PharmaCoNets of Acetylsalicylic-acid (SPCN: 124.66 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Acetylsalicylic-acidhsa00020Citrate cycle (TCA cycle)4.06E-044Q9P2R7, P50213, P40925, O14521SUCLA2, IDH3A, MDH1, SDHDMore
Acetylsalicylic-acidhsa00030Pentose phosphate pathway2.82E-033P51854, P52209, P37837TKTL1, PGD, TALDO1More
Acetylsalicylic-acidhsa00040Pentose and glucuronate interconversions6.07E-031P15121AKR1B1More
Acetylsalicylic-acidhsa00051Fructose and mannose metabolism4.10E-043P15121, P19367, P08237AKR1B1, HK1, PFKMMore
Acetylsalicylic-acidhsa00052Galactose metabolism7.54E-055P06280, P08237, O43451, P15121, P19367GLA, PFKM, MGAM, AKR1B1, HK1More
Acetylsalicylic-acidhsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Acetylsalicylic-acidhsa00100Steroid biosynthesis3.94E-021P35610SOAT1More
Acetylsalicylic-acidhsa00190Oxidative phosphorylation2.11E-043Q16718, Q13488, O14521NDUFA5, TCIRG1, SDHDMore
Acetylsalicylic-acidhsa00220Arginine biosynthesis1.15E-063P15104, P05089, P49448GLUL, ARG1, GLUD2More
Acetylsalicylic-acidhsa00250Alanine, aspartate and glutamate metabolism4.40E-032P49448, P15104GLUD2, GLULMore
Acetylsalicylic-acidhsa00310Lysine degradation4.14E-021Q02809PLOD1More
Acetylsalicylic-acidhsa00350Tyrosine metabolism4.50E-021P00325ADH1BMore
Acetylsalicylic-acidhsa00471D-Glutamine and D-glutamate metabolism3.94E-021P49448GLUD2More
Acetylsalicylic-acidhsa00480Glutathione metabolism3.29E-044Q9UJ14, Q16772, P09211, P30041GGTL3, GSTA3, GSTP1, PRDX6More
Acetylsalicylic-acidhsa00500Starch and sucrose metabolism1.70E-053O43451, P46976, P06737MGAM, GYG1, PYGLMore
Acetylsalicylic-acidhsa00512Mucin type O-glycan biosynthesis2.27E-022O95395, Q8N4A0GCNT3, GALNT4More
Acetylsalicylic-acidhsa00514Other types of O-glycan biosynthesis1.42E-022P15907, Q8N4A0ST6GAL1, GALNT4More
Acetylsalicylic-acidhsa00520Amino sugar and nucleotide sugar metabolism1.59E-023Q16222, Q9Y223, P06865UAP1, GNE, HEXAMore
Acetylsalicylic-acidhsa00531Glycosaminoglycan degradation3.78E-021P15586GNSMore
Acetylsalicylic-acidhsa00561Glycerolipid metabolism1.51E-021P15121AKR1B1More
Acetylsalicylic-acidhsa00562Inositol phosphate metabolism4.55E-022P27987, P42338ITPKB, PIK3CBMore
Acetylsalicylic-acidhsa00564Glycerophospholipid metabolism3.56E-023P48651, Q9Y6K0, P35790PTDSS1, CEPT1, CHKAMore
Acetylsalicylic-acidhsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Acetylsalicylic-acidhsa00603Glycosphingolipid biosynthesis - globo and isoglobo series7.10E-032P06865, O75752HEXA, B3GALNT1More
Acetylsalicylic-acidhsa00620Pyruvate metabolism3.19E-022P40926, P14550MDH2, AKR1A1More
Acetylsalicylic-acidhsa00730Thiamine metabolism1.55E-032P05186, P24666ALPL, ACP1More
Acetylsalicylic-acidhsa00785Lipoic acid metabolism4.57E-021Q9Y234LIPT1More
Acetylsalicylic-acidhsa00790Folate biosynthesis9.61E-043Q92820, P07101, P15121GGH, TH, AKR1B1More
Acetylsalicylic-acidhsa00830Retinol metabolism1.63E-034P00325, P00352, Q9BPW9, O75911ADH1B, ALDH1A1, DHRS9, DHRS3More
Acetylsalicylic-acidhsa00910Nitrogen metabolism4.40E-032P15104, P49448GLUL, GLUD2More
Acetylsalicylic-acidhsa00980Metabolism of xenobiotics by cytochrome P4505.46E-032Q16772, P09211GSTA3, GSTP1More
Acetylsalicylic-acidhsa00982Drug metabolism - cytochrome P4501.06E-022Q16772, P09211GSTA3, GSTP1More
Acetylsalicylic-acidhsa00983Drug metabolism - other enzymes1.45E-035P20839, P32320, P05164, Q16772, P09211IMPDH1, CDA, MPO, GSTA3, GSTP1More
Acetylsalicylic-acidhsa01100Metabolic pathways9.38E-0652Q9NR34, Q9Y234, P35790, P05089, P21953, Q16772, P09211, Q9UJ14, P30041, P15104, P19367, P42338, P48426, P27987, P22557, P32320, P20839, P22748, P40926, P55809, P06280, Q16875, O43286, O43451, P53004, Q7KZN9, Q9Y6K0, P05186, P24666, P15121, P08237, O95861, Q9HCC0, P33121, Q9UHK6, Q86VZ5, P09917, P48651, P57054, Q9UNP4, Q9BX95, P32321, P49448, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q9BQB6, Q969G6, P14927MAN1C1, LIPT1, CHKA, ARG1, BCKDHB, GSTA3, GSTP1, GGTL3, PRDX6, GLUL, HK1, PIK3CB, PIP4K2A, ITPKB, ALAS2, CDA, IMPDH1, CA4, MDH2, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, BLVRA, COX15, CEPT1, ALPL, ACP1, AKR1B1, PFKM, BPNT1, MCCC2, ACSL1, AMACR, SGMS1, ALOX5, PTDSS1, PIGP, ST3GAL5, SGPP1, DCTD, GLUD2, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, VKORC1, RFK, UQCRBMore
