PharmaCoNets of Adapalene (SPCN: 142.19 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Adapalenehsa00052Galactose metabolism4.27E-022P06280, O43451GLA, MGAMMore
Adapalenehsa00190Oxidative phosphorylation3.56E-023Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Adapalenehsa00230Purine metabolism1.81E-022P20839, Q02153IMPDH1, GUCY1B3More
Adapalenehsa00250Alanine, aspartate and glutamate metabolism1.22E-022Q96RQ9, P15104IL4I1, GLULMore
Adapalenehsa00260Glycine, serine and threonine metabolism1.99E-021P22557ALAS2More
Adapalenehsa00270Cysteine and methionine metabolism3.39E-022Q96RQ9, P40926IL4I1, MDH2More
Adapalenehsa00500Starch and sucrose metabolism6.17E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Adapalenehsa00512Mucin type O-glycan biosynthesis3.78E-022O95395, Q8N4A0GCNT3, GALNT4More
Adapalenehsa00520Amino sugar and nucleotide sugar metabolism4.36E-043Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Adapalenehsa00524Neomycin, kanamycin and gentamicin biosynthesis2.03E-021P35557GCKMore
Adapalenehsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Adapalenehsa00561Glycerolipid metabolism4.97E-045Q8NEB5, P51648, P14550, P23743, Q86XP1PPAPDC1B, ALDH3A2, AKR1A1, DGKA, DGKHMore
Adapalenehsa00562Inositol phosphate metabolism7.30E-044P27987, Q96PE3, P19174, P42338ITPKB, INPP4A, PLCG1, PIK3CBMore
Adapalenehsa00565Ether lipid metabolism3.94E-021Q8N661TMEM86BMore
Adapalenehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Adapalenehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Adapalenehsa00603Glycosphingolipid biosynthesis - globo and isoglobo series4.30E-032P06865, O75752HEXA, B3GALNT1More
Adapalenehsa00620Pyruvate metabolism2.51E-022P40925, P51648MDH1, ALDH3A2More
Adapalenehsa00630Glyoxylate and dicarboxylate metabolism1.54E-052P40925, P15104MDH1, GLULMore
Adapalenehsa00730Thiamine metabolism1.20E-043Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Adapalenehsa00740Riboflavin metabolism4.03E-021P24666ACP1More
Adapalenehsa00770Pantothenate and CoA biosynthesis1.15E-022O95498, Q9NRN7VNN2, AASDHPPTMore
Adapalenehsa00900Terpenoid backbone biosynthesis1.22E-022P49354, Q9UHG3FNTA, PCYOX1More
Adapalenehsa00920Sulfur metabolism2.29E-021Q16762TSTMore
Adapalenehsa00970Aminoacyl-tRNA biosynthesis3.78E-022O95363, Q15046FARS2, KARSMore
Adapalenehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Adapalenehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Adapalenehsa01100Metabolic pathways4.12E-0212P15104, P51648, P42338, Q96PE3, P19174, P27987, Q13370, P40925, P23743, P43034, P09917, Q53FZ2GLUL, ALDH3A2, PIK3CB, INPP4A, PLCG1, ITPKB, PDE3B, MDH1, DGKA, PAFAH1B1, ALOX5, ACSM3More
Adapalenehsa01200Carbon metabolism4.06E-025P37837, O14521, P50213, P60891, Q02252TALDO1, SDHD, IDH3A, PRPS1, ALDH6A1More
Adapalenehsa01521EGFR tyrosine kinase inhibitor resistance7.30E-044Q92529, P19174, P42338, Q9NRA1SHC3, PLCG1, PIK3CB, PDGFCMore
Adapalenehsa01524Platinum drug resistance1.79E-022O15392, P11388BIRC5, TOP2AMore
Adapalenehsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Adapalenehsa03013RNA transport5.45E-0310P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, P78345, Q9Y6A5NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, RPP38, TACC3More
Adapalenehsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Adapalenehsa03020RNA polymerase3.59E-022P30876, P62487POLR2B, POLR2GMore
Adapalenehsa03040Spliceosome2.92E-0614Q14562, O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643DHX8, DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1More
Adapalenehsa03050Proteasome4.83E-021P55036PSMD4More
Adapalenehsa03320PPAR signaling pathway3.78E-022Q6PCB7, Q9UNU6SLC27A1, CYP8B1More
Adapalenehsa04012ErbB signaling pathway9.49E-033Q92529, P19174, P42338SHC3, PLCG1, PIK3CBMore
Adapalenehsa04014Ras signaling pathway7.65E-0510P42338, Q92529, P20827, Q9NRA1, P49767, Q13009, Q7LDG7, P63218, P50151, P19174PIK3CB, SHC3, EFNA1, PDGFC, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1More
Adapalenehsa04015Rap1 signaling pathway2.22E-039P20827, Q9NRA1, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174EFNA1, PDGFC, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1More
Adapalenehsa04020Calcium signaling pathway1.55E-039P27987, Q96DU7, Q13557, P21860, P19174, P26678, P63092, Q9NRA1, P49767ITPKB, ITPKC, CAMK2D, ERBB3, PLCG1, PLN, GNAS, PDGFC, VEGFCMore
Adapalenehsa04062Chemokine signaling pathway2.01E-0411P09769, P07948, P42338, P19174, Q92529, P63218, P50151, P43250, Q7LDG7, Q13009, Q8WYR1FGR, LYN, PIK3CB, PLCG1, SHC3, GNG5, GNG10, GRK6, RASGRP2, TIAM1, PIK3R5More
Adapalenehsa04064NF-kappa B signaling pathway1.09E-0411P10415, Q13489, O00463, Q13546, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341, Q9UNE0BCL2, BIRC3, TRAF5, RIPK1, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1, EDARMore
Adapalenehsa04070Phosphatidylinositol signaling system3.19E-045P19174, P42338, P23743, Q96PE3, P27987PLCG1, PIK3CB, DGKA, INPP4A, ITPKBMore
Adapalenehsa04071Sphingolipid signaling pathway8.69E-057P17252, P21453, Q9H228, Q13362, Q9BX95, Q16539, P10415PRKCA, S1PR1, EDG8, PPP2R5C, SGPP1, MAPK14, BCL2More
Adapalenehsa04072Phospholipase D signaling pathway1.85E-046P42338, Q92529, P19174, Q14344, P23743, Q9NRA1PIK3CB, SHC3, PLCG1, GNA13, DGKA, PDGFCMore
Adapalenehsa04080Neuroactive ligand-receptor interaction1.00E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2More
Adapalenehsa04114Oocyte meiosis4.51E-035Q9Y6D9, P51812, Q02750, P16298, Q17RY0MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Adapalenehsa04120Ubiquitin mediated proteolysis2.51E-036Q14145, Q13042, P62837, Q15751, O95071, P0CG47KEAP1, CDC16, UBE2D2, HERC1, UBR5, UBBMore
Adapalenehsa04122Sulfur relay system2.29E-021Q16762TSTMore
Adapalenehsa04137Mitophagy - animal9.52E-032Q07817, P0CG47BCL2L1, UBBMore
Adapalenehsa04140Autophagy - animal3.19E-024P22694, Q14643, P10415, Q04759PRKACB, ITPR1, BCL2, PRKCQMore
Adapalenehsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Adapalenehsa04145Phagosome1.65E-0510O75015, Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOBMore
Adapalenehsa04151PI3K-Akt signaling pathway7.72E-0413P42338, P43657, P20827, Q9NRA1, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281PIK3CB, P2RY5, EFNA1, PDGFC, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3More
Adapalenehsa04210Apoptosis3.44E-027Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1More
Adapalenehsa04211Longevity regulating pathway1.18E-023Q12778, Q9UEF7, Q96KQ7FOXO1, KL, EHMT2More
Adapalenehsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Adapalenehsa04217Necroptosis3.89E-0613P01375, P01568, P48023, Q13489, Q13546, Q14765, P07900, P15104, P05141, P01584, P0C0S5, Q99878, Q13557TNF, IFNA21, FASLG, BIRC3, RIPK1, STAT4, HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC14, CAMK2DMore
Adapalenehsa04270Vascular smooth muscle contraction2.89E-022P35579, P35318MYH9, ADMMore
Adapalenehsa04310Wnt signaling pathway1.79E-022P17612, P67870PRKACA, CSNK2BMore
Adapalenehsa04330Notch signaling pathway1.12E-023Q92542, P49768, P46531NCSTN, PSEN1, NOTCH1More
Adapalenehsa04340Hedgehog signaling pathway1.92E-034P17612, P22694, Q13635, P10415PRKACA, PRKACB, PTCH1, BCL2More
Adapalenehsa04350TGF-beta signaling pathway4.88E-021P37173TGFBR2More
Adapalenehsa04360Axon guidance4.04E-026P16333, P20827, O95631, P42338, P07332, P19174NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1More
Adapalenehsa04370VEGF signaling pathway6.63E-055P19174, P16298, P42338, Q05397, Q02750PLCG1, PPP3CB, PIK3CB, PTK2, MAP2K1More
Adapalenehsa04371Apelin signaling pathway4.48E-048P63218, P50151, Q8WYR1, Q13370, Q14814, Q14344, Q13485, P84022GNG5, GNG10, PIK3R5, PDE3B, MEF2D, GNA13, SMAD4, SMAD3More
Adapalenehsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Adapalenehsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Adapalenehsa04510Focal adhesion1.55E-025P42338, O15335, Q9NRA1, P49767, Q92529PIK3CB, CHAD, PDGFC, VEGFC, SHC3More
Adapalenehsa04512ECM-receptor interaction2.00E-022P07359, P08514GP1BA, ITGA2BMore
Adapalenehsa04514Cell adhesion molecules3.82E-022P16109, O00501SELP, CLDN5More
Adapalenehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Adapalenehsa04610Complement and coagulation cascades3.16E-032P00734, P0C0L4F2, C4AMore
Adapalenehsa04611Platelet activation4.86E-069Q9Y490, P08514, P42338, Q14344, Q15746, Q8WYR1, P17612, P07359, P07948TLN1, ITGA2B, PIK3CB, GNA13, MYLK, PIK3R5, PRKACA, GP1BA, LYNMore
Adapalenehsa04612Antigen processing and presentation4.48E-025P13765, P26715, P26717, Q13241, P01732HLA-DOB, KLRC1, KLRC2, KLRD1, CD8AMore
Adapalenehsa04613Neutrophil extracellular trap formation6.81E-0724P17252, P16109, O60603, P05164, P08246, Q9UM07, Q92769, Q6FI13, Q99878, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, O75015, P21730, P08514, P21462, P07359, O43315, Q16539PRKCA, SELP, TLR2, MPO, ELA2, PADI4, HDAC2, H2AC18; H2AC19, H2AC14, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, FCGR3B, C5AR1, ITGA2B, FPR1, GP1BA, AQP9, MAPK14More
Adapalenehsa04614Renin-angiotensin system1.52E-021P50052AGTR2More
Adapalenehsa04620Toll-like receptor signaling pathway4.16E-022Q13546, P01568RIPK1, IFNA21More
Adapalenehsa04621NOD-like receptor signaling pathway4.72E-023P01568, Q13489, Q13546IFNA21, BIRC3, RIPK1More
Adapalenehsa04622RIG-I-like receptor signaling pathway5.23E-034P01568, Q13546, Q12933, P10145IFNA21, RIPK1, TRAF2, IL8More
Adapalenehsa04623Cytosolic DNA-sensing pathway2.20E-032P01568, Q13546IFNA21, RIPK1More
Adapalenehsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Adapalenehsa04650Natural killer cell mediated cytotoxicity2.18E-039P16298, P50591, O60880, P20963, Q02750, Q13241, P26718, P26717, P26715PPP3CB, TNFSF10, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, KLRC2, KLRC1More
