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Adenosine-phosphatehsa00010Glycolysis / Gluconeogenesis4.41E-024P04075, P06733, P04406, P60174ALDOA, ENO1, GAPDH, TPI1More
Adenosine-phosphatehsa00030Pentose phosphate pathway1.09E-065P60891, P51854, P08237, P52209, P37837PRPS1, TKTL1, PFKM, PGD, TALDO1More
Adenosine-phosphatehsa00051Fructose and mannose metabolism2.21E-023O14772, P60174, P04075FPGT, TPI1, ALDOAMore
Adenosine-phosphatehsa00052Galactose metabolism6.10E-033P06280, O43451, P35557GLA, MGAM, GCKMore
Adenosine-phosphatehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Adenosine-phosphatehsa00061Fatty acid biosynthesis1.52E-031Q9UKU0ACSL6More
Adenosine-phosphatehsa00071Fatty acid degradation4.55E-031Q9UKU0ACSL6More
Adenosine-phosphatehsa00100Steroid biosynthesis1.84E-031P35610SOAT1More
Adenosine-phosphatehsa00190Oxidative phosphorylation4.56E-037O95298, Q16718, O15239, P12074, P36542, P05496, O14521NDUFC2, NDUFA5, NDUFA1, COX6A1, ATP5C1, ATP5G1, SDHDMore
Adenosine-phosphatehsa00220Arginine biosynthesis1.84E-053P15104, P05089, P49448GLUL, ARG1, GLUD2More
Adenosine-phosphatehsa00230Purine metabolism2.11E-023Q7LG56, P31350, P21589RRM2B, RRM2, NT5EMore
Adenosine-phosphatehsa00240Pyrimidine metabolism6.02E-096Q7LG56, P31350, P21589, P32320, P04183, P04818RRM2B, RRM2, NT5E, CDA, TK1, TYMSMore
Adenosine-phosphatehsa00250Alanine, aspartate and glutamate metabolism4.40E-032P49448, P15104GLUD2, GLULMore
Adenosine-phosphatehsa00280Valine, leucine and isoleucine degradation3.30E-024P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Adenosine-phosphatehsa00310Lysine degradation3.73E-033Q96KQ7, Q02809, P51648EHMT2, PLOD1, ALDH3A2More
Adenosine-phosphatehsa00410beta-Alanine metabolism3.98E-021Q6ZQY3GADL1More
Adenosine-phosphatehsa00440Phosphonate and phosphinate metabolism3.98E-021Q9Y6K0CEPT1More
Adenosine-phosphatehsa00471D-Glutamine and D-glutamate metabolism1.54E-032Q7Z3D6, P49448C14orf159, GLUD2More
Adenosine-phosphatehsa00480Glutathione metabolism3.85E-022Q7LG56, P31350RRM2B, RRM2More
Adenosine-phosphatehsa00500Starch and sucrose metabolism2.31E-074O43451, P46976, P35557, P06737MGAM, GYG1, GCK, PYGLMore
Adenosine-phosphatehsa00512Mucin type O-glycan biosynthesis1.22E-022O95395, Q8N4A0GCNT3, GALNT4More
Adenosine-phosphatehsa00524Neomycin, kanamycin and gentamicin biosynthesis8.73E-041P35557GCKMore
Adenosine-phosphatehsa00562Inositol phosphate metabolism4.55E-022P27987, P42338ITPKB, PIK3CBMore
Adenosine-phosphatehsa00564Glycerophospholipid metabolism2.07E-033P48651, Q9Y6K0, P35790PTDSS1, CEPT1, CHKAMore
Adenosine-phosphatehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Adenosine-phosphatehsa00600Sphingolipid metabolism3.76E-021P15289ARSAMore
Adenosine-phosphatehsa00630Glyoxylate and dicarboxylate metabolism1.57E-053P40925, P40926, P15104MDH1, MDH2, GLULMore
Adenosine-phosphatehsa00730Thiamine metabolism1.55E-032P05186, P24666ALPL, ACP1More
Adenosine-phosphatehsa00740Riboflavin metabolism3.98E-021Q969G6RFKMore
Adenosine-phosphatehsa00770Pantothenate and CoA biosynthesis7.20E-043O95498, Q6ZQY3, Q9NRN7VNN2, GADL1, AASDHPPTMore
Adenosine-phosphatehsa00910Nitrogen metabolism4.40E-032P15104, P49448GLUL, GLUD2More
Adenosine-phosphatehsa00983Drug metabolism - other enzymes2.03E-086P04183, P20839, P32320, Q7LG56, P31350, P05164TK1, IMPDH1, CDA, RRM2B, RRM2, MPOMore
Adenosine-phosphatehsa01040Biosynthesis of unsaturated fatty acids4.28E-021P22307SCP2More
Adenosine-phosphatehsa01100Metabolic pathways1.28E-0455Q9NR34, Q9Y234, P35790, P05089, P21953, Q16772, P15144, P30041, P15104, P42338, O14732, P27987, P32320, Q02153, Q16774, P20839, P00918, P22748, P10768, P55809, P06280, Q16875, O43286, O43451, P53004, Q9Y6K0, P05186, P24666, P08237, P21399, Q9HCC0, P33121, Q9UHK6, P51854, Q86VZ5, P09917, Q9BVK2, P15907, P57054, Q9UNP4, O96024, Q9BX95, P37837, P32321, P49448, P50213, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q969G6, Q13029, Q9NVH6MAN1C1, LIPT1, CHKA, ARG1, BCKDHB, GSTA3, ANPEP, PRDX6, GLUL, PIK3CB, IMPA2, ITPKB, CDA, GUCY1B3, GUK1, IMPDH1, CA2, CA4, ESD, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, BLVRA, CEPT1, ALPL, ACP1, PFKM, ACO1, MCCC2, ACSL1, AMACR, TKTL1, SGMS1, ALOX5, ALG8, ST6GAL1, PIGP, ST3GAL5, B3GALT4, SGPP1, TALDO1, DCTD, GLUD2, IDH3A, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, RFK, PRDM2, TMLHEMore
Adenosine-phosphatehsa01200Carbon metabolism3.30E-0413P04075, P51854, P04406, P08237, P60174, P37837, P06733, O14521, Q9P2R7, P50213, P21399, P10768, Q02252ALDOA, TKTL1, GAPDH, PFKM, TPI1, TALDO1, ENO1, SDHD, SUCLA2, IDH3A, ACO1, ESD, ALDH6A1More
Adenosine-phosphatehsa012102-Oxocarboxylic acid metabolism6.11E-042P21399, P50213ACO1, IDH3AMore
Adenosine-phosphatehsa01212Fatty acid metabolism7.59E-031Q9UKU0ACSL6More
Adenosine-phosphatehsa01230Biosynthesis of amino acids2.08E-0410P60174, P04406, P06733, P04075, P08237, P51854, Q99707, P21399, P50213, P37837TPI1, GAPDH, ENO1, ALDOA, PFKM, TKTL1, MTR, ACO1, IDH3A, TALDO1More
Adenosine-phosphatehsa01522Endocrine resistance3.10E-035P22694, Q9UM47, P04637, P42773, P46527PRKACB, NOTCH3, TP53, CDKN2C, CDKN1BMore
Adenosine-phosphatehsa01523Antifolate resistance1.68E-022Q92820, P04818GGH, TYMSMore
Adenosine-phosphatehsa01524Platinum drug resistance4.94E-022P78417, P52701GSTO1, MSH6More
Adenosine-phosphatehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Adenosine-phosphatehsa03008Ribosome biogenesis in eukaryotes8.16E-033Q9NYH9, P78345, Q9GZY0UTP6, RPP38, NXF2; NXF2BMore
Adenosine-phosphatehsa03010Ribosome8.03E-048P62753, P62829, P46777, P62888, P61927, P61513, P36578, P50914RPS6, RPL23, RPL5, RPL30, RPL37, RPL37A, RPL4, RPL14More
Adenosine-phosphatehsa03013RNA transport4.45E-0516O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, P47813, Q14152, O75822, P78345, Q14240, Q9BZI7, Q9Y6A5, Q06787, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF1AX, EIF3A, EIF3J, RPP38, EIF4A2, UPF3B, TACC3, FMR1, FXR1More
Adenosine-phosphatehsa03015mRNA surveillance pathway3.37E-023O43148, Q9GZY0, P52298RNMT, NXF2; NXF2B, NCBP2More
Adenosine-phosphatehsa03020RNA polymerase2.70E-054P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Adenosine-phosphatehsa03022Basal transcription factors3.50E-023P20226, O00268, Q15544TBP, TAF4, TAF11More
Adenosine-phosphatehsa03040Spliceosome4.80E-0817Q14562, O43143, O60508, P17844, P08579, P26368, P51991, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, DDX5, SNRPB2, U2AF2, HNRPA3, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Adenosine-phosphatehsa03050Proteasome4.83E-021P55036PSMD4More
Adenosine-phosphatehsa03060Protein export2.83E-022P37108, Q15005SRP14, SPCS2More
Adenosine-phosphatehsa03320PPAR signaling pathway9.10E-031Q9UKU0ACSL6More
Adenosine-phosphatehsa03430Mismatch repair4.38E-021P20585MSH3More
Adenosine-phosphatehsa04015Rap1 signaling pathway9.14E-032P06213, O00522INSR, KRIT1More
Adenosine-phosphatehsa04020Calcium signaling pathway2.80E-0512P27987, Q96DU7, Q08828, P21796, P45880, Q13557, P21860, P30679, P19174, P0DP23, P05141, P23634ITPKB, ITPKC, ADCY1, VDAC1, VDAC2, CAMK2D, ERBB3, GNA15, PLCG1, CALM1, SLC25A5, ATP2B4More
Adenosine-phosphatehsa04022cGMP-PKG signaling pathway2.26E-038Q14814, Q99941, P18848, P05141, P21796, P45880, P0DP23, P01042MEF2D, CREBL1, ATF4, SLC25A5, VDAC1, VDAC2, CALM1, KNG1More
Adenosine-phosphatehsa04061Viral protein interaction with cytokine and cytokine receptor4.90E-021Q99731CCL19More
Adenosine-phosphatehsa04062Chemokine signaling pathway2.94E-024P07948, P42338, P50151, P49407LYN, PIK3CB, GNG10, ARRB1More
Adenosine-phosphatehsa04064NF-kappa B signaling pathway3.70E-0817P10415, P51617, O00463, P14778, P01584, Q04759, Q9UDY8, Q13077, Q16548, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, Q9NQC7BCL2, IRAK1, TRAF5, IL1R1, IL1B, PRKCQ, MALT1, TRAF1, BCL2A1, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CYLDMore