Acetylsalicylic-acidhsa01200Carbon metabolism8.75E-035P04406, P40925, O14521, Q9P2R7, Q02252GAPDH, MDH1, SDHD, SUCLA2, ALDH6A1More
Acetylsalicylic-acidhsa012102-Oxocarboxylic acid metabolism1.40E-021P50213IDH3AMore
Acetylsalicylic-acidhsa01230Biosynthesis of amino acids3.91E-023P51854, Q99707, P50213TKTL1, MTR, IDH3AMore
Acetylsalicylic-acidhsa01240Biosynthesis of cofactors4.63E-023Q969G6, P22557, Q9Y234RFK, ALAS2, LIPT1More
Acetylsalicylic-acidhsa01522Endocrine resistance4.51E-022P04637, P42773TP53, CDKN2CMore
Acetylsalicylic-acidhsa01523Antifolate resistance1.68E-022Q92820, P04818GGH, TYMSMore
Acetylsalicylic-acidhsa01524Platinum drug resistance7.33E-045Q14790, P48023, Q16772, P09211, P31751CASP8, FASLG, GSTA3, GSTP1, AKT2More
Acetylsalicylic-acidhsa02010ABC transporters2.17E-033P45844, P08183, Q8IZY2ABCG1, ABCB1, ABCA7More
Acetylsalicylic-acidhsa03010Ribosome3.38E-038P62753, P62829, P46777, P62888, P61927, P61513, P36578, P50914RPS6, RPL23, RPL5, RPL30, RPL37, RPL37A, RPL4, RPL14More
Acetylsalicylic-acidhsa03013RNA transport4.49E-025P62826, Q9UBU9, P63279, P68104, Q14232RAN, NXF1, UBE2I, EEF1A1, EIF2B1More
Acetylsalicylic-acidhsa03020RNA polymerase4.09E-054P30876, P24928, P62487, Q9Y535POLR2B, POLR2A, POLR2G, POLR3HMore
Acetylsalicylic-acidhsa03022Basal transcription factors3.32E-022O00268, Q15544TAF4, TAF11More
Acetylsalicylic-acidhsa03040Spliceosome6.18E-0412Q14562, O43143, P08579, O75940, O75494, Q07955, Q01130, Q13243, P11142, O95777, O43447, O43395DHX8, DHX15, SNRPB2, SMNDC1, FUSIP1, SFRS1, SFRS2, SFRS5, HSPA8, LSM8, PPIH, PRPF3More
Acetylsalicylic-acidhsa04010MAPK signaling pathway4.93E-021Q16828DUSP6More
Acetylsalicylic-acidhsa04012ErbB signaling pathway3.15E-023P16333, P19174, P01106NCK1, PLCG1, MYCMore
Acetylsalicylic-acidhsa04014Ras signaling pathway7.30E-032P31751, P0DP23AKT2, CALM1More
Acetylsalicylic-acidhsa04015Rap1 signaling pathway1.27E-046P07737, P25116, Q8TEU7, P31751, P0DP23, P08514PFN1, F2R, RAPGEF6, AKT2, CALM1, ITGA2BMore
Acetylsalicylic-acidhsa04020Calcium signaling pathway1.27E-039P27987, Q08828, P21796, P45880, Q13557, P19174, P0DP23, P05141, P51828ITPKB, ADCY1, VDAC1, VDAC2, CAMK2D, PLCG1, CALM1, SLC25A5, ADCY7More
Acetylsalicylic-acidhsa04022cGMP-PKG signaling pathway1.29E-0714P24844, Q14814, Q99941, P18848, Q8WYR1, P31751, Q08828, P51828, P05141, P21796, P45880, Q15746, P0DP23, P01042MYL9, MEF2D, CREBL1, ATF4, PIK3R5, AKT2, ADCY1, ADCY7, SLC25A5, VDAC1, VDAC2, MYLK, CALM1, KNG1More
Acetylsalicylic-acidhsa04024cAMP signaling pathway1.19E-047Q08828, P51828, P31751, P0DP23, P48058, P25116, P24844ADCY1, ADCY7, AKT2, CALM1, GRIA4, F2R, MYL9More
Acetylsalicylic-acidhsa04060Cytokine-cytokine receptor interaction1.59E-0413P14784, P27930, P14778, P26842, Q06643, Q13651, Q9HBE5, P25024, Q9UBD3, P47992, P09341, P01730, Q93038IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, IL21R, CXCR1, XCL2, XCL1, CXCL1, CD4, TNFRSF25More
Acetylsalicylic-acidhsa04061Viral protein interaction with cytokine and cytokine receptor7.72E-057Q8NHW4, P09341, P25024, P47992, Q9UBD3, Q13651, P14784CCL4L2, CXCL1, CXCR1, XCL1, XCL2, IL10RA, IL2RBMore
Acetylsalicylic-acidhsa04062Chemokine signaling pathway1.90E-0611P25024, P09341, P47992, Q9UBD3, P07948, P42338, P63218, P50151, P43250, P49407, Q08881CXCR1, CXCL1, XCL1, XCL2, LYN, PIK3CB, GNG5, GNG10, GRK6, ARRB1, ITKMore
Acetylsalicylic-acidhsa04064NF-kappa B signaling pathway1.83E-0718P10415, O00463, P14778, P01584, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, Q06643, Q9NQC7BCL2, TRAF5, IL1R1, IL1B, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, LTB, CYLDMore
Acetylsalicylic-acidhsa04068FoxO signaling pathway1.25E-022P48023, Q96BR1FASLG, SGK3More
Acetylsalicylic-acidhsa04070Phosphatidylinositol signaling system3.43E-059P19174, P0DP23, O14986, P23743, Q86XP1, Q16760, P48426, P27987, Q96DU7PLCG1, CALM1, PIP5K1B, DGKA, DGKH, DGKD, PIP4K2A, ITPKB, ITPKCMore
