PharmaCoNets of Adenine (SPCN: 2.32 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Adeninehsa00010Glycolysis / Gluconeogenesis4.41E-024P04075, P06733, P04406, P60174ALDOA, ENO1, GAPDH, TPI1More
Adeninehsa00051Fructose and mannose metabolism2.21E-023O14772, P60174, P04075FPGT, TPI1, ALDOAMore
Adeninehsa00052Galactose metabolism2.33E-032P06280, O43451GLA, MGAMMore
Adeninehsa00190Oxidative phosphorylation2.21E-023Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Adeninehsa00280Valine, leucine and isoleucine degradation1.67E-024P55809, Q9HCC0, Q02252, P11310OXCT1, MCCC2, ALDH6A1, ACADMMore
Adeninehsa00310Lysine degradation2.59E-022Q96KQ7, P51648EHMT2, ALDH3A2More
Adeninehsa00500Starch and sucrose metabolism6.17E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Adeninehsa00512Mucin type O-glycan biosynthesis4.86E-022O95395, Q9NY28GCNT3, GALNT8More
Adeninehsa00561Glycerolipid metabolism2.21E-023O14494, P06280, P23743PLPP1, GLA, DGKAMore
Adeninehsa00600Sphingolipid metabolism3.96E-023Q9BX95, O14494, P06280SGPP1, PLPP1, GLAMore
Adeninehsa00630Glyoxylate and dicarboxylate metabolism9.62E-043P40925, P40926, P15104MDH1, MDH2, GLULMore
Adeninehsa00730Thiamine metabolism5.68E-042P05186, P24666ALPL, ACP1More
Adeninehsa00830Retinol metabolism1.08E-023Q9BPW9, O75911, P11712DHRS9, DHRS3, CYP2C9More
Adeninehsa01200Carbon metabolism5.71E-037P04075, P04406, P60174, P06733, O14521, Q9P2R7, Q02252ALDOA, GAPDH, TPI1, ENO1, SDHD, SUCLA2, ALDH6A1More
Adeninehsa012102-Oxocarboxylic acid metabolism3.43E-021P50213IDH3AMore
Adeninehsa01230Biosynthesis of amino acids9.38E-035P60174, P04406, P06733, P04075, Q99707TPI1, GAPDH, ENO1, ALDOA, MTRMore
Adeninehsa01523Antifolate resistance1.68E-022Q92820, P04818GGH, TYMSMore
Adeninehsa03040Spliceosome4.48E-0410Q14562, O43143, O60508, P17844, P51991, P61978, Q07955, Q01130, Q13243, P11142DHX8, DHX15, CDC40, DDX5, HNRPA3, HNRPK, SFRS1, SFRS2, SFRS5, HSPA8More
Adeninehsa04014Ras signaling pathway8.66E-037Q9NRA1, Q13009, P0DP23, P62873, P63218, P50151, P19174PDGFC, TIAM1, CALM1, GNB1, GNG5, GNG10, PLCG1More
Adeninehsa04062Chemokine signaling pathway1.59E-039P07948, P19174, P62873, P63218, P50151, Q13009, P14598, P42224, P25963LYN, PLCG1, GNB1, GNG5, GNG10, TIAM1, NCF1, STAT1, NFKBIAMore
Adeninehsa04070Phosphatidylinositol signaling system2.93E-024P19174, P0DP23, P23743, P27987PLCG1, CALM1, DGKA, ITPKBMore
Adeninehsa04110Cell cycle6.63E-046P06493, O60566, P30304, P33981, P42773, P01106CDK1, BUB1B, CDC25A, TTK, CDKN2C, MYCMore
Adeninehsa04141Protein processing in endoplasmic reticulum7.41E-0614P18848, P30101, P07384, O95487, Q15437, P60604, Q99941, P11142, P07900, P08238, Q9NR31, O95816, Q9H173, Q9UNL2ATF4, PDIA3, CAPN1, SEC24B, SEC23B, UBE2G2, CREBL1, HSPA8, HSP90AA1, HSP90AB1, SAR1A, BAG2, SIL1, SSR3More
