PharmaCoNets

PharmaCoNets of Acemetacin (S_PCN: 101.22 )

Acemetacin regulated-network (S_DN: 17.42)

Drug Name

Pathway ID

Pathway name

P-value

No. of gene members

UniProt AC

Gene name

Detail of Coexpression

Acemetacin

hsa00053

Ascorbate and aldarate metabolism

4.93E-02

P14550

AKR1A1

Acemetacin

hsa00190

Oxidative phosphorylation

3.56E-02

Q16718, Q13488, O14521

NDUFA5, TCIRG1, SDHD

Acemetacin

hsa00220

Arginine biosynthesis

1.94E-03

P15104, P05089, P49448

GLUL, ARG1, GLUD2

Acemetacin

hsa00230

Purine metabolism

1.81E-02

P20839, Q02153

IMPDH1, GUCY1B3

Acemetacin

hsa00250

Alanine, aspartate and glutamate metabolism

4.32E-02

P49448, P15104

GLUD2, GLUL

Acemetacin

hsa00260

Glycine, serine and threonine metabolism

1.99E-02

P22557

ALAS2

Acemetacin

hsa00280

Valine, leucine and isoleucine degradation

4.31E-02

P26440, Q02252

IVD, ALDH6A1

Acemetacin

hsa00480

Glutathione metabolism

3.29E-04

Q9UJ14, Q16772, P09211, P30041

GGTL3, GSTA3, GSTP1, PRDX6

Acemetacin

hsa00500

Starch and sucrose metabolism

1.42E-03

O43451, P46976, P06737

MGAM, GYG1, PYGL

Acemetacin

hsa00510

N-Glycan biosynthesis

1.00E-02

O94777, Q9BVK2

DPM2, ALG8

Acemetacin

hsa00512

Mucin type O-glycan biosynthesis

3.78E-02

O95395, Q8N4A0

GCNT3, GALNT4

Acemetacin

hsa00533

Glycosaminoglycan biosynthesis - keratan sulfate

1.91E-02

Q9NY97

B3GNT2

Acemetacin

hsa00561

Glycerolipid metabolism

3.09E-02

P14550, Q86XP1

AKR1A1, DGKH

Acemetacin

hsa00563

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis

3.47E-03

O94777, Q14442

DPM2, PIGH

Acemetacin

hsa00565

Ether lipid metabolism

1.44E-05

Q9Y6K0, Q8N661

CEPT1, TMEM86B

Acemetacin

hsa00600

Sphingolipid metabolism

4.47E-02

Q96G23, Q86VZ5

LASS2, SGMS1

Acemetacin

hsa00601

Glycosphingolipid biosynthesis - lacto and neolacto series

3.78E-02

Q9NY97

B3GNT2

Acemetacin

hsa00630

Glyoxylate and dicarboxylate metabolism

2.48E-02

P40926, P15104

MDH2, GLUL

Acemetacin

hsa00730

Thiamine metabolism

2.54E-03

P05186, P24666

ALPL, ACP1

Acemetacin

hsa00860

Porphyrin and chlorophyll metabolism

5.29E-03

P53004, P30043

BLVRA, BLVRB

Acemetacin

hsa00910

Nitrogen metabolism

4.32E-02

P15104, P49448

GLUL, GLUD2

Acemetacin

hsa00920

Sulfur metabolism

1.78E-02

Q16762

TST

Acemetacin

hsa00970

Aminoacyl-tRNA biosynthesis

3.78E-02

O95363, Q15046

FARS2, KARS

Acemetacin

hsa00980

Metabolism of xenobiotics by cytochrome P450

5.46E-03

Q16772, P09211

GSTA3, GSTP1

Acemetacin

hsa00982

Drug metabolism - cytochrome P450

1.06E-02

Q16772, P09211

GSTA3, GSTP1

Acemetacin

hsa00983

Drug metabolism - other enzymes

1.72E-02

Q16772, P09211

GSTA3, GSTP1

Acemetacin

hsa01100

Metabolic pathways

2.14E-05

Q9Y234, P35790, Q16772, P09211, Q9UJ14, P30041, Q6ZQY3, P20839, P40926, O94777, Q7KZN9, Q9Y6K0, P15121, Q86XP1, P14550, Q9UHK6, Q86VZ5, Q96G23, Q9BVK2, Q14442, Q9BQB6, Q06055, Q99437, Q9NVH6

LIPT1, CHKA, GSTA3, GSTP1, GGTL3, PRDX6, GADL1, IMPDH1, MDH2, DPM2, COX15, CEPT1, AKR1B1, DGKH, AKR1A1, AMACR, SGMS1, LASS2, ALG8, PIGH, VKORC1, ATP5G2, ATP6V0B, TMLHE

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P10145	IL8	Interleukin-8	Q9Y234	LIPT1	Lipoyltransferase 1, mitochondrial	0.766
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P35790	CHKA	Choline kinase alpha	-0.717
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q16772	GSTA3	Glutathione S-transferase A3	-0.793
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P09211	GSTP1	Glutathione S-transferase P	0.712
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UJ14	GGTL3	Glutathione hydrolase 7	0.748
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P30041	PRDX6	Peroxiredoxin-6	0.75
P10145	IL8	Interleukin-8	Q6ZQY3	GADL1	Acidic amino acid decarboxylase GADL1	0.753
P10145	IL8	Interleukin-8	P20839	IMPDH1	Inosine-5'-monophosphate dehydrogenase 1	0.764
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P40926	MDH2	Malate dehydrogenase, mitochondrial	0.81
P10145	IL8	Interleukin-8	O94777	DPM2	Dolichol phosphate-mannose biosynthesis regulatory protein	0.757
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q7KZN9	COX15	Cytochrome c oxidase assembly protein COX15 homolog	0.764
P10145	IL8	Interleukin-8	Q9Y6K0	CEPT1	Choline/ethanolaminephosphotransferase 1	0.758
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	P15121	AKR1B1	Aldo-keto reductase family 1 member B1	1
P10145	IL8	Interleukin-8	Q86XP1	DGKH	Diacylglycerol kinase eta	-0.805
P10145	IL8	Interleukin-8	P14550	AKR1A1	Aldo-keto reductase family 1 member A1	0.723
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.704
P10145	IL8	Interleukin-8	Q9UHK6	AMACR	Alpha-methylacyl-CoA racemase	-0.744
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.736
P10145	IL8	Interleukin-8	Q86VZ5	SGMS1	Phosphatidylcholine:ceramide cholinephosphotransferase 1	-0.758
P10145	IL8	Interleukin-8	Q96G23	LASS2	Ceramide synthase 2	-0.796
P10145	IL8	Interleukin-8	Q9BVK2	ALG8	Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase	-0.844
P10145	IL8	Interleukin-8	Q14442	PIGH	Phosphatidylinositol N-acetylglucosaminyltransferase subunit H	-0.752
P15121	AKR1B1	Aldo-keto reductase family 1 member B1	Q9BQB6	VKORC1	Vitamin K epoxide reductase complex subunit 1	0.731
P10145	IL8	Interleukin-8	Q06055	ATP5G2	ATP synthase F(0) complex subunit C2, mitochondrial	-0.753
P10145	IL8	Interleukin-8	Q99437	ATP6V0B	V-type proton ATPase 21 kDa proteolipid subunit c''	0.732
P10145	IL8	Interleukin-8	Q9NVH6	TMLHE	Trimethyllysine dioxygenase, mitochondrial	-0.73