Acetylsalicylic-acidhsa04071Sphingolipid signaling pathway2.68E-058P21453, Q9H228, P01375, Q13510, Q13362, Q9BX95, P10415, Q9UQC2S1PR1, EDG8, TNF, ASAH1, PPP2R5C, SGPP1, BCL2, GAB2More
Acetylsalicylic-acidhsa04072Phospholipase D signaling pathway6.70E-057P31751, Q9UQC2, O14986, Q15438, Q08828, P51828, Q16760AKT2, GAB2, PIP5K1B, PSCD1, ADCY1, ADCY7, DGKDMore
Acetylsalicylic-acidhsa04080Neuroactive ligand-receptor interaction6.75E-048P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, ADRB2More
Acetylsalicylic-acidhsa04110Cell cycle3.31E-0611P30260, P06493, O60566, O75293, P04637, P49918, P30304, P33981, P42773, P01106, Q13547CDC27, CDK1, BUB1B, GADD45B, TP53, CDKN1C, CDC25A, TTK, CDKN2C, MYC, HDAC1More
Acetylsalicylic-acidhsa04114Oocyte meiosis3.52E-0513Q9Y6D9, P51812, Q02750, Q9UJX4, P30260, P0DP23, P16298, Q17RY0, Q08828, P51828, Q16539, Q13362, Q14738MAD1L1, RPS6KA3, MAP2K1, ANAPC5, CDC27, CALM1, PPP3CB, CPEB4, ADCY1, ADCY7, MAPK14, PPP2R5C, PPP2R5DMore
Acetylsalicylic-acidhsa04137Mitophagy - animal1.41E-033P67870, P19532, P18848CSNK2B, TFE3, ATF4More
Acetylsalicylic-acidhsa04140Autophagy - animal1.92E-039P31751, Q7L523, O75460, P22694, Q14643, P10415, Q04759, Q96GC9, Q8TEV9AKT2, RRAGA, ERN1, PRKACB, ITPR1, BCL2, PRKCQ, TMEM49, SMCR8More
Acetylsalicylic-acidhsa04141Protein processing in endoplasmic reticulum6.42E-038P18848, P30101, Q15437, Q15436, Q99941, P11142, P07900, P08238ATF4, PDIA3, SEC23B, SEC23A, CREBL1, HSPA8, HSP90AA1, HSP90AB1More
Acetylsalicylic-acidhsa04144Endocytosis3.45E-022P0DMV8, Q14161HSPA1A, GIT2More
Acetylsalicylic-acidhsa04145Phagosome2.76E-037O75015, Q15080, P05164, P78380, O60603, P35443, P13765FCGR3B, NCF4, MPO, OLR1, TLR2, THBS4, HLA-DOBMore
Acetylsalicylic-acidhsa04151PI3K-Akt signaling pathway1.97E-0315P62753, P04637, P27348, P07900, P08238, P62873, P63218, Q16363, P22105, P14784, Q99941, P18848, Q96BR1, P30279, P56279RPS6, TP53, YWHAQ, HSP90AA1, HSP90AB1, GNB1, GNG5, LAMA4, TNXB, IL2RB, CREBL1, ATF4, SGK3, CCND2, TCL1AMore
Acetylsalicylic-acidhsa04152AMPK signaling pathway3.76E-022Q96RR4, Q13362CAMKK2, PPP2R5CMore
Acetylsalicylic-acidhsa04210Apoptosis4.67E-0411Q13315, P04637, P10415, O76075, Q14790, P48023, P24522, Q16548, P43234, Q14643, P42575ATM, TP53, BCL2, DFFB, CASP8, FASLG, GADD45A, BCL2A1, CTSO, ITPR1, CASP2More
Acetylsalicylic-acidhsa04211Longevity regulating pathway1.93E-035P31751, Q08828, P51828, P18848, Q96RR4AKT2, ADCY1, ADCY7, ATF4, CAMKK2More
Acetylsalicylic-acidhsa04213Longevity regulating pathway - multiple species4.21E-044P31751, Q08828, P51828, P0DMV8AKT2, ADCY1, ADCY7, HSPA1AMore
Acetylsalicylic-acidhsa04217Necroptosis1.12E-0411Q9NQC7, P42224, P07900, P08238, P15104, P05141, P01584, Q13557, Q9H444, P21796, P45880CYLD, STAT1, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, CAMK2D, CHMP4B, VDAC1, VDAC2More
Acetylsalicylic-acidhsa04218Cellular senescence3.65E-032P31751, P0DP23AKT2, CALM1More
Acetylsalicylic-acidhsa04261Adrenergic signaling in cardiomyocytes2.65E-057Q08828, P51828, P31751, P18848, Q13362, Q14738, P0DP23ADCY1, ADCY7, AKT2, ATF4, PPP2R5C, PPP2R5D, CALM1More
Acetylsalicylic-acidhsa04270Vascular smooth muscle contraction4.65E-022Q15746, P24844MYLK, MYL9More
Acetylsalicylic-acidhsa04310Wnt signaling pathway1.79E-022P17612, P67870PRKACA, CSNK2BMore
Acetylsalicylic-acidhsa04330Notch signaling pathway2.29E-022Q92769, Q92830HDAC2, KAT2AMore
Acetylsalicylic-acidhsa04340Hedgehog signaling pathway2.39E-046P17612, P22694, Q13635, O43791, P30279, P10415PRKACA, PRKACB, PTCH1, SPOP, CCND2, BCL2More
Acetylsalicylic-acidhsa04360Axon guidance2.19E-023P42338, O14639, P24844PIK3CB, ABLIM1, MYL9More
Acetylsalicylic-acidhsa04370VEGF signaling pathway1.46E-034P16298, P31751, Q05397, Q02750PPP3CB, AKT2, PTK2, MAP2K1More
Acetylsalicylic-acidhsa04371Apelin signaling pathway2.48E-034P31751, Q08828, P51828, P0DP23AKT2, ADCY1, ADCY7, CALM1More