Adeninehsa04145Phagosome9.18E-049P11215, P60709, Q15075, Q15080, P14598, Q71U36, Q13509, P68371, Q13488ITGAM, ACTB, EEA1, NCF4, NCF1, TUBA1A, TUBB3, TUBB2C, TCIRG1More
Adeninehsa04151PI3K-Akt signaling pathway3.91E-037P62753, P27348, P07900, P22105, Q99941, P18848, O00141RPS6, YWHAQ, HSP90AA1, TNXB, CREBL1, ATF4, SGKMore
Adeninehsa04211Longevity regulating pathway2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Adeninehsa04261Adrenergic signaling in cardiomyocytes1.46E-024P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Adeninehsa04360Axon guidance1.50E-023P20827, P23528, Q06124EFNA1, CFL1, PTPN11More
Adeninehsa04371Apelin signaling pathway7.95E-047P62873, P63218, P50151, Q13370, Q14344, P84022, P0DP23GNB1, GNG5, GNG10, PDE3B, GNA13, SMAD3, CALM1More
Adeninehsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Adeninehsa04530Tight junction2.08E-023P63261, Q9Y478, Q92974ACTG1, PRKAB1, ARHGEF2More
Adeninehsa04540Gap junction1.08E-024Q13509, P68371, Q71U36, Q9NRA1TUBB3, TUBB2C, TUBA1A, PDGFCMore
Adeninehsa04623Cytosolic DNA-sensing pathway2.59E-022P01568, P25963IFNA21, NFKBIAMore
Adeninehsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Adeninehsa04640Hematopoietic cell lineage4.95E-023P01730, P06127, P09564CD4, CD5, CD7More
Adeninehsa04657IL-17 signaling pathway1.36E-025O00463, Q16539, P49841, P14780, P01375TRAF5, MAPK14, GSK3B, MMP9, TNFMore
Adeninehsa04659Th17 cell differentiation1.11E-026P25963, P19174, P42224, P14784, P84022, P08238NFKBIA, PLCG1, STAT1, IL2RB, SMAD3, HSP90AB1More
Adeninehsa04664Fc epsilon RI signaling pathway7.09E-047P01375, P04141, Q16539, Q9UQC2, P07948, P19174, P09917TNF, CSF2, MAPK14, GAB2, LYN, PLCG1, ALOX5More
Adeninehsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Adeninehsa04713Circadian entrainment2.18E-024P0DP23, P62873, P63218, P50151CALM1, GNB1, GNG5, GNG10More
Adeninehsa04714Thermogenesis9.85E-047P15336, P51828, P63261, P62753, Q9Y478, P12074, O15239ATF2, ADCY7, ACTG1, RPS6, PRKAB1, COX6A1, NDUFA1More
Adeninehsa04724Glutamatergic synapse1.57E-024P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Adeninehsa04725Cholinergic synapse2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Adeninehsa04726Serotonergic synapse3.80E-024P62873, P63218, P50151, P09917GNB1, GNG5, GNG10, ALOX5More
Adeninehsa04727GABAergic synapse4.18E-034P62873, P63218, P50151, P15104GNB1, GNG5, GNG10, GLULMore
Adeninehsa04728Dopaminergic synapse4.78E-023Q99941, P18848, Q13557CREBL1, ATF4, CAMK2DMore
Adeninehsa04730Long-term depression4.86E-022Q14344, P07948GNA13, LYNMore
Adeninehsa04744Phototransduction9.21E-032P62873, P0DP23GNB1, CALM1More
Adeninehsa04911Insulin secretion4.03E-044P51828, Q99941, P18848, Q13557ADCY7, CREBL1, ATF4, CAMK2DMore
Adeninehsa04912GnRH signaling pathway2.17E-023P51828, P18848, Q13557ADCY7, ATF4, CAMK2DMore
