PharmaCoNets of Aceclofenac (SPCN: 43.99 )

Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Aceclofenachsa00053Ascorbate and aldarate metabolism4.93E-021P14550AKR1A1More
Aceclofenachsa00480Glutathione metabolism3.29E-044Q9UJ14, Q16772, P09211, P30041GGTL3, GSTA3, GSTP1, PRDX6More
Aceclofenachsa00500Starch and sucrose metabolism1.79E-023O43451, P46976, P06737MGAM, GYG1, PYGLMore
Aceclofenachsa00510N-Glycan biosynthesis1.00E-022O94777, Q9BVK2DPM2, ALG8More
Aceclofenachsa00561Glycerolipid metabolism3.09E-022P14550, Q86XP1AKR1A1, DGKHMore
Aceclofenachsa00563Glycosylphosphatidylinositol (GPI)-anchor biosynthesis3.47E-032O94777, Q14442DPM2, PIGHMore
Aceclofenachsa00565Ether lipid metabolism1.61E-042Q9Y6K0, Q8N661CEPT1, TMEM86BMore
Aceclofenachsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Aceclofenachsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Aceclofenachsa00600Sphingolipid metabolism4.47E-022Q96G23, Q86VZ5LASS2, SGMS1More
Aceclofenachsa00730Thiamine metabolism4.66E-022P05186, P24666ALPL, ACP1More
Aceclofenachsa00770Pantothenate and CoA biosynthesis7.90E-033O95498, O95497, Q9NRN7VNN2, VNN1, AASDHPPTMore
Aceclofenachsa00970Aminoacyl-tRNA biosynthesis7.90E-033O95363, P54136, Q15046FARS2, RARS1, KARSMore
Aceclofenachsa00980Metabolism of xenobiotics by cytochrome P4509.14E-054Q16772, P78417, P09211, P11712GSTA3, GSTO1, GSTP1, CYP2C9More
Aceclofenachsa00982Drug metabolism - cytochrome P4501.77E-044P11712, Q16772, P09211, P78417CYP2C9, GSTA3, GSTP1, GSTO1More
Aceclofenachsa00983Drug metabolism - other enzymes1.92E-035P04183, P32320, P05164, Q16772, P09211TK1, CDA, MPO, GSTA3, GSTP1More
Aceclofenachsa01100Metabolic pathways2.14E-0524Q9Y234, P35790, Q16772, P09211, Q9UJ14, P30041, Q6ZQY3, P20839, P40926, O94777, Q7KZN9, Q9Y6K0, P15121, Q86XP1, P14550, Q9UHK6, Q86VZ5, Q96G23, Q9BVK2, Q14442, Q9BQB6, Q06055, Q99437, Q9NVH6LIPT1, CHKA, GSTA3, GSTP1, GGTL3, PRDX6, GADL1, IMPDH1, MDH2, DPM2, COX15, CEPT1, AKR1B1, DGKH, AKR1A1, AMACR, SGMS1, LASS2, ALG8, PIGH, VKORC1, ATP5G2, ATP6V0B, TMLHEMore
Aceclofenachsa01524Platinum drug resistance4.44E-022Q16772, P09211GSTA3, GSTP1More
Aceclofenachsa02010ABC transporters4.93E-021Q8IZY2ABCA7More
Aceclofenachsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Aceclofenachsa03020RNA polymerase3.59E-022P30876, P62487POLR2B, POLR2GMore
Aceclofenachsa04062Chemokine signaling pathway3.93E-0310P25024, P25025, P47992, Q9UBD3, P07948, P63218, P50151, P49407, Q08881, P49841CXCR1, CXCR2, XCL1, XCL2, LYN, GNG5, GNG10, ARRB1, ITK, GSK3BMore
Aceclofenachsa04064NF-kappa B signaling pathway2.30E-048P10415, O00463, Q04759, Q9UDY8, Q16548, Q13315, P24522, P09341BCL2, TRAF5, PRKCQ, MALT1, BCL2A1, ATM, GADD45A, CXCL1More
Aceclofenachsa04071Sphingolipid signaling pathway1.00E-035P21453, Q9H228, Q13362, Q9BX95, P10415S1PR1, EDG8, PPP2R5C, SGPP1, BCL2More
Aceclofenachsa04080Neuroactive ligand-receptor interaction1.05E-038P08311, Q15722, P21453, Q9H228, O00398, P21730, Q16581, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, C3AR1, ADRB2More
Aceclofenachsa04115p53 signaling pathway3.98E-025P24522, Q13315, Q53FA7, O95067, P10415GADD45A, ATM, TP53I3, CCNB2, BCL2More
Aceclofenachsa04140Autophagy - animal3.19E-024P22694, Q14643, P10415, Q04759PRKACB, ITPR1, BCL2, PRKCQMore
Aceclofenachsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Aceclofenachsa04145Phagosome4.48E-025Q15080, P05164, O60603, P35443, P13765NCF4, MPO, TLR2, THBS4, HLA-DOBMore