Acetylsalicylic-acidhsa04380Osteoclast differentiation2.94E-0710Q9NQC7, Q9UQC2, Q16539, P23458, P31751, P01584, P14778, O75015, P01375, Q8N149CYLD, GAB2, MAPK14, JAK1, AKT2, IL1B, IL1R1, FCGR3B, TNF, LILRA2More
Acetylsalicylic-acidhsa04510Focal adhesion3.11E-036P08514, Q15746, P24844, Q15942, P30281, Q9NQU5ITGA2B, MYLK, MYL9, ZYX, CCND3, PAK6More
Acetylsalicylic-acidhsa04512ECM-receptor interaction2.44E-022P07359, P08514GP1BA, ITGA2BMore
Acetylsalicylic-acidhsa04514Cell adhesion molecules4.65E-022P16109, O00501SELP, CLDN5More
Acetylsalicylic-acidhsa04530Tight junction7.42E-044Q8TEU7, O00501, Q14247, P24844RAPGEF6, CLDN5, CTTN, MYL9More
Acetylsalicylic-acidhsa04550Signaling pathways regulating pluripotency of stem cells2.16E-022P04628, P40189WNT1, IL6STMore
Acetylsalicylic-acidhsa04610Complement and coagulation cascades9.25E-063P25116, P0C0L4, P10909F2R, C4A, CLUMore
Acetylsalicylic-acidhsa04611Platelet activation1.07E-067P25116, Q9Y490, P08514, Q15746, Q8WYR1, P17612, P07359F2R, TLN1, ITGA2B, MYLK, PIK3R5, PRKACA, GP1BAMore
Acetylsalicylic-acidhsa04612Antigen processing and presentation4.24E-058P13765, P48382, P01730, P26715, P26717, Q13241, P01732, P01375HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRD1, CD8A, TNFMore
Acetylsalicylic-acidhsa04613Neutrophil extracellular trap formation3.88E-0416O60603, P05164, P08246, Q9UM07, P04908, Q93077, P68431, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, H2AC4; H2AC8, HIST1H2AC, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Acetylsalicylic-acidhsa04620Toll-like receptor signaling pathway4.91E-043P01584, P31751, Q8NHW4IL1B, AKT2, CCL4L2More
Acetylsalicylic-acidhsa04621NOD-like receptor signaling pathway2.92E-023P01584, P07900, P43490IL1B, HSP90AA1, PBEF1More
Acetylsalicylic-acidhsa04622RIG-I-like receptor signaling pathway1.81E-021Q9NQC7CYLDMore
Acetylsalicylic-acidhsa04623Cytosolic DNA-sensing pathway2.21E-043P01584, Q9Y535, Q8NHW4IL1B, POLR3H, CCL4L2More
Acetylsalicylic-acidhsa04625C-type lectin receptor signaling pathway7.60E-068Q9ULY5, P01584, Q9NQC7, P20749, P01375, P31751, P0DP23, Q16539CLEC4E, IL1B, CYLD, BCL3, TNF, AKT2, CALM1, MAPK14More
Acetylsalicylic-acidhsa04630JAK-STAT signaling pathway3.25E-036P31751, O75925, P23458, P40189, Q13651, Q06124AKT2, PIAS1, JAK1, IL6ST, IL10RA, PTPN11More
Acetylsalicylic-acidhsa04640Hematopoietic cell lineage1.44E-0713P13612, P14778, P27930, P11215, P20023, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765ITGA4, IL1R1, IL1R2, ITGAM, CR2, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOBMore
Acetylsalicylic-acidhsa04650Natural killer cell mediated cytotoxicity4.83E-0610P01375, P06239, O60880, P20963, Q13241, P26718, O14931, O75015, P26717, P26715TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Acetylsalicylic-acidhsa04657IL-17 signaling pathway2.64E-0614P25963, P07900, P08238, O00463, Q07955, Q16539, P49841, P09341, P14780, P04141, P80188, P01375, P06702, P01584NFKBIA, HSP90AA1, HSP90AB1, TRAF5, SFRS1, MAPK14, GSK3B, CXCL1, MMP9, CSF2, LCN2, TNF, S100A9, IL1BMore
Acetylsalicylic-acidhsa04658Th1 and Th2 cell differentiation3.17E-1714Q04759, P07766, P20963, P09693, P19174, P01730, P06239, P42224, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, PLCG1, CD4, LCK, STAT1, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Acetylsalicylic-acidhsa04659Th17 cell differentiation1.39E-1216Q04759, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, Q9UL17, P23771, P07900, P08238, P07766, P09693, P20963PRKCQ, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, TBX21, GATA3, HSP90AA1, HSP90AB1, CD3E, CD3G, CD247More
Acetylsalicylic-acidhsa04660T cell receptor signaling pathway1.77E-0916P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P16333, P07766, P20963, P09693, P01730, P01732, Q13191, P06239TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, NCK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCKMore
Acetylsalicylic-acidhsa04662B cell receptor signaling pathway4.94E-086P31751, P42338, P60033, P07948, P21854, Q8N149AKT2, PIK3CB, CD81, LYN, CD72, LILRA2More