Adenosine-phosphatehsa04070Phosphatidylinositol signaling system1.16E-037P19174, P0DP23, O14986, P23743, Q86XP1, P27987, Q96DU7PLCG1, CALM1, PIP5K1B, DGKA, DGKH, ITPKB, ITPKCMore
Adenosine-phosphatehsa04071Sphingolipid signaling pathway1.13E-059P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Adenosine-phosphatehsa04080Neuroactive ligand-receptor interaction1.07E-039P08311, P00734, Q15722, P21453, Q9H228, Q96G91, P21462, P21730, P07550CTSG, F2, LTB4R, S1PR1, EDG8, P2RY11, FPR1, C5AR1, ADRB2More
Adenosine-phosphatehsa04110Cell cycle2.76E-059P30260, P06493, O60566, P04637, P49918, P30304, P33981, P42773, P01106CDC27, CDK1, BUB1B, TP53, CDKN1C, CDC25A, TTK, CDKN2C, MYCMore
Adenosine-phosphatehsa04115p53 signaling pathway1.37E-058P24522, Q13315, Q7LG56, P31350, Q9HA38, P04637, O95067, P10415GADD45A, ATM, RRM2B, RRM2, ZMAT3, TP53, CCNB2, BCL2More
Adenosine-phosphatehsa04120Ubiquitin mediated proteolysis3.44E-024Q14145, Q13042, P62837, Q15751KEAP1, CDC16, UBE2D2, HERC1More
Adenosine-phosphatehsa04141Protein processing in endoplasmic reticulum7.24E-059P18848, P30101, Q15437, Q15436, Q99941, P11142, P07900, P08238, Q9NR31ATF4, PDIA3, SEC23B, SEC23A, CREBL1, HSPA8, HSP90AA1, HSP90AB1, SAR1AMore
Adenosine-phosphatehsa04142Lysosome5.39E-059P22304, P38571, Q13510, Q9UJJ9, P07602, P49279, P61916, Q04900, Q9Y227IDS, LIPA, ASAH1, GNPTG, PSAP, SLC11A1, NPC2, CD164, ENTPD4More
Adenosine-phosphatehsa04144Endocytosis1.09E-0312Q13191, P0DMV8, P11142, Q9H444, P62491, P25024, P43250, Q8WU79, Q14161, P14784, Q9UMY4, Q9Y5X3CBLB, HSPA1A, HSPA8, CHMP4B, RAB11A, CXCR1, GRK6, SMAP1L, GIT2, IL2RB, SNX12, SNX5More
Adenosine-phosphatehsa04145Phagosome1.73E-047O75015, Q15080, P68371, P05164, P78380, P35443, P13765FCGR3B, NCF4, TUBB2C, MPO, OLR1, THBS4, HLA-DOBMore
Adenosine-phosphatehsa04146Peroxisome9.47E-047O43933, O96011, P56589, Q9UKG9, O75521, P33121, Q9UKU0PEX1, PEX11B, PEX3, CROT, ECI2, ACSL1, ACSL6More
Adenosine-phosphatehsa04151PI3K-Akt signaling pathway4.39E-0516P62753, P04637, P27348, P07900, P08238, P62873, P63218, Q16363, P22105, P14784, Q99941, P18848, Q96BR1, O00141, P30279, P56279RPS6, TP53, YWHAQ, HSP90AA1, HSP90AB1, GNB1, GNG5, LAMA4, TNXB, IL2RB, CREBL1, ATF4, SGK3, SGK, CCND2, TCL1AMore
Adenosine-phosphatehsa04211Longevity regulating pathway2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Adenosine-phosphatehsa04213Longevity regulating pathway - multiple species4.79E-022Q08828, P0DMV8ADCY1, HSPA1AMore
Adenosine-phosphatehsa04216Ferroptosis1.52E-021Q9UKU0ACSL6More
Adenosine-phosphatehsa04217Necroptosis1.18E-0617P01375, P23458, P48023, Q9NQC7, P42224, Q14765, P07900, P08238, P15104, P05141, P01584, Q99878, Q13557, Q9H444, O75351, P21796, P45880TNF, JAK1, FASLG, CYLD, STAT1, STAT4, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AC14, CAMK2D, CHMP4B, VPS4B, VDAC1, VDAC2More
Adenosine-phosphatehsa04261Adrenergic signaling in cardiomyocytes7.00E-047P07550, P51828, P22694, Q99941, P18848, Q13362, Q13557ADRB2, ADCY7, PRKACB, CREBL1, ATF4, PPP2R5C, CAMK2DMore
Adenosine-phosphatehsa04270Vascular smooth muscle contraction1.47E-034P0DP23, Q08828, P35579, P35318CALM1, ADCY1, MYH9, ADMMore
Adenosine-phosphatehsa04310Wnt signaling pathway2.28E-045P30279, Q13485, O43318, P17612, P67870CCND2, SMAD4, MAP3K7, PRKACA, CSNK2BMore
Adenosine-phosphatehsa04330Notch signaling pathway3.28E-034Q92542, P49768, Q92830, P78504NCSTN, PSEN1, KAT2A, JAG1More
Adenosine-phosphatehsa04340Hedgehog signaling pathway3.91E-021P17612PRKACAMore
Adenosine-phosphatehsa04360Axon guidance2.19E-023P42338, O14639, P24844PIK3CB, ABLIM1, MYL9More
Adenosine-phosphatehsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Adenosine-phosphatehsa04510Focal adhesion4.60E-023Q15942, P51636, P30281ZYX, CAV2, CCND3More
Adenosine-phosphatehsa04520Adherens junction3.91E-022Q13485, O43318SMAD4, MAP3K7More
Adenosine-phosphatehsa04550Signaling pathways regulating pluripotency of stem cells2.16E-022P04628, P40189WNT1, IL6STMore
Adenosine-phosphatehsa04610Complement and coagulation cascades4.31E-074P00734, P0C0L4, P05107, P21730F2, C4A, ITGB2, C5AR1More
Adenosine-phosphatehsa04611Platelet activation2.12E-022Q9Y490, P17612TLN1, PRKACAMore
Adenosine-phosphatehsa04612Antigen processing and presentation7.59E-047P13765, P48382, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Adenosine-phosphatehsa04613Neutrophil extracellular trap formation3.66E-0516P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, P68431, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Adenosine-phosphatehsa04620Toll-like receptor signaling pathway2.22E-043P01584, P45985, Q8NHW4IL1B, MAP2K4, CCL4L2More
Adenosine-phosphatehsa04621NOD-like receptor signaling pathway1.90E-038P01584, P07900, P25963, P43490, Q05823, P01375, P49913, P12838IL1B, HSP90AA1, NFKBIA, PBEF1, RNASEL, TNF, CAMP, DEFA4More
Adenosine-phosphatehsa04622RIG-I-like receptor signaling pathway1.36E-022Q12933, P10145TRAF2, IL8More
Adenosine-phosphatehsa04623Cytosolic DNA-sensing pathway6.29E-063P01584, Q9Y535, Q8NHW4IL1B, POLR3H, CCL4L2More
Adenosine-phosphatehsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Adenosine-phosphatehsa04630JAK-STAT signaling pathway3.09E-033O75925, P40189, Q06124PIAS1, IL6ST, PTPN11More
Adenosine-phosphatehsa04640Hematopoietic cell lineage4.95E-023P01730, P06127, P09564CD4, CD5, CD7More
Adenosine-phosphatehsa04650Natural killer cell mediated cytotoxicity4.34E-038P01375, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Adenosine-phosphatehsa04657IL-17 signaling pathway3.41E-0610P07900, O00463, Q16539, P49841, P09341, P14780, Q9UJX4, P80188, P01375, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, LCN2, TNF, IL1BMore
Adenosine-phosphatehsa04658Th1 and Th2 cell differentiation1.75E-0512Q04759, P07766, P20963, Q16539, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, MAPK14, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Adenosine-phosphatehsa04659Th17 cell differentiation1.01E-0616Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P14778, Q9HBE5, Q9UL17, Q13485, P07900, P08238, P07766, P09693, P20963PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, IL1R1, IL21R, TBX21, SMAD4, HSP90AA1, HSP90AB1, CD3E, CD3G, CD247More
Adenosine-phosphatehsa04660T cell receptor signaling pathway2.11E-0614P01375, Q04759, P10747, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841TNF, PRKCQ, CD28, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Adenosine-phosphatehsa04662B cell receptor signaling pathway1.12E-055P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Adenosine-phosphatehsa04664Fc epsilon RI signaling pathway3.92E-056P01375, Q16539, P42338, Q9UQC2, P07948, P09917TNF, MAPK14, PIK3CB, GAB2, LYN, ALOX5More
Adenosine-phosphatehsa04666Fc gamma R-mediated phagocytosis2.66E-025O75015, P06396, O14494, Q9UQC2, P17252FCGR3B, GSN, PLPP1, GAB2, PRKCAMore
Adenosine-phosphatehsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Adenosine-phosphatehsa04710Circadian rhythm4.40E-021O15516CLOCKMore
Adenosine-phosphatehsa04713Circadian entrainment4.76E-024P0DP23, Q13557, P62873, P63218CALM1, CAMK2D, GNB1, GNG5More
Adenosine-phosphatehsa04714Thermogenesis8.35E-035P51828, P62753, Q9UKU0, P12074, O15239ADCY7, RPS6, ACSL6, COX6A1, NDUFA1More
Adenosine-phosphatehsa04721Synaptic vesicle cycle3.77E-021P43003SLC1A3More
Adenosine-phosphatehsa04722Neurotrophin signaling pathway3.27E-023P49841, O43524, P48023GSK3B, FOXO3, FASLGMore
Adenosine-phosphatehsa04724Glutamatergic synapse3.88E-044O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Adenosine-phosphatehsa04725Cholinergic synapse4.15E-047P51828, P62873, P63218, P50151, P18848, Q13557, P42338ADCY7, GNB1, GNG5, GNG10, ATF4, CAMK2D, PIK3CBMore