Adapalenehsa04657IL-17 signaling pathway1.14E-037P07900, O00463, Q16539, P49841, P14780, P01375, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, MMP9, TNF, IL1BMore
Adapalenehsa04658Th1 and Th2 cell differentiation3.54E-0511Q04759, P07766, P20963, P09693, P19174, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, PLCG1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Adapalenehsa04659Th17 cell differentiation1.02E-0514P25963, Q04759, P19174, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963NFKBIA, PRKCQ, PLCG1, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247More
Adapalenehsa04660T cell receptor signaling pathway1.00E-027Q9UDY8, Q04759, P10747, Q08881, P20963, P09693, P01732MALT1, PRKCQ, CD28, ITK, CD247, CD3G, CD8AMore
Adapalenehsa04662B cell receptor signaling pathway1.04E-055P42338, P60033, P07948, P21854, Q8N149PIK3CB, CD81, LYN, CD72, LILRA2More
Adapalenehsa04664Fc epsilon RI signaling pathway4.92E-088P01375, Q16539, P42338, Q9UQC2, P07948, P19174, P09917, P20292TNF, MAPK14, PIK3CB, GAB2, LYN, PLCG1, ALOX5, ALOX5APMore
Adapalenehsa04666Fc gamma R-mediated phagocytosis1.56E-038P07948, P42338, P19174, P23528, P06396, O14494, P14598, P17252LYN, PIK3CB, PLCG1, CFL1, GSN, PLPP1, NCF1, PRKCAMore
Adapalenehsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Adapalenehsa04672Intestinal immune network for IgA production1.62E-023P29965, P10747, P13765CD40LG, CD28, HLA-DOBMore
Adapalenehsa04710Circadian rhythm1.67E-022Q16526, Q9Y478CRY1, PRKAB1More
Adapalenehsa04713Circadian entrainment1.75E-024Q13557, Q02153, P61952, P63092CAMK2D, GUCY1B3, GNG11, GNASMore
Adapalenehsa04720Long-term potentiation2.35E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Adapalenehsa04722Neurotrophin signaling pathway3.94E-036P42338, P19174, Q92529, P49841, O43524, P48023PIK3CB, PLCG1, SHC3, GSK3B, FOXO3, FASLGMore
Adapalenehsa04723Retrograde endocannabinoid signaling1.75E-025Q14643, P17252, P22694, Q16539, Q16718ITPR1, PRKCA, PRKACB, MAPK14, NDUFA5More
Adapalenehsa04724Glutamatergic synapse2.62E-044O15399, P63218, P50151, P15104GRIN2D, GNG5, GNG10, GLULMore
Adapalenehsa04725Cholinergic synapse1.84E-033P63218, P50151, P42338GNG5, GNG10, PIK3CBMore
Adapalenehsa04726Serotonergic synapse3.41E-023P63218, P50151, P09917GNG5, GNG10, ALOX5More
Adapalenehsa04727GABAergic synapse2.70E-043P63218, P50151, P15104GNG5, GNG10, GLULMore
Adapalenehsa04728Dopaminergic synapse2.41E-025P63092, P61952, Q99941, Q13557, O15516GNAS, GNG11, CREBL1, CAMK2D, CLOCKMore
Adapalenehsa04730Long-term depression1.56E-022Q14344, P07948GNA13, LYNMore
Adapalenehsa04742Taste transduction3.91E-021P17612PRKACAMore
Adapalenehsa04744Phototransduction2.80E-022P62873, P0DP23GNB1, CALM1More
Adapalenehsa04910Insulin signaling pathway4.11E-023Q92529, Q13370, P42338SHC3, PDE3B, PIK3CBMore
Adapalenehsa04911Insulin secretion4.88E-023P63092, Q99941, Q13557GNAS, CREBL1, CAMK2DMore
Adapalenehsa04912GnRH signaling pathway2.96E-045P17252, Q16539, Q9Y6R4, Q14643, P22694PRKCA, MAPK14, MAP3K4, ITPR1, PRKACBMore
Adapalenehsa04914Progesterone-mediated oocyte maturation3.89E-047Q17RY0, P42338, Q13370, Q9Y6D9, P08238, P51812, Q02750CPEB4, PIK3CB, PDE3B, MAD1L1, HSP90AB1, RPS6KA3, MAP2K1More
Adapalenehsa04915Estrogen signaling pathway4.76E-034P42338, Q92529, P08238, P11142PIK3CB, SHC3, HSP90AB1, HSPA8More
