| Drug Name | Pathway ID | Pathway name | P-value | No. of gene members | UniProt AC | Gene name | Detail of Coexpression | |
|---|
| Acalabrutinib | hsa00020 | Citrate cycle (TCA cycle) | 3.41E-02 | 2 | P50213, O14521 | IDH3A, SDHD | More | | | Acalabrutinib | hsa00030 | Pentose phosphate pathway | 5.43E-06 | 4 | P60891, P51854, P52209, P37837 | PRPS1, TKTL1, PGD, TALDO1 | More | | | Acalabrutinib | hsa00040 | Pentose and glucuronate interconversions | 4.00E-02 | 1 | P15121 | AKR1B1 | More | | | Acalabrutinib | hsa00051 | Fructose and mannose metabolism | 3.92E-03 | 3 | P15121, P19367, P08237 | AKR1B1, HK1, PFKM | More | | | Acalabrutinib | hsa00052 | Galactose metabolism | 3.77E-04 | 5 | P06280, P08237, O43451, P15121, P19367 | GLA, PFKM, MGAM, AKR1B1, HK1 | More | | | Acalabrutinib | hsa00071 | Fatty acid degradation | 3.50E-02 | 4 | O75521, P00325, P11766, P33121 | ECI2, ADH1B, ADH5, ACSL1 | More | | | Acalabrutinib | hsa00072 | Synthesis and degradation of ketone bodies | 2.78E-02 | 1 | Q01581 | HMGCS1 | More | | | Acalabrutinib | hsa00190 | Oxidative phosphorylation | 5.31E-06 | 3 | Q16718, Q13488, O14521 | NDUFA5, TCIRG1, SDHD | More | | | Acalabrutinib | hsa00220 | Arginine biosynthesis | 6.43E-05 | 3 | P15104, P05089, P49448 | GLUL, ARG1, GLUD2 | More | | | Acalabrutinib | hsa00250 | Alanine, aspartate and glutamate metabolism | 2.42E-02 | 1 | P15104 | GLUL | More | | | Acalabrutinib | hsa00310 | Lysine degradation | 1.44E-03 | 3 | Q96KQ7, Q02809, P51648 | EHMT2, PLOD1, ALDH3A2 | More | | | Acalabrutinib | hsa00410 | beta-Alanine metabolism | 3.98E-02 | 1 | Q6ZQY3 | GADL1 | More | | | Acalabrutinib | hsa00471 | D-Glutamine and D-glutamate metabolism | 3.98E-02 | 1 | Q7Z3D6 | C14orf159 | More | | | Acalabrutinib | hsa00500 | Starch and sucrose metabolism | 6.81E-07 | 4 | O43451, P46976, P35573, P06737 | MGAM, GYG1, AGL, PYGL | More | | | Acalabrutinib | hsa00510 | N-Glycan biosynthesis | 3.15E-02 | 2 | P15907, Q9NR34 | ST6GAL1, MAN1C1 | More | | | Acalabrutinib | hsa00512 | Mucin type O-glycan biosynthesis | 3.78E-02 | 2 | O95395, Q8N4A0 | GCNT3, GALNT4 | More | | | Acalabrutinib | hsa00513 | Various types of N-glycan biosynthesis | 4.83E-02 | 1 | Q9NR34 | MAN1C1 | More | | | Acalabrutinib | hsa00520 | Amino sugar and nucleotide sugar metabolism | 4.15E-05 | 3 | Q16222, Q9Y223, P06865 | UAP1, GNE, HEXA | More | | | Acalabrutinib | hsa00564 | Glycerophospholipid metabolism | 3.56E-02 | 3 | P48651, Q9Y6K0, P35790 | PTDSS1, CEPT1, CHKA | More | | | Acalabrutinib | hsa00590 | Arachidonic acid metabolism | 3.85E-02 | 2 | P11712, P09960 | CYP2C9, LTA4H | More | | | Acalabrutinib | hsa00591 | Linoleic acid metabolism | 4.07E-02 | 1 | P11712 | CYP2C9 | More | | | Acalabrutinib | hsa00600 | Sphingolipid metabolism | 2.67E-04 | 4 | Q9BX95, Q8TCT0, Q06136, P15289 | SGPP1, CERK, FVT1, ARSA | More | | | Acalabrutinib | hsa00603 | Glycosphingolipid biosynthesis - globo and isoglobo series | 6.13E-05 | 2 | P06865, O75752 | HEXA, B3GALNT1 | More | | | Acalabrutinib | hsa00604 | Glycosphingolipid biosynthesis - ganglio series | 2.46E-02 | 2 | P06865, Q9H4F1 | HEXA, ST6GALNAC4 | More | | | Acalabrutinib | hsa00630 | Glyoxylate and dicarboxylate