Acemetacin

hsa01210

2-Oxocarboxylic acid metabolism

1.91E-02

P50213

IDH3A

Acemetacin

hsa01524

Platinum drug resistance

4.44E-02

Q16772, P09211

GSTA3, GSTP1

Acemetacin

hsa02010

ABC transporters

4.93E-02

Q8IZY2

ABCA7

Acemetacin

hsa03010

Ribosome

4.08E-06

P62753, P25398, P32969, P62906, P62829, P46776, Q07020, P18077, P61513, P36578, P27635, P62249, P23396

RPS6, RPS12, RPL9, RPL10A, RPL23, RPL27A, RPL18, RPL35A, RPL37A, RPL4, RPL10, RPS16, RPS3

Acemetacin

hsa03013

RNA transport

6.22E-05

P52298, Q09161, O14893, P61326, Q15287, Q9UBU9, Q7Z3B4, P35658, P63279, Q14152, P55884, O15371, O75822, P78345, P20042, Q9Y6A5

NCBP2, NCBP1, GEMIN2, MAGOH, RNPS1, NXF1, NUP54, NUP214, UBE2I, EIF3A, EIF3B, EIF3D, EIF3J, RPP38, EIF2S2, TACC3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P22748	CA4	Carbonic anhydrase 4	P52298	NCBP2	Nuclear cap-binding protein subunit 2	-0.879
P10415	BCL2	Apoptosis regulator Bcl-2	P52298	NCBP2	Nuclear cap-binding protein subunit 2	0.888
P10415	BCL2	Apoptosis regulator Bcl-2	Q09161	NCBP1	Nuclear cap-binding protein subunit 1	0.742
P22748	CA4	Carbonic anhydrase 4	O14893	GEMIN2	Gem-associated protein 2	-0.709
P10415	BCL2	Apoptosis regulator Bcl-2	O14893	GEMIN2	Gem-associated protein 2	0.853
P22748	CA4	Carbonic anhydrase 4	P61326	MAGOH	Protein mago nashi homolog	-0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15287	RNPS1	RNA-binding protein with serine-rich domain 1	0.756
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q9UBU9	NXF1	Nuclear RNA export factor 1	0.723
P22748	CA4	Carbonic anhydrase 4	Q7Z3B4	NUP54	Nucleoporin p54	-0.776
P10415	BCL2	Apoptosis regulator Bcl-2	Q7Z3B4	NUP54	Nucleoporin p54	0.774
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P35658	NUP214	Nuclear pore complex protein Nup214	-0.725
P22748	CA4	Carbonic anhydrase 4	P35658	NUP214	Nuclear pore complex protein Nup214	0.827
P10415	BCL2	Apoptosis regulator Bcl-2	P35658	NUP214	Nuclear pore complex protein Nup214	-0.751
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P63279	UBE2I	SUMO-conjugating enzyme UBC9	0.736
P22748	CA4	Carbonic anhydrase 4	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	-0.786
P10415	BCL2	Apoptosis regulator Bcl-2	Q14152	EIF3A	Eukaryotic translation initiation factor 3 subunit A	0.734
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P55884	EIF3B	Eukaryotic translation initiation factor 3 subunit B	-0.731
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	0.77
P22748	CA4	Carbonic anhydrase 4	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	-0.869
P10415	BCL2	Apoptosis regulator Bcl-2	O75822	EIF3J	Eukaryotic translation initiation factor 3 subunit J	0.837
P22748	CA4	Carbonic anhydrase 4	P78345	RPP38	Ribonuclease P protein subunit p38	-0.731
P10415	BCL2	Apoptosis regulator Bcl-2	P78345	RPP38	Ribonuclease P protein subunit p38	0.852
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P20042	EIF2S2	Eukaryotic translation initiation factor 2 subunit 2	0.733
P22748	CA4	Carbonic anhydrase 4	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	0.912
P10415	BCL2	Apoptosis regulator Bcl-2	Q9Y6A5	TACC3	Transforming acidic coiled-coil-containing protein 3	-0.812

Acemetacin

hsa03020

RNA polymerase

3.59E-02

P30876, P62487

POLR2B, POLR2G

Acemetacin

hsa03040

Spliceosome

8.50E-08

O43143, O60508, P17844, P08579, Q15427, P26368, P51991, P38159, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643

DHX15, CDC40, DDX5, SNRPB2, SF3B4, U2AF2, HNRPA3, RBMX, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43143	DHX15	ATP-dependent RNA helicase DHX15	-0.76
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O60508	CDC40	Pre-mRNA-processing factor 17	-0.812
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P17844	DDX5	Probable ATP-dependent RNA helicase DDX5	0.73
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08579	SNRPB2	U2 small nuclear ribonucleoprotein B''	-0.822
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q15427	SF3B4	Splicing factor 3B subunit 4	0.71
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P26368	U2AF2	Splicing factor U2AF 65 kDa subunit	-0.751
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P51991	HNRPA3	Heterogeneous nuclear ribonucleoprotein A3	0.787
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P38159	RBMX	RNA-binding motif protein, X chromosome	0.733
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.827
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P61978	HNRPK	Heterogeneous nuclear ribonucleoprotein K	0.784
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13595	TRA2A	Transformer-2 protein homolog alpha	-0.74
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q07955	SFRS1	Serine/arginine-rich splicing factor 1	-0.749
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q01130	SFRS2	Serine/arginine-rich splicing factor 2	-0.798
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84103	SFRS3	Serine/arginine-rich splicing factor 3	-0.773
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13243	SFRS5	Serine/arginine-rich splicing factor 5	-0.822
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.709
P49354	FNTA	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P11142	HSPA8	Heat shock cognate 71 kDa protein	0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P11142	HSPA8	Heat shock cognate 71 kDa protein	-0.802
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q9Y2W2	WBP11	WW domain-binding protein 11	-0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O43447	PPIH	Peptidyl-prolyl cis-trans isomerase H	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75643	ASCC3L1	U5 small nuclear ribonucleoprotein 200 kDa helicase	-0.745

Acemetacin

hsa03050

Proteasome

4.83E-02

P55036

PSMD4

Acemetacin

hsa03060

Protein export

1.43E-02

P37108, Q15005

SRP14, SPCS2

Acemetacin

hsa03450

Non-homologous end-joining

4.32E-02

Q9NP87

POLM

Acemetacin

hsa04012

ErbB signaling pathway

3.74E-02

P21860, Q13557, O14944

ERBB3, CAMK2D, EREG

Acemetacin

hsa04014

Ras signaling pathway

2.36E-02

P42338, P20827, P49767, Q13009, Q7LDG7, P63218, P50151, P19174

PIK3CB, EFNA1, VEGFC, TIAM1, RASGRP2, GNG5, GNG10, PLCG1

Acemetacin

hsa04015

Rap1 signaling pathway

1.79E-02

P20827, P49767, Q96FS4, P11215, Q13009, Q7LDG7, P42338, P19174

EFNA1, VEGFC, SIPA1, ITGAM, TIAM1, RASGRP2, PIK3CB, PLCG1

Acemetacin

hsa04020

Calcium signaling pathway

6.50E-04

Q96DU7, P45880, Q13557, P21860, P51828, P23634

ITPKC, VDAC2, CAMK2D, ERBB3, ADCY7, ATP2B4

Acemetacin

hsa04022

cGMP-PKG signaling pathway

4.72E-02

Q99941, P23634, P51828, P45880

CREBL1, ATP2B4, ADCY7, VDAC2

Acemetacin

hsa04062

Chemokine signaling pathway

9.68E-04

P25024, P25025, P09769, P07948, P42338, P19174, P63218, P50151, P43250, P49407, Q7LDG7, Q13009, P49841, Q8WYR1

CXCR1, CXCR2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ARRB1, RASGRP2, TIAM1, GSK3B, PIK3R5