Adenosine-phosphatehsa04727GABAergic synapse3.26E-055P62873, P63218, P50151, P15104, P46459GNB1, GNG5, GNG10, GLUL, NSFMore
Adenosine-phosphatehsa04728Dopaminergic synapse3.11E-0411P62873, P63218, P50151, P49841, Q99941, P18848, Q16539, Q13557, P49407, P0DP23, P48058GNB1, GNG5, GNG10, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, CALM1, GRIA4More
Adenosine-phosphatehsa04740Olfactory transduction9.79E-033P62873, Q13557, P0DP23GNB1, CAMK2D, CALM1More
Adenosine-phosphatehsa04742Taste transduction3.91E-021P17612PRKACAMore
Adenosine-phosphatehsa04744Phototransduction1.42E-022P62873, P0DP23GNB1, CALM1More
Adenosine-phosphatehsa04750Inflammatory mediator regulation of TRP channels6.12E-047P01584, Q08828, Q13557, P19174, P24723, P0DP23, P01042IL1B, ADCY1, CAMK2D, PLCG1, PRKCH, CALM1, KNG1More
Adenosine-phosphatehsa04911Insulin secretion5.39E-055P51828, P22694, Q99941, P18848, Q13557ADCY7, PRKACB, CREBL1, ATF4, CAMK2DMore
Adenosine-phosphatehsa04912GnRH signaling pathway5.60E-049P17252, Q08828, P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P0DP23PRKCA, ADCY1, ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, CALM1More
Adenosine-phosphatehsa04913Ovarian steroidogenesis2.52E-021P06213INSRMore
Adenosine-phosphatehsa04915Estrogen signaling pathway1.13E-0710Q99941, P18848, Q08828, P51828, P07900, P08238, P0DMV8, P11142, P0DP23, Q15788CREBL1, ATF4, ADCY1, ADCY7, HSP90AA1, HSP90AB1, HSPA1A, HSPA8, CALM1, NCOA1More
Adenosine-phosphatehsa04916Melanogenesis3.82E-023Q13557, P0DP23, Q08828CAMK2D, CALM1, ADCY1More
Adenosine-phosphatehsa04918Thyroid hormone synthesis1.94E-045P22694, P51828, Q99941, P18848, P02768PRKACB, ADCY7, CREBL1, ATF4, ALBMore
Adenosine-phosphatehsa04920Adipocytokine signaling pathway1.88E-043Q06124, Q9UKU0, Q9Y478PTPN11, ACSL6, PRKAB1More
Adenosine-phosphatehsa04921Oxytocin signaling pathway4.38E-024P0DP23, Q08828, Q13557, Q96RR4CALM1, ADCY1, CAMK2D, CAMKK2More
Adenosine-phosphatehsa04923Regulation of lipolysis in adipocytes5.74E-033P22694, P07550, P06213PRKACB, ADRB2, INSRMore
Adenosine-phosphatehsa04924Renin secretion1.45E-044P22694, P07550, Q14643, P0DP23PRKACB, ADRB2, ITPR1, CALM1More
Adenosine-phosphatehsa04925Aldosterone synthesis and secretion3.47E-045Q99941, P18848, P51828, P0DP23, Q13557CREBL1, ATF4, ADCY7, CALM1, CAMK2DMore
Adenosine-phosphatehsa04926Relaxin signaling pathway5.84E-069P42338, P63218, P50151, Q99941, P18848, P49767, P51828, P30679, P49407PIK3CB, GNG5, GNG10, CREBL1, ATF4, VEGFC, ADCY7, GNA15, ARRB1More
Adenosine-phosphatehsa04927Cortisol synthesis and secretion1.73E-044Q99941, P18848, P51828, P22694CREBL1, ATF4, ADCY7, PRKACBMore
Adenosine-phosphatehsa04928Parathyroid hormone synthesis, secretion and action2.17E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Adenosine-phosphatehsa04929GnRH secretion1.54E-032P42338, P49407PIK3CB, ARRB1More
Adenosine-phosphatehsa04930Type II diabetes mellitus3.14E-021P06213INSRMore
Adenosine-phosphatehsa04931Insulin resistance1.48E-022Q06124, Q9Y478PTPN11, PRKAB1More
Adenosine-phosphatehsa04932Non-alcoholic fatty liver disease2.27E-059P01375, P49841, O43521, P48023, O75460, P01584, P12074, O15239, O95298TNF, GSK3B, BCL2L11, FASLG, ERN1, IL1B, COX6A1, NDUFA1, NDUFC2More
Adenosine-phosphatehsa04934Cushing syndrome1.15E-046Q99941, P18848, P51828, P22694, Q13557, P46527CREBL1, ATF4, ADCY7, PRKACB, CAMK2D, CDKN1BMore
Adenosine-phosphatehsa04935Growth hormone synthesis, secretion and action2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Adenosine-phosphatehsa04940Type I diabetes mellitus5.08E-054P10747, P48023, P13765, P01375CD28, FASLG, HLA-DOB, TNFMore
Adenosine-phosphatehsa04950Maturity onset diabetes of the young8.73E-041P35557GCKMore
Adenosine-phosphatehsa04960Aldosterone-regulated sodium reabsorption7.59E-032O00141, P06213SGK, INSRMore
Adenosine-phosphatehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Adenosine-phosphatehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Adenosine-phosphatehsa04970Salivary secretion2.76E-056P07550, Q08828, P22694, Q14643, P0DP23, P49913ADRB2, ADCY1, PRKACB, ITPR1, CALM1, CAMPMore
Adenosine-phosphatehsa04971Gastric acid secretion1.74E-035Q08828, P51828, P15311, P0DP23, Q13557ADCY1, ADCY7, VIL2, CALM1, CAMK2DMore
Adenosine-phosphatehsa04979Cholesterol metabolism6.61E-033Q5SW96, P38571, P61916LDLRAP1, LIPA, NPC2More
Adenosine-phosphatehsa05010Alzheimer disease4.33E-0316O15239, O95298, P19404, P05496, P13073, P12074, Q00535, O75460, P0DP23, P01584, P18848, Q71U36, Q13509, P05141, P21796, P45880NDUFA1, NDUFC2, NDUFV2, ATP5G1, COX4I1, COX6A1, CDK5, ERN1, CALM1, IL1B, ATF4, TUBA1A, TUBB3, SLC25A5, VDAC1, VDAC2More
Adenosine-phosphatehsa05012Parkinson disease1.47E-0517P62987, O15239, O95298, P19404, P13073, P12074, P05496, P05141, P21796, P45880, O75460, P18848, P19174, P0DP23, Q13557, Q71U36, Q13509UBA52, NDUFA1, NDUFC2, NDUFV2, COX4I1, COX6A1, ATP5G1, SLC25A5, VDAC1, VDAC2, ERN1, ATF4, PLCG1, CALM1, CAMK2D, TUBA1A, TUBB3More
Adenosine-phosphatehsa05014Amyotrophic lateral sclerosis2.72E-0210P01375, Q16718, O14521, P36542, P09651, Q7Z3B4, P35658, P43243, Q09161, Q16629TNF, NDUFA5, SDHD, ATP5C1, HNRNPA1, NUP54, NUP214, MATR3, NCBP1, SFRS7More
Adenosine-phosphatehsa05016Huntington disease1.16E-0316O15239, O95298, P19404, P13073, P12074, P05496, Q13547, P24928, P30876, P62487, P05141, P21796, P45880, O75460, Q71U36, Q13509NDUFA1, NDUFC2, NDUFV2, COX4I1, COX6A1, ATP5G1, HDAC1, POLR2A, POLR2B, POLR2G, SLC25A5, VDAC1, VDAC2, ERN1, TUBA1A, TUBB3More
Adenosine-phosphatehsa05017Spinocerebellar ataxia1.93E-035Q92915, Q8TB72, O15399, P42338, P21796FGF14, PUM2, GRIN2D, PIK3CB, VDAC1More
Adenosine-phosphatehsa05020Prion disease9.64E-0310P11142, P19404, P13073, P18848, P05141, P21796, P45880, Q71U36, Q13509, Q99941HSPA8, NDUFV2, COX4I1, ATF4, SLC25A5, VDAC1, VDAC2, TUBA1A, TUBB3, CREBL1More
Adenosine-phosphatehsa05022Pathways of neurodegeneration - multiple diseases1.68E-0421Q71U36, Q13509, O15239, O95298, P19404, P13073, P12074, P05496, Q8TEV9, P21796, O75460, P18848, P19174, P05141, P45880, P20333, Q00535, P01584, P0DP23, Q13557, P62987TUBA1A, TUBB3, NDUFA1, NDUFC2, NDUFV2, COX4I1, COX6A1, ATP5G1, SMCR8, VDAC1, ERN1, ATF4, PLCG1, SLC25A5, VDAC2, TNFRSF1B, CDK5, IL1B, CALM1, CAMK2D, UBA52More
Adenosine-phosphatehsa05030Cocaine addiction4.44E-033P22694, Q99941, P18848PRKACB, CREBL1, ATF4More
Adenosine-phosphatehsa05031Amphetamine addiction1.49E-045P0DP23, Q13557, Q99941, P18848, Q13547CALM1, CAMK2D, CREBL1, ATF4, HDAC1More
Adenosine-phosphatehsa05034Alcoholism1.27E-027Q99941, P18848, Q13547, P0DP23, P62873, P63218, O60814CREBL1, ATF4, HDAC1, CALM1, GNB1, GNG5, H2BC12More
Adenosine-phosphatehsa05110Vibrio cholerae infection2.11E-032Q99437, P17612ATP6V0B, PRKACAMore
Adenosine-phosphatehsa05120Epithelial cell signaling in Helicobacter pylori infection5.36E-056Q16539, Q99437, P09341, P25024, P25025, P41240MAPK14, ATP6V0B, CXCL1, CXCR1, CXCR2, CSKMore
Adenosine-phosphatehsa05133Pertussis8.35E-053P05107, P10145, P0C0L4ITGB2, IL8, C4AMore
Adenosine-phosphatehsa05134Legionellosis3.35E-024P11215, P68104, P11142, P19875ITGAM, EEF1A1, HSPA8, CXCL2More
Adenosine-phosphatehsa05140Leishmaniasis2.69E-025O75015, P13765, O60603, P49006, Q16539FCGR3B, HLA-DOB, TLR2, MARCKSL1, MAPK14More
Adenosine-phosphatehsa05143African trypanosomiasis4.74E-054P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Adenosine-phosphatehsa05144Malaria1.48E-055P69905, P68871, O60603, P05107, P10145HBA2, HBB, TLR2, ITGB2, IL8More
Adenosine-phosphatehsa05146Amoebiasis1.25E-049P09341, P14778, P27930, P01375, O60603, P05089, P22694, P12814, P08311CXCL1, IL1R1, IL1R2, TNF, TLR2, ARG1, PRKACB, ACTN1, CTSGMore
