PharmaCoNets

PharmaCoNets of Acenocoumarol (S_PCN: 69.27 )

Acenocoumarol regulated-network (S_DN: 13.80)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Acenocoumarol

hsa00051

Fructose and mannose metabolism

4.17E-02

P15121, P60174

AKR1B1, TPI1

Acenocoumarol

hsa00052

Galactose metabolism

1.03E-02

P06280, O43451

GLA, MGAM

Acenocoumarol

hsa00220

Arginine biosynthesis

7.34E-04

P15104, P05089, P49448

GLUL, ARG1, GLUD2

Acenocoumarol

hsa00250

Alanine, aspartate and glutamate metabolism

2.61E-02

P49448, P15104

GLUD2, GLUL

Acenocoumarol

hsa00480

Glutathione metabolism

3.29E-04

Q9UJ14, Q16772, P09211, P30041

GGTL3, GSTA3, GSTP1, PRDX6

Acenocoumarol

hsa00500

Starch and sucrose metabolism

1.67E-02

O43451, P06737

MGAM, PYGL

Acenocoumarol

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Acenocoumarol

hsa00520

Amino sugar and nucleotide sugar metabolism

2.11E-02

Q16222, Q9Y223, P06865

UAP1, GNE, HEXA

Acenocoumarol

hsa00590

Arachidonic acid metabolism

3.85E-02

P11712, P09960

CYP2C9, LTA4H

Acenocoumarol

hsa00591

Linoleic acid metabolism

4.07E-02

P11712

CYP2C9

Acenocoumarol

hsa00603

Glycosphingolipid biosynthesis - globo and isoglobo series

8.72E-03

P06865, O75752

HEXA, B3GALNT1

Acenocoumarol

hsa00604

Glycosphingolipid biosynthesis - ganglio series

2.46E-02

P06865, Q9H4F1

HEXA, ST6GALNAC4

Acenocoumarol

hsa00730

Thiamine metabolism

5.29E-03

P05186, P24666

ALPL, ACP1

Acenocoumarol

hsa00830

Retinol metabolism

3.93E-02

P00352, Q9BPW9, O75911

ALDH1A1, DHRS9, DHRS3

Acenocoumarol

hsa00910

Nitrogen metabolism

2.61E-02

P15104, P49448

GLUL, GLUD2

Acenocoumarol

hsa00920

Sulfur metabolism

3.18E-02

Q16762

TST

Acenocoumarol

hsa00970

Aminoacyl-tRNA biosynthesis

3.78E-02

O95363, Q15046

FARS2, KARS

Acenocoumarol

hsa00980

Metabolism of xenobiotics by cytochrome P450

9.14E-05

Q16772, P78417, P09211, P11712

GSTA3, GSTO1, GSTP1, CYP2C9

Acenocoumarol

hsa00982

Drug metabolism - cytochrome P450

1.77E-04

P11712, Q16772, P09211, P78417

CYP2C9, GSTA3, GSTP1, GSTO1

Acenocoumarol

hsa00983

Drug metabolism - other enzymes

8.59E-04

P32320, P05164, Q16772, P09211

CDA, MPO, GSTA3, GSTP1

Acenocoumarol

hsa01100

Metabolic pathways

8.43E-03

P35790, Q16772, P09211, Q9UJ14, P30041, P40926, Q7KZN9, P15121, Q9UHK6, Q86VZ5, Q9BQB6

CHKA, GSTA3, GSTP1, GGTL3, PRDX6, MDH2, COX15, AKR1B1, AMACR, SGMS1, VKORC1

Acenocoumarol

hsa01524

Platinum drug resistance

4.44E-02

Q16772, P09211

GSTA3, GSTP1

Acenocoumarol

hsa03010

Ribosome

4.60E-06

P62753, P42677, P25398, P32969, P30050, P40429, P62829, P46776, Q9H0U6, Q07020, P62910, P18077, P36578, P05386, P62249, P23396