Acetylsalicylic-acidhsa04664Fc epsilon RI signaling pathway6.45E-067P01375, P31751, Q16539, P42338, Q9UQC2, P07948, P09917TNF, AKT2, MAPK14, PIK3CB, GAB2, LYN, ALOX5More
Acetylsalicylic-acidhsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Acetylsalicylic-acidhsa04670Leukocyte transendothelial migration4.66E-024P11215, P60709, P19174, P12814ITGAM, ACTB, PLCG1, ACTN1More
Acetylsalicylic-acidhsa04710Circadian rhythm4.40E-021O15516CLOCKMore
Acetylsalicylic-acidhsa04713Circadian entrainment5.62E-036P0DP23, Q13557, P62873, P63218, Q08828, P51828CALM1, CAMK2D, GNB1, GNG5, ADCY1, ADCY7More
Acetylsalicylic-acidhsa04714Thermogenesis5.21E-034Q16539, P33121, Q16718, O14521MAPK14, ACSL1, NDUFA5, SDHDMore
Acetylsalicylic-acidhsa04720Long-term potentiation5.63E-047P16298, P0DP23, Q15418, P51812, P18848, Q08828, Q02750PPP3CB, CALM1, RPS6KA1, RPS6KA3, ATF4, ADCY1, MAP2K1More
Acetylsalicylic-acidhsa04721Synaptic vesicle cycle1.80E-022Q13488, P31645TCIRG1, SLC6A4More
Acetylsalicylic-acidhsa04722Neurotrophin signaling pathway2.83E-032P31751, P0DP23AKT2, CALM1More
Acetylsalicylic-acidhsa04724Glutamatergic synapse2.87E-046P48058, P43003, P63218, P50151, P15104, Q9NSB8GRIA4, SLC1A3, GNG5, GNG10, GLUL, HOMER2More
Acetylsalicylic-acidhsa04725Cholinergic synapse1.61E-049Q08828, P51828, P62873, P63218, P50151, P18848, Q13557, P42338, P31751ADCY1, ADCY7, GNB1, GNG5, GNG10, ATF4, CAMK2D, PIK3CB, AKT2More
Acetylsalicylic-acidhsa04727GABAergic synapse3.21E-056P51828, P62873, P63218, P50151, P15104, P46459ADCY7, GNB1, GNG5, GNG10, GLUL, NSFMore
Acetylsalicylic-acidhsa04728Dopaminergic synapse4.53E-059P62873, P63218, P31751, Q99941, P18848, Q13557, Q13362, Q14738, P0DP23GNB1, GNG5, AKT2, CREBL1, ATF4, CAMK2D, PPP2R5C, PPP2R5D, CALM1More
Acetylsalicylic-acidhsa04740Olfactory transduction1.44E-033P62873, Q13557, P0DP23GNB1, CAMK2D, CALM1More
Acetylsalicylic-acidhsa04742Taste transduction3.91E-021P17612PRKACAMore
Acetylsalicylic-acidhsa04744Phototransduction2.13E-032P62873, P0DP23GNB1, CALM1More
Acetylsalicylic-acidhsa04750Inflammatory mediator regulation of TRP channels2.81E-0511P14778, P01584, Q08828, P51828, Q13557, P19174, P42338, P24723, Q04759, P0DP23, P01042IL1R1, IL1B, ADCY1, ADCY7, CAMK2D, PLCG1, PIK3CB, PRKCH, PRKCQ, CALM1, KNG1More
Acetylsalicylic-acidhsa04810Regulation of actin cytoskeleton4.36E-045P07737, P24844, Q15746, P08514, P25116PFN1, MYL9, MYLK, ITGA2B, F2RMore
Acetylsalicylic-acidhsa04910Insulin signaling pathway9.82E-042P0DP23, P31751CALM1, AKT2More
Acetylsalicylic-acidhsa04911Insulin secretion2.40E-023Q08828, P51828, P18848ADCY1, ADCY7, ATF4More
Acetylsalicylic-acidhsa04912GnRH signaling pathway1.39E-024Q08828, P51828, P18848, P0DP23ADCY1, ADCY7, ATF4, CALM1More
Acetylsalicylic-acidhsa04914Progesterone-mediated oocyte maturation6.28E-047Q17RY0, Q9UJX4, P30260, Q9Y6D9, P51812, Q02750, Q16539CPEB4, ANAPC5, CDC27, MAD1L1, RPS6KA3, MAP2K1, MAPK14More
Acetylsalicylic-acidhsa04915Estrogen signaling pathway2.23E-0611Q99941, P18848, Q08828, P51828, P31751, P07900, P08238, P0DMV8, P11142, P0DP23, Q15788CREBL1, ATF4, ADCY1, ADCY7, AKT2, HSP90AA1, HSP90AB1, HSPA1A, HSPA8, CALM1, NCOA1More
Acetylsalicylic-acidhsa04916Melanogenesis4.69E-033P0DP23, Q08828, P51828CALM1, ADCY1, ADCY7More
Acetylsalicylic-acidhsa04917Prolactin signaling pathway2.41E-021P31751AKT2More
Acetylsalicylic-acidhsa04918Thyroid hormone synthesis4.48E-022P18848, P05543ATF4, SERPINA7More
Acetylsalicylic-acidhsa04920Adipocytokine signaling pathway3.82E-043Q06124, Q9Y478, P31751PTPN11, PRKAB1, AKT2More
Acetylsalicylic-acidhsa04921Oxytocin signaling pathway6.37E-033Q15746, P24844, Q8WYR1MYLK, MYL9, PIK3R5More
Acetylsalicylic-acidhsa04922Glucagon signaling pathway3.14E-036P22694, P06737, Q12778, P31751, P0DP23, Q14643PRKACB, PYGL, FOXO1, AKT2, CALM1, ITPR1More
Acetylsalicylic-acidhsa04923Regulation of lipolysis in adipocytes6.65E-043Q08828, P51828, P31751ADCY1, ADCY7, AKT2More
Acetylsalicylic-acidhsa04924Renin secretion9.33E-054P22694, P07550, Q14643, P0DP23PRKACB, ADRB2, ITPR1, CALM1More
