PharmaCoNets of Acetohexamide (SPCN: 37.40 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Acetohexamidehsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Acetohexamidehsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Acetohexamidehsa00071Fatty acid degradation2.52E-023O75521, P11766, P33121ECI2, ADH5, ACSL1More
Acetohexamidehsa00500Starch and sucrose metabolism1.07E-033O43451, P46976, P06737MGAM, GYG1, PYGLMore
Acetohexamidehsa00565Ether lipid metabolism4.93E-021Q8N661TMEM86BMore
Acetohexamidehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Acetohexamidehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Acetohexamidehsa00630Glyoxylate and dicarboxylate metabolism4.12E-032P40925, P15104MDH1, GLULMore
Acetohexamidehsa00730Thiamine metabolism8.96E-043Q9Y6K8, P05186, P24666AK5, ALPL, ACP1More
Acetohexamidehsa00760Nicotinate and nicotinamide metabolism3.52E-021P21589NT5EMore
Acetohexamidehsa00770Pantothenate and CoA biosynthesis2.27E-022O95498, O95497VNN2, VNN1More
Acetohexamidehsa00860Porphyrin and chlorophyll metabolism1.69E-022P36551, P30043CPOX, BLVRBMore
Acetohexamidehsa00970Aminoacyl-tRNA biosynthesis2.77E-044O95363, P54136, P14868, Q15046FARS2, RARS1, DARS, KARSMore
Acetohexamidehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Acetohexamidehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Acetohexamidehsa01100Metabolic pathways3.52E-0223P05089, O95455, P21953, P32320, P11766, P06280, Q16875, O43286, O43451, P05186, P24666, Q9HCC0, P33121, Q08477, P15907, Q9UNP4, P37837, P32321, Q9BPW9, Q9UHY7, P43490, P46976, P06737ARG1, TGDS, BCKDHB, CDA, ADH5, GLA, PFKFB3, B4GALT5, MGAM, ALPL, ACP1, MCCC2, ACSL1, CYP4F3, ST6GAL1, ST3GAL5, TALDO1, DCTD, DHRS9, ENOPH1, PBEF1, GYG1, PYGLMore
Acetohexamidehsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Acetohexamidehsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Acetohexamidehsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Acetohexamidehsa03013RNA transport2.35E-0510O14980, P52298, O14893, P61326, Q7Z3B4, P35658, Q14152, Q14240, P23588, Q9Y6A5XPO1, NCBP2, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF4A2, EIF4B, TACC3More
Acetohexamidehsa04060Cytokine-cytokine receptor interaction4.71E-022P78552, O75509IL13RA1, TNFRSF21More
Acetohexamidehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Acetohexamidehsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Acetohexamidehsa04064NF-kappa B signaling pathway2.15E-027P14778, P19174, Q04759, P06239, P09341, P19875, Q06643IL1R1, PLCG1, PRKCQ, LCK, CXCL1, CXCL2, LTBMore
Acetohexamidehsa04071Sphingolipid signaling pathway4.56E-026Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2More
Acetohexamidehsa04072Phospholipase D signaling pathway5.17E-037P42338, Q92529, P43657, P25024, P25025, P19174, Q14344PIK3CB, SHC3, P2RY5, CXCR1, CXCR2, PLCG1, GNA13More
Acetohexamidehsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Acetohexamidehsa04150mTOR signaling pathway2.23E-023P42338, Q13322, P49841PIK3CB, GRB10, GSK3BMore
Acetohexamidehsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Acetohexamidehsa04340Hedgehog signaling pathway3.46E-024P49841, P22694, Q13635, P10415GSK3B, PRKACB, PTCH1, BCL2More
Acetohexamidehsa04380Osteoclast differentiation4.80E-024P06239, P42338, P14778, Q8N149LCK, PIK3CB, IL1R1, LILRA2More
Acetohexamidehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Acetohexamidehsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Acetohexamidehsa04612Antigen processing and presentation1.14E-038P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNFMore
Acetohexamidehsa04613Neutrophil extracellular trap formation3.49E-0419O60603, P05164, P08246, Q9UM07, Q13547, Q92769, Q6FI13, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14More
Acetohexamidehsa04621NOD-like receptor signaling pathway1.75E-0311Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P12838MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, DEFA4More
Acetohexamidehsa04625C-type lectin receptor signaling pathway4.80E-026Q9ULY5, P20749, Q14643, P01375, Q13191, Q16539CLEC4E, BCL3, ITPR1, TNF, CBLB, MAPK14More
Acetohexamidehsa04640Hematopoietic cell lineage1.19E-0313P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P09564, P13765, P01375ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD7, HLA-DOB, TNFMore
Acetohexamidehsa04650Natural killer cell mediated cytotoxicity2.05E-0413P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q13241, P26718, O14931, O75015, P26717, P26715PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1More
Acetohexamidehsa04657IL-17 signaling pathway1.26E-047O00463, Q16539, P49841, P09341, P14780, P80188, P01375TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNFMore
Acetohexamidehsa04658Th1 and Th2 cell differentiation4.28E-0713Q04759, P07766, P20963, P09693, Q16539, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Acetohexamidehsa04659Th17 cell differentiation3.21E-0512Q04759, Q16539, P19174, P06239, P14784, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, MAPK14, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Acetohexamidehsa04660T cell receptor signaling pathway1.56E-0615P01375, Q9UDY8, Q04759, P42338, O95267, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, MALT1, PRKCQ, PIK3CB, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Acetohexamidehsa04662B cell receptor signaling pathway7.25E-034P49841, P42338, P21854, Q8N149GSK3B, PIK3CB, CD72, LILRA2More
Acetohexamidehsa04730Long-term depression3.52E-021Q14344GNA13More
Acetohexamidehsa04750Inflammatory mediator regulation of TRP channels7.26E-045P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Acetohexamidehsa04912GnRH signaling pathway4.72E-024Q16539, Q9Y6R4, Q14643, P22694MAPK14, MAP3K4, ITPR1, PRKACBMore
Acetohexamidehsa04920Adipocytokine signaling pathway4.72E-024P33121, Q04759, Q9Y4H2, P01375ACSL1, PRKCQ, IRS2, TNFMore
Acetohexamidehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Acetohexamidehsa04929GnRH secretion3.63E-022P42338, P49407PIK3CB, ARRB1More
Acetohexamidehsa04960Aldosterone-regulated sodium reabsorption4.38E-021P48048KCNJ1More
Acetohexamidehsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Acetohexamidehsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Acetohexamidehsa04973Carbohydrate digestion and absorption6.19E-052O43451, P42338MGAM, PIK3CBMore
Acetohexamidehsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Acetohexamidehsa05120Epithelial cell signaling in Helicobacter pylori infection1.80E-046Q16539, P09341, P19875, P19174, P25024, P25025MAPK14, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Acetohexamidehsa05133Pertussis4.20E-021P0C0L4C4AMore
Acetohexamidehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Acetohexamidehsa05140Leishmaniasis5.63E-058P13612, O75015, P13765, O60603, P01375, P49006, Q16539, Q15080ITGA4, FCGR3B, HLA-DOB, TLR2, TNF, MARCKSL1, MAPK14, NCF4More
Acetohexamidehsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Acetohexamidehsa05144Malaria2.19E-037P60033, P69905, P68871, O60603, P01375, P35443, P26718CD81, HBA2, HBB, TLR2, TNF, THBS4, KLRK1More
Acetohexamidehsa05146Amoebiasis3.04E-0712P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSGMore
Acetohexamidehsa05163Human cytomegalovirus infection3.28E-027P01375, P50151, P49841, P14778, P25025, Q16539, O00463TNF, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Acetohexamidehsa05202Transcriptional misregulation in cancer3.06E-0416P41732, P14780, P27930, Q15744, Q16548, Q13077, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522TSPAN7, MMP9, IL1R2, CEBPE, BCL2A1, TRAF1, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45AMore
Acetohexamidehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Acetohexamidehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Acetohexamidehsa05225Hepatocellular carcinoma1.85E-022Q92529, P51531SHC3, SMARCA2More
Acetohexamidehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer8.27E-036P42338, P19174, P07766, P20963, P06239, Q04759PIK3CB, PLCG1, CD3E, CD247, LCK, PRKCQMore
Acetohexamidehsa05310Asthma2.81E-023P13765, P12724, P01375HLA-DOB, RNASE3, TNFMore
Acetohexamidehsa05321Inflammatory bowel disease1.67E-056O60603, P01375, P13765, Q14765, Q9UL17, P23771TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3More
Acetohexamidehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Acetohexamidehsa05332Graft-versus-host disease2.06E-034P13765, P01375, P26715, Q13241HLA-DOB, TNF, KLRC1, KLRD1More
Acetohexamidehsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Acetohexamidehsa05418Fluid shear stress and atherosclerosis2.43E-037Q16539, P42338, P10599, P14780, P01375, P14778, P27930MAPK14, PIK3CB, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Acetohexamide (SDC: 4.24)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P48048KCNJ1ATPNonesensitive inward rectifier potassium channel 1Reported00.00420.2820.12740.6935
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P21730C5AR1C5a anaphylatoxin chemotactic receptor 1Predicted10.02580.21670.53960.986
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P14780MMP9Matrix metalloproteinaseNone9Predicted10.16960.84240.73152.5012
P78508KCNJ10ATPNonesensitive inward rectifier potassium channel 10Predicted00.07310.08780.20670.4189
Q99712KCNJ15ATPNonesensitive inward rectifier potassium channel 15Predicted00.15870.07790.12670.3619
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)