RPS6, RPS27, RPS12, RPL9, RPL12, RPL13A, RPL23, RPL27A, MRPL18, RPL18, RPL32, RPL35A, RPL4, RPLP1, RPS16, RPS3

Acenocoumarol

hsa03013

RNA transport

7.27E-03

O14980, P52298, Q09161, O14893, P61326, Q7Z3B4, P35658, Q14152, O75822, Q14240, Q9Y6A5, P51114

XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, NUP54, NUP214, EIF3A, EIF3J, EIF4A2, TACC3, FXR1

Acenocoumarol

hsa03020

RNA polymerase

3.59E-02

P30876, P62487

POLR2B, POLR2G

Acenocoumarol

hsa03040

Spliceosome

1.28E-05

O43143, O60508, P08579, P26368, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX15, CDC40, SNRPB2, U2AF2, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Acenocoumarol

hsa03410

Base excision repair

4.17E-02

P49005, P29372

POLD2, MPG

Acenocoumarol

hsa04012

ErbB signaling pathway

3.15E-02

P16333, P19174, P01106

NCK1, PLCG1, MYC

Acenocoumarol

hsa04014

Ras signaling pathway

2.36E-02

P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174

PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1

Acenocoumarol

hsa04015

Rap1 signaling pathway

2.69E-03

P20827, P49767, Q96FS4, P11215, P25116, Q8TEU7, Q13009, Q7LDG7, P42338, P08514, P19174

EFNA1, VEGFC, SIPA1, ITGAM, F2R, RAPGEF6, TIAM1, RASGRP2, PIK3CB, ITGA2B, PLCG1

Acenocoumarol

hsa04060

Cytokine-cytokine receptor interaction

5.34E-03

P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730

IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4

Acenocoumarol

hsa04061

Viral protein interaction with cytokine and cytokine receptor

1.32E-02

P09341, P25024, P47992, Q9UBD3, Q13651, P14784

CXCL1, CXCR1, XCL1, XCL2, IL10RA, IL2RB

Acenocoumarol

hsa04062

Chemokine signaling pathway

2.28E-04

P25024, P09341, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q08881, Q7LDG7, Q13009, Q8WYR1

CXCR1, CXCL1, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ITK, RASGRP2, TIAM1, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06239	LCK	Tyrosine-protein kinase Lck	P25024	CXCR1	C-X-C chemokine receptor type 1	-0.779
P06239	LCK	Tyrosine-protein kinase Lck	P09341	CXCL1	Growth-regulated alpha protein	-0.805
P06239	LCK	Tyrosine-protein kinase Lck	P47992	XCL1	Lymphotactin	0.715
P06239	LCK	Tyrosine-protein kinase Lck	Q9UBD3	XCL2	Cytokine SCM-1 beta	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
P06239	LCK	Tyrosine-protein kinase Lck	P07948	LYN	Tyrosine-protein kinase Lyn	-0.701
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P06239	LCK	Tyrosine-protein kinase Lck	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	-0.728
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P06239	LCK	Tyrosine-protein kinase Lck	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	-0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P06239	LCK	Tyrosine-protein kinase Lck	P43250	GRK6	G protein-coupled receptor kinase 6	-0.702
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Acenocoumarol