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25024	CXCR1	C-X-C chemokine receptor type 1	0.909
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P25025	CXCR2	C-X-C chemokine receptor type 2	0.86
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P09769	FGR	Tyrosine-protein kinase Fgr	0.796
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07948	LYN	Tyrosine-protein kinase Lyn	0.971
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.733
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.875
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43250	GRK6	G protein-coupled receptor kinase 6	0.818
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49407	ARRB1	Beta-arrestin-1	-0.853
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13009	TIAM1	Rho guanine nucleotide exchange factor TIAM1	0.706
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752

Acemetacin

hsa04064

NF-kappa B signaling pathway

5.05E-04

P10415, O00463, P01375, Q04759, Q9UDY8, Q13077, Q16548, Q8WV28, Q13315, P24522, P09341

BCL2, TRAF5, TNF, PRKCQ, MALT1, TRAF1, BCL2A1, BLNK, ATM, GADD45A, CXCL1

Acemetacin

hsa04071

Sphingolipid signaling pathway

6.09E-07

P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, Q16539, P10415, Q9UQC2

PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, MAPK14, BCL2, GAB2

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q15722	LTB4R	Leukotriene B4 receptor 1	P17252	PRKCA	Protein kinase C alpha type	-0.757
Q15722	LTB4R	Leukotriene B4 receptor 1	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	-0.832
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21453	S1PR1	Sphingosine 1-phosphate receptor 1	0.934
P06737	PYGL	Glycogen phosphorylase, liver form	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.841
Q15722	LTB4R	Leukotriene B4 receptor 1	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.733
P22748	CA4	Carbonic anhydrase 4	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	-0.814
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9H228	EDG8	Sphingosine 1-phosphate receptor 5	0.777
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P22748	CA4	Carbonic anhydrase 4	P01375	TNF	Tumor necrosis factor	0.744
P06737	PYGL	Glycogen phosphorylase, liver form	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.716
Q15722	LTB4R	Leukotriene B4 receptor 1	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.773
P22748	CA4	Carbonic anhydrase 4	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	-0.758
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13362	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform	0.721
P06737	PYGL	Glycogen phosphorylase, liver form	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.781
Q15722	LTB4R	Leukotriene B4 receptor 1	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.884
P22748	CA4	Carbonic anhydrase 4	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	-0.88
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9BX95	SGPP1	Sphingosine-1-phosphate phosphatase 1	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
Q15722	LTB4R	Leukotriene B4 receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.721
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
Q15722	LTB4R	Leukotriene B4 receptor 1	P10415	BCL2	Apoptosis regulator Bcl-2	-0.865
P22748	CA4	Carbonic anhydrase 4	P10415	BCL2	Apoptosis regulator Bcl-2	-0.863
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10415	BCL2	Apoptosis regulator Bcl-2	0.713
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UQC2	GAB2	GRB2-associated-binding protein 2	0.822

Acemetacin

hsa04080

Neuroactive ligand-receptor interaction

9.01E-04

P08311, Q15722, P21453, Q9H228, O00398, P21462, P21730, Q16581, P07550, P35318

CTSG, LTB4R, S1PR1, EDG8, P2RY10, FPR1, C5AR1, C3AR1, ADRB2, ADM

Acemetacin

hsa04120

Ubiquitin mediated proteolysis

2.89E-02

O95071, P0CG47

UBR5, UBB

Acemetacin

hsa04122

Sulfur relay system

1.78E-02

Q16762

TST

Acemetacin

hsa04136

Autophagy - other

3.53E-02

O94817

ATG12

Acemetacin

hsa04137

Mitophagy - animal

9.52E-03

Q07817, P0CG47

BCL2L1, UBB

Acemetacin

hsa04140

Autophagy - animal

3.19E-02

P22694, Q14643, P10415, Q04759

PRKACB, ITPR1, BCL2, PRKCQ

Acemetacin

hsa04141

Protein processing in endoplasmic reticulum

7.15E-06

P18848, Q15437, Q15436, O60337, Q99941, O75460, P11142, Q9H3Z4, P07900, Q9NR31, P14625

ATF4, SEC23B, SEC23A, MARH6, CREBL1, ERN1, HSPA8, DNAJC5, HSP90AA1, SAR1A, HSP90B1

Acemetacin

hsa04145

Phagosome

1.65E-05

O75015, Q15080, P14598, Q13509, P68371, Q13488, P05164, O60603, P35443, P13765

FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, MPO, TLR2, THBS4, HLA-DOB

Acemetacin

hsa04146

Peroxisome

2.42E-02

O43933, P56589, Q9UKG9, O75521, P33121

PEX1, PEX3, CROT, ECI2, ACSL1

Acemetacin

hsa04150

mTOR signaling pathway

2.72E-02

P42338, Q9NQL2, Q13322, P49841

PIK3CB, RRAGD, GRB10, GSK3B

Acemetacin

hsa04151

PI3K-Akt signaling pathway

1.70E-04

P62753, P42338, P43657, P27348, P20827, P49767, P07900, P08238, P14625, Q8WYR1, P63218, P50151, O15335, Q16363, Q13751, P22105, P14784, Q99941, P18848, O00141, P30281

RPS6, PIK3CB, P2RY5, YWHAQ, EFNA1, VEGFC, HSP90AA1, HSP90AB1, HSP90B1, PIK3R5, GNG5, GNG10, CHAD, LAMA4, LAMB3, TNXB, IL2RB, CREBL1, ATF4, SGK, CCND3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P14625	HSP90B1	Endoplasmin	P62753	RPS6	40S ribosomal protein S6	0.738
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P62753	RPS6	40S ribosomal protein S6	0.722
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P27348	YWHAQ	14-3-3 protein theta	0.833
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P20827	EFNA1	Ephrin-A1	0.715
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P14625	HSP90B1	Endoplasmin	P14625	HSP90B1	Endoplasmin	1
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q8WYR1	PIK3R5	Phosphoinositide 3-kinase regulatory subunit 5	0.752
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O15335	CHAD	Chondroadherin	0.795
P14625	HSP90B1	Endoplasmin	Q16363	LAMA4	Laminin subunit alpha-4	0.818
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P22105	TNXB	Tenascin-X	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	Q99941	CREBL1	Cyclic AMP-dependent transcription factor ATF-6 beta	0.777
P14625	HSP90B1	Endoplasmin	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.739
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	P18848	ATF4	Cyclic AMP-dependent transcription factor ATF-4	0.783
P07900	HSP90AA1	Heat shock protein HSP 90-alpha	O00141	SGK	Serine/threonine-protein kinase Sgk1	0.709
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743