Adapalenehsa04916Melanogenesis4.80E-024P0DP23, Q9UJU2, P17252, P04628CALM1, LEF1, PRKCA, WNT1More
Adapalenehsa04920Adipocytokine signaling pathway4.31E-022Q9Y478, Q96RR4PRKAB1, CAMKK2More
Adapalenehsa04921Oxytocin signaling pathway4.91E-022Q15746, Q8WYR1MYLK, PIK3R5More
Adapalenehsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Adapalenehsa04923Regulation of lipolysis in adipocytes3.64E-022Q13370, P42338PDE3B, PIK3CBMore
Adapalenehsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Adapalenehsa04926Relaxin signaling pathway2.50E-056P42338, P63218, P50151, P49767, Q92529, P49407PIK3CB, GNG5, GNG10, VEGFC, SHC3, ARRB1More
Adapalenehsa04928Parathyroid hormone synthesis, secretion and action4.10E-035Q14643, P22694, P23771, P17252, P10415ITPR1, PRKACB, GATA3, PRKCA, BCL2More
Adapalenehsa04929GnRH secretion4.62E-022P42338, P49407PIK3CB, ARRB1More
Adapalenehsa04932Non-alcoholic fatty liver disease6.43E-047P01375, P49841, P18848, P48023, P01584, P13073, O15239TNF, GSK3B, ATF4, FASLG, IL1B, COX4I1, NDUFA1More
Adapalenehsa04933AGE-RAGE signaling pathway in diabetic complications2.54E-046P84022, Q13485, P10415, P42338, P49767, P19174SMAD3, SMAD4, BCL2, PIK3CB, VEGFC, PLCG1More
Adapalenehsa04934Cushing syndrome1.75E-024Q99941, P63092, O15169, Q13557CREBL1, GNAS, AXIN1, CAMK2DMore
Adapalenehsa04935Growth hormone synthesis, secretion and action2.78E-023P19174, P42338, Q92529PLCG1, PIK3CB, SHC3More
Adapalenehsa04940Type I diabetes mellitus1.87E-022P48023, P01375FASLG, TNFMore
Adapalenehsa04950Maturity onset diabetes of the young2.03E-021P35557GCKMore
Adapalenehsa04962Vasopressin-regulated water reabsorption7.22E-032P52566, P62491ARHGDIB, RAB11AMore
Adapalenehsa04972Pancreatic secretion3.86E-023Q14643, P20020, P17252ITPR1, ATP2B1, PRKCAMore
Adapalenehsa04975Fat digestion and absorption9.50E-041O14494PLPP1More
Adapalenehsa05012Parkinson disease2.53E-025O15239, P13073, P05141, P18848, Q13557NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2DMore
Adapalenehsa05016Huntington disease3.21E-025O15239, P13073, P30876, P62487, P05141NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5More
Adapalenehsa05020Prion disease3.37E-037P13591, P01584, P11142, O15239, P13073, P18848, P05141NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5More
Adapalenehsa05022Pathways of neurodegeneration - multiple diseases3.80E-026O15239, P13073, P18848, P05141, P01584, Q13557NDUFA1, COX4I1, ATF4, SLC25A5, IL1B, CAMK2DMore
Adapalenehsa05031Amphetamine addiction4.88E-023Q13557, P63092, Q99941CAMK2D, GNAS, CREBL1More
Adapalenehsa05032Morphine addiction2.22E-023P63218, P50151, Q13370GNG5, GNG10, PDE3BMore
Adapalenehsa05034Alcoholism1.96E-046Q96RR4, Q93077, P62807, O60814, P84243, P68431CAMKK2, HIST1H2AC, HIST1H2BC, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Adapalenehsa05100Bacterial invasion of epithelial cells3.64E-022P42338, Q92529PIK3CB, SHC3More
Adapalenehsa05110Vibrio cholerae infection2.11E-032Q99437, P17612ATP6V0B, PRKACAMore
Adapalenehsa05132Salmonella infection2.41E-0413P51617, P25963, Q9UJU2, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, O60282, Q13509, P68371IRAK1, NFKBIA, LEF1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, KIF5C, TUBB3, TUBB2CMore