Adenosine-phosphatehsa05150Staphylococcus aureus infection1.33E-0612P0C0L4, P21730, P21462, O75015, P13765, P13646, Q14532, P05107, P59665, P59666, P12838, P49913C4A, C5AR1, FPR1, FCGR3B, HLA-DOB, KRT13, KRT32, ITGB2, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Adenosine-phosphatehsa05152Tuberculosis1.95E-025P48382, P10415, P13765, Q9UDY8, P51617RFX5, BCL2, HLA-DOB, MALT1, IRAK1More
Adenosine-phosphatehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Adenosine-phosphatehsa05161Hepatitis B3.34E-023Q99941, P18848, P27348CREBL1, ATF4, YWHAQMore
Adenosine-phosphatehsa05162Measles8.38E-034P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Adenosine-phosphatehsa05163Human cytomegalovirus infection1.27E-0515P01375, P50151, Q14643, P0DP23, Q8NHW4, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P04637, O00463TNF, GNG10, ITPR1, CALM1, CCL4L2, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, TP53, TRAF5More
Adenosine-phosphatehsa05165Human papillomavirus infection9.48E-048P46527, P35443, P01375, Q08999, Q9UM47, P22694, Q13362, Q13315CDKN1B, THBS4, TNF, RBL2, NOTCH3, PRKACB, PPP2R5C, ATMMore
Adenosine-phosphatehsa05166Human T-cell leukemia virus 1 infection4.93E-026P22694, P18848, P25963, P25208, Q13315, P01375PRKACB, ATF4, NFKBIA, NFYB, ATM, TNFMore
Adenosine-phosphatehsa05167Kaposi sarcoma-associated herpesvirus infection3.15E-027P42224, P62873, P63218, P19875, P19174, P07948, P0DP23STAT1, GNB1, GNG5, CXCL2, PLCG1, LYN, CALM1More
Adenosine-phosphatehsa05169Epstein-Barr virus infection4.48E-039Q13547, P42338, P07948, P30101, Q13761, O75293, P30279, P42224, P07766HDAC1, PIK3CB, LYN, PDIA3, RUNX3, GADD45B, CCND2, STAT1, CD3EMore
Adenosine-phosphatehsa05171Coronavirus disease - COVID-193.18E-037P01584, P62753, P36578, P62888, P61927, P61513, P62829IL1B, RPS6, RPL4, RPL30, RPL37, RPL37A, RPL23More
Adenosine-phosphatehsa05200Pathways in cancer1.83E-0419Q16363, P07900, P08238, P42224, P19174, P43246, Q13485, P20585, P52701, Q13547, P30279, P62873, P63218, P78417, O75293, P0DP23, Q13557, P14784, P01042LAMA4, HSP90AA1, HSP90AB1, STAT1, PLCG1, MSH2, SMAD4, MSH3, MSH6, HDAC1, CCND2, GNB1, GNG5, GSTO1, GADD45B, CALM1, CAMK2D, IL2RB, KNG1More
Adenosine-phosphatehsa05202Transcriptional misregulation in cancer2.64E-1024Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P46527, P04637, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P68431, Q92769, P12980, P24522FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, CDKN1B, TP53, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, HDAC2, LYL1, GADD45AMore
Adenosine-phosphatehsa05203Viral carcinogenesis5.01E-0616Q08999, Q99941, P18848, P06746, P07948, P30279, P27348, P29083, Q7KZF4, P46527, Q13547, P06396, P25963, P61978, P22694, O60814RBL2, CREBL1, ATF4, POLB, LYN, CCND2, YWHAQ, GTF2E1, SND1, CDKN1B, HDAC1, GSN, NFKBIA, HNRPK, PRKACB, H2BC12More
Adenosine-phosphatehsa05206MicroRNAs in cancer1.67E-024P46527, Q9UM47, P35226, Q13315CDKN1B, NOTCH3, BMI1, ATMMore
Adenosine-phosphatehsa05210Colorectal cancer4.94E-022Q13485, P52701SMAD4, MSH6More
Adenosine-phosphatehsa05214Glioma1.76E-024P0DP23, Q13557, P19174, O75293CALM1, CAMK2D, PLCG1, GADD45BMore
Adenosine-phosphatehsa05217Basal cell carcinoma3.30E-024Q13635, P49841, Q9UJU2, P24522PTCH1, GSK3B, LEF1, GADD45AMore
Adenosine-phosphatehsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Adenosine-phosphatehsa05221Acute myeloid leukemia3.29E-023P14923, Q15744, P05164JUP, CEBPE, MPOMore
Adenosine-phosphatehsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Adenosine-phosphatehsa05226Gastric cancer2.94E-022P04628, P10826WNT1, RARBMore
Adenosine-phosphatehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer3.48E-059O95267, P07766, P20963, P09693, P06239, O60603, Q04759, Q16539, P01730RASGRP1, CD3E, CD247, CD3G, LCK, TLR2, PRKCQ, MAPK14, CD4More
Adenosine-phosphatehsa05310Asthma4.06E-043P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Adenosine-phosphatehsa05321Inflammatory bowel disease2.56E-047O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Adenosine-phosphatehsa05322Systemic lupus erythematosus4.51E-026O75015, P08246, P08311, P01375, P10747, P13765FCGR3B, ELA2, CTSG, TNF, CD28, HLA-DOBMore
Adenosine-phosphatehsa05323Rheumatoid arthritis2.62E-024P01375, P13765, P10747, P09341TNF, HLA-DOB, CD28, CXCL1More
Adenosine-phosphatehsa05330Allograft rejection2.06E-044P13765, P48023, P10747, P01375HLA-DOB, FASLG, CD28, TNFMore
Adenosine-phosphatehsa05332Graft-versus-host disease5.75E-056P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Adenosine-phosphatehsa05410Hypertrophic cardiomyopathy2.60E-022P26012, P09493ITGB8, TPM1More
Adenosine-phosphatehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Adenosine-phosphatehsa05415Diabetic cardiomyopathy5.24E-0312P17252, Q15080, O15239, Q16718, O95298, O14521, P05496, P12074, Q16539, P49841, Q13557, P14780PRKCA, NCF4, NDUFA1, NDUFA5, NDUFC2, SDHD, ATP5G1, COX6A1, MAPK14, GSK3B, CAMK2D, MMP9More
Adenosine-phosphatehsa05418Fluid shear stress and atherosclerosis1.26E-048Q16539, Q14145, P10599, P14780, P01375, P04637, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2More
Adenosinehsa00010Glycolysis / Gluconeogenesis4.41E-024P04075, P06733, P04406, P60174ALDOA, ENO1, GAPDH, TPI1More
Adenosinehsa00030Pentose phosphate pathway1.67E-075P60891, P51854, P08237, P52209, P37837PRPS1, TKTL1, PFKM, PGD, TALDO1More
Adenosinehsa00051Fructose and mannose metabolism2.21E-023O14772, P60174, P04075FPGT, TPI1, ALDOAMore
Adenosinehsa00052Galactose metabolism1.51E-043P06280, O43451, P35557GLA, MGAM, GCKMore
Adenosinehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Adenosinehsa00100Steroid biosynthesis4.70E-021P35610SOAT1More
Adenosinehsa00120Primary bile acid biosynthesis3.72E-022P22680, P22307CYP7A1, SCP2More
Adenosinehsa00190Oxidative phosphorylation2.29E-022Q16718, O14521NDUFA5, SDHDMore
Adenosinehsa00220Arginine biosynthesis3.73E-032P05089, P49448ARG1, GLUD2More
Adenosinehsa00230Purine metabolism2.15E-035Q7LG56, P31350, P51828, P21589, Q9Y227RRM2B, RRM2, ADCY7, NT5E, ENTPD4More
Adenosinehsa00240Pyrimidine metabolism6.73E-107Q7LG56, P31350, Q9Y227, P21589, P32320, P04183, P04818RRM2B, RRM2, ENTPD4, NT5E, CDA, TK1, TYMSMore
Adenosinehsa00250Alanine, aspartate and glutamate metabolism4.88E-021P49448GLUD2More
Adenosinehsa00280Valine, leucine and isoleucine degradation3.41E-034P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Adenosinehsa00310Lysine degradation3.73E-033Q96KQ7, Q02809, P51648EHMT2, PLOD1, ALDH3A2More
Adenosinehsa00340Histidine metabolism4.52E-021O95954FTCDMore
Adenosinehsa00410beta-Alanine metabolism3.98E-021Q6ZQY3GADL1More
Adenosinehsa00440Phosphonate and phosphinate metabolism3.98E-021Q9Y6K0CEPT1More
Adenosinehsa00471D-Glutamine and D-glutamate metabolism6.90E-042Q7Z3D6, P49448C14orf159, GLUD2More
Adenosinehsa00480Glutathione metabolism3.36E-056Q9UJ14, Q16772, P09211, Q7LG56, P31350, P30041GGTL3, GSTA3, GSTP1, RRM2B, RRM2, PRDX6More
Adenosinehsa00500Starch and sucrose metabolism2.00E-084O43451, P46976, P35557, P06737MGAM, GYG1, GCK, PYGLMore
Adenosinehsa00512Mucin type O-glycan biosynthesis1.31E-032O95395, Q8N4A0GCNT3, GALNT4More
Adenosinehsa00524Neomycin, kanamycin and gentamicin biosynthesis8.73E-041P35557GCKMore
Adenosinehsa00531Glycosaminoglycan degradation4.51E-022P22304, P06865IDS, HEXAMore
Adenosinehsa00533Glycosaminoglycan biosynthesis - keratan sulfate1.91E-021Q9NY97B3GNT2More
Adenosinehsa00564Glycerophospholipid metabolism4.77E-055P48651, Q9Y6K0, P35790, Q9Y259, P49619PTDSS1, CEPT1, CHKA, CHKB, DGKGMore
Adenosinehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Adenosinehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Adenosinehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Adenosinehsa00600Sphingolipid metabolism3.76E-021P15289ARSAMore