Adeninehsa04915Estrogen signaling pathway2.75E-035Q99941, P18848, P51828, P07900, P11142CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8More
Adeninehsa04918Thyroid hormone synthesis1.69E-034P51828, Q99941, P18848, P02768ADCY7, CREBL1, ATF4, ALBMore
Adeninehsa04920Adipocytokine signaling pathway2.80E-022Q06124, Q9Y478PTPN11, PRKAB1More
Adeninehsa04925Aldosterone synthesis and secretion1.69E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Adeninehsa04926Relaxin signaling pathway3.34E-023Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Adeninehsa04927Cortisol synthesis and secretion4.16E-033Q99941, P18848, P51828CREBL1, ATF4, ADCY7More
Adeninehsa04928Parathyroid hormone synthesis, secretion and action2.17E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Adeninehsa04934Cushing syndrome1.12E-034Q99941, P18848, P51828, Q13557CREBL1, ATF4, ADCY7, CAMK2DMore
Adeninehsa04935Growth hormone synthesis, secretion and action2.72E-023P51828, Q99941, P18848ADCY7, CREBL1, ATF4More
Adeninehsa05012Parkinson disease1.77E-026P60604, P19174, P0DP23, Q71U36, Q13509, P68371UBE2G2, PLCG1, CALM1, TUBA1A, TUBB3, TUBB2CMore
Adeninehsa05030Cocaine addiction4.87E-022Q99941, P18848CREBL1, ATF4More
Adeninehsa05031Amphetamine addiction6.41E-033Q13557, Q99941, P18848CAMK2D, CREBL1, ATF4More
Adeninehsa05032Morphine addiction2.18E-024P62873, P63218, P50151, Q13370GNB1, GNG5, GNG10, PDE3BMore
Adeninehsa05110Vibrio cholerae infection4.50E-034Q13488, P17252, P19174, P60709TCIRG1, PRKCA, PLCG1, ACTBMore
Adeninehsa05120Epithelial cell signaling in Helicobacter pylori infection8.38E-047Q16539, P25963, Q13488, P19174, P25024, P25025, P07948MAPK14, NFKBIA, TCIRG1, PLCG1, CXCR1, CXCR2, LYNMore
Adeninehsa05130Pathogenic Escherichia coli infection1.44E-0310Q71U36, P16333, Q92974, Q13509, P68371, P63261, Q14344, P25963, Q06124, O95487TUBA1A, NCK1, ARHGEF2, TUBB3, TUBB2C, ACTG1, GNA13, NFKBIA, PTPN11, SEC24BMore
Adeninehsa05132Salmonella infection2.75E-027P25963, P08238, O75369, Q71U36, Q13509, P68371, P49754NFKBIA, HSP90AB1, FLNB, TUBA1A, TUBB3, TUBB2C, VPS41More
Adeninehsa05134Legionellosis4.75E-023P25963, P11215, P11142NFKBIA, ITGAM, HSPA8More
Adeninehsa05140Leishmaniasis5.98E-036P14598, P11215, P42224, P25963, P29350, Q15080NCF1, ITGAM, STAT1, NFKBIA, PTPN6, NCF4More
Adeninehsa05161Hepatitis B3.34E-023Q99941, P18848, P27348CREBL1, ATF4, YWHAQMore
Adeninehsa05163Human cytomegalovirus infection2.50E-0414P01375, P25963, P62873, P63218, P50151, P0DP23, Q14344, P49841, P14778, P25025, Q16539, O00463, P30101, P01568TNF, NFKBIA, GNB1, GNG5, GNG10, CALM1, GNA13, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5, PDIA3, IFNA21More
Adeninehsa05167Kaposi sarcoma-associated herpesvirus infection8.62E-0510P01568, P42224, P25963, P62873, P63218, P50151, P19174, P07948, P04141, P0DP23IFNA21, STAT1, NFKBIA, GNB1, GNG5, GNG10, PLCG1, LYN, CSF2, CALM1More