hsa04064

NF-kappa B signaling pathway

7.24E-03

O00463, P14778, Q04759, P07948, P06239, P24522, P09341, Q06643

TRAF5, IL1R1, PRKCQ, LYN, LCK, GADD45A, CXCL1, LTB

Acenocoumarol

hsa04071

Sphingolipid signaling pathway

4.77E-03

P17252, Q9H228, P01375, Q13362, Q9BX95, P10415, Q9UQC2

PRKCA, EDG8, TNF, PPP2R5C, SGPP1, BCL2, GAB2

Acenocoumarol

hsa04110

Cell cycle

1.44E-02

P06493, O75293, P30304, P33981, P42773, P01106, Q13547

CDK1, GADD45B, CDC25A, TTK, CDKN2C, MYC, HDAC1

Acenocoumarol

hsa04114

Oocyte meiosis

8.38E-04

Q9Y6D9, P51812, Q02750, P16298, Q17RY0

MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4

Acenocoumarol

hsa04122

Sulfur relay system

3.18E-02

Q16762

TST

Acenocoumarol

hsa04141

Protein processing in endoplasmic reticulum

4.88E-02

P18848, O60337, P11142, P07900

ATF4, MARH6, HSPA8, HSP90AA1

Acenocoumarol

hsa04150

mTOR signaling pathway

3.60E-02

Q02750, Q9NQL2, P51812

MAP2K1, RRAGD, RPS6KA3

Acenocoumarol

hsa04151

PI3K-Akt signaling pathway

3.70E-02

P42338, P43657, P20827, P49767, P08238, Q8WYR1, P63218, P50151, O15335, Q13751, P14784, P30281

PIK3CB, P2RY5, EFNA1, VEGFC, HSP90AB1, PIK3R5, GNG5, GNG10, CHAD, LAMB3, IL2RB, CCND3

Acenocoumarol

hsa04210

Apoptosis

3.58E-02

O76075, P01375, Q9NR28, Q16548

DFFB, TNF, DIABLO, BCL2A1

Acenocoumarol

hsa04217

Necroptosis

4.42E-04

P07900, P15104, P05141, P01584, P0C0S5, Q13557

HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2D

Acenocoumarol

hsa04340

Hedgehog signaling pathway

3.32E-02

P49841, P22694

GSK3B, PRKACB

Acenocoumarol

hsa04360

Axon guidance

4.04E-02

P16333, P20827, O95631, P42338, P07332, P19174

NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1

Acenocoumarol

hsa04370

VEGF signaling pathway

9.32E-05

P16298, Q05397, Q02750

PPP3CB, PTK2, MAP2K1

Acenocoumarol

hsa04371

Apelin signaling pathway

1.00E-02

P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022

GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3

Acenocoumarol

hsa04512

ECM-receptor interaction

3.73E-02

P07359, P08514

GP1BA, ITGA2B

Acenocoumarol

hsa04514

Cell adhesion molecules

8.19E-03

P16109, P56750, O00501

SELP, CLDN17, CLDN5

Acenocoumarol

hsa04530

Tight junction

2.47E-05

Q8TEU7, P16989, P56750, O00501, Q14247

RAPGEF6, CSDA, CLDN17, CLDN5, CTTN

Acenocoumarol

hsa04610

Complement and coagulation cascades

4.47E-02

P25116, P09871

F2R, C1S

Acenocoumarol

hsa04611

Platelet activation

5.18E-05

P25116, P08514, Q15746, Q8WYR1, P07359

F2R, ITGA2B, MYLK, PIK3R5, GP1BA

Acenocoumarol

hsa04612

Antigen processing and presentation

1.39E-03

P04233, P13765, P01730, P26715, P26717, Q13241, P01732, P01889, P10321, Q06323

CD74, HLA-DOB, CD4, KLRC1, KLRC2, KLRD1, CD8A, HLA-B, HLA-C, PSME1

Acenocoumarol

hsa04613

Neutrophil extracellular trap formation

1.46E-03

P16109, Q93077, P62807, O60814, P68431, P08514, P07359

SELP, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, ITGA2B, GP1BA

Acenocoumarol

hsa04640

Hematopoietic cell lineage

1.60E-04

P13612, P14778, P27930, P25063, P07766, P09693, P01732, P01730, P09564, P13765

ITGA4, IL1R1, IL1R2, CD24, CD3E, CD3G, CD8A, CD4, CD7, HLA-DOB

Acenocoumarol

hsa04650

Natural killer cell mediated cytotoxicity

1.62E-04

P16298, P50591, P06239, O60880, P20963, Q02750, Q13241, P26718, O14931, P26717, P26715

PPP3CB, TNFSF10, LCK, SH2D1A, CD247, MAP2K1, KLRD1, KLRK1, NCR3, KLRC2, KLRC1

Acenocoumarol

hsa04657

IL-17 signaling pathway

4.48E-03

P07900, P49841, P14780, P01375, P01584

HSP90AA1, GSK3B, MMP9, TNF, IL1B

Acenocoumarol

hsa04658

Th1 and Th2 cell differentiation

2.79E-12

Q04759, P07766, P20963, P09693, P19174, P01730, P06239, P42224, P23771, Q9UL17, P14784, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, PLCG1, CD4, LCK, STAT1, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	Q04759	PRKCQ	Protein kinase C theta type	0.726
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.907
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.788
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.73