Adenosinehsa00601Glycosphingolipid biosynthesis - lacto and neolacto series3.78E-021Q9NY97B3GNT2More
Adenosinehsa00630Glyoxylate and dicarboxylate metabolism1.96E-092P40925, P15104MDH1, GLULMore
Adenosinehsa00730Thiamine metabolism2.53E-042P05186, P24666ALPL, ACP1More
Adenosinehsa00740Riboflavin metabolism3.98E-021Q969G6RFKMore
Adenosinehsa00750Vitamin B6 metabolism4.45E-021O00764PDXKMore
Adenosinehsa00770Pantothenate and CoA biosynthesis3.98E-021Q6ZQY3GADL1More
Adenosinehsa00900Terpenoid backbone biosynthesis3.05E-021Q01581HMGCS1More
Adenosinehsa00910Nitrogen metabolism4.88E-021P49448GLUD2More
Adenosinehsa00970Aminoacyl-tRNA biosynthesis3.78E-022O95363, Q15046FARS2, KARSMore
Adenosinehsa00980Metabolism of xenobiotics by cytochrome P4508.69E-065Q16772, P78417, P11766, P09211, P11712GSTA3, GSTO1, ADH5, GSTP1, CYP2C9More
Adenosinehsa00982Drug metabolism - cytochrome P4501.66E-055P11712, Q16772, P09211, P78417, P11766CYP2C9, GSTA3, GSTP1, GSTO1, ADH5More
Adenosinehsa00983Drug metabolism - other enzymes2.72E-107P04183, P32320, Q7LG56, P31350, P05164, Q16772, P09211TK1, CDA, RRM2B, RRM2, MPO, GSTA3, GSTP1More
Adenosinehsa01040Biosynthesis of unsaturated fatty acids4.28E-021P22307SCP2More
Adenosinehsa01100Metabolic pathways6.27E-0541Q9Y234, P35790, Q9Y259, Q16772, P09211, Q9UJ14, P15144, P30041, O14732, Q13956, Q02153, Q16774, P20839, P00918, P40926, P10768, P55809, P06280, Q7KZN9, Q9Y6K0, P15121, P08237, P49619, P21399, O95954, Q02318, Q9UHK6, P51854, Q86VZ5, Q9BVK2, P15907, Q9UBX8, O96024, P37837, P50213, P43490, P35573, Q9BQB6, Q969G6, Q13029, Q9NVH6LIPT1, CHKA, CHKB, GSTA3, GSTP1, GGTL3, ANPEP, PRDX6, IMPA2, PDE6H, GUCY1B3, GUK1, IMPDH1, CA2, MDH2, ESD, OXCT1, GLA, COX15, CEPT1, AKR1B1, PFKM, DGKG, ACO1, FTCD, CYP27A1, AMACR, TKTL1, SGMS1, ALG8, ST6GAL1, B4GALT6, B3GALT4, TALDO1, IDH3A, PBEF1, AGL, VKORC1, RFK, PRDM2, TMLHEMore
Adenosinehsa01200Carbon metabolism4.00E-0514P04075, P51854, P04406, P08237, P60174, P37837, P06733, O14521, Q9P2R7, P50213, P21399, P60891, P10768, Q02252ALDOA, TKTL1, GAPDH, PFKM, TPI1, TALDO1, ENO1, SDHD, SUCLA2, IDH3A, ACO1, PRPS1, ESD, ALDH6A1More
Adenosinehsa012102-Oxocarboxylic acid metabolism1.90E-052P21399, P50213ACO1, IDH3AMore
Adenosinehsa01230Biosynthesis of amino acids2.15E-0613P60174, P04406, P06733, P04075, P08237, P51854, P60891, Q99707, P21399, P50213, P05089, P15104, P37837TPI1, GAPDH, ENO1, ALDOA, PFKM, TKTL1, PRPS1, MTR, ACO1, IDH3A, ARG1, GLUL, TALDO1More
Adenosinehsa01521EGFR tyrosine kinase inhibitor resistance2.82E-022P49841, P42338GSK3B, PIK3CBMore
Adenosinehsa01524Platinum drug resistance8.80E-047Q13489, P98170, Q16772, P09211, P78417, P43246, P52701BIRC3, BIRC4, GSTA3, GSTP1, GSTO1, MSH2, MSH6More
Adenosinehsa02010ABC transporters2.17E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Adenosinehsa03008Ribosome biogenesis in eukaryotes8.16E-033Q9NYH9, P78345, Q9GZY0UTP6, RPP38, NXF2; NXF2BMore
Adenosinehsa03010Ribosome1.22E-022P46777, P50914RPL5, RPL14More
Adenosinehsa03013RNA transport7.73E-0413P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, P47813, O14602, Q14152, O75822, P78345, Q9Y6A5, P51114NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF1AX, EIF1AY, EIF3A, EIF3J, RPP38, TACC3, FXR1More
Adenosinehsa03015mRNA surveillance pathway3.37E-023O43148, Q9GZY0, P52298RNMT, NXF2; NXF2B, NCBP2More
Adenosinehsa03020RNA polymerase8.48E-065P30876, P24928, P62487, Q9GZM3, P52435POLR2B, POLR2A, POLR2G, POLR2J2, POLR2JMore
Adenosinehsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Adenosinehsa03040Spliceosome4.37E-1414Q14562, O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Adenosinehsa03050Proteasome1.21E-021P28074PSMB5More
Adenosinehsa03060Protein export6.86E-053Q15070, P37108, Q15005OXA1L, SRP14, SPCS2More
Adenosinehsa03320PPAR signaling pathway1.62E-022Q13133, Q02318NR1H3, CYP27A1More
Adenosinehsa03430Mismatch repair4.38E-021P20585MSH3More
Adenosinehsa04012ErbB signaling pathway2.82E-022P49841, P42338GSK3B, PIK3CBMore
Adenosinehsa04014Ras signaling pathway2.36E-028P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1More
Adenosinehsa04015Rap1 signaling pathway2.64E-0310P20827, P49767, P06213, Q96FS4, P11215, Q13009, O00522, Q7LDG7, P42338, P19174EFNA1, VEGFC, INSR, SIPA1, ITGAM, TIAM1, KRIT1, RASGRP2, PIK3CB, PLCG1More
Adenosinehsa04020Calcium signaling pathway5.11E-049P27987, P21796, P45880, Q13557, P30679, P19174, P0DP23, P05141, P23634ITPKB, VDAC1, VDAC2, CAMK2D, GNA15, PLCG1, CALM1, SLC25A5, ATP2B4More
Adenosinehsa04022cGMP-PKG signaling pathway2.26E-038Q14814, Q99941, P18848, P05141, P21796, P45880, P0DP23, P01042MEF2D, CREBL1, ATF4, SLC25A5, VDAC1, VDAC2, CALM1, KNG1More
Adenosinehsa04024cAMP signaling pathway4.38E-024P42338, P0DP23, Q13370, Q13009PIK3CB, CALM1, PDE3B, TIAM1More
Adenosinehsa04060Cytokine-cytokine receptor interaction3.03E-0312P27930, P14778, P26842, Q13651, P25024, P25025, Q9UBD3, P47992, O75509, P09341, P18510, P01730IL1R2, IL1R1, CD27, IL10RA, CXCR1, CXCR2, XCL2, XCL1, TNFRSF21, CXCL1, IL1RN, CD4More
Adenosinehsa04061Viral protein interaction with cytokine and cytokine receptor5.16E-0410P51684, P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784, P01375CCR6, CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB, TNFMore
Adenosinehsa04062Chemokine signaling pathway1.72E-0720P25024, P25025, P09341, P19875, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P62873, P63218, P50151, P43250, P49407, Q08881, Q7LDG7, Q13009, P49841, Q8WYR1CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNB1, GNG5, GNG10, GRK6, ARRB1, ITK, RASGRP2, TIAM1, GSK3B, PIK3R5More
Adenosinehsa04064NF-kappa B signaling pathway5.07E-1124P10415, Q13489, P51617, O00463, Q13546, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9UNE0, Q9NQC7BCL2, BIRC3, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, EDAR, CYLDMore
Adenosinehsa04070Phosphatidylinositol signaling system1.67E-036P19174, P0DP23, P42338, O14986, P23743, P27987PLCG1, CALM1, PIK3CB, PIP5K1B, DGKA, ITPKBMore
Adenosinehsa04071Sphingolipid signaling pathway1.71E-078P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2More
Adenosinehsa04072Phospholipase D signaling pathway3.32E-049P42338, Q9UQC2, P43657, P25024, P25025, P19174, Q8WYR1, Q15438, P51828PIK3CB, GAB2, P2RY5, CXCR1, CXCR2, PLCG1, PIK3R5, PSCD1, ADCY7More
Adenosinehsa04080Neuroactive ligand-receptor interaction3.92E-0410P00734, P28472, P21453, Q9H228, Q96G91, Q01726, P41968, P21730, P14416, P07550F2, GABRB3, S1PR1, EDG8, P2RY11, MC1R, MC3R, C5AR1, DRD2, ADRB2More
Adenosinehsa04110Cell cycle3.57E-023Q9UBD5, P06493, P33981ORC3, CDK1, TTKMore
Adenosinehsa04115p53 signaling pathway1.13E-069P24522, O15151, Q13315, Q7LG56, P31350, Q9HA38, P04637, O95067, P10415GADD45A, MDM4, ATM, RRM2B, RRM2, ZMAT3, TP53, CCNB2, BCL2More
Adenosinehsa04141Protein processing in endoplasmic reticulum6.42E-038P18848, P30101, Q15437, Q15436, Q99941, P11142, P07900, P08238ATF4, PDIA3, SEC23B, SEC23A, CREBL1, HSPA8, HSP90AA1, HSP90AB1More
Adenosinehsa04142Lysosome1.95E-048P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916, Q04900HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2, CD164More
Adenosinehsa04144Endocytosis1.13E-0314Q13191, P0DMV8, P11142, Q9H444, O75351, P62491, P25024, Q96B97, P43250, Q15438, Q14161, P14784, Q9UMY4, Q9Y5X3CBLB, HSPA1A, HSPA8, CHMP4B, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, PSCD1, GIT2, IL2RB, SNX12, SNX5More
Adenosinehsa04145Phagosome2.54E-048Q15080, P14598, Q13509, P68371, P05164, P78380, P35443, P13765NCF4, NCF1, TUBB3, TUBB2C, MPO, OLR1, THBS4, HLA-DOBMore
Adenosinehsa04146Peroxisome2.42E-025O43933, P56589, Q9UKG9, O75521, P33121PEX1, PEX3, CROT, ECI2, ACSL1More
Adenosinehsa04150mTOR signaling pathway3.46E-022P42338, P49841PIK3CB, GSK3BMore