Acemetacin

hsa04210

Apoptosis

3.44E-02

Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643

ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1

Acemetacin

hsa04211

Longevity regulating pathway

2.72E-02

P51828, Q99941, P18848

ADCY7, CREBL1, ATF4

Acemetacin

hsa04217

Necroptosis

4.42E-04

P07900, P15104, P05141, P01584, P0C0S5, Q13557

HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2D

Acemetacin

hsa04261

Adrenergic signaling in cardiomyocytes

1.68E-03

P51828, Q99941, P18848, Q13557, P23634

ADCY7, CREBL1, ATF4, CAMK2D, ATP2B4

Acemetacin

hsa04330

Notch signaling pathway

2.70E-03

Q92542, P49768, P78504, P46531

NCSTN, PSEN1, JAG1, NOTCH1

Acemetacin

hsa04340

Hedgehog signaling pathway

1.05E-03

P49841, P22694, Q13635, P10415

GSK3B, PRKACB, PTCH1, BCL2

Acemetacin

hsa04360

Axon guidance

4.04E-02

P16333, P20827, O95631, P42338, P07332, P19174

NCK1, EFNA1, NTN1, PIK3CB, FES, PLCG1

Acemetacin

hsa04371

Apelin signaling pathway

1.00E-02

P63218, P50151, Q8WYR1, Q14814, Q14344, Q13485, P84022

GNG5, GNG10, PIK3R5, MEF2D, GNA13, SMAD4, SMAD3

Acemetacin

hsa04380

Osteoclast differentiation

4.71E-02

Q16539, P06239, P42338, P14778, O75015, Q8N149

MAPK14, LCK, PIK3CB, IL1R1, FCGR3B, LILRA2

Acemetacin

hsa04390

Hippo signaling pathway

4.35E-02

P63261, O15105

ACTG1, SMAD7

Acemetacin

hsa04514

Cell adhesion molecules

2.37E-02

P16109, O00501

SELP, CLDN5

Acemetacin

hsa04530

Tight junction

3.64E-03

P63261, O00501, Q92974, P24844

ACTG1, CLDN5, ARHGEF2, MYL9

Acemetacin

hsa04610

Complement and coagulation cascades

2.33E-03

P0C0L4

C4A

Acemetacin

hsa04612

Antigen processing and presentation

5.83E-03

P13765, P48382, P26715, P26717, Q13241, O43908, P01732, P01375

HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, KLRC4, CD8A, TNF

Acemetacin

hsa04613

Neutrophil extracellular trap formation

2.13E-06

P17252, O60603, P05164, P08246, Q9UM07, Q6FI13, Q15080, P20160, P08311, O75015, P21730, P21462, O43315, Q16539

PRKCA, TLR2, MPO, ELA2, PADI4, H2AC18; H2AC19, NCF4, AZU1, CTSG, FCGR3B, C5AR1, FPR1, AQP9, MAPK14

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q15722	LTB4R	Leukotriene B4 receptor 1	P17252	PRKCA	Protein kinase C alpha type	-0.757
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
Q15722	LTB4R	Leukotriene B4 receptor 1	O60603	TLR2	Toll-like receptor 2	0.942
P22748	CA4	Carbonic anhydrase 4	O60603	TLR2	Toll-like receptor 2	0.919
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O60603	TLR2	Toll-like receptor 2	-0.717
P06737	PYGL	Glycogen phosphorylase, liver form	P05164	MPO	Myeloperoxidase	0.858
Q15722	LTB4R	Leukotriene B4 receptor 1	P05164	MPO	Myeloperoxidase	0.805
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P06737	PYGL	Glycogen phosphorylase, liver form	P08246	ELA2	Neutrophil elastase	0.817
Q15722	LTB4R	Leukotriene B4 receptor 1	P08246	ELA2	Neutrophil elastase	0.846
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.813
Q15722	LTB4R	Leukotriene B4 receptor 1	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.799
P22748	CA4	Carbonic anhydrase 4	Q9UM07	PADI4	Protein-arginine deiminase type-4	0.856
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UM07	PADI4	Protein-arginine deiminase type-4	-0.819
Q15722	LTB4R	Leukotriene B4 receptor 1	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.833
P22748	CA4	Carbonic anhydrase 4	Q6FI13	H2AC18; H2AC19	Histone H2A type 2-A	0.866
P06737	PYGL	Glycogen phosphorylase, liver form	Q15080	NCF4	Neutrophil cytosol factor 4	0.836
Q15722	LTB4R	Leukotriene B4 receptor 1	Q15080	NCF4	Neutrophil cytosol factor 4	0.918
P22748	CA4	Carbonic anhydrase 4	Q15080	NCF4	Neutrophil cytosol factor 4	0.951
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q15080	NCF4	Neutrophil cytosol factor 4	-0.731
P06737	PYGL	Glycogen phosphorylase, liver form	P20160	AZU1	Azurocidin	0.781
P22748	CA4	Carbonic anhydrase 4	P20160	AZU1	Azurocidin	0.747
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20160	AZU1	Azurocidin	-0.799
P06737	PYGL	Glycogen phosphorylase, liver form	P08311	CTSG	Cathepsin G	0.829
P22748	CA4	Carbonic anhydrase 4	P08311	CTSG	Cathepsin G	0.717
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08311	CTSG	Cathepsin G	-0.811
P06737	PYGL	Glycogen phosphorylase, liver form	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.852
Q15722	LTB4R	Leukotriene B4 receptor 1	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.737
P22748	CA4	Carbonic anhydrase 4	O75015	FCGR3B	Low affinity immunoglobulin gamma Fc region receptor III-B	0.81
P06737	PYGL	Glycogen phosphorylase, liver form	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.888
Q15722	LTB4R	Leukotriene B4 receptor 1	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.875
P22748	CA4	Carbonic anhydrase 4	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	0.826
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P21730	C5AR1	C5a anaphylatoxin chemotactic receptor 1	-0.772
P06737	PYGL	Glycogen phosphorylase, liver form	P21462	FPR1	fMet-Leu-Phe receptor	0.833
Q15722	LTB4R	Leukotriene B4 receptor 1	P21462	FPR1	fMet-Leu-Phe receptor	0.888
P22748	CA4	Carbonic anhydrase 4	P21462	FPR1	fMet-Leu-Phe receptor	0.895
P06737	PYGL	Glycogen phosphorylase, liver form	O43315	AQP9	Aquaporin-9	0.897
Q15722	LTB4R	Leukotriene B4 receptor 1	O43315	AQP9	Aquaporin-9	0.79
P22748	CA4	Carbonic anhydrase 4	O43315	AQP9	Aquaporin-9	0.771
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
Q15722	LTB4R	Leukotriene B4 receptor 1	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.721
P22748	CA4	Carbonic anhydrase 4	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.767

Acemetacin

hsa04621

NOD-like receptor signaling pathway

1.78E-03

Q16539, Q14643, P10599, Q9H1Y0, P43490, O00463, P10415, Q05823, P01375, P09341, P49913, P59665, P59666, P12838

MAPK14, ITPR1, TXN, ATG5, PBEF1, TRAF5, BCL2, RNASEL, TNF, CXCL1, CAMP, DEFA1; DEFA1B, DEFA3, DEFA4

Acemetacin

hsa04650

Natural killer cell mediated cytotoxicity

1.11E-03

P01375, O60880, P20963, Q13241, P26718, O75015, P26717, P26715

TNF, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1

Acemetacin

hsa04657

IL-17 signaling pathway

1.60E-04

P07900, O00463, Q16539, P49841, P09341, P14780, Q9UJX4, P80188, P01375, P01584

HSP90AA1, TRAF5, MAPK14, GSK3B, CXCL1, MMP9, ANAPC5, LCN2, TNF, IL1B

Acemetacin

hsa04658

Th1 and Th2 cell differentiation

1.47E-07

Q04759, P07766, P20963, P09693, Q16539, P01730, P06239, Q14765, P42226, P23771, Q9UL17, P13765, Q13761

PRKCQ, CD3E, CD247, CD3G, MAPK14, CD4, LCK, STAT4, STAT6, GATA3, TBX21, HLA-DOB, RUNX3

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P06737	PYGL	Glycogen phosphorylase, liver form	Q14765	STAT4	Signal transducer and activator of transcription 4	-0.736
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q14765	STAT4	Signal transducer and activator of transcription 4	0.742
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725