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P01730	CD4	T-cell surface glycoprotein CD4	0.845
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P06239	LCK	Tyrosine-protein kinase Lck	0.799
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.721
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	Q13761	RUNX3	Runt-related transcription factor 3	0.755
P06239	LCK	Tyrosine-protein kinase Lck	Q13761	RUNX3	Runt-related transcription factor 3	0.85
P30304	CDC25A	M-phase inducer phosphatase 1	Q13761	RUNX3	Runt-related transcription factor 3	-0.721

Acenocoumarol

hsa04659

Th17 cell differentiation

2.54E-10

Q04759, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963

PRKCQ, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	Q04759	PRKCQ	Protein kinase C theta type	0.726
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.73
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P01730	CD4	T-cell surface glycoprotein CD4	0.845
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P06239	LCK	Tyrosine-protein kinase Lck	0.799
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767
P30304	CDC25A	M-phase inducer phosphatase 1	P42224	STAT1	Signal transducer and activator of transcription 1-alpha/beta	-0.75
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.721
P06239	LCK	Tyrosine-protein kinase Lck	P14784	IL2RB	Interleukin-2 receptor subunit beta	0.727
P30304	CDC25A	M-phase inducer phosphatase 1	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P06239	LCK	Tyrosine-protein kinase Lck	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.777
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P14778	IL1R1	Interleukin-1 receptor type 1	-0.72
P06239	LCK	Tyrosine-protein kinase Lck	P14778	IL1R1	Interleukin-1 receptor type 1	-0.782
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P06239	LCK	Tyrosine-protein kinase Lck	Q9UL17	TBX21	T-box transcription factor TBX21	0.866
P06239	LCK	Tyrosine-protein kinase Lck	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.77
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.907
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.788
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927

Acenocoumarol

hsa04660

T cell receptor signaling pathway

1.35E-05

Q04759, Q08881, P19174, P16333, P07766, P20963, P09693, P01730, P01732, Q13191, P06239

PRKCQ, ITK, PLCG1, NCK1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	Q04759	PRKCQ	Protein kinase C theta type	0.726
P06239	LCK	Tyrosine-protein kinase Lck	Q04759	PRKCQ	Protein kinase C theta type	0.779
P06239	LCK	Tyrosine-protein kinase Lck	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.774
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	0.73
P30304	CDC25A	M-phase inducer phosphatase 1	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.762
P30304	CDC25A	M-phase inducer phosphatase 1	P16333	NCK1	Cytoplasmic protein NCK1	-0.781
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.907
P06239	LCK	Tyrosine-protein kinase Lck	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	0.928
P30304	CDC25A	M-phase inducer phosphatase 1	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.761
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.788
P06239	LCK	Tyrosine-protein kinase Lck	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.927
P06239	LCK	Tyrosine-protein kinase Lck	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.752
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P01730	CD4	T-cell surface glycoprotein CD4	0.845
P06239	LCK	Tyrosine-protein kinase Lck	P01730	CD4	T-cell surface glycoprotein CD4	0.746
P30304	CDC25A	M-phase inducer phosphatase 1	P01730	CD4	T-cell surface glycoprotein CD4	-0.708
P06239	LCK	Tyrosine-protein kinase Lck	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.841
P06239	LCK	Tyrosine-protein kinase Lck	Q13191	CBLB	E3 ubiquitin-protein ligase CBL-B	0.714
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P06239	LCK	Tyrosine-protein kinase Lck	0.799
P06239	LCK	Tyrosine-protein kinase Lck	P06239	LCK	Tyrosine-protein kinase Lck	1
P30304	CDC25A	M-phase inducer phosphatase 1	P06239	LCK	Tyrosine-protein kinase Lck	-0.767