Acetylsalicylic-acidhsa04925Aldosterone synthesis and secretion9.58E-046Q99941, P18848, Q08828, P51828, P0DP23, Q13557CREBL1, ATF4, ADCY1, ADCY7, CALM1, CAMK2DMore
Acetylsalicylic-acidhsa04926Relaxin signaling pathway1.80E-037P31751, P42338, P50151, P18848, Q08828, P51828, P49407AKT2, PIK3CB, GNG10, ATF4, ADCY1, ADCY7, ARRB1More
Acetylsalicylic-acidhsa04927Cortisol synthesis and secretion1.59E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Acetylsalicylic-acidhsa04928Parathyroid hormone synthesis, secretion and action4.23E-024Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Acetylsalicylic-acidhsa04929GnRH secretion6.70E-043P42338, P31751, P49407PIK3CB, AKT2, ARRB1More
Acetylsalicylic-acidhsa04931Insulin resistance1.48E-022Q06124, Q9Y478PTPN11, PRKAB1More
Acetylsalicylic-acidhsa04932Non-alcoholic fatty liver disease7.19E-0612P31751, P49841, Q14790, P18848, P48023, O75460, P01584, P12074, O15239, Q16718, O95298, O14521AKT2, GSK3B, CASP8, ATF4, FASLG, ERN1, IL1B, COX6A1, NDUFA1, NDUFA5, NDUFC2, SDHDMore
Acetylsalicylic-acidhsa04934Cushing syndrome4.54E-023P18848, Q08828, P51828ATF4, ADCY1, ADCY7More
Acetylsalicylic-acidhsa04935Growth hormone synthesis, secretion and action1.88E-024Q08828, P51828, P18848, P31751ADCY1, ADCY7, ATF4, AKT2More
Acetylsalicylic-acidhsa04940Type I diabetes mellitus1.55E-023P10747, P13765, P01375CD28, HLA-DOB, TNFMore
Acetylsalicylic-acidhsa04960Aldosterone-regulated sodium reabsorption4.40E-021O00141SGKMore
Acetylsalicylic-acidhsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Acetylsalicylic-acidhsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Acetylsalicylic-acidhsa04970Salivary secretion1.57E-047P07550, Q08828, P51828, P22694, Q14643, P0DP23, P49913ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, CALM1, CAMPMore
Acetylsalicylic-acidhsa04971Gastric acid secretion4.91E-044Q08828, P51828, P15311, P0DP23ADCY1, ADCY7, VIL2, CALM1More
Acetylsalicylic-acidhsa04973Carbohydrate digestion and absorption9.61E-043O43451, P42338, P31751MGAM, PIK3CB, AKT2More
Acetylsalicylic-acidhsa04976Bile secretion9.77E-045O43315, Q08828, P51828, P08183, Q14032AQP9, ADCY1, ADCY7, ABCB1, BAATMore
Acetylsalicylic-acidhsa05010Alzheimer disease1.60E-0516O95298, P19404, P13073, Q00535, O75460, P0DP23, P01584, P18848, Q71U36, Q13509, P67870, P31751, P05141, P21796, P45880, P28070NDUFC2, NDUFV2, COX4I1, CDK5, ERN1, CALM1, IL1B, ATF4, TUBA1A, TUBB3, CSNK2B, AKT2, SLC25A5, VDAC1, VDAC2, PSMB4More
Acetylsalicylic-acidhsa05012Parkinson disease6.70E-0411P19404, P13073, P05141, P21796, P45880, P18848, P19174, P0DP23, Q13557, Q71U36, Q13509NDUFV2, COX4I1, SLC25A5, VDAC1, VDAC2, ATF4, PLCG1, CALM1, CAMK2D, TUBA1A, TUBB3More
Acetylsalicylic-acidhsa05014Amyotrophic lateral sclerosis4.20E-025Q71U36, Q13148, P21796, P43243, P84103TUBA1A, TARDBP, VDAC1, MATR3, SFRS3More
Acetylsalicylic-acidhsa05016Huntington disease6.51E-0414O95298, P19404, P13073, Q13547, P24928, P30876, P62487, P05141, P21796, P45880, O75460, Q71U36, Q13509, P28070NDUFC2, NDUFV2, COX4I1, HDAC1, POLR2A, POLR2B, POLR2G, SLC25A5, VDAC1, VDAC2, ERN1, TUBA1A, TUBB3, PSMB4More
Acetylsalicylic-acidhsa05017Spinocerebellar ataxia3.94E-024O75460, P31751, P28070, P05141ERN1, AKT2, PSMB4, SLC25A5More
Acetylsalicylic-acidhsa05020Prion disease1.99E-0415P11142, Q16718, P19404, O14521, P13073, P18848, P05141, P21796, P45880, Q71U36, Q13509, P49841, P67870, Q99941, Q16539HSPA8, NDUFA5, NDUFV2, SDHD, COX4I1, ATF4, SLC25A5, VDAC1, VDAC2, TUBA1A, TUBB3, GSK3B, CSNK2B, CREBL1, MAPK14More
Acetylsalicylic-acidhsa05022Pathways of neurodegeneration - multiple diseases1.34E-0524Q71U36, Q13509, P49841, Q16718, O95298, P19404, O14521, P13073, Q8TEV9, P21796, O75460, P18848, Q13561, P19174, P05141, P45880, P20333, Q16539, Q00535, P01584, Q08752, P0DP23, Q13557, P28070TUBA1A, TUBB3, GSK3B, NDUFA5, NDUFC2, NDUFV2, SDHD, COX4I1, SMCR8, VDAC1, ERN1, ATF4, DCTN2, PLCG1, SLC25A5, VDAC2, TNFRSF1B, MAPK14, CDK5, IL1B, PPID, CALM1, CAMK2D, PSMB4More
Acetylsalicylic-acidhsa05030Cocaine addiction4.19E-021Q00535CDK5More
Acetylsalicylic-acidhsa05031Amphetamine addiction1.32E-035P0DP23, Q13557, Q99941, P18848, Q13547CALM1, CAMK2D, CREBL1, ATF4, HDAC1More
