PharmaCoNets of Acitretin (SPCN: 24.57 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Acitretinhsa00480Glutathione metabolism3.29E-044Q9UJ14, Q16772, P09211, P30041GGTL3, GSTA3, GSTP1, PRDX6More
Acitretinhsa00520Amino sugar and nucleotide sugar metabolism7.87E-033Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Acitretinhsa00533Glycosaminoglycan biosynthesis - keratan sulfate3.43E-021Q9NY97B3GNT2More
Acitretinhsa00562Inositol phosphate metabolism1.28E-022Q14642, P29218INPP5A, IMPA1More
Acitretinhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series4.30E-032P06865, O75752HEXA, B3GALNT1More
Acitretinhsa00980Metabolism of xenobiotics by cytochrome P4505.46E-032Q16772, P09211GSTA3, GSTP1More
Acitretinhsa00982Drug metabolism - cytochrome P4501.06E-022Q16772, P09211GSTA3, GSTP1More
Acitretinhsa00983Drug metabolism - other enzymes1.72E-022Q16772, P09211GSTA3, GSTP1More
Acitretinhsa01100Metabolic pathways9.02E-0416P35790, Q16772, P09211, Q9UJ14, P30041, Q14642, P29218, P40926, Q7KZN9, Q14376, P15121, P07101, Q9UHK6, Q86VZ5, Q9BQB6, P12074CHKA, GSTA3, GSTP1, GGTL3, PRDX6, INPP5A, IMPA1, MDH2, COX15, GALE, AKR1B1, TH, AMACR, SGMS1, VKORC1, COX6A1More
Acitretinhsa01522Endocrine resistance4.74E-023P22694, P10415, Q13323PRKACB, BCL2, BIKMore
Acitretinhsa01524Platinum drug resistance3.80E-034O15392, Q16772, P09211, P11388BIRC5, GSTA3, GSTP1, TOP2AMore
Acitretinhsa03018RNA degradation5.00E-021Q9NQT4EXOSC5More
Acitretinhsa03020RNA polymerase1.81E-021P24928POLR2AMore
Acitretinhsa03320PPAR signaling pathway3.78E-022Q6PCB7, Q9UNU6SLC27A1, CYP8B1More
Acitretinhsa04012ErbB signaling pathway3.31E-021Q13153PAK1More
Acitretinhsa04024cAMP signaling pathway4.80E-021Q13153PAK1More
Acitretinhsa04064NF-kappa B signaling pathway4.09E-038P10415, O00463, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341BCL2, TRAF5, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1More
Acitretinhsa04070Phosphatidylinositol signaling system2.65E-022P29218, Q14642IMPA1, INPP5AMore
Acitretinhsa04071Sphingolipid signaling pathway1.19E-025P21453, Q9H228, Q13362, Q9BX95, P10415S1PR1, EDG8, PPP2R5C, SGPP1, BCL2More
Acitretinhsa04080Neuroactive ligand-receptor interaction1.71E-047P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2More
Acitretinhsa04114Oocyte meiosis4.51E-035Q9Y6D9, P51812, Q02750, P16298, Q17RY0MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Acitretinhsa04140Autophagy - animal3.75E-034P22694, Q14643, P10415, Q04759PRKACB, ITPR1, BCL2, PRKCQMore
Acitretinhsa04145Phagosome4.48E-025Q15080, P05164, O60603, P35443, P13765NCF4, MPO, TLR2, THBS4, HLA-DOBMore
Acitretinhsa04210Apoptosis3.44E-027Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1More
Acitretinhsa04215Apoptosis - multiple species1.56E-022Q13489, P10415BIRC3, BCL2More
Acitretinhsa04340Hedgehog signaling pathway7.64E-043P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Acitretinhsa04370VEGF signaling pathway2.47E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Acitretinhsa04390Hippo signaling pathway2.08E-023P84022, Q13485, Q13489SMAD3, SMAD4, BIRC3More
Acitretinhsa04392Hippo signaling pathway - multiple species1.51E-021Q13153PAK1More
Acitretinhsa04540Gap junction2.86E-023P22694, P68371, Q14643PRKACB, TUBB2C, ITPR1More
Acitretinhsa04612Antigen processing and presentation4.48E-025P13765, P26715, P26717, Q13241, P01732HLA-DOB, KLRC1, KLRC2, KLRD1, CD8AMore
Acitretinhsa04613Neutrophil extracellular trap formation4.93E-028O60603, P05164, P08246, Q9UM07, Q15080, P20160, P08311, P21730TLR2, MPO, ELA2, PADI4, NCF4, AZU1, CTSG, C5AR1More
Acitretinhsa04625C-type lectin receptor signaling pathway3.31E-021Q13153PAK1More
Acitretinhsa04650Natural killer cell mediated cytotoxicity4.25E-0410P16298, P50591, O60880, P20963, Q02750, Q13153, Q13241, P26718, P26717, P26715PPP3CB, TNFSF10, SH2D1A, CD247, MAP2K1, PAK1, KLRD1, KLRK1, KLRC2, KLRC1More
Acitretinhsa04658Th1 and Th2 cell differentiation1.07E-037Q04759, P20963, P09693, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, STAT4, GATA3, TBX21, HLA-DOBMore
Acitretinhsa04659Th17 cell differentiation2.05E-039P25963, Q04759, P13765, Q9UL17, P23771, P84022, Q13485, P09693, P20963NFKBIA, PRKCQ, HLA-DOB, TBX21, GATA3, SMAD3, SMAD4, CD3G, CD247More