Acemetacin

hsa04659

Th17 cell differentiation

4.86E-06

Q04759, Q16539, P19174, P01730, P06239, P42226, P14784, P13765, P14778, Q9UL17, P23771, P84022, Q13485, P08238, P07766, P09693, P20963

PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT6, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, SMAD3, SMAD4, HSP90AB1, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P06737	PYGL	Glycogen phosphorylase, liver form	P42226	STAT6	Signal transducer and activator of transcription 6	0.852
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P14778	IL1R1	Interleukin-1 receptor type 1	0.936
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14778	IL1R1	Interleukin-1 receptor type 1	0.764
P06737	PYGL	Glycogen phosphorylase, liver form	Q9UL17	TBX21	T-box transcription factor TBX21	-0.738
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q9UL17	TBX21	T-box transcription factor TBX21	-0.752
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UL17	TBX21	T-box transcription factor TBX21	0.735
P06737	PYGL	Glycogen phosphorylase, liver form	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	-0.753
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P23771	GATA3	Trans-acting T-cell-specific transcription factor GATA-3	0.85
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.838
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74

Acemetacin

hsa04660

T cell receptor signaling pathway

2.81E-05

P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P07766, P20963, P09693, P01730, P01732, P06239, Q16539, P49841

TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, CD3E, CD247, CD3G, CD4, CD8A, LCK, MAPK14, GSK3B

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9UDY8	MALT1	Mucosa-associated lymphoid tissue lymphoma translocation protein 1	0.723
P06737	PYGL	Glycogen phosphorylase, liver form	Q04759	PRKCQ	Protein kinase C theta type	-0.812
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q04759	PRKCQ	Protein kinase C theta type	0.776
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P10747	CD28	T-cell-specific surface glycoprotein CD28	0.794
P06737	PYGL	Glycogen phosphorylase, liver form	O95267	RASGRP1	RAS guanyl-releasing protein 1	-0.73
P06737	PYGL	Glycogen phosphorylase, liver form	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	-0.8
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q08881	ITK	Tyrosine-protein kinase ITK/TSK	0.746
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	0.74
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	0.744
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P01730	CD4	T-cell surface glycoprotein CD4	-0.84
P06737	PYGL	Glycogen phosphorylase, liver form	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	-0.72
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P01732	CD8A	T-cell surface glycoprotein CD8 alpha chain	0.92
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P06239	LCK	Tyrosine-protein kinase Lck	-0.825
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
P06737	PYGL	Glycogen phosphorylase, liver form	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.815
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P49841	GSK3B	Glycogen synthase kinase-3 beta	0.812