Adenosinehsa04151PI3K-Akt signaling pathway1.64E-0321P62753, P42338, P43657, P27348, P20827, P49767, P07900, P08238, Q8WYR1, P62873, P63218, P50151, O15335, Q16363, Q13751, P22105, P14784, Q99941, P18848, P30279, P30281RPS6, PIK3CB, P2RY5, YWHAQ, EFNA1, VEGFC, HSP90AA1, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, CHAD, LAMA4, LAMB3, TNXB, IL2RB, CREBL1, ATF4, CCND2, CCND3More
Adenosinehsa04152AMPK signaling pathway2.34E-022Q96EB6, P36956SIRT1, SREBF1More
Adenosinehsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Adenosinehsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Adenosinehsa04213Longevity regulating pathway - multiple species2.43E-047P42338, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547PIK3CB, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1More
Adenosinehsa04217Necroptosis5.13E-0512P01568, Q13489, P98170, Q13546, P42224, P07900, P08238, P15104, P05141, Q13557, P21796, P45880IFNA21, BIRC3, BIRC4, RIPK1, STAT1, HSP90AA1, HSP90AB1, GLUL, SLC25A5, CAMK2D, VDAC1, VDAC2More
Adenosinehsa04261Adrenergic signaling in cardiomyocytes7.16E-048P67936, P07550, P51828, P22694, Q8WYR1, P18848, Q13362, P0DP24TPM4, ADRB2, ADCY7, PRKACB, PIK3R5, ATF4, PPP2R5C, CALM2More
Adenosinehsa04270Vascular smooth muscle contraction3.79E-047P0DP24, P0DP23, Q08828, P51828, P35579, P35749, P35318CALM2, CALM1, ADCY1, ADCY7, MYH9, MYH11, ADMMore
Adenosinehsa04310Wnt signaling pathway5.60E-033P30279, Q13485, O43318CCND2, SMAD4, MAP3K7More
Adenosinehsa04330Notch signaling pathway3.28E-034Q92542, P49768, Q92830, P78504NCSTN, PSEN1, KAT2A, JAG1More
Adenosinehsa04340Hedgehog signaling pathway1.29E-045P49841, P22694, Q13635, P49407, P10415GSK3B, PRKACB, PTCH1, ARRB1, BCL2More
Adenosinehsa04360Axon guidance2.47E-037P16333, P20827, O95631, P42338, P07332, P23528, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, PLCG1More
Adenosinehsa04371Apelin signaling pathway3.02E-0610P62873, P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022, Q16566, P0DP23GNB1, GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3, CAMK4, CALM1More
Adenosinehsa04380Osteoclast differentiation1.79E-047Q9UQC2, Q16539, P42338, P14778, O75015, P01375, Q8N149GAB2, MAPK14, PIK3CB, IL1R1, FCGR3B, TNF, LILRA2More
Adenosinehsa04390Hippo signaling pathway4.35E-022P63261, O15105ACTG1, SMAD7More
Adenosinehsa04510Focal adhesion4.60E-023Q15942, P51636, P30281ZYX, CAV2, CCND3More
Adenosinehsa04520Adherens junction3.91E-022Q13485, O43318SMAD4, MAP3K7More
Adenosinehsa04530Tight junction3.60E-035P63261, P16989, P56750, Q92974, Q14247ACTG1, CSDA, CLDN17, ARHGEF2, CTTNMore
Adenosinehsa04540Gap junction7.81E-033Q13509, P68371, Q9NRA1TUBB3, TUBB2C, PDGFCMore
Adenosinehsa04550Signaling pathways regulating pluripotency of stem cells2.16E-022P04628, P40189WNT1, IL6STMore
Adenosinehsa04610Complement and coagulation cascades4.31E-074P00734, P0C0L4, P05107, P21730F2, C4A, ITGB2, C5AR1More
Adenosinehsa04612Antigen processing and presentation2.08E-048P13765, P48382, Q14953, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, KIR2DS5, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Adenosinehsa04613Neutrophil extracellular trap formation5.45E-0619O60603, P05164, P08246, Q9UM07, P04908, Q6FI13, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC4; H2AC8, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Adenosinehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Adenosinehsa04621NOD-like receptor signaling pathway1.18E-0213Q16539, Q14643, P01568, Q13489, Q9H1Y0, P43490, O00463, P10415, Q13546, P01375, P09341, P49913, P12838MAPK14, ITPR1, IFNA21, BIRC3, ATG5, PBEF1, TRAF5, BCL2, RIPK1, TNF, CXCL1, CAMP, DEFA4More
Adenosinehsa04622RIG-I-like receptor signaling pathway1.53E-034P01568, Q13546, Q12933, P10145IFNA21, RIPK1, TRAF2, IL8More
Adenosinehsa04623Cytosolic DNA-sensing pathway9.06E-054P01584, P01568, Q13546, Q8NHW4IL1B, IFNA21, RIPK1, CCL4L2More
Adenosinehsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Adenosinehsa04630JAK-STAT signaling pathway3.09E-033O75925, P40189, Q06124PIAS1, IL6ST, PTPN11More
Adenosinehsa04640Hematopoietic cell lineage1.48E-0412P13612, P14778, P27930, P11215, P11836, P25063, P07766, P09693, P01732, P01730, P09564, P13765ITGA4, IL1R1, IL1R2, ITGAM, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOBMore
Adenosinehsa04650Natural killer cell mediated cytotoxicity1.23E-0614P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, Q14953, P26715PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KIR2DS5, KLRC1More
Adenosinehsa04657IL-17 signaling pathway2.54E-058O00463, Q16539, P49841, P19875, P14780, Q9UJX4, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL2, MMP9, ANAPC5, LCN2, TNFMore
Adenosinehsa04658Th1 and Th2 cell differentiation5.81E-1314Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Adenosinehsa04659Th17 cell differentiation2.58E-1420Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, P40189, Q9UL17, P23771, P84022, Q13485, P07900, P08238, P07766, P09693, P20963PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, IL6ST, TBX21, GATA3, SMAD3, SMAD4, HSP90AA1, HSP90AB1, CD3E, CD3G, CD247More
Adenosinehsa04660T cell receptor signaling pathway3.09E-1217P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Adenosinehsa04662B cell receptor signaling pathway5.84E-086P49841, P42338, P60033, P07948, P21854, Q8N149GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2More
Adenosinehsa04664Fc epsilon RI signaling pathway1.75E-057P01375, Q16539, P42338, Q9UQC2, P07948, P19174, P09917TNF, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5More
Adenosinehsa04666Fc gamma R-mediated phagocytosis3.17E-034P42338, P23528, Q9UQC2, P14598PIK3CB, CFL1, GAB2, NCF1More
Adenosinehsa04668TNF signaling pathway2.12E-037P01375, O00463, Q16539, P18848, P19875, P20749, P14780TNF, TRAF5, MAPK14, ATF4, CXCL2, BCL3, MMP9More
Adenosinehsa04713Circadian entrainment3.99E-046O15399, P0DP23, Q13557, P62873, P63218, P50151GRIN2D, CALM1, CAMK2D, GNB1, GNG5, GNG10More
Adenosinehsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Adenosinehsa04720Long-term potentiation2.33E-023Q16566, P0DP23, O15399CAMK4, CALM1, GRIN2DMore
Adenosinehsa04721Synaptic vesicle cycle3.77E-021P43003SLC1A3More
Adenosinehsa04724Glutamatergic synapse1.56E-065O15399, P62873, P63218, P50151, P15104GRIN2D, GNB1, GNG5, GNG10, GLULMore
Adenosinehsa04725Cholinergic synapse1.78E-047P62873, P63218, P50151, P18848, Q16566, Q13557, P42338GNB1, GNG5, GNG10, ATF4, CAMK4, CAMK2D, PIK3CBMore
Adenosinehsa04726Serotonergic synapse2.38E-024P62873, P63218, P50151, P09917GNB1, GNG5, GNG10, ALOX5More
Adenosinehsa04727GABAergic synapse3.96E-065P62873, P63218, P50151, P15104, P46459GNB1, GNG5, GNG10, GLUL, NSFMore
Adenosinehsa04728Dopaminergic synapse1.82E-0412P14416, P62873, P63218, P50151, P49841, Q99941, P18848, Q16539, Q13557, P49407, P0DP23, P48058DRD2, GNB1, GNG5, GNG10, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, CALM1, GRIA4More
Adenosinehsa04730Long-term depression3.20E-022Q14344, P07948GNA13, LYNMore
Adenosinehsa04740Olfactory transduction9.79E-033P62873, Q13557, P0DP23GNB1, CAMK2D, CALM1More
Adenosinehsa04744Phototransduction1.49E-042P62873, P0DP23GNB1, CALM1More
Adenosinehsa04750Inflammatory mediator regulation of TRP channels7.24E-0611P14778, P01584, Q08828, P51828, Q13557, P19174, P42338, P24723, Q04759, P0DP23, P01042IL1R1, IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1, KNG1More
Adenosinehsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Adenosinehsa04913Ovarian steroidogenesis2.45E-033P42330, P22694, P06213AKR1C3, PRKACB, INSRMore
Adenosinehsa04914Progesterone-mediated oocyte maturation3.92E-023P42338, Q13370, P08238PIK3CB, PDE3B, HSP90AB1More