Acetylsalicylic-acidhsa05034Alcoholism1.27E-027Q99941, P18848, Q13547, P0DP23, P62873, P63218, O60814CREBL1, ATF4, HDAC1, CALM1, GNB1, GNG5, H2BC12More
Acetylsalicylic-acidhsa05100Bacterial invasion of epithelial cells4.54E-023Q14141, Q05397, Q96JJ3SEPT6, PTK2, ELMO2More
Acetylsalicylic-acidhsa05110Vibrio cholerae infection2.11E-032Q99437, P17612ATP6V0B, PRKACAMore
Acetylsalicylic-acidhsa05120Epithelial cell signaling in Helicobacter pylori infection1.30E-036Q16539, Q99437, P09341, P25024, P25025, P41240MAPK14, ATP6V0B, CXCL1, CXCR1, CXCR2, CSKMore
Acetylsalicylic-acidhsa05130Pathogenic Escherichia coli infection2.49E-036Q14247, O00501, P25116, Q15438, P35579, P55061CTTN, CLDN5, F2R, PSCD1, MYH9, TEGTMore
Acetylsalicylic-acidhsa05131Shigellosis1.05E-027Q9NQL2, P0CG47, Q14141, Q96JJ3, Q05397, Q13315, P07737RRAGD, UBB, SEPT6, ELMO2, PTK2, ATM, PFN1More
Acetylsalicylic-acidhsa05133Pertussis2.70E-032P10145, P0C0L4IL8, C4AMore
Acetylsalicylic-acidhsa05134Legionellosis3.40E-035P11215, P68104, P0DMV8, P11142, P19875ITGAM, EEF1A1, HSPA1A, HSPA8, CXCL2More
Acetylsalicylic-acidhsa05135Yersinia infection1.82E-024P60709, P06239, P19174, P01730ACTB, LCK, PLCG1, CD4More
Acetylsalicylic-acidhsa05140Leishmaniasis4.21E-049O75015, P14598, P13765, O60603, P25963, P29350, P49006, Q16539, Q15080FCGR3B, NCF1, HLA-DOB, TLR2, NFKBIA, PTPN6, MARCKSL1, MAPK14, NCF4More
Acetylsalicylic-acidhsa05142Chagas disease2.70E-022P48023, Q14790FASLG, CASP8More
Acetylsalicylic-acidhsa05143African trypanosomiasis1.00E-032P69905, P68871HBA2, HBBMore
Acetylsalicylic-acidhsa05144Malaria3.09E-022P69905, P68871HBA2, HBBMore
Acetylsalicylic-acidhsa05145Toxoplasmosis6.35E-032P23458, P0DMV8JAK1, HSPA1AMore
Acetylsalicylic-acidhsa05146Amoebiasis1.99E-0711Q13751, P09341, P14778, P27930, P01375, O60603, P42338, P05089, P22694, P12814, P08311LAMB3, CXCL1, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ARG1, PRKACB, ACTN1, CTSGMore
Acetylsalicylic-acidhsa05150Staphylococcus aureus infection2.66E-036P21730, P21462, O75015, P13765, P12838, P49913C5AR1, FPR1, FCGR3B, HLA-DOB, DEFA4, CAMPMore
Acetylsalicylic-acidhsa05152Tuberculosis9.92E-032P0DP23, P31751CALM1, AKT2More
Acetylsalicylic-acidhsa05162Measles5.50E-046P23458, P0DMV8, P11142, Q13191, P30279, O43318JAK1, HSPA1A, HSPA8, CBLB, CCND2, MAP3K7More
Acetylsalicylic-acidhsa05163Human cytomegalovirus infection1.70E-0617P31751, P01375, Q14643, P0DP23, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, Q13651, P25025, Q16539, P18848, P04637, O00463AKT2, TNF, ITPR1, CALM1, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, IL10RA, CXCR2, MAPK14, ATF4, TP53, TRAF5More
Acetylsalicylic-acidhsa05164Influenza A4.49E-025P31751, P01584, P23458, P05141, Q9UBU9AKT2, IL1B, JAK1, SLC25A5, NXF1More
Acetylsalicylic-acidhsa05166Human T-cell leukemia virus 1 infection3.90E-027P23458, P05141, P62826, Q08828, P51828, P18848, P31751JAK1, SLC25A5, RAN, ADCY1, ADCY7, ATF4, AKT2More
Acetylsalicylic-acidhsa05167Kaposi sarcoma-associated herpesvirus infection3.59E-038P31751, P42224, P62873, P63218, P19875, P19174, P07948, P0DP23AKT2, STAT1, GNB1, GNG5, CXCL2, PLCG1, LYN, CALM1More
Acetylsalicylic-acidhsa05169Epstein-Barr virus infection7.49E-0516P13765, P01106, Q13547, Q92769, O00463, O43318, P07948, P30101, Q13761, P24522, O75293, P30279, P42224, P07766, P09693, P20963HLA-DOB, MYC, HDAC1, HDAC2, TRAF5, MAP3K7, LYN, PDIA3, RUNX3, GADD45A, GADD45B, CCND2, STAT1, CD3E, CD3G, CD247More
Acetylsalicylic-acidhsa05170Human immunodeficiency virus 1 infection3.76E-037P31751, Q02750, P62879, P16298, P0DP23, Q05397, Q13315AKT2, MAP2K1, GNB2, PPP3CB, CALM1, PTK2, ATMMore
Acetylsalicylic-acidhsa05171Coronavirus disease - COVID-193.18E-037P01584, P62753, P36578, P62888, P61927, P61513, P62829IL1B, RPS6, RPL4, RPL30, RPL37, RPL37A, RPL23More
Acetylsalicylic-acidhsa05200Pathways in cancer3.06E-0418Q16363, P07900, P08238, P42224, P19174, P43246, P20585, Q13547, P30279, P31751, P62873, P63218, P78417, O75293, P0DP23, Q13557, P14784, P01042LAMA4, HSP90AA1, HSP90AB1, STAT1, PLCG1, MSH2, MSH3, HDAC1, CCND2, AKT2, GNB1, GNG5, GSTO1, GADD45B, CALM1, CAMK2D, IL2RB, KNG1More