Acemetacin

hsa04662

B cell receptor signaling pathway

1.49E-04

P49841, P42338, P60033, P07948, P21854, Q8N149

GSK3B, PIK3CB, CD81, LYN, CD72, LILRA2

Acemetacin

hsa04664

Fc epsilon RI signaling pathway

1.14E-03

Q16539, P42338, P07948, P19174, P09917

MAPK14, PIK3CB, LYN, PLCG1, ALOX5

Acemetacin

hsa04666

Fc gamma R-mediated phagocytosis

2.42E-02

P23528, P06396, O14494, P14598, P17252

CFL1, GSN, PLPP1, NCF1, PRKCA

Acemetacin

hsa04668

TNF signaling pathway

4.74E-02

Q99941, P01584, O95429

CREBL1, IL1B, BAG4

Acemetacin

hsa04672

Intestinal immune network for IgA production

1.62E-02

P29965, P10747, P13765

CD40LG, CD28, HLA-DOB

Acemetacin

hsa04714

Thermogenesis

3.31E-02

P51828, P62753, P12074, O15239

ADCY7, RPS6, COX6A1, NDUFA1

Acemetacin

hsa04721

Synaptic vesicle cycle

3.09E-02

Q99437, P43005

ATP6V0B, SLC1A1

Acemetacin

hsa04723

Retrograde endocannabinoid signaling

1.71E-03

Q14643, P17252, P63218, P50151, P48058, P22694, Q16539, Q16718

ITPR1, PRKCA, GNG5, GNG10, GRIA4, PRKACB, MAPK14, NDUFA5

Acemetacin

hsa04724

Glutamatergic synapse

7.09E-03

P48058, P43003, P63218, P50151, P15104

GRIA4, SLC1A3, GNG5, GNG10, GLUL

Acemetacin

hsa04725

Cholinergic synapse

2.17E-02

P51828, P18848, Q13557

ADCY7, ATF4, CAMK2D

Acemetacin

hsa04728

Dopaminergic synapse

3.36E-03

P63218, P50151, P49841, Q99941, P18848, Q16539, Q13557, P49407, P48058

GNG5, GNG10, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, GRIA4

Acemetacin

hsa04744

Phototransduction

2.80E-02

P62873, P0DP23

GNB1, CALM1

Acemetacin

hsa04750

Inflammatory mediator regulation of TRP channels

3.74E-02

P01584, P51828, Q13557

IL1B, ADCY7, CAMK2D

Acemetacin

hsa04911

Insulin secretion

2.03E-05

P51828, Q99941, P18848, Q13557

ADCY7, CREBL1, ATF4, CAMK2D

Acemetacin

hsa04912

GnRH signaling pathway

6.52E-04

P17252, P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P22694

PRKCA, ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, PRKACB

Acemetacin

hsa04915

Estrogen signaling pathway

5.03E-04

Q99941, P18848, P51828, P07900, P11142

CREBL1, ATF4, ADCY7, HSP90AA1, HSPA8

Acemetacin

hsa04916

Melanogenesis

4.80E-02

P0DP23, Q9UJU2, P17252, P04628

CALM1, LEF1, PRKCA, WNT1

Acemetacin

hsa04918

Thyroid hormone synthesis

1.98E-04

P51828, Q99941, P18848, P14625, P02768

ADCY7, CREBL1, ATF4, HSP90B1, ALB

Acemetacin

hsa04922

Glucagon signaling pathway

4.23E-02

P22694, P06737, Q12778, Q14643

PRKACB, PYGL, FOXO1, ITPR1

Acemetacin

hsa04924

Renin secretion

1.04E-02

P22694, P07550, Q14643

PRKACB, ADRB2, ITPR1

Acemetacin

hsa04925

Aldosterone synthesis and secretion

2.51E-05

Q99941, P18848, P51828, Q13557, P23634

CREBL1, ATF4, ADCY7, CAMK2D, ATP2B4

Acemetacin

hsa04926

Relaxin signaling pathway

3.34E-02

Q99941, P18848, P51828

CREBL1, ATF4, ADCY7

Acemetacin

hsa04927

Cortisol synthesis and secretion

4.16E-03

Q99941, P18848, P51828

CREBL1, ATF4, ADCY7

Acemetacin

hsa04928

Parathyroid hormone synthesis, secretion and action

4.11E-04

Q14643, P51828, P22694, P23771, P17252, Q99941, P18848, P10415

ITPR1, ADCY7, PRKACB, GATA3, PRKCA, CREBL1, ATF4, BCL2

Acemetacin

hsa04932

Non-alcoholic fatty liver disease

9.70E-03

P18848, P01584, P13073, O15239

ATF4, IL1B, COX4I1, NDUFA1

Acemetacin

hsa04933

AGE-RAGE signaling pathway in diabetic complications

3.21E-02

P84022, Q13485, P42338, P49767, P19174

SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1

Acemetacin

hsa04934

Cushing syndrome

1.09E-05

Q99941, P18848, P51828, O15169, Q13557

CREBL1, ATF4, ADCY7, AXIN1, CAMK2D

Acemetacin

hsa04935

Growth hormone synthesis, secretion and action

2.72E-02

P51828, Q99941, P18848

ADCY7, CREBL1, ATF4

Acemetacin

hsa04964

Proximal tubule bicarbonate reclamation

4.93E-02

P00918

CA2

Acemetacin

hsa04966

Collecting duct acid secretion

4.93E-02

P00918

CA2

Acemetacin

hsa04971

Gastric acid secretion

1.48E-02

P51828, P15311, Q13557

ADCY7, VIL2, CAMK2D

Acemetacin

hsa04973

Carbohydrate digestion and absorption

1.57E-02

O43451, P42338

MGAM, PIK3CB

Acemetacin

hsa05010

Alzheimer disease

2.07E-02

Q92542, P05496, P12074, O75460, P01584, O15169, P45880

NCSTN, ATP5G1, COX6A1, ERN1, IL1B, AXIN1, VDAC2

Acemetacin

hsa05012

Parkinson disease

2.53E-02

O15239, P13073, P05141, P18848, Q13557

NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2D

Acemetacin

hsa05016

Huntington disease

3.21E-02

O15239, P13073, P30876, P62487, P05141

NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5

Acemetacin

hsa05020

Prion disease

2.29E-04

P13591, P01584, P46531, P11142, O15239, P05496, P13073, P12074, P18848, P05141, P45880, Q99941

NCAM1, IL1B, NOTCH1, HSPA8, NDUFA1, ATP5G1, COX4I1, COX6A1, ATF4, SLC25A5, VDAC2, CREBL1

Acemetacin

hsa05022

Pathways of neurodegeneration - multiple diseases

3.80E-02

O15239, P13073, P18848, P05141, P01584, Q13557

NDUFA1, COX4I1, ATF4, SLC25A5, IL1B, CAMK2D

Acemetacin

hsa05030

Cocaine addiction

4.87E-02

Q99941, P18848

CREBL1, ATF4

Acemetacin

hsa05031

Amphetamine addiction

6.41E-03

Q13557, Q99941, P18848

CAMK2D, CREBL1, ATF4

Acemetacin

hsa05120

Epithelial cell signaling in Helicobacter pylori infection

2.65E-03

Q16539, Q99437, P10145, P25024, P25025, P07948

MAPK14, ATP6V0B, IL8, CXCR1, CXCR2, LYN

Acemetacin

hsa05132

Salmonella infection

2.93E-02

P51617, Q9UJU2, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, Q13509, P68371

IRAK1, LEF1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C

Acemetacin

hsa05133

Pertussis

4.20E-02

P0C0L4

C4A

Acemetacin

hsa05134

Legionellosis

1.28E-02

P01584, P68104, P11142

IL1B, EEF1A1, HSPA8

Acemetacin

hsa05135

Yersinia infection

9.51E-03

P13612, P06239, Q16539, P42338, P49841, P01730

ITGA4, LCK, MAPK14, PIK3CB, GSK3B, CD4

Acemetacin

hsa05143

African trypanosomiasis

1.31E-02

P69905, P68871

HBA2, HBB

Acemetacin

hsa05144

Malaria

3.76E-03

P60033, P69905, P68871, P01375, P35443, P26718

CD81, HBA2, HBB, TNF, THBS4, KLRK1

Acemetacin

hsa05150

Staphylococcus aureus infection

2.92E-04

P21730, P21462, O75015, P13765, Q16581, P59665, P59666, P12838, P49913

C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, DEFA1; DEFA1B, DEFA3, DEFA4, CAMP

Acemetacin

hsa05152

Tuberculosis

2.24E-04

Q13488, P0DP23, O75015, P48382, O60603, P10415, P13765, P01568, Q9UDY8, Q16539, P51617

TCIRG1, CALM1, FCGR3B, RFX5, TLR2, BCL2, HLA-DOB, IFNA21, MALT1, MAPK14, IRAK1

Acemetacin

hsa05161

Hepatitis B

3.34E-02

Q99941, P18848, P27348

CREBL1, ATF4, YWHAQ

Acemetacin

hsa05162

Measles

4.02E-02

P11142, P01584, Q9NP90

HSPA8, IL1B, RAB9B

Acemetacin

hsa05163

Human cytomegalovirus infection

3.69E-03

P42338, P63218, P50151, P49841, P14778, Q13651, P25025, Q16539, O00463

PIK3CB, GNG5, GNG10, GSK3B, IL1R1, IL10RA, CXCR2, MAPK14, TRAF5

Acemetacin

hsa05169

Epstein-Barr virus infection

3.39E-03

P13765, Q13547, O00463, P16070, P10415, Q16539, P42338, P07948, Q13761, P24522, Q8WV28, P01375, O60603, P07766, P09693, P20963

HLA-DOB, HDAC1, TRAF5, CD44, BCL2, MAPK14, PIK3CB, LYN, RUNX3, GADD45A, BLNK, TNF, TLR2, CD3E, CD3G, CD247

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P06737	PYGL	Glycogen phosphorylase, liver form	P13765	HLA-DOB	HLA class II histocompatibility antigen, DO beta chain	-0.845
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13547	HDAC1	Histone deacetylase 1	-0.773
P06737	PYGL	Glycogen phosphorylase, liver form	O00463	TRAF5	TNF receptor-associated factor 5	-0.924
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	O00463	TRAF5	TNF receptor-associated factor 5	-0.719
P06737	PYGL	Glycogen phosphorylase, liver form	P16070	CD44	CD44 antigen	0.803
P06737	PYGL	Glycogen phosphorylase, liver form	P10415	BCL2	Apoptosis regulator Bcl-2	-0.766
P06737	PYGL	Glycogen phosphorylase, liver form	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.863
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q16539	MAPK14	Mitogen-activated protein kinase 14	0.817
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.751
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07948	LYN	Tyrosine-protein kinase Lyn	0.795
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	Q13761	RUNX3	Runt-related transcription factor 3	-0.725
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.724
P06737	PYGL	Glycogen phosphorylase, liver form	Q8WV28	BLNK	B-cell linker protein	-0.706
P06737	PYGL	Glycogen phosphorylase, liver form	P01375	TNF	Tumor necrosis factor	0.759
P06737	PYGL	Glycogen phosphorylase, liver form	O60603	TLR2	Toll-like receptor 2	0.836
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P07766	CD3E	T-cell surface glycoprotein CD3 epsilon chain	-0.852
P06737	PYGL	Glycogen phosphorylase, liver form	P09693	CD3G	T-cell surface glycoprotein CD3 gamma chain	-0.723
P06737	PYGL	Glycogen phosphorylase, liver form	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.728
Q9BPW9	DHRS9	Dehydrogenase/reductase SDR family member 9	P20963	CD247	T-cell surface glycoprotein CD3 zeta chain	-0.775

Acemetacin

hsa05170

Human immunodeficiency virus 1 infection

5.94E-03

P62873, P0DP23, P17252, O00463, Q14643, P01568, P51617, O60603, P23528, P10415, Q93034, Q9Y6Q5

GNB1, CALM1, PRKCA, TRAF5, ITPR1, IFNA21, IRAK1, TLR2, CFL1, BCL2, CUL5, AP1M2

Acemetacin

hsa05171

Coronavirus disease - COVID-19

3.99E-06

P01584, P23396, P62753, P25398, P62249, P62906, P36578, P32969, P27635, Q07020, P46776, P18077, P61513, P62829

IL1B, RPS3, RPS6, RPS12, RPS16, RPL10A, RPL4, RPL9, RPL10, RPL18, RPL27A, RPL35A, RPL37A, RPL23

Acemetacin

hsa05200

Pathways in cancer

9.46E-03

Q13751, P42338, P08238, P19174, P43246, P84022, Q13485, Q13547, P30281, P49767, P43657, P63218, P50151, Q14344, Q7LDG7, O75293, P14784