metabolism | 3.96E-09 | 4 | P40925, P40926, P05166, P15104 | MDH1, MDH2, PCCB, GLUL | More | | | Acalabrutinib | hsa00670 | One carbon pool by folate | 4.72E-04 | 3 | O95954, P04818, Q99707 | FTCD, TYMS, MTR | More | | | Acalabrutinib | hsa00730 | Thiamine metabolism | 1.55E-03 | 2 | P05186, P24666 | ALPL, ACP1 | More | | | Acalabrutinib | hsa00750 | Vitamin B6 metabolism | 4.45E-02 | 1 | O00764 | PDXK | More | | | Acalabrutinib | hsa00770 | Pantothenate and CoA biosynthesis | 1.19E-03 | 3 | O95498, Q6ZQY3, Q9NRN7 | VNN2, GADL1, AASDHPPT | More | | | Acalabrutinib | hsa00785 | Lipoic acid metabolism | 4.32E-02 | 1 | Q9Y234 | LIPT1 | More | | | Acalabrutinib | hsa00790 | Folate biosynthesis | 2.02E-02 | 1 | P15121 | AKR1B1 | More | | | Acalabrutinib | hsa00830 | Retinol metabolism | 2.27E-03 | 5 | P00325, P11766, P00352, Q9BPW9, O75911 | ADH1B, ADH5, ALDH1A1, DHRS9, DHRS3 | More | | | Acalabrutinib | hsa00860 | Porphyrin and chlorophyll metabolism | 5.86E-04 | 2 | P36551, P30043 | CPOX, BLVRB | More | | | Acalabrutinib | hsa00900 | Terpenoid backbone biosynthesis | 9.84E-04 | 3 | Q01581, P49354, Q9UHG3 | HMGCS1, FNTA, PCYOX1 | More | | | Acalabrutinib | hsa00910 | Nitrogen metabolism | 2.42E-02 | 1 | P15104 | GLUL | More | | | Acalabrutinib | hsa00970 | Aminoacyl-tRNA biosynthesis | 2.24E-03 | 3 | O95363, P14868, Q15046 | FARS2, DARS, KARS | More | | | Acalabrutinib | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 6.38E-04 | 3 | P78417, P09211, P11712 | GSTO1, GSTP1, CYP2C9 | More | | | Acalabrutinib | hsa00982 | Drug metabolism - cytochrome P450 | 9.14E-03 | 2 | P11712, P78417 | CYP2C9, GSTO1 | More | | | Acalabrutinib | hsa00983 | Drug metabolism - other enzymes | 9.66E-04 | 4 | P04183, P20839, P32320, P05164 | TK1, IMPDH1, CDA, MPO | More | | | Acalabrutinib | hsa01040 | Biosynthesis of unsaturated fatty acids | 2.60E-03 | 2 | P22307, Q9H5J4 | SCP2, ELOVL6 | More | | | Acalabrutinib | hsa01100 | Metabolic pathways | 2.92E-03 | 39 | Q9NR34, Q9Y234, P35790, P05089, Q16772, P30041, P19367, P48426, P22557, P32320, P20839, P22748, P55809, P06280, Q16875, O43286, O43451, Q9Y6K0, P05186, P24666, P15121, P08237, O95861, Q9HCC0, P33121, Q86VZ5, P48651, P57054, Q9UNP4, Q9BX95, P32321, Q9BPW9, O75911, Q9UHY7, P43490, P46976, P06737, Q969G6, P14927 | MAN1C1, LIPT1, CHKA, ARG1, GSTA3, PRDX6, HK1, PIP4K2A, ALAS2, CDA, IMPDH1, CA4, OXCT1, GLA, PFKFB3, B4GALT5, MGAM, CEPT1, ALPL, ACP1, AKR1B1, PFKM, BPNT1, MCCC2, ACSL1, SGMS1, PTDSS1, PIGP, ST3GAL5, SGPP1, DCTD, DHRS9, DHRS3, ENOPH1, PBEF1, GYG1, PYGL, RFK, UQCRB | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9NR34 | MAN1C1 | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC | -0.716 | | P19784 | CSNK2A2 | Casein kinase II subunit alpha' | Q9Y234 | LIPT1 | Lipoyltransferase 1, mitochondrial | 0.829 | | P19784 | CSNK2A2 | Casein kinase II subunit alpha' | P35790 | CHKA | Choline kinase alpha | -0.778 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P05089 | ARG1 | Arginase-1 | 0.702 | | P19784 | CSNK2A2 | Casein kinase II subunit alpha' | Q16772 | GSTA3 | Glutathione S-transferase A3 | -0.791 | | P19784 | CSNK2A2 | Casein kinase II subunit alpha' | P30041 | PRDX6 | Peroxiredoxin-6 | 0.893 | | P19784 | CSNK2A2 | Casein kinase II subunit alpha' | P19367 | HK1 | Hexokinase-1 | 0.777 | | P19784 | CSNK2A2 | Casein kinase II subunit alpha' | P48426 | PIP4K2A | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | 0.745 | | P19784 | CSNK2A2 | Casein kinase II subunit alpha' | P22557 | ALAS2 | 5-aminolevulinate synthase, erythroid-specific, mitochondrial | 0.707 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P32320 | CDA | Cytidine deaminase | 0.701 | | P19784 | CSNK2A2 | Casein kinase II subunit alpha' | P20839 | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | 0.828 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P22748 | CA4 | Carbonic anhydrase 4 | 0.767 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P55809 | OXCT1 | Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial | -0.746 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P06280 | GLA | Alpha-galactosidase A | 0.714 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16875 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 0.849 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O43286 | B4GALT5 | Beta-1,4-galactosyltransferase 5 | 0.917 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O43451 | MGAM | Maltase-glucoamylase | 0.871 | | P19784 | CSNK2A2 | Casein kinase II subunit alpha' | Q9Y6K0 | CEPT1 | Choline/ethanolaminephosphotransferase 1 | 0.802 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P05186 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | 0.901 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P24666 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | -0.832 | | P19784 | CSNK2A2 | Casein kinase II subunit alpha' | P15121 | AKR1B1 | Aldo-keto reductase family 1 member B1 | 0.732 | | P19784 | CSNK2A2 | Casein kinase II subunit alpha' | P08237 | PFKM | ATP-dependent 6-phosphofructokinase, muscle type | 0.82 | | P19784 | CSNK2A2 | Casein kinase II subunit alpha' | O95861 | BPNT1 | 3'(2'),5'-bisphosphate nucleotidase 1 | -0.702 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9HCC0 | MCCC2 | Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial | -0.782 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P33121 | ACSL1 | Long-chain-fatty-acid--CoA ligase 1 | 0.886 | | P19784 | CSNK2A2 | Casein kinase II subunit alpha' | Q86VZ5 | SGMS1 | Phosphatidylcholine:ceramide cholinephosphotransferase 1 | -0.795 | | P19784 | CSNK2A2 | Casein kinase II subunit alpha' | P48651 | PTDSS1 | Phosphatidylserine synthase 1 | 0.802 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P57054 | PIGP | Phosphatidylinositol N-acetylglucosaminyltransferase subunit P | -0.881 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9UNP4 | ST3GAL5 | Lactosylceramide alpha-2,3-sialyltransferase | -0.819 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9BX95 | SGPP1 | Sphingosine-1-phosphate phosphatase 1 | -0.743 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P32321 | DCTD | Deoxycytidylate deaminase | -0.748 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9BPW9 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | 0.817 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O75911 | DHRS3 | Short-chain