Acenocoumarol

hsa04662

B cell receptor signaling pathway

1.74E-02

P42338, P60033, P07948, P21854, Q8N149

PIK3CB, CD81, LYN, CD72, LILRA2

Acenocoumarol

hsa04664

Fc epsilon RI signaling pathway

2.47E-02

P42338, P07948, P19174, P09917

PIK3CB, LYN, PLCG1, ALOX5

Acenocoumarol

hsa04720

Long-term potentiation

1.38E-02

P16298, P51812, Q02750

PPP3CB, RPS6KA3, MAP2K1

Acenocoumarol

hsa04810

Regulation of actin cytoskeleton

2.58E-02

Q15746, P08514, P25116

MYLK, ITGA2B, F2R

Acenocoumarol

hsa04910

Insulin signaling pathway

2.35E-02

P22694, P06737, P49841

PRKACB, PYGL, GSK3B

Acenocoumarol

hsa04914

Progesterone-mediated oocyte maturation

2.06E-03

Q17RY0, Q9Y6D9, P51812, Q02750

CPEB4, MAD1L1, RPS6KA3, MAP2K1

Acenocoumarol

hsa04919

Thyroid hormone signaling pathway

7.11E-03

P49841, P22694, O60244, Q9NVC6

GSK3B, PRKACB, MED14, MED17

Acenocoumarol

hsa04931

Insulin resistance

1.94E-02

P01375, P49841, P06737

TNF, GSK3B, PYGL

Acenocoumarol

hsa04932

Non-alcoholic fatty liver disease

9.70E-03

P18848, P01584, P13073, O15239

ATF4, IL1B, COX4I1, NDUFA1

Acenocoumarol

hsa04933

AGE-RAGE signaling pathway in diabetic complications

3.21E-02

P84022, Q13485, P42338, P49767, P19174

SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1

Acenocoumarol

hsa04964

Proximal tubule bicarbonate reclamation

2.61E-02

P49448, P40925

GLUD2, MDH1

Acenocoumarol

hsa04976

Bile secretion

2.44E-02

P22694, P08183

PRKACB, ABCB1

Acenocoumarol

hsa05012

Parkinson disease

2.53E-02

O15239, P13073, P05141, P18848, Q13557

NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2D

Acenocoumarol

hsa05016

Huntington disease

3.21E-02

O15239, P13073, P30876, P62487, P05141

NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5

Acenocoumarol

hsa05020

Prion disease

3.37E-03

P13591, P01584, P11142, O15239, P13073, P18848, P05141

NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5

Acenocoumarol

hsa05022

Pathways of neurodegeneration - multiple diseases

3.80E-02

O15239, P13073, P18848, P05141, P01584, Q13557

NDUFA1, COX4I1, ATF4, SLC25A5, IL1B, CAMK2D

Acenocoumarol

hsa05034

Alcoholism

8.41E-04

Q02930, P50151, Q9BTM1, Q93077, P62807, Q16778, O60814, P68431

CREB5, GNG10, H2AFJ, HIST1H2AC, HIST1H2BC, HIST2H2BE, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Acenocoumarol