LAMB3, PIK3CB, HSP90AB1, PLCG1, MSH2, SMAD3, SMAD4, HDAC1, CCND3, VEGFC, P2RY5, GNG5, GNG10, GNA13, RASGRP2, GADD45B, IL2RB

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13751	LAMB3	Laminin subunit beta-3	0.844
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P42338	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0.777
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P08238	HSP90AB1	Heat shock protein HSP 90-beta	-0.823
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P19174	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	-0.766
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43246	MSH2	DNA mismatch repair protein Msh2	-0.811
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P84022	SMAD3	Mothers against decapentaplegic homolog 3	0.725
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13485	SMAD4	Mothers against decapentaplegic homolog 4	-0.746
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q13547	HDAC1	Histone deacetylase 1	-0.754
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P30281	CCND3	G1/S-specific cyclin-D3	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P49767	VEGFC	Vascular endothelial growth factor C	0.743
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P43657	P2RY5	Lysophosphatidic acid receptor 6	-0.735
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P63218	GNG5	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	0.941
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P50151	GNG10	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	0.948
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	0.87
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	Q7LDG7	RASGRP2	RAS guanyl-releasing protein 2	0.704
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	O75293	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta	0.731
P09917	ALOX5	Polyunsaturated fatty acid 5-lipoxygenase	P14784	IL2RB	Interleukin-2 receptor subunit beta	-0.835

Acemetacin

hsa05202

Transcriptional misregulation in cancer

7.55E-09

Q12778, Q15532, Q13315, P41732, P14780, P27930, P14923, Q16548, Q13489, Q13077, Q15652, O15550, P35226, P05164, P12838, P08246, Q9C0K0, P41182, P24522

FOXO1, SS18, ATM, TSPAN7, MMP9, IL1R2, JUP, BCL2A1, BIRC3, TRAF1, JMJD1C, UTX, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, GADD45A

Genes in community(ComG)	Gene name of ComG	Protein name of ComG	Co-expressed genes in pathway (PathG)	Gene name of PathG	Protein name of PathG	Coexpression
Q15722	LTB4R	Leukotriene B4 receptor 1	Q12778	FOXO1	Forkhead box protein O1	-0.769
P10415	BCL2	Apoptosis regulator Bcl-2	Q12778	FOXO1	Forkhead box protein O1	0.794
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q12778	FOXO1	Forkhead box protein O1	0.795
P06737	PYGL	Glycogen phosphorylase, liver form	Q15532	SS18	Protein SSXT	-0.772
Q15722	LTB4R	Leukotriene B4 receptor 1	Q15532	SS18	Protein SSXT	-0.803
P22748	CA4	Carbonic anhydrase 4	Q15532	SS18	Protein SSXT	-0.862
P10415	BCL2	Apoptosis regulator Bcl-2	Q15532	SS18	Protein SSXT	0.877
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q13315	ATM	Serine-protein kinase ATM	0.723
Q15722	LTB4R	Leukotriene B4 receptor 1	P41732	TSPAN7	Tetraspanin-7	0.775
P22748	CA4	Carbonic anhydrase 4	P41732	TSPAN7	Tetraspanin-7	0.706
P06737	PYGL	Glycogen phosphorylase, liver form	P14780	MMP9	Matrix metalloproteinase-9	0.917
Q15722	LTB4R	Leukotriene B4 receptor 1	P14780	MMP9	Matrix metalloproteinase-9	0.861
P22748	CA4	Carbonic anhydrase 4	P14780	MMP9	Matrix metalloproteinase-9	0.925
P10415	BCL2	Apoptosis regulator Bcl-2	P14780	MMP9	Matrix metalloproteinase-9	-0.765
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P14780	MMP9	Matrix metalloproteinase-9	-0.746
P06737	PYGL	Glycogen phosphorylase, liver form	P27930	IL1R2	Interleukin-1 receptor type 2	0.881
Q15722	LTB4R	Leukotriene B4 receptor 1	P27930	IL1R2	Interleukin-1 receptor type 2	0.734
P22748	CA4	Carbonic anhydrase 4	P27930	IL1R2	Interleukin-1 receptor type 2	0.708
P22748	CA4	Carbonic anhydrase 4	P14923	JUP	Junction plakoglobin	-0.772
P10415	BCL2	Apoptosis regulator Bcl-2	P14923	JUP	Junction plakoglobin	0.861
P06737	PYGL	Glycogen phosphorylase, liver form	Q16548	BCL2A1	Bcl-2-related protein A1	0.967
Q15722	LTB4R	Leukotriene B4 receptor 1	Q16548	BCL2A1	Bcl-2-related protein A1	0.837
P22748	CA4	Carbonic anhydrase 4	Q16548	BCL2A1	Bcl-2-related protein A1	0.833
P10415	BCL2	Apoptosis regulator Bcl-2	Q16548	BCL2A1	Bcl-2-related protein A1	-0.746
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q16548	BCL2A1	Bcl-2-related protein A1	-0.701
Q15722	LTB4R	Leukotriene B4 receptor 1	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	-0.797
P10415	BCL2	Apoptosis regulator Bcl-2	Q13489	BIRC3	Baculoviral IAP repeat-containing protein 3	0.848
P06737	PYGL	Glycogen phosphorylase, liver form	Q13077	TRAF1	TNF receptor-associated factor 1	-0.783
P22748	CA4	Carbonic anhydrase 4	Q13077	TRAF1	TNF receptor-associated factor 1	-0.718
P10415	BCL2	Apoptosis regulator Bcl-2	Q13077	TRAF1	TNF receptor-associated factor 1	0.816
P06737	PYGL	Glycogen phosphorylase, liver form	Q15652	JMJD1C	Probable JmjC domain-containing histone demethylation protein 2C	0.754
P06737	PYGL	Glycogen phosphorylase, liver form	O15550	UTX	Lysine-specific demethylase 6A	0.724
Q15722	LTB4R	Leukotriene B4 receptor 1	O15550	UTX	Lysine-specific demethylase 6A	0.789
P22748	CA4	Carbonic anhydrase 4	O15550	UTX	Lysine-specific demethylase 6A	0.714
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	O15550	UTX	Lysine-specific demethylase 6A	-0.778
P06737	PYGL	Glycogen phosphorylase, liver form	P35226	BMI1	Polycomb complex protein BMI-1	-0.73
Q15722	LTB4R	Leukotriene B4 receptor 1	P35226	BMI1	Polycomb complex protein BMI-1	-0.779
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
P10415	BCL2	Apoptosis regulator Bcl-2	P35226	BMI1	Polycomb complex protein BMI-1	0.78
P06737	PYGL	Glycogen phosphorylase, liver form	P35226	BMI1	Polycomb complex protein BMI-1	-0.73
Q15722	LTB4R	Leukotriene B4 receptor 1	P35226	BMI1	Polycomb complex protein BMI-1	-0.779
P22748	CA4	Carbonic anhydrase 4	P35226	BMI1	Polycomb complex protein BMI-1	-0.834
P10415	BCL2	Apoptosis regulator Bcl-2	P35226	BMI1	Polycomb complex protein BMI-1	0.78
P06737	PYGL	Glycogen phosphorylase, liver form	P05164	MPO	Myeloperoxidase	0.858
Q15722	LTB4R	Leukotriene B4 receptor 1	P05164	MPO	Myeloperoxidase	0.805
P22748	CA4	Carbonic anhydrase 4	P05164	MPO	Myeloperoxidase	0.826
P10415	BCL2	Apoptosis regulator Bcl-2	P05164	MPO	Myeloperoxidase	-0.81
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P05164	MPO	Myeloperoxidase	-0.866
P06737	PYGL	Glycogen phosphorylase, liver form	P12838	DEFA4	Neutrophil defensin 4	0.7
P06737	PYGL	Glycogen phosphorylase, liver form	P08246	ELA2	Neutrophil elastase	0.817
Q15722	LTB4R	Leukotriene B4 receptor 1	P08246	ELA2	Neutrophil elastase	0.846
P22748	CA4	Carbonic anhydrase 4	P08246	ELA2	Neutrophil elastase	0.921
P10415	BCL2	Apoptosis regulator Bcl-2	P08246	ELA2	Neutrophil elastase	-0.942
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P08246	ELA2	Neutrophil elastase	-0.76
P06737	PYGL	Glycogen phosphorylase, liver form	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.742
Q15722	LTB4R	Leukotriene B4 receptor 1	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	-0.808
P10415	BCL2	Apoptosis regulator Bcl-2	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.766
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	Q9C0K0	BCL11B	B-cell lymphoma/leukemia 11B	0.879
P06737	PYGL	Glycogen phosphorylase, liver form	P41182	BCL6	B-cell lymphoma 6 protein	0.847
P06737	PYGL	Glycogen phosphorylase, liver form	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.822
Q15722	LTB4R	Leukotriene B4 receptor 1	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.764
P22748	CA4	Carbonic anhydrase 4	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	0.769
P42330	AKR1C3	Aldo-keto reductase family 1 member C3	P24522	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha	-0.734