dehydrogenase/reductase 3 | -0.81 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q9UHY7 | ENOPH1 | Enolase-phosphatase E1 | -0.737 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | 0.883 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P46976 | GYG1 | Glycogenin-1 | 0.817 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P06737 | PYGL | Glycogen phosphorylase, liver form | 0.863 | | P19784 | CSNK2A2 | Casein kinase II subunit alpha' | Q969G6 | RFK | Riboflavin kinase | 0.797 | | P19784 | CSNK2A2 | Casein kinase II subunit alpha' | P14927 | UQCRB | Cytochrome b-c1 complex subunit 7 | 0.721 |
| | Acalabrutinib | hsa01230 | Biosynthesis of amino acids | 1.87E-05 | 7 | P51854, P60891, Q99707, P50213, P05089, P15104, P37837 | TKTL1, PRPS1, MTR, IDH3A, ARG1, GLUL, TALDO1 | More | | | Acalabrutinib | hsa01240 | Biosynthesis of cofactors | 4.06E-03 | 5 | Q969G6, P13716, P22557, P14618, Q9Y234 | RFK, ALAD, ALAS2, PKM2, LIPT1 | More | | | Acalabrutinib | hsa01521 | EGFR tyrosine kinase inhibitor resistance | 3.45E-04 | 4 | P49841, P04049, P08069, Q9NRA1 | GSK3B, RAF1, IGF1R, PDGFC | More | | | Acalabrutinib | hsa01522 | Endocrine resistance | 1.47E-04 | 9 | P14780, P22694, P04049, Q02750, Q9UM47, P46527, P08069, P10415, Q13323 | MMP9, PRKACB, RAF1, MAP2K1, NOTCH3, CDKN1B, IGF1R, BCL2, BIK | More | | | Acalabrutinib | hsa01523 | Antifolate resistance | 1.68E-02 | 2 | Q92820, P04818 | GGH, TYMS | More | | | Acalabrutinib | hsa01524 | Platinum drug resistance | 4.94E-02 | 2 | P78417, P52701 | GSTO1, MSH6 | More | | | Acalabrutinib | hsa02010 | ABC transporters | 1.98E-03 | 3 | P45844, P08183, Q8IZY2 | ABCG1, ABCB1, ABCA7 | More | | | Acalabrutinib | hsa03008 | Ribosome biogenesis in eukaryotes | 1.88E-02 | 3 | O14980, O60832, Q9BVP2 | XPO1, DKC1, GNL3 | More | | | Acalabrutinib | hsa03010 | Ribosome | 2.25E-04 | 5 | P40429, Q07020, P27635, P05386, P62249 | RPL13A, RPL18, RPL10, RPLP1, RPS16 | More | | | Acalabrutinib | hsa03013 | RNA transport | 1.31E-09 | 23 | P62826, O14980, P52298, O14893, P61326, Q15287, Q9UBU9, Q9H307, Q7Z3B4, P35658, P63279, P68104, O14602, Q14152, P55884, P78345, Q9H777, Q14240, Q9BZI7, P23588, Q9Y6A5, Q06787, P51114 | RAN, XPO1, NCBP2, GEMIN2, MAGOH, RNPS1, NXF1, PNN, NUP54, NUP214, UBE2I, EEF1A1, EIF1AY, EIF3A, EIF3B, RPP38, ELAC1, EIF4A2, UPF3B, EIF4B, TACC3, FMR1, FXR1 | More | | | Acalabrutinib | hsa03020 | RNA polymerase | 2.49E-05 | 5 | P30876, P24928, P62487, Q9GZM3, P52435 | POLR2B, POLR2A, POLR2G, POLR2J2, POLR2J | More | | | Acalabrutinib | hsa03022 | Basal transcription factors | 2.68E-04 | 3 | O00268, Q5H9L4, Q15544 | TAF4, TAF7L, TAF11 | More | | | Acalabrutinib | hsa03040 | Spliceosome | 9.63E-13 | 18 | Q14562, O43143, O60508, P17844, P08579, P26368, P52298, P51991, P61978, Q13595, Q07955, Q01130, P84103, Q13243, P11142, Q9Y2W2, O43447, O75643 | DHX8, DHX15, CDC40, DDX5, SNRPB2, U2AF2, NCBP2, HNRPA3, HNRPK, TRA2A, SFRS1, SFRS2, SFRS3, SFRS5, HSPA8, WBP11, PPIH, ASCC3L1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | -0.708 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | 0.781 | | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | Q14562 | DHX8 | ATP-dependent RNA helicase