hsa05130

Pathogenic Escherichia coli infection

7.39E-03

Q14247, P56750, O00501, P25116

CTTN, CLDN17, CLDN5, F2R

Acenocoumarol

hsa05133

Pertussis

2.41E-02

P09871, Q02556

C1S, IRF8

Acenocoumarol

hsa05134

Legionellosis

1.28E-02

P01584, P68104, P11142

IL1B, EEF1A1, HSPA8

Acenocoumarol

hsa05146

Amoebiasis

9.73E-03

P09341, P14778, P27930, P05089, P12814, P08311

CXCL1, IL1R1, IL1R2, ARG1, ACTN1, CTSG

Acenocoumarol

hsa05162

Measles

4.02E-02

P11142, P01584, Q9NP90

HSPA8, IL1B, RAB9B

Acenocoumarol

hsa05167

Kaposi sarcoma-associated herpesvirus infection

1.94E-02

P62879, P16298, Q02750, P0CG47

GNB2, PPP3CB, MAP2K1, UBB

Acenocoumarol

hsa05169

Epstein-Barr virus infection

5.99E-04

P13765, P01106, Q13547, O00463, P07948, O00232, P30101, Q13761, P24522, P29728, P07766, P09693, P20963

HLA-DOB, MYC, HDAC1, TRAF5, LYN, PSMD12, PDIA3, RUNX3, GADD45A, OAS2, CD3E, CD3G, CD247

Acenocoumarol

hsa05170

Human immunodeficiency virus 1 infection

6.02E-03

Q02750, P62879, P16298, Q05397, P20333

MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1B

Acenocoumarol

hsa05171

Coronavirus disease - COVID-19

3.10E-05

P01584, P23396, P62753, P25398, P62249, P42677, P40429, P36578, P32969, P30050, Q07020, P46776, P62910, P18077, P05386, P62829

IL1B, RPS3, RPS6, RPS12, RPS16, RPS27, RPL13A, RPL4, RPL9, RPL12, RPL18, RPL27A, RPL32, RPL35A, RPLP1, RPL23

Acenocoumarol

hsa05200

Pathways in cancer

9.46E-03

Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784

LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835

Acenocoumarol

hsa05203

Viral carcinogenesis

7.11E-05

Q12933, Q02930, P42229, P06746, P07948, Q15283, P06396, P12814, P01889, P10321, P06493, P62807, Q16778, O60814

TRAF2, CREB5, STAT5A, POLB, LYN, RASA2, GSN, ACTN1, HLA-B, HLA-C, CDK1, HIST1H2BC, HIST2H2BE, H2BC12

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q12933	TRAF2	TNF receptor-associated factor 2	0.704
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	Q02930	CREB5	Cyclic AMP-responsive element-binding protein 5	0.701
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P42229	STAT5A	Signal transducer and activator of transcription 5A	0.756
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P06746	POLB	DNA polymerase beta	0.817
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P07948	LYN	Tyrosine-protein kinase Lyn	-0.752
Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.718
P11712	CYP2C9	Cytochrome P450 2C9	Q15283	RASA2	Ras GTPase-activating protein 2	-0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q15283	RASA2	Ras GTPase-activating protein 2	-0.717
Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	P06396	GSN	Gelsolin	0.703
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P12814	ACTN1	Alpha-actinin-1	-0.876
Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	P01889	HLA-B	HLA class I histocompatibility antigen, B alpha chain	0.706
Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	P10321	HLA-C	HLA class I histocompatibility antigen, C alpha chain	0.706
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P06493	CDK1	Cyclin-dependent kinase 1	-0.702
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.764
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	-0.764
P11712	CYP2C9	Cytochrome P450 2C9	P62807	HIST1H2BC	Histone H2B type 1-C/E/F/G/I	0.717
Q16549	PCSK7	Proprotein convertase subtilisin/kexin type 7	Q16778	HIST2H2BE	Histone H2B type 2-E	-0.702
P11712	CYP2C9	Cytochrome P450 2C9	O60814	H2BC12	Histone H2B type 1-K	0.728