Adeninehsa05168Herpes simplex virus 1 infection3.79E-029P25963, P01568, P42224, Q07955, Q01130, Q13243, P30101, Q13398, O75820NFKBIA, IFNA21, STAT1, SFRS1, SFRS2, SFRS5, PDIA3, ZNF211, ZNF189More
Adeninehsa05170Human immunodeficiency virus 1 infection1.19E-028P62873, P63218, P50151, P0DP23, P30101, P01568, P25963, P19174GNB1, GNG5, GNG10, CALM1, PDIA3, IFNA21, NFKBIA, PLCG1More
Adeninehsa05200Pathways in cancer1.99E-0315P08238, P42224, P25963, P19174, P43246, P84022, P20585, P62873, P63218, P50151, Q14344, O75293, P0DP23, P01568, P14784HSP90AB1, STAT1, NFKBIA, PLCG1, MSH2, SMAD3, MSH3, GNB1, GNG5, GNG10, GNA13, GADD45B, CALM1, IFNA21, IL2RBMore
Adeninehsa05203Viral carcinogenesis1.46E-024Q99941, P18848, P27348, P61978CREBL1, ATF4, YWHAQ, HNRPKMore
Adeninehsa05211Renal cell carcinoma1.06E-022Q06124, Q99814PTPN11, EPAS1More
Adeninehsa05212Pancreatic cancer4.75E-023P42224, P84022, O75293STAT1, SMAD3, GADD45BMore
Adeninehsa05214Glioma4.75E-023P0DP23, P19174, O75293CALM1, PLCG1, GADD45BMore
Adeninehsa05223Non-small cell lung cancer3.99E-024P17252, O43524, P19174, O75293PRKCA, FOXO3, PLCG1, GADD45BMore
Adeninehsa05231Choline metabolism in cancer3.99E-024P19174, P23743, O14494, P17252PLCG1, DGKA, PLPP1, PRKCAMore
Adeninehsa05415Diabetic cardiomyopathy3.94E-026P17252, P14598, Q15080, Q16718, O14521, P04406PRKCA, NCF1, NCF4, NDUFA5, SDHD, GAPDHMore
Adeninehsa05418Fluid shear stress and atherosclerosis1.08E-037Q16539, Q14145, P10599, P14780, P01375, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2More
Flavin-adenine-dinucleotidehsa00071Fatty acid degradation2.45E-023P11310, P28332, P33121ACADM, ADH6, ACSL1More
Flavin-adenine-dinucleotidehsa00220Arginine biosynthesis3.96E-043P15104, P05089, P49448GLUL, ARG1, GLUD2More
Flavin-adenine-dinucleotidehsa00250Alanine, aspartate and glutamate metabolism2.48E-042Q96RQ9, P15104IL4I1, GLULMore
Flavin-adenine-dinucleotidehsa00270Cysteine and methionine metabolism4.90E-021Q96RQ9IL4I1More
Flavin-adenine-dinucleotidehsa00280Valine, leucine and isoleucine degradation3.29E-021Q96RQ9IL4I1More
Flavin-adenine-dinucleotidehsa00350Tyrosine metabolism3.29E-021Q96RQ9IL4I1More
Flavin-adenine-dinucleotidehsa00360Phenylalanine metabolism1.66E-021Q96RQ9IL4I1More
Flavin-adenine-dinucleotidehsa00380Tryptophan metabolism1.66E-021Q96RQ9IL4I1More
Flavin-adenine-dinucleotidehsa00400Phenylalanine, tyrosine and tryptophan biosynthesis1.66E-021Q96RQ9IL4I1More
Flavin-adenine-dinucleotidehsa00830Retinol metabolism3.15E-021P00325ADH1BMore
Flavin-adenine-dinucleotidehsa00910Nitrogen metabolism1.66E-021P15104GLULMore
Flavin-adenine-dinucleotidehsa01200Carbon metabolism4.29E-024P04406, O14521, Q9P2R7, Q02252GAPDH, SDHD, SUCLA2, ALDH6A1More