Adenosinehsa04915Estrogen signaling pathway5.83E-0511Q99941, P18848, Q08828, P51828, P07900, P08238, P0DMV8, P11142, P0DP24, P0DP23, Q15788CREBL1, ATF4, ADCY1, ADCY7, HSP90AA1, HSP90AB1, HSPA1A, HSPA8, CALM2, CALM1, NCOA1More
Adenosinehsa04916Melanogenesis2.82E-022P49841, Q01726GSK3B, MC1RMore
Adenosinehsa04917Prolactin signaling pathway2.82E-022P42338, P49841PIK3CB, GSK3BMore
Adenosinehsa04918Thyroid hormone synthesis3.95E-023P51828, P02768, P05543ADCY7, ALB, SERPINA7More
Adenosinehsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Adenosinehsa04920Adipocytokine signaling pathway4.76E-032Q06124, Q9Y478PTPN11, PRKAB1More
Adenosinehsa04921Oxytocin signaling pathway2.92E-024P0DP24, P51828, Q96RR4, Q8WYR1CALM2, ADCY7, CAMKK2, PIK3R5More
Adenosinehsa04923Regulation of lipolysis in adipocytes4.24E-034P07550, P06213, P42338, Q9Y4H2ADRB2, INSR, PIK3CB, IRS2More
Adenosinehsa04924Renin secretion3.16E-045P22694, P07550, Q14643, Q13370, P0DP23PRKACB, ADRB2, ITPR1, PDE3B, CALM1More
Adenosinehsa04925Aldosterone synthesis and secretion3.35E-024Q99941, P18848, P0DP23, Q13557CREBL1, ATF4, CALM1, CAMK2DMore
Adenosinehsa04926Relaxin signaling pathway6.18E-059P42338, P63218, P50151, P18848, P22694, P49767, P14780, P30679, P49407PIK3CB, GNG5, GNG10, ATF4, PRKACB, VEGFC, MMP9, GNA15, ARRB1More
Adenosinehsa04927Cortisol synthesis and secretion2.54E-022P18848, P22694ATF4, PRKACBMore
Adenosinehsa04929GnRH secretion1.13E-032P42338, P49407PIK3CB, ARRB1More
Adenosinehsa04930Type II diabetes mellitus3.14E-021P06213INSRMore
Adenosinehsa04931Insulin resistance9.16E-045P01375, P49841, Q06124, P06737, Q9Y478TNF, GSK3B, PTPN11, PYGL, PRKAB1More
Adenosinehsa04932Non-alcoholic fatty liver disease9.65E-049P49841, O43521, O75460, P01584, P13073, P12074, Q16718, O95298, O14521GSK3B, BCL2L11, ERN1, IL1B, COX4I1, COX6A1, NDUFA5, NDUFC2, SDHDMore
Adenosinehsa04933AGE-RAGE signaling pathway in diabetic complications3.21E-025P84022, Q13485, P42338, P49767, P19174SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1More
Adenosinehsa04950Maturity onset diabetes of the young8.73E-041P35557GCKMore
Adenosinehsa04960Aldosterone-regulated sodium reabsorption6.19E-043P06213, P42338, P48048INSR, PIK3CB, KCNJ1More
Adenosinehsa04964Proximal tubule bicarbonate reclamation4.53E-032P00918, P49448CA2, GLUD2More
Adenosinehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Adenosinehsa04970Salivary secretion2.43E-036P07550, Q08828, P51828, P22694, P0DP23, P49913ADRB2, ADCY1, ADCY7, PRKACB, CALM1, CAMPMore
Adenosinehsa04971Gastric acid secretion3.46E-022P48048, P78508KCNJ1, KCNJ10More
Adenosinehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Adenosinehsa04975Fat digestion and absorption2.80E-021O14494PLPP1More
Adenosinehsa04976Bile secretion1.90E-046O43315, Q08828, P51828, P22694, P08183, Q14032AQP9, ADCY1, ADCY7, PRKACB, ABCB1, BAATMore
Adenosinehsa05010Alzheimer disease4.56E-029P19404, P13073, P0DP23, P18848, Q71U36, Q13509, P05141, P21796, P45880NDUFV2, COX4I1, CALM1, ATF4, TUBA1A, TUBB3, SLC25A5, VDAC1, VDAC2More
Adenosinehsa05012Parkinson disease6.70E-0411P19404, P13073, P05141, P21796, P45880, P18848, P19174, P0DP23, Q13557, Q71U36, Q13509NDUFV2, COX4I1, SLC25A5, VDAC1, VDAC2, ATF4, PLCG1, CALM1, CAMK2D, TUBA1A, TUBB3More
Adenosinehsa05016Huntington disease5.53E-0619O95298, P19404, P13073, P12074, Q13547, Q9GZM3, P24928, P30876, P62487, P52435, P05141, P21796, P45880, Q9NYC9, O75460, Q71U36, Q13509, P28070, O00232NDUFC2, NDUFV2, COX4I1, COX6A1, HDAC1, POLR2J2, POLR2A, POLR2B, POLR2G, POLR2J, SLC25A5, VDAC1, VDAC2, DNAH9, ERN1, TUBA1A, TUBB3, PSMB4, PSMD12More
Adenosinehsa05017Spinocerebellar ataxia1.32E-036Q92915, Q8TB72, O15399, P42338, P28074, P21796FGF14, PUM2, GRIN2D, PIK3CB, PSMB5, VDAC1More
Adenosinehsa05020Prion disease9.73E-0414P11142, Q16718, P19404, O14521, P13073, P18848, P05141, P21796, P45880, Q71U36, Q13509, P49841, Q99941, Q16539HSPA8, NDUFA5, NDUFV2, SDHD, COX4I1, ATF4, SLC25A5, VDAC1, VDAC2, TUBA1A, TUBB3, GSK3B, CREBL1, MAPK14More
Adenosinehsa05022Pathways of neurodegeneration - multiple diseases6.33E-0418Q71U36, Q13509, P49841, Q16718, P19404, O14521, P13073, P21796, P18848, Q13561, P19174, P05141, P45880, P20333, Q16539, Q08752, P0DP23, Q13557TUBA1A, TUBB3, GSK3B, NDUFA5, NDUFV2, SDHD, COX4I1, VDAC1, ATF4, DCTN2, PLCG1, SLC25A5, VDAC2, TNFRSF1B, MAPK14, PPID, CALM1, CAMK2DMore
Adenosinehsa05031Amphetamine addiction7.46E-046P0DP23, Q13557, P22694, Q99941, P18848, Q13547CALM1, CAMK2D, PRKACB, CREBL1, ATF4, HDAC1More
Adenosinehsa05032Morphine addiction3.52E-045P62873, P63218, P50151, Q07343, P43250GNB1, GNG5, GNG10, PDE4B, GRK6More
Adenosinehsa05034Alcoholism3.07E-0614O15399, Q99941, P18848, Q16566, Q13547, P0DP23, P62873, P63218, P50151, Q93077, P62807, Q93079, O60814, P68431GRIN2D, CREBL1, ATF4, CAMK4, HDAC1, CALM1, GNB1, GNG5, GNG10, HIST1H2AC, HIST1H2BC, H2BC9, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Adenosinehsa05100Bacterial invasion of epithelial cells4.50E-021Q92529SHC3More
Adenosinehsa05120Epithelial cell signaling in Helicobacter pylori infection1.28E-079Q16539, Q99437, P09341, P19875, P19174, P25024, P25025, P41240, P07948MAPK14, ATP6V0B, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, CSK, LYNMore
Adenosinehsa05131Shigellosis1.80E-025Q13546, Q9UDY8, Q12778, Q13315, P10415RIPK1, MALT1, FOXO1, ATM, BCL2More
Adenosinehsa05132Salmonella infection1.63E-036Q13546, Q13489, P10415, O60282, Q13509, P68371RIPK1, BIRC3, BCL2, KIF5C, TUBB3, TUBB2CMore
Adenosinehsa05133Pertussis8.35E-053P05107, P10145, P0C0L4ITGB2, IL8, C4AMore
Adenosinehsa05134Legionellosis1.03E-048P01584, Q9NR31, P11215, P68104, P0DMV8, P11142, P09341, P19875IL1B, SAR1A, ITGAM, EEF1A1, HSPA1A, HSPA8, CXCL1, CXCL2More
Adenosinehsa05135Yersinia infection1.66E-026P13612, P06239, Q16539, P49841, P01730, P01732ITGA4, LCK, MAPK14, GSK3B, CD4, CD8AMore
Adenosinehsa05143African trypanosomiasis7.35E-042P69905, P68871HBA2, HBBMore
Adenosinehsa05144Malaria2.43E-078P69905, P68871, O60603, P01375, P05107, P35443, P10145, P26718HBA2, HBB, TLR2, TNF, ITGB2, THBS4, IL8, KLRK1More
Adenosinehsa05145Toxoplasmosis3.55E-023P23458, Q8WYR1, P0DMV8JAK1, PIK3R5, HSPA1AMore
Adenosinehsa05146Amoebiasis7.21E-0913P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P30679, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, GNA15, PRKACB, ACTN1, CTSGMore
Adenosinehsa05150Staphylococcus aureus infection5.19E-0512P0C0L4, P21730, P21462, O75015, P13765, P13646, Q14532, P05107, P59665, P59666, P12838, P49913C4A, C5AR1, FPR1, FCGR3B, HLA-DOB, KRT13, KRT32, ITGB2, DEFA1; DEFA1B, DEFA3, DEFA4, CAMPMore
Adenosinehsa05152Tuberculosis1.16E-0310O75015, P48382, O60603, P01375, P10415, P13765, P49913, Q9UDY8, Q16539, P51617FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CAMP, MALT1, MAPK14, IRAK1More
Adenosinehsa05162Measles3.18E-024P23458, P0DMV8, P01584, Q9NP90JAK1, HSPA1A, IL1B, RAB9BMore
Adenosinehsa05163Human cytomegalovirus infection5.02E-0819P42338, P01375, P62873, P63218, P50151, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, O00463, P30101, P01568PIK3CB, TNF, GNB1, GNG5, GNG10, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, TRAF5, PDIA3, IFNA21More
Adenosinehsa05167Kaposi sarcoma-associated herpesvirus infection1.98E-039P01568, P42224, P62873, P63218, P50151, P19875, P19174, P07948, P0DP23IFNA21, STAT1, GNB1, GNG5, GNG10, CXCL2, PLCG1, LYN, CALM1More
Adenosinehsa05168Herpes simplex virus 1 infection1.78E-0313P01568, P42224, Q07955, Q01130, P84103, Q13243, Q13489, P30101, P42338, Q13398, Q03923, Q9NZL3, Q9UDV6IFNA21, STAT1, SFRS1, SFRS2, SFRS3, SFRS5, BIRC3, PDIA3, PIK3CB, ZNF211, ZNF85, ZNF224, ZNF212More
Adenosinehsa05169Epstein-Barr virus infection3.52E-0516P13765, Q13547, O00463, Q16539, P42338, P07948, P30101, Q13761, P24522, O75293, P30279, P42224, P29728, P07766, P09693, P20963HLA-DOB, HDAC1, TRAF5, MAPK14, PIK3CB, LYN, PDIA3, RUNX3, GADD45A, GADD45B, CCND2, STAT1, OAS2, CD3E, CD3G, CD247More