DHX8 | -0.75 | | P29375 | JARID1A | Lysine-specific demethylase 5A | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | 0.794 | | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | -0.841 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O43143 | DHX15 | ATP-dependent RNA helicase DHX15 | -0.76 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | O60508 | CDC40 | Pre-mRNA-processing factor 17 | -0.837 | | P07948 | LYN | Tyrosine-protein kinase Lyn | O60508 | CDC40 | Pre-mRNA-processing factor 17 | -0.814 | | P29375 | JARID1A | Lysine-specific demethylase 5A | O60508 | CDC40 | Pre-mRNA-processing factor 17 | 0.875 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O60508 | CDC40 | Pre-mRNA-processing factor 17 | -0.812 | | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P17844 | DDX5 | Probable ATP-dependent RNA helicase DDX5 | 0.73 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | -0.702 | | P07948 | LYN | Tyrosine-protein kinase Lyn | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | -0.739 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08579 | SNRPB2 | U2 small nuclear ribonucleoprotein B'' | -0.822 | | P07948 | LYN | Tyrosine-protein kinase Lyn | P26368 | U2AF2 | Splicing factor U2AF 65 kDa subunit | -0.775 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P26368 | U2AF2 | Splicing factor U2AF 65 kDa subunit | -0.751 | | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | P52298 | NCBP2 | Nuclear cap-binding protein subunit 2 | 0.72 | | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P51991 | HNRPA3 | Heterogeneous nuclear ribonucleoprotein A3 | 0.787 | | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P61978 | HNRPK | Heterogeneous nuclear ribonucleoprotein K | 0.827 | | P07948 | LYN | Tyrosine-protein kinase Lyn | Q13595 | TRA2A | Transformer-2 protein homolog alpha | -0.742 | | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | Q13595 | TRA2A | Transformer-2 protein homolog alpha | -0.722 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13595 | TRA2A | Transformer-2 protein homolog alpha | -0.74 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | 0.725 | | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | -0.757 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q07955 | SFRS1 | Serine/arginine-rich splicing factor 1 | -0.749 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.835 | | P07948 | LYN | Tyrosine-protein kinase Lyn | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.716 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | 0.862 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q01130 | SFRS2 | Serine/arginine-rich splicing factor 2 | -0.798 | | P07948 | LYN | Tyrosine-protein kinase Lyn | P84103 | SFRS3 | Serine/arginine-rich splicing factor 3 | -0.79 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84103 | SFRS3 | Serine/arginine-rich splicing factor 3 | -0.773 | | P07948 | LYN | Tyrosine-protein kinase Lyn | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | -0.781 | | P29375 | JARID1A | Lysine-specific demethylase 5A | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | 0.732 | | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | -0.71 