Acemetacin

hsa05203

Viral carcinogenesis

1.75E-03

Q12933, Q99941, P18848, P42229, P27348, Q15283, P61978

TRAF2, CREBL1, ATF4, STAT5A, YWHAQ, RASA2, HNRPK

Acemetacin

hsa05204

Chemical carcinogenesis

5.46E-03

Q16772, P09211

GSTA3, GSTP1

Acemetacin

hsa05205

Proteoglycans in cancer

1.09E-02

Q13009, Q12955, Q14643, O75369, P14780, P17252, O60603, P04628, Q13635, P08962

TIAM1, ANK3, ITPR1, FLNB, MMP9, PRKCA, TLR2, WNT1, PTCH1, CD63

Acemetacin

hsa05206

MicroRNAs in cancer

2.97E-03

P15311, P21860, P61978, P46531, P63279, P22105

VIL2, ERBB3, HNRPK, NOTCH1, UBE2I, TNXB

Acemetacin

hsa05212

Pancreatic cancer

3.94E-02

P42338, P84022, Q13485, O75293

PIK3CB, SMAD3, SMAD4, GADD45B

Acemetacin

hsa05215

Prostate cancer

4.48E-02

P18848, P14625

ATF4, HSP90B1

Acemetacin

hsa05217

Basal cell carcinoma

1.43E-02

Q13635, P49841, Q9UJU2, P24522

PTCH1, GSK3B, LEF1, GADD45A

Acemetacin

hsa05220

Chronic myeloid leukemia

2.16E-02

Q13547, Q13485, P84022, P42338, O75293

HDAC1, SMAD4, SMAD3, PIK3CB, GADD45B

Acemetacin

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

1.05E-03

P42338, P07766, P20963, P09693, P06239, O60603, P10747, Q04759, Q16539, P01730

PIK3CB, CD3E, CD247, CD3G, LCK, TLR2, CD28, PRKCQ, MAPK14, CD4

Acemetacin

hsa05320

Autoimmune thyroid disease

8.64E-03

P13765, P29965, P01568, P10747

HLA-DOB, CD40LG, IFNA21, CD28

Acemetacin

hsa05321

Inflammatory bowel disease

4.06E-07

O60603, P01375, P13765, Q14765, Q9UL17, P42226, P23771

TLR2, TNF, HLA-DOB, STAT4, TBX21, STAT6, GATA3

Acemetacin

hsa05323

Rheumatoid arthritis

1.60E-02

P13765, P10747, P09341, O60603

HLA-DOB, CD28, CXCL1, TLR2

Acemetacin

hsa05332

Graft-versus-host disease

1.16E-04

P13765, P10747, P26715, Q13241

HLA-DOB, CD28, KLRC1, KLRD1

Acemetacin

hsa05412

Arrhythmogenic right ventricular cardiomyopathy

4.93E-02

P54284

CACNB3

Acemetacin

hsa05415

Diabetic cardiomyopathy

2.87E-02

P05141, O15239, P13073, Q13557

SLC25A5, NDUFA1, COX4I1, CAMK2D

Community members of Acemetacin (S_DC: 5.81)

UniProtAC

Gene Name

Protein Name

Reported/
Predicted

S_PV

AKR1C3

AldoNoneketo reductase family 1 member C3

Predicted

0.4017

0.8348

0.1748

2.0453

P15121

AKR1B1

AldoNoneketo reductase family 1 member B1

Predicted

0.5683

0.629

0.214

1.7562

P09917

ALOX5

Polyunsaturated fatty acid 5Nonelipoxygenase

Predicted

0.3822

0.2701

2.4612

P10145

IL8

InterleukinNone8

Predicted

0.1967

0.1304

1.3591

P02768

ALB

Albumin

Predicted

0.2848

0.9111

0.0857

2.0502

Q9BPW9

DHRS9

Dehydrogenase/reductase SDR family member 9

Predicted

0.0454

0.0453

0.1543

0.2677

O14684

PTGES

Prostaglandin E synthase

Predicted

0.4531

0.6358

0.1565

1.6547

Q07817

BCL2L1

BclNone2Nonelike protein 1

Predicted

0.0872

0.4349

1.9134

P10415

BCL2

Apoptosis regulator BclNone2

Predicted

0.0341

0.5271

2.0714

Q15722

LTB4R

Leukotriene B4 receptor 1

Predicted

0.0677

0.2199

0.4736

P00918

CA2

Carbonic anhydrase 2

Predicted

0.1125

0.2215

2.2778

P22748

CA4

Carbonic anhydrase 4

Predicted

0.0056

0.8267

0.1609

1.8171

O15151

MDM4

Protein Mdm4

Predicted

0.1014

0.0898

0.2489

0.4791

Q07343

PDE4B

cAMPNonespecific 3',5'Nonecyclic phosphodiesterase 4B

Predicted

0.0253

0.9946

0.22

2.2219

P49354

FNTA

Protein farnesyltransferase/geranylgeranyltransferase typeNone1 subunit alpha

Predicted

0.5303

0.7588

1.7827

P06737

PYGL

Glycogen phosphorylase, liver form

Predicted

0.3733

0.2211

0.3169

0.9457

P01375

TNF

Tumor necrosis factor

Predicted

0.1865

0.551

2.1953

P10619

CTSA

Lysosomal protective protein

Predicted

0.1226

0.1531

0.1901

0.5575

P14625

HSP90B1

Endoplasmin

Predicted

0.2336

0.1497

0.5384

0.9546

P07900

HSP90AA1

Heat shock protein HSP 90Nonealpha

Predicted

0.4727

0.6064

0.741

2.1901

PharmaCoNets of Acemetacin (SPCN: 101.22 )

Acemetacin regulated-network (SDN: 17.42)

Community members of Acemetacin (SDC: 5.81)

PharmaCoNets of Acemetacin (S_PCN: 101.22 )

Acemetacin regulated-network (S_DN: 17.42)

Community members of Acemetacin (S_DC: 5.81)