Adenosinehsa05170Human immunodeficiency virus 1 infection4.81E-0420P62873, P63218, P50151, P0DP23, P01375, O00463, P30101, Q14643, P01568, P01730, Q16539, O60603, Q13315, P23528, P07766, P09693, P20963, P10415, Q93034, Q9Y6Q5GNB1, GNG5, GNG10, CALM1, TNF, TRAF5, PDIA3, ITPR1, IFNA21, CD4, MAPK14, TLR2, ATM, CFL1, CD3E, CD3G, CD247, BCL2, CUL5, AP1M2More
Adenosinehsa05200Pathways in cancer4.31E-0933Q16363, Q13751, P42338, P07900, P08238, P42224, P19174, P43246, P84022, Q13485, P20585, P52701, Q13547, P14923, P30279, P30281, Q13489, P98170, P49767, P43657, P62873, P63218, P50151, Q14344, Q7LDG7, P78417, O75293, P0DP23, Q13557, P01568, P14784, P40189, P01042LAMA4, LAMB3, PIK3CB, HSP90AA1, HSP90AB1, STAT1, PLCG1, MSH2, SMAD3, SMAD4, MSH3, MSH6, HDAC1, JUP, CCND2, CCND3, BIRC3, BIRC4, VEGFC, P2RY5, GNB1, GNG5, GNG10, GNA13, RASGRP2, GSTO1, GADD45B, CALM1, CAMK2D, IFNA21, IL2RB, IL6ST, KNG1More
Adenosinehsa05202Transcriptional misregulation in cancer6.65E-0819Q15532, Q13315, P41732, P14780, P27930, P14923, Q15744, Q16548, Q13077, O15550, P04637, P35226, P05164, P12838, P08246, Q9C0K0, Q92769, P12980, P24522SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, CEBPE, BCL2A1, TRAF1, UTX, TP53, BMI1, MPO, DEFA4, ELA2, BCL11B, HDAC2, LYL1, GADD45AMore
Adenosinehsa05203Viral carcinogenesis5.00E-0514Q12933, Q99941, P18848, P42229, P06746, P07948, P30279, P27348, P29083, Q7KZF4, Q13547, Q15283, P62807, O60814TRAF2, CREBL1, ATF4, STAT5A, POLB, LYN, CCND2, YWHAQ, GTF2E1, SND1, HDAC1, RASA2, HIST1H2BC, H2BC12More
Adenosinehsa05204Chemical carcinogenesis1.77E-044Q16772, P09211, P78417, P11712GSTA3, GSTP1, GSTO1, CYP2C9More
Adenosinehsa05205Proteoglycans in cancer3.68E-025P14780, P01375, P23588, Q13635, P22694MMP9, TNF, EIF4B, PTCH1, PRKACBMore
Adenosinehsa05210Colorectal cancer7.33E-035P84022, Q13485, P43246, P52701, O75293SMAD3, SMAD4, MSH2, MSH6, GADD45BMore
Adenosinehsa05212Pancreatic cancer1.92E-045P42338, P42224, P84022, Q13485, O75293PIK3CB, STAT1, SMAD3, SMAD4, GADD45BMore
Adenosinehsa05213Endometrial cancer2.82E-022P49841, P42338GSK3B, PIK3CBMore
Adenosinehsa05214Glioma7.31E-056P0DP23, Q16566, Q13557, P42338, P19174, O75293CALM1, CAMK4, CAMK2D, PIK3CB, PLCG1, GADD45BMore
Adenosinehsa05215Prostate cancer9.10E-046P10415, Q12778, Q9NRA1, P49841, P42338, P27930BCL2, FOXO1, PDGFC, GSK3B, PIK3CB, IL1R2More
Adenosinehsa05220Chronic myeloid leukemia2.16E-025Q13547, Q13485, P84022, P42338, O75293HDAC1, SMAD4, SMAD3, PIK3CB, GADD45BMore
Adenosinehsa05221Acute myeloid leukemia3.29E-023P14923, Q15744, P05164JUP, CEBPE, MPOMore
Adenosinehsa05222Small cell lung cancer3.80E-024Q13751, Q13489, P98170, O75293LAMB3, BIRC3, BIRC4, GADD45BMore
Adenosinehsa05224Breast cancer4.88E-022P42338, P49841PIK3CB, GSK3BMore
Adenosinehsa05225Hepatocellular carcinoma3.69E-023P42338, P49841, P51531PIK3CB, GSK3B, SMARCA2More
Adenosinehsa05226Gastric cancer2.94E-022P04628, P10826WNT1, RARBMore
Adenosinehsa05231Choline metabolism in cancer2.00E-022Q9Y259, P49619CHKB, DGKGMore
Adenosinehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.39E-0912P42338, O95267, P19174, P07766, P20963, P09693, P06239, O60603, P10747, Q04759, Q16539, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, CD28, PRKCQ, MAPK14, CD4More
Adenosinehsa05310Asthma1.68E-033P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Adenosinehsa05321Inflammatory bowel disease3.23E-067O60603, P01375, P13765, Q14765, Q9UL17, P23771, Q9HBE5TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Adenosinehsa05322Systemic lupus erythematosus2.77E-0413O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSBMore
Adenosinehsa05323Rheumatoid arthritis2.84E-025P01375, P13765, P10747, P09341, O60603TNF, HLA-DOB, CD28, CXCL1, TLR2More
Adenosinehsa05332Graft-versus-host disease5.72E-065P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Adenosinehsa05340Primary immunodeficiency3.99E-024P01730, P01732, P07766, P06239CD4, CD8A, CD3E, LCKMore
Adenosinehsa05410Hypertrophic cardiomyopathy2.60E-022P26012, P09493ITGB8, TPM1More
Adenosinehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Adenosinehsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Adenosinehsa05418Fluid shear stress and atherosclerosis1.02E-0511Q16539, P42338, Q14145, P14598, P10599, P14780, P01375, P14778, P27930, P0DP23, P08238MAPK14, PIK3CB, KEAP1, NCF1, TXN, MMP9, TNF, IL1R1, IL1R2, CALM1, HSP90AB1More

Community members of Adenosine (SDC: 7.12)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P04406GAPDHGlyceraldehydeNone3Nonephosphate dehydrogenasePredicted00.45350.12230.46660.938
P20839IMPDH1InosineNone5'Nonemonophosphate dehydrogenase 1Predicted00.19280.13070.16530.5231
P11142HSPA8Heat shock cognate 71 kDa proteinPredicted00.96820.07730.67291.3115
O43318MAP3K7MitogenNoneactivated protein kinase kinase kinase 7Predicted00.00590.364911.7327
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P04183TK1Thymidine kinase, cytosolicPredicted00.27170.16370.16530.6286
Q53EL6PDCD4Programmed cell death protein 4Predicted00.38990.06530.32020.6457
P15144ANPEPAminopeptidase NPredicted10.18750.23650.29340.8601
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P11388TOP2ADNA topoisomerase 2NonealphaPredicted00.19920.46590.19271.2242
P43003SLC1A3Excitatory amino acid transporter 1Predicted00.09730.07740.16580.3692
P43005SLC1A1Excitatory amino acid transporter 3Predicted00.08270.06630.0190.193
P06213INSRInsulin receptorPredicted00.27940.78130.72092.4232
P51813BMXCytoplasmic tyrosineNoneprotein kinase BMXPredicted00.05970.326300.6825
P09769FGRTyrosineNoneprotein kinase FgrPredicted00.06220.32440.2250.9049
P07948LYNTyrosineNoneprotein kinase LynPredicted00.0910.53190.6061.7154
P21589NT5E5'NonenucleotidasePredicted10.29240.08550.15390.4711
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P29375JARID1ALysineNonespecific demethylase 5APredicted00.36050.705201.5906
P51531SMARCA2Probable global transcription activator SNF2L2Predicted00.22310.0450.13750.3391
P35557GCKHexokinaseNone4Predicted00.00490.05580.32420.4382
P23458JAK1TyrosineNoneprotein kinase JAK1Predicted10.55460.921113.1195
P22748CA4Carbonic anhydrase 4Predicted00.00560.82670.16091.8171
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P22001KCNA3Potassium voltageNonegated channel subfamily A member 3Predicted10.13960.505501.0809
Q9HB89NMUR1NeuromedinNoneU receptor 1Predicted00.00240.30300.6072
P11169SLC2A3Solute carrier family 2, facilitated glucose transporter member 3Predicted00.13570.065800.1995
P15121AKR1B1AldoNoneketo reductase family 1 member B1Predicted10.56830.6290.2141.7562
O14684PTGESProstaglandin E synthasePredicted10.45310.63580.15651.6547
P17707AMD1SNoneadenosylmethionine decarboxylase proenzymePredicted00.80270.05050.16450.6667
Q96KQ7EHMT2HistoneNonelysine NNonemethyltransferase EHMT2Predicted00.07280.21650.29090.7603
P28074PSMB5Proteasome subunit beta typeNone5Predicted10.28390.47230.54391.6305
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
Q15788NCOA1Nuclear receptor coactivator 1Predicted00.43680.08280.31140.6954
P32320CDACytidine deaminasePredicted00.05160.05690.16530.3049
P26358DNMT1DNAPredicted00.34040.28090.26590.998
P31645SLC6A4SodiumNonedependent serotonin transporterPredicted00.047710.02032.0442
Q07912TNK2Activated CDC42 kinase 1Predicted00.0090.347200.6988
P60891PRPS1RiboseNonephosphate pyrophosphokinase 1Predicted00.34670.01740.29030.4984
Q9Y478PRKAB15'NoneAMPNoneactivated protein kinase subunit betaNone1Predicted10.14780.10880.55640.8479
Q96G91P2RY11P2Y purinoceptor 11Predicted00.18040.024100.1383
P07550ADRB2BetaNone2 adrenergic receptorPredicted00.007110.22052.224
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
PRKAB1Q9Y478Kd3700