Adapalenehsa05133Pertussis2.24E-022P0DP23, P0C0L4CALM1, C4AMore
Adapalenehsa05134Legionellosis1.28E-023P01584, P68104, P11142IL1B, EEF1A1, HSPA8More
Adapalenehsa05135Yersinia infection2.58E-024Q05397, P51812, Q02750, Q96JJ3PTK2, RPS6KA3, MAP2K1, ELMO2More
Adapalenehsa05143African trypanosomiasis3.01E-034P01375, P69905, P68871, P48023TNF, HBA2, HBB, FASLGMore
Adapalenehsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Adapalenehsa05150Staphylococcus aureus infection3.32E-022Q14532, P16109KRT32, SELPMore
Adapalenehsa05152Tuberculosis2.24E-0411Q13488, P0DP23, O75015, P48382, O60603, P10415, P13765, P01568, Q9UDY8, Q16539, P51617TCIRG1, CALM1, FCGR3B, RFX5, TLR2, BCL2, HLA-DOB, IFNA21, MALT1, MAPK14, IRAK1More
Adapalenehsa05160Hepatitis C1.27E-024P60033, P49841, P01375, P48023CD81, GSK3B, TNF, FASLGMore
Adapalenehsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Adapalenehsa05162Measles4.15E-036P14784, P07766, P42338, P11142, P01584, Q9NP90IL2RB, CD3E, PIK3CB, HSPA8, IL1B, RAB9BMore
Adapalenehsa05163Human cytomegalovirus infection1.10E-0311P42338, P01375, P63218, P50151, Q14344, P49841, P14778, P25025, Q16539, O00463, P30101PIK3CB, TNF, GNG5, GNG10, GNA13, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5, PDIA3More
Adapalenehsa05167Kaposi sarcoma-associated herpesvirus infection1.14E-025P42338, P63218, P50151, P19174, P07948PIK3CB, GNG5, GNG10, PLCG1, LYNMore
Adapalenehsa05169Epstein-Barr virus infection3.61E-037Q13547, P42338, P07948, P30101, Q13761, O75293, P07766HDAC1, PIK3CB, LYN, PDIA3, RUNX3, GADD45B, CD3EMore
Adapalenehsa05170Human immunodeficiency virus 1 infection2.45E-0522P42338, Q02750, P62873, P62879, P63218, P50151, P16298, P0DP23, Q05397, P17252, O00463, P30101, Q14643, P01568, P51617, O60603, P19174, P23528, P07766, P10415, Q93034, Q9Y6Q5PIK3CB, MAP2K1, GNB1, GNB2, GNG5, GNG10, PPP3CB, CALM1, PTK2, PRKCA, TRAF5, PDIA3, ITPR1, IFNA21, IRAK1, TLR2, PLCG1, CFL1, CD3E, BCL2, CUL5, AP1M2More
Adapalenehsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Adapalenehsa05200Pathways in cancer1.13E-0317Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RBMore
Adapalenehsa05202Transcriptional misregulation in cancer4.06E-0516Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q16548, Q13489, Q13077, O15550, P35226, P05164, P08246, Q9C0K0, P24522FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, BIRC3, TRAF1, UTX, BMI1, MPO, ELA2, BCL11B, GADD45AMore
Adapalenehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Adapalenehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Adapalenehsa05205Proteoglycans in cancer1.09E-0210Q13009, Q12955, Q14643, O75369, P14780, P17252, O60603, P04628, Q13635, P08962TIAM1, ANK3, ITPR1, FLNB, MMP9, PRKCA, TLR2, WNT1, PTCH1, CD63More
Adapalenehsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Adapalenehsa05212Pancreatic cancer9.87E-045P42338, P37173, P84022, Q13485, O75293PIK3CB, TGFBR2, SMAD3, SMAD4, GADD45BMore
Adapalenehsa05214Glioma9.49E-033Q92529, P42338, P19174SHC3, PIK3CB, PLCG1More
Adapalenehsa05215Prostate cancer4.87E-023Q9NRA1, P08238, P42338PDGFC, HSP90AB1, PIK3CBMore
Adapalenehsa05218Melanoma3.64E-022Q9NRA1, P42338PDGFC, PIK3CBMore
Adapalenehsa05220Chronic myeloid leukemia1.44E-036Q13547, Q13485, P25963, P84022, P42338, O75293HDAC1, SMAD4, NFKBIA, SMAD3, PIK3CB, GADD45BMore