Acitretinhsa04660T cell receptor signaling pathway9.38E-048Q9UDY8, Q04759, P10747, Q08881, Q13153, P20963, P09693, P01732MALT1, PRKCQ, CD28, ITK, PAK1, CD247, CD3G, CD8AMore
Acitretinhsa04710Circadian rhythm1.65E-044O00327, O15055, Q16526, Q9Y478ARNTL, PER2, CRY1, PRKAB1More
Acitretinhsa04720Long-term potentiation2.35E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Acitretinhsa04725Cholinergic synapse3.74E-023P22694, Q14643, P10415PRKACB, ITPR1, BCL2More
Acitretinhsa04913Ovarian steroidogenesis2.72E-022P42330, P22694AKR1C3, PRKACBMore
Acitretinhsa04914Progesterone-mediated oocyte maturation7.70E-034Q17RY0, Q9Y6D9, P51812, Q02750CPEB4, MAD1L1, RPS6KA3, MAP2K1More
Acitretinhsa04920Adipocytokine signaling pathway4.31E-022Q9Y478, Q96RR4PRKAB1, CAMKK2More
Acitretinhsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Acitretinhsa04924Renin secretion7.24E-053P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Acitretinhsa04927Cortisol synthesis and secretion2.72E-022Q14643, P22694ITPR1, PRKACBMore
Acitretinhsa04928Parathyroid hormone synthesis, secretion and action1.32E-034Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Acitretinhsa04933AGE-RAGE signaling pathway in diabetic complications1.25E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Acitretinhsa04934Cushing syndrome4.74E-023Q14643, P22694, P04628ITPR1, PRKACB, WNT1More
Acitretinhsa04970Salivary secretion2.11E-023P07550, P22694, Q14643ADRB2, PRKACB, ITPR1More
Acitretinhsa04975Fat digestion and absorption3.43E-021O14494PLPP1More
Acitretinhsa05120Epithelial cell signaling in Helicobacter pylori infection1.81E-021Q13153PAK1More
Acitretinhsa05132Salmonella infection2.04E-024P25963, Q13489, P10415, Q9BQS8NFKBIA, BIRC3, BCL2, FYCO1More
Acitretinhsa05135Yersinia infection2.58E-024Q05397, P51812, Q02750, Q96JJ3PTK2, RPS6KA3, MAP2K1, ELMO2More
Acitretinhsa05145Toxoplasmosis2.78E-023P25963, P10415, Q13489NFKBIA, BCL2, BIRC3More
Acitretinhsa05161Hepatitis B8.49E-034P25963, Q13485, P10415, P84022NFKBIA, SMAD4, BCL2, SMAD3More
Acitretinhsa05170Human immunodeficiency virus 1 infection4.37E-024Q02750, P62879, P16298, Q05397MAP2K1, GNB2, PPP3CB, PTK2More
Acitretinhsa05202Transcriptional misregulation in cancer2.90E-029Q12778, Q13315, P14780, Q16548, O15550, P05164, P08246, Q9C0K0, P24522FOXO1, ATM, MMP9, BCL2A1, UTX, MPO, ELA2, BCL11B, GADD45AMore
Acitretinhsa05203Viral carcinogenesis4.62E-023Q12933, P42229, Q15283TRAF2, STAT5A, RASA2More
Acitretinhsa05204Chemical carcinogenesis5.46E-032Q16772, P09211GSTA3, GSTP1More
Acitretinhsa05210Colorectal cancer1.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Acitretinhsa05211Renal cell carcinoma2.42E-021Q13153PAK1More
Acitretinhsa05212Pancreatic cancer3.52E-022P84022, Q13485SMAD3, SMAD4More
Acitretinhsa05220Chronic myeloid leukemia1.25E-023Q13485, P25963, P84022SMAD4, NFKBIA, SMAD3More
Acitretinhsa05222Small cell lung cancer1.50E-023Q13489, P10415, P25963BIRC3, BCL2, NFKBIAMore
Acitretinhsa05226Gastric cancer2.78E-023P84022, Q13485, P10415SMAD3, SMAD4, BCL2More
Acitretinhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.84E-025P20963, P09693, O60603, P10747, Q04759CD247, CD3G, TLR2, CD28, PRKCQMore
Acitretinhsa05321Inflammatory bowel disease1.17E-035O60603, P13765, Q14765, Q9UL17, P23771TLR2, HLA-DOB, STAT4, TBX21, GATA3More
Acitretinhsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Acitretinhsa05332Graft-versus-host disease3.45E-034P13765, P10747, P26715, Q13241HLA-DOB, CD28, KLRC1, KLRD1More

Community members of Acitretin (SDC: 3.00)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P10826RARBRetinoic acid receptor betaReported00.00940.34660.30050.9983
Q09472EP300Histone acetyltransferase p300Predicted00.41820.06720.93071.2742
P21453S1PR1Sphingosine 1Nonephosphate receptor 1Predicted10.14340.38470.2211.0621
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
P15121AKR1B1AldoNoneketo reductase family 1 member B1Predicted10.56830.6290.2141.7562
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
Q13153PAK1Serine/threonineNoneprotein kinase PAK 1Predicted10.46470.34710.78191.7084
P10588NR2F6Nuclear receptor subfamily 2 group F member 6Predicted00.39230.06800.3321
Q13133NR1H3Oxysterols receptor LXRNonealphaPredicted00.01620.4390.20861.0947
O75469NR1I2Nuclear receptor subfamily 1 group I member 2Predicted10.03150.949301.9143
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)