Aceclofenachsa04210Apoptosis3.83E-038Q13315, P10415, O76075, P24522, Q16548, P43234, P18848, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ATF4, ITPR1More
Aceclofenachsa04217Necroptosis4.42E-046P07900, P15104, P05141, P01584, P0C0S5, Q13557HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2DMore
Aceclofenachsa04330Notch signaling pathway3.09E-022P49768, P78504PSEN1, JAG1More
Aceclofenachsa04340Hedgehog signaling pathway3.09E-023P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Aceclofenachsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Aceclofenachsa04610Complement and coagulation cascades2.33E-031P0C0L4C4AMore
Aceclofenachsa04612Antigen processing and presentation3.90E-036P13765, P48382, P26715, P26717, Q13241, P01732HLA-DOB, RFX5, KLRC1, KLRC2, KLRD1, CD8AMore
Aceclofenachsa04613Neutrophil extracellular trap formation3.77E-0312O60603, P05164, P08246, Q9UM07, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, P21730TLR2, MPO, ELA2, PADI4, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, C5AR1More
Aceclofenachsa04650Natural killer cell mediated cytotoxicity1.46E-049P01375, P06239, O60880, P20963, Q13241, P26718, O75015, P26717, P26715TNF, LCK, SH2D1A, CD247, KLRD1, KLRK1, FCGR3B, KLRC2, KLRC1More
Aceclofenachsa04657IL-17 signaling pathway4.87E-022P07900, P01584HSP90AA1, IL1BMore
Aceclofenachsa04658Th1 and Th2 cell differentiation1.07E-037Q04759, P20963, P09693, Q14765, P23771, Q9UL17, P13765PRKCQ, CD247, CD3G, STAT4, GATA3, TBX21, HLA-DOBMore
Aceclofenachsa04659Th17 cell differentiation1.90E-026Q04759, P13765, Q9UL17, P23771, P09693, P20963PRKCQ, HLA-DOB, TBX21, GATA3, CD3G, CD247More
Aceclofenachsa04660T cell receptor signaling pathway8.92E-0412P01375, Q9UDY8, Q04759, P10747, Q08881, P20963, P09693, P01732, Q13191, P06239, Q16539, P49841TNF, MALT1, PRKCQ, CD28, ITK, CD247, CD3G, CD8A, CBLB, LCK, MAPK14, GSK3BMore
Aceclofenachsa04721Synaptic vesicle cycle3.09E-022Q99437, P43005ATP6V0B, SLC1A1More
Aceclofenachsa04725Cholinergic synapse4.83E-024P22694, Q14643, P18848, P10415PRKACB, ITPR1, ATF4, BCL2More
Aceclofenachsa04728Dopaminergic synapse2.82E-026P14416, P63218, P50151, P49841, Q16539, P49407DRD2, GNG5, GNG10, GSK3B, MAPK14, ARRB1More
Aceclofenachsa04915Estrogen signaling pathway2.96E-025P14780, P22694, P18848, Q14643, P10415MMP9, PRKACB, ATF4, ITPR1, BCL2More
Aceclofenachsa04918Thyroid hormone synthesis3.50E-023P22694, P18848, Q14643PRKACB, ATF4, ITPR1More
Aceclofenachsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Aceclofenachsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Aceclofenachsa04927Cortisol synthesis and secretion8.60E-033Q14643, P18848, P22694ITPR1, ATF4, PRKACBMore
Aceclofenachsa04928Parathyroid hormone synthesis, secretion and action2.33E-035Q14643, P22694, P23771, P18848, P10415ITPR1, PRKACB, GATA3, ATF4, BCL2More
Aceclofenachsa04932Non-alcoholic fatty liver disease9.70E-034P18848, P01584, P13073, O15239ATF4, IL1B, COX4I1, NDUFA1More
Aceclofenachsa04964Proximal tubule bicarbonate reclamation4.93E-021P00918CA2More
Aceclofenachsa04966Collecting duct acid secretion4.93E-021P00918CA2More
Aceclofenachsa05012Parkinson disease2.53E-025O15239, P13073, P05141, P18848, Q13557NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2DMore
Aceclofenachsa05016Huntington disease3.21E-025O15239, P13073, P30876, P62487, P05141NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5More