Adapalenehsa05222Small cell lung cancer3.77E-037P10826, Q13489, P10415, P25963, Q13077, O00463, P24522RARB, BIRC3, BCL2, NFKBIA, TRAF1, TRAF5, GADD45AMore
Adapalenehsa05226Gastric cancer2.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Adapalenehsa05231Choline metabolism in cancer1.17E-034P42338, Q9NRA1, P19174, P23743PIK3CB, PDGFC, PLCG1, DGKAMore
Adapalenehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.84E-025P20963, P09693, O60603, P10747, Q04759CD247, CD3G, TLR2, CD28, PRKCQMore
Adapalenehsa05320Autoimmune thyroid disease8.64E-034P13765, P29965, P01568, P10747HLA-DOB, CD40LG, IFNA21, CD28More
Adapalenehsa05321Inflammatory bowel disease1.66E-045O60603, P13765, Q14765, Q9UL17, P23771TLR2, HLA-DOB, STAT4, TBX21, GATA3More
Adapalenehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Adapalenehsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Adapalenehsa05330Allograft rejection2.72E-022P48023, P01375FASLG, TNFMore
Adapalenehsa05332Graft-versus-host disease1.41E-056P13765, P48023, P10747, P01375, P26715, Q13241HLA-DOB, FASLG, CD28, TNF, KLRC1, KLRD1More
Adapalenehsa05415Diabetic cardiomyopathy7.28E-0311P17252, P05141, P14598, Q15080, O15239, Q16718, O14521, P13073, Q16539, Q13557, P14780PRKCA, SLC25A5, NCF1, NCF4, NDUFA1, NDUFA5, SDHD, COX4I1, MAPK14, CAMK2D, MMP9More
Adapalenehsa05418Fluid shear stress and atherosclerosis1.08E-037Q16539, Q14145, P10599, P14780, P01375, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Adapalene (SDC: 6.38)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P10826RARBRetinoic acid receptor betaReported00.00940.34660.30050.9983
O60603TLR2TollNonelike receptor 2Reported10.21260.080511.2673
Q15722LTB4RLeukotriene B4 receptor 1Predicted00.06770.219900.4736
Q13822ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2Predicted00.1130.3050.00630.6729
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
P09917ALOX5Polyunsaturated fatty acid 5NonelipoxygenasePredicted00.382210.27012.4612
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P20292ALOX5APArachidonate 5NonelipoxygenaseNoneactivating proteinPredicted00.13030.24180.09070.6395
P16109SELPPNoneselectinPredicted10.15230.07220.57330.7938
P50052AGTR2TypeNone2 angiotensin II receptorPredicted10.06040.43650.15411.0572
P08235NR3C2Mineralocorticoid receptorPredicted10.185510.01372.1064
P06746POLBDNA polymerase betaPredicted00.45730.18680.48561.0878
Q07343PDE4BcAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4BPredicted00.02530.99460.222.2219
P14416DRD2D(2) dopamine receptorPredicted00.060410.47792.5081
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
Q07817BCL2L1BclNone2Nonelike protein 1Predicted10.08720.434911.9134
P10415BCL2Apoptosis regulator BclNone2Predicted10.03410.527112.0714
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
P42338PIK3CBPhosphatidylinositol 4,5Nonebisphosphate 3Nonekinase catalytic subunit beta isoformPredicted10.04470.941612.9055
P00734F2ProthrombinPredicted10.09630.7070.49771.9598
Q9BXR5TLR10TollNonelike receptor 10Predicted00.19630.00200.1022
P10588NR2F6Nuclear receptor subfamily 2 group F member 6Predicted00.39230.06800.3321
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)
RARBP10826Ki34