Acenocoumarol

hsa05204

Chemical carcinogenesis

1.77E-04

Q16772, P09211, P78417, P11712

GSTA3, GSTP1, GSTO1, CYP2C9

Acenocoumarol

hsa05212

Pancreatic cancer

3.94E-02

P42338, P84022, Q13485, O75293

PIK3CB, SMAD3, SMAD4, GADD45B

Acenocoumarol

hsa05213

Endometrial cancer

3.79E-02

O15169, Q02750

AXIN1, MAP2K1

Acenocoumarol

hsa05220

Chronic myeloid leukemia

2.16E-02

Q13547, Q13485, P84022, P42338, O75293

HDAC1, SMAD4, SMAD3, PIK3CB, GADD45B

Acenocoumarol

hsa05223

Non-small cell lung cancer

4.24E-02

P19174, Q9HC35, O75293

PLCG1, EML4, GADD45B

Acenocoumarol

hsa05226

Gastric cancer

3.79E-02

Q02750, O15169

MAP2K1, AXIN1

Acenocoumarol

hsa05231

Choline metabolism in cancer

4.24E-02

Q9Y259, P19174, P49619

CHKB, PLCG1, DGKG

Acenocoumarol

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.64E-06

P19174, P07766, P20963, P09693, P06239, P42224, Q04759, Q9HC35, P01730

PLCG1, CD3E, CD247, CD3G, LCK, STAT1, PRKCQ, EML4, CD4

Acenocoumarol

hsa05322

Systemic lupus erythematosus

1.31E-04

P09871, Q93077, P62807, O60814, P68431

C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12

Acenocoumarol

hsa05332

Graft-versus-host disease

3.93E-02

P13765, P26715, Q13241

HLA-DOB, KLRC1, KLRD1

Acenocoumarol

hsa05340

Primary immunodeficiency

2.18E-04

P01730, P01732, P07766, P06239

CD4, CD8A, CD3E, LCK

Acenocoumarol

hsa05415

Diabetic cardiomyopathy

2.87E-02

P05141, O15239, P13073, Q13557

SLC25A5, NDUFA1, COX4I1, CAMK2D

Community members of Acenocoumarol (S_DC: 5.02)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

VKORC1

Vitamin K epoxide reductase complex subunit 1

Reported

0.2806

0.04

0.1697

0.39

P21462

FPR1

fMetNoneLeuNonePhe receptor

Predicted

0.1205

0.3492

0.4378

1.1964

P02768

ALB

Albumin

Predicted

0.2848

0.9111

0.0857

2.0502

Q16549

PCSK7

Proprotein convertase subtilisin/kexin type 7

Predicted

0.2746

0.0279

0.1931

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

P18054

ALOX12

Polyunsaturated fatty acid lipoxygenase ALOX12

Predicted

0.0075

0.3703

0.2416

0.986

P09917

ALOX5

Polyunsaturated fatty acid 5Nonelipoxygenase

Predicted

0.3822

0.2701

2.4612

P30304

CDC25A

MNonephase inducer phosphatase 1

Predicted

0.1795

0.2347

0.4274

0.9865

P11511

CYP19A1

Aromatase

Predicted

0.8156

0.1588

2.5666

P06239

LCK

TyrosineNoneprotein kinase Lck

Predicted

0.0576

0.7287

2.7575

Q02750

MAP2K1

Dual specificity mitogenNoneactivated protein kinase kinase 1

Predicted

0.312

0.5129

2.1819

P15121

AKR1B1

AldoNoneketo reductase family 1 member B1

Predicted

0.5683

0.629

0.214

1.7562

P08183

ABCB1

ATPNonedependent translocase ABCB1

Predicted

0.0788

0.2052

2.2446

P11712

CYP2C9

Cytochrome P450 2C9

Predicted

0.0106

0.1524

2.1577

PharmaCoNets of Acenocoumarol (SPCN: 69.27 )

Acenocoumarol regulated-network (SDN: 13.80)

Community members of Acenocoumarol (SDC: 5.02)

PharmaCoNets of Acenocoumarol (S_PCN: 69.27 )

Acenocoumarol regulated-network (S_DN: 13.80)

Community members of Acenocoumarol (S_DC: 5.02)