Aceclofenachsa05020Prion disease3.37E-037P13591, P01584, P11142, O15239, P13073, P18848, P05141NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5More
Aceclofenachsa05022Pathways of neurodegeneration - multiple diseases3.80E-026O15239, P13073, P18848, P05141, P01584, Q13557NDUFA1, COX4I1, ATF4, SLC25A5, IL1B, CAMK2DMore
Aceclofenachsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Aceclofenachsa05120Epithelial cell signaling in Helicobacter pylori infection3.09E-036Q16539, Q99437, P10145, P25024, P25025, P07948MAPK14, ATP6V0B, IL8, CXCR1, CXCR2, LYNMore
Aceclofenachsa05133Pertussis4.20E-021P0C0L4C4AMore
Aceclofenachsa05134Legionellosis1.28E-023P01584, P68104, P11142IL1B, EEF1A1, HSPA8More
Aceclofenachsa05135Yersinia infection4.65E-025P13612, P06239, Q16539, P01375, P49841ITGA4, LCK, MAPK14, TNF, GSK3BMore
Aceclofenachsa05143African trypanosomiasis1.31E-022P69905, P68871HBA2, HBBMore
Aceclofenachsa05144Malaria2.24E-036P60033, P69905, P68871, P01375, P35443, P26718CD81, HBA2, HBB, TNF, THBS4, KLRK1More
Aceclofenachsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Aceclofenachsa05163Human cytomegalovirus infection1.72E-028P01375, P63218, P50151, P49841, P14778, P25025, Q16539, O00463TNF, GNG5, GNG10, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Aceclofenachsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Aceclofenachsa05202Transcriptional misregulation in cancer1.63E-0312Q12778, Q15532, Q13315, P14780, Q15744, Q16548, O15550, P05164, P12838, P08246, Q9C0K0, P24522FOXO1, SS18, ATM, MMP9, CEBPE, BCL2A1, UTX, MPO, DEFA4, ELA2, BCL11B, GADD45AMore
Aceclofenachsa05203Viral carcinogenesis6.22E-035Q12933, P42229, Q15283, P62807, O60814TRAF2, STAT5A, RASA2, HIST1H2BC, H2BC12More
Aceclofenachsa05204Chemical carcinogenesis1.77E-044Q16772, P09211, P78417, P11712GSTA3, GSTP1, GSTO1, CYP2C9More
Aceclofenachsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer2.84E-025P20963, P09693, O60603, P10747, Q04759CD247, CD3G, TLR2, CD28, PRKCQMore
Aceclofenachsa05321Inflammatory bowel disease8.69E-056O60603, P13765, Q14765, Q9UL17, P23771, Q9HBE5TLR2, HLA-DOB, STAT4, TBX21, GATA3, IL21RMore
Aceclofenachsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Aceclofenachsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Aceclofenachsa05332Graft-versus-host disease6.43E-054P13765, P10747, P26715, Q13241HLA-DOB, CD28, KLRC1, KLRD1More
Aceclofenachsa05412Arrhythmogenic right ventricular cardiomyopathy4.93E-021P54284CACNB3More
Aceclofenachsa05415Diabetic cardiomyopathy2.87E-024P05141, O15239, P13073, Q13557SLC25A5, NDUFA1, COX4I1, CAMK2DMore
Aceclofenachsa05418Fluid shear stress and atherosclerosis3.61E-026Q16539, P10599, P14780, P01375, P14778, P27930MAPK14, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Aceclofenac (SDC: 4.25)

UniProtACGene NameProtein NameReported/
Predicted
DisGeNETSPVSdrugabilitySHiSBiNSDisG
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P10145IL8InterleukinNone8Predicted10.19670.130411.3591
P00918CA2Carbonic anhydrase 2Predicted10.112510.22152.2778
P15121AKR1B1AldoNoneketo reductase family 1 member B1Predicted10.56830.6290.2141.7562
P25024CXCR1CNoneXNoneC chemokine receptor type 1Predicted10.16560.42320.40091.33
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P05164MPOMyeloperoxidasePredicted10.20350.53680.55021.7255
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)