Acetylsalicylic-acidhsa05202Transcriptional misregulation in cancer1.73E-0514Q12778, Q13315, P41732, P14780, Q15744, Q16548, O15550, P35226, P05164, P12838, P08246, Q16828, Q9C0K0, P24522FOXO1, ATM, TSPAN7, MMP9, CEBPE, BCL2A1, UTX, BMI1, MPO, DEFA4, ELA2, DUSP6, BCL11B, GADD45AMore
Acetylsalicylic-acidhsa05203Viral carcinogenesis2.47E-0413Q12933, Q99941, P18848, P42229, P06746, P07948, P30279, P27348, P29083, Q7KZF4, Q13547, Q15283, O60814TRAF2, CREBL1, ATF4, STAT5A, POLB, LYN, CCND2, YWHAQ, GTF2E1, SND1, HDAC1, RASA2, H2BC12More
Acetylsalicylic-acidhsa05204Chemical carcinogenesis5.46E-032Q16772, P09211GSTA3, GSTP1More
Acetylsalicylic-acidhsa05211Renal cell carcinoma4.78E-021P31751AKT2More
Acetylsalicylic-acidhsa05212Pancreatic cancer4.69E-033P31751, Q15311, P23458AKT2, RALBP1, JAK1More
Acetylsalicylic-acidhsa05213Endometrial cancer3.60E-021P31751AKT2More
Acetylsalicylic-acidhsa05214Glioma5.03E-045P0DP23, Q13557, P31751, P19174, O75293CALM1, CAMK2D, AKT2, PLCG1, GADD45BMore
Acetylsalicylic-acidhsa05216Thyroid cancer2.72E-022P04637, P24522TP53, GADD45AMore
Acetylsalicylic-acidhsa05217Basal cell carcinoma4.79E-022P04637, P24522TP53, GADD45AMore
Acetylsalicylic-acidhsa05218Melanoma2.78E-033P04637, P31751, P24522TP53, AKT2, GADD45AMore
Acetylsalicylic-acidhsa05219Bladder cancer4.07E-022P14780, P04637MMP9, TP53More
Acetylsalicylic-acidhsa05220Chronic myeloid leukemia4.19E-021P31751AKT2More
Acetylsalicylic-acidhsa05221Acute myeloid leukemia1.25E-032P31751, Q16828AKT2, DUSP6More
Acetylsalicylic-acidhsa05222Small cell lung cancer4.78E-021P31751AKT2More
Acetylsalicylic-acidhsa05223Non-small cell lung cancer3.31E-034P31751, P19174, Q9HC35, O75293AKT2, PLCG1, EML4, GADD45BMore
Acetylsalicylic-acidhsa05224Breast cancer4.75E-024P49841, Q92837, P04637, P24522GSK3B, FRAT1, TP53, GADD45AMore
Acetylsalicylic-acidhsa05226Gastric cancer2.04E-033P31751, P04628, P10826AKT2, WNT1, RARBMore
Acetylsalicylic-acidhsa05230Central carbon metabolism in cancer4.78E-021P31751AKT2More
Acetylsalicylic-acidhsa05231Choline metabolism in cancer2.02E-048P31751, P42338, O15245, Q9Y259, P19174, P49619, Q16760, O14986AKT2, PIK3CB, SLC22A1, CHKB, PLCG1, DGKG, DGKD, PIP5K1BMore
Acetylsalicylic-acidhsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer4.00E-0914P42338, O95267, P19174, P07766, P20963, P09693, P06239, P42224, O60603, P10747, Q04759, Q16539, Q9HC35, P01730PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, STAT1, TLR2, CD28, PRKCQ, MAPK14, EML4, CD4More
Acetylsalicylic-acidhsa05310Asthma6.83E-033P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Acetylsalicylic-acidhsa05321Inflammatory bowel disease6.79E-066O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Acetylsalicylic-acidhsa05322Systemic lupus erythematosus4.51E-026O75015, P08246, P08311, P01375, P10747, P13765FCGR3B, ELA2, CTSG, TNF, CD28, HLA-DOBMore
Acetylsalicylic-acidhsa05323Rheumatoid arthritis1.05E-035P01375, P13765, P10747, P09341, O60603TNF, HLA-DOB, CD28, CXCL1, TLR2More
Acetylsalicylic-acidhsa05330Allograft rejection2.83E-023P13765, P10747, P01375HLA-DOB, CD28, TNFMore
Acetylsalicylic-acidhsa05332Graft-versus-host disease5.77E-075P13765, P10747, P01375, P26715, Q13241HLA-DOB, CD28, TNF, KLRC1, KLRD1More
Acetylsalicylic-acidhsa05340Primary immunodeficiency2.67E-055P01730, P01732, P11912, P07766, P06239CD4, CD8A, CD79A, CD3E, LCKMore
Acetylsalicylic-acidhsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Acetylsalicylic-acidhsa05415Diabetic cardiomyopathy1.28E-024Q16718, O14521, Q16539, P49841NDUFA5, SDHD, MAPK14, GSK3BMore
Acetylsalicylic-acidhsa05418Fluid shear stress and atherosclerosis1.47E-0611Q16539, P31751, P42338, Q14145, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23MAPK14, AKT2, PIK3CB, KEAP1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1More

Community members of Acetylsalicylic-acid (SDC: 4.55)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)