Flavin-adenine-dinucleotidehsa03020RNA polymerase1.31E-022P24928, P62487POLR2A, POLR2GMore
Flavin-adenine-dinucleotidehsa04020Calcium signaling pathway2.63E-022P05141, P63092SLC25A5, GNASMore
Flavin-adenine-dinucleotidehsa04217Necroptosis4.39E-022Q12933, P15104TRAF2, GLULMore
Flavin-adenine-dinucleotidehsa04270Vascular smooth muscle contraction2.03E-022P63092, P35579GNAS, MYH9More
Flavin-adenine-dinucleotidehsa04390Hippo signaling pathway2.40E-022P35240, Q92796NF2, DLG3More
Flavin-adenine-dinucleotidehsa04612Antigen processing and presentation8.21E-035P26715, P26717, Q07444, Q13241, P01732KLRC1, KLRC2, KLRC3, KLRD1, CD8AMore
Flavin-adenine-dinucleotidehsa04622RIG-I-like receptor signaling pathway4.90E-021Q12933TRAF2More
Flavin-adenine-dinucleotidehsa04650Natural killer cell mediated cytotoxicity8.48E-058P06239, P20963, Q13241, P26718, O14931, P26717, Q07444, P26715LCK, CD247, KLRD1, KLRK1, NCR3, KLRC2, KLRC3, KLRC1More
Flavin-adenine-dinucleotidehsa04658Th1 and Th2 cell differentiation7.09E-057Q04759, P20963, P09693, P06239, P23771, Q9UL17, Q13761PRKCQ, CD247, CD3G, LCK, GATA3, TBX21, RUNX3More
Flavin-adenine-dinucleotidehsa04659Th17 cell differentiation2.34E-036Q04759, P06239, Q9UL17, P23771, P09693, P20963PRKCQ, LCK, TBX21, GATA3, CD3G, CD247More
Flavin-adenine-dinucleotidehsa04660T cell receptor signaling pathway8.49E-047Q04759, O95267, Q08881, P20963, P09693, P01732, P06239PRKCQ, RASGRP1, ITK, CD247, CD3G, CD8A, LCKMore
Flavin-adenine-dinucleotidehsa04972Pancreatic secretion1.31E-022Q08828, P62491ADCY1, RAB11AMore
Flavin-adenine-dinucleotidehsa04974Protein digestion and absorption1.52E-021P02452COL1A1More
Flavin-adenine-dinucleotidehsa05146Amoebiasis2.73E-024P09341, P05089, P12814, P08311CXCL1, ARG1, ACTN1, CTSGMore
Flavin-adenine-dinucleotidehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.88E-035O95267, P20963, P09693, P06239, Q04759RASGRP1, CD247, CD3G, LCK, PRKCQMore
Flavin-adenine-dinucleotidehsa05322Systemic lupus erythematosus1.57E-024P08311, P62807, Q16778, P12814CTSG, HIST1H2BC, HIST2H2BE, ACTN1More

Community members of Adenine (SDC: 0.89)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P24666ACP1Low molecular weight phosphotyrosine protein phosphataseReported00.07040.10480.23610.481
P08238HSP90AB1Heat shock protein HSP 90NonebetaPredicted00.06110.52080.7411.8131
P06493CDK1CyclinNonedependent kinase 1Predicted00.01310.6042.6105
P04406GAPDHGlyceraldehydeNone3Nonephosphate dehydrogenasePredicted00.45350.12230.46660.938
P29350PTPN6TyrosineNoneprotein phosphatase nonNonereceptor type 6Predicted10.28070.24590.56831.2004
Q06124PTPN11TyrosineNoneprotein phosphatase nonNonereceptor type 11Predicted10.15130.45660.6131.6017
P07900HSP90AA1Heat shock protein HSP 90NonealphaPredicted10.47270.60640.7412.1901
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)