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13243 | SFRS5 | Serine/arginine-rich splicing factor 5 | -0.822 | | P07948 | LYN | Tyrosine-protein kinase Lyn | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | -0.732 | | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 0.709 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | -0.802 | | P07948 | LYN | Tyrosine-protein kinase Lyn | Q9Y2W2 | WBP11 | WW domain-binding protein 11 | -0.734 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q9Y2W2 | WBP11 | WW domain-binding protein 11 | -0.743 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | O43447 | PPIH | Peptidyl-prolyl cis-trans isomerase H | -0.761 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O43447 | PPIH | Peptidyl-prolyl cis-trans isomerase H | -0.766 | | P07948 | LYN | Tyrosine-protein kinase Lyn | O75643 | ASCC3L1 | U5 small nuclear ribonucleoprotein 200 kDa helicase | -0.742 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O75643 | ASCC3L1 | U5 small nuclear ribonucleoprotein 200 kDa helicase | -0.745 |
| | Acalabrutinib | hsa03050 | Proteasome | 1.53E-03 | 1 | P55036 | PSMD4 | More | | | Acalabrutinib | hsa03060 | Protein export | 4.42E-02 | 2 | P37108, Q15005 | SRP14, SPCS2 | More | | | Acalabrutinib | hsa03320 | PPAR signaling pathway | 4.33E-02 | 2 | Q6PCB7, Q9UNU6 | SLC27A1, CYP8B1 | More | | | Acalabrutinib | hsa03430 | Mismatch repair | 4.38E-02 | 1 | P20585 | MSH3 | More | | | Acalabrutinib | hsa03450 | Non-homologous end-joining | 1.58E-04 | 3 | Q9NP87, P78527, P13010 | POLM, PRKDC, XRCC5 | More | | | Acalabrutinib | hsa03460 | Fanconi anemia pathway | 1.75E-02 | 3 | P40692, O60673, Q9UNA4 | MLH1, REV3L, POLI | More | | | Acalabrutinib | hsa04010 | MAPK signaling pathway | 1.69E-03 | 2 | P04049, P08069 | RAF1, IGF1R | More | | | Acalabrutinib | hsa04012 | ErbB signaling pathway | 6.63E-03 | 4 | P16333, P19174, P01106, P04049 | NCK1, PLCG1, MYC, RAF1 | More | | | Acalabrutinib | hsa04014 | Ras signaling pathway | 6.27E-04 | 16 | Q02750, P04049, P42338, P20827, Q15389, P49767, P08069, Q13009, P17252, Q7LDG7, P21359, P62879, P63218, P50151, P19174, P22694 | MAP2K1, RAF1, PIK3CB, EFNA1, ANGPT1, VEGFC, IGF1R, TIAM1, PRKCA, RASGRP2, NF1, GNB2, GNG5, GNG10, PLCG1, PRKACB | More | | | Acalabrutinib | hsa04015 | Rap1 signaling pathway | 2.05E-04 | 12 | P04049, P20827, P49767, P08069, P06213, Q96FS4, P11215, Q13009, O00522, Q7LDG7, P42338, P19174 | RAF1, EFNA1, VEGFC, IGF1R, INSR, SIPA1, ITGAM, TIAM1, KRIT1, RASGRP2, PIK3CB, PLCG1 | More | | | Acalabrutinib | hsa04020 | Calcium signaling pathway | 7.07E-04 | 9 | Q96DU7, Q08828, P21796, Q13557, P21860, P30679, P0DP24, P05141, P23634 | ITPKC, ADCY1, VDAC1, CAMK2D, ERBB3, GNA15, CALM2, SLC25A5, ATP2B4 | More | | | Acalabrutinib | hsa04022 | cGMP-PKG signaling pathway | 1.13E-02 | 7 | Q02153, P04049, Q99941, P18848, Q08828, P05141, P0DP24 | GUCY1B3, RAF1, CREBL1, ATF4, ADCY1, SLC25A5, CALM2 | More | | | Acalabrutinib | hsa04024 | cAMP signaling pathway | 1.02E-02 | 5 | P42338, P0DP23, P04049, Q13370, Q13009 | PIK3CB, CALM1, RAF1, PDE3B, TIAM1 | More | | | Acalabrutinib | hsa04060 | Cytokine-cytokine receptor interaction | 5.34E-03 | 11 | P14784, P27930, P14778, P26842, Q06643, Q13651, P25024, Q9UBD3, P47992, P09341, P01730 | IL2RB, IL1R2, IL1R1, CD27, LTB, IL10RA, CXCR1, XCL2, XCL1, CXCL1, CD4 | More | | | Acalabrutinib | hsa04061 | Viral protein interaction with cytokine and cytokine receptor | 1.70E-03 | 8 | P09341, P19875, P25024, P25025, P47992, Q9UBD3, Q13651, P14784 | CXCL1, CXCL2, CXCR1, CXCR2, XCL1, XCL2, IL10RA, IL2RB | More | | | Acalabrutinib | hsa04062 | Chemokine signaling pathway | 7.01E-06 | 18 | P25024, P25025, P09341, P19875, P47992, Q9UBD3, P09769, P07948, P42338, P19174, P63218, P50151, P43250, Q08881, Q7LDG7, Q13009, P04049, Q8WYR1 | CXCR1, CXCR2, CXCL1, CXCL2, XCL1, XCL2, FGR, LYN, PIK3CB, PLCG1, GNG5, GNG10, GRK6, ITK, RASGRP2, TIAM1, RAF1, PIK3R5 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P06239 | LCK | Tyrosine-protein kinase Lck | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | -0.779 | | Q13547 | HDAC1 | Histone deacetylase 1 | P25024 | CXCR1 | C-X-C chemokine receptor type 1 | -0.803 | | Q13547 | HDAC1 | Histone deacetylase 1 | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | -0.719 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09341 | CXCL1 | Growth-regulated alpha protein | -0.805 | | Q13547 | HDAC1 | Histone deacetylase 1 | P09341 | CXCL1 | Growth-regulated alpha protein | -0.736 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.862 | | P06239 | LCK | Tyrosine-protein kinase Lck | P47992 | XCL1 | Lymphotactin | 0.715 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q9UBD3 | XCL2 | Cytokine SCM-1 beta | 0.715 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P09769 | FGR | Tyrosine-protein kinase Fgr | 0.796 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.701 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P07948 | LYN | Tyrosine-protein kinase Lyn | 0.971 | | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | | P06239 | LCK | Tyrosine-protein kinase Lck | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.728 | | Q13547 | HDAC1 | Histone deacetylase 1 | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.864 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | | P06239 | LCK | Tyrosine-protein kinase Lck | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.71 | | Q13547 | HDAC1 | Histone deacetylase 1 | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | -0.716 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | | P06239 | LCK | Tyrosine-protein kinase Lck | P43250 | GRK6 | G protein-coupled receptor kinase 6 | -0.702 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43250 | GRK6 | G protein-coupled receptor kinase 6 | 0.818 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.774 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13009 | TIAM1 | Rho guanine nucleotide exchange factor TIAM1 | 0.706 | | P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | 1 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q8WYR1 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | 0.752 |
| | Acalabrutinib | hsa04064 | NF-kappa B signaling pathway | 1.47E-14 | 24 | P10415, Q13489, P51617, O00463, Q13546, P14778, P01584, P01375, P19174, Q04759, Q9UDY8, Q13077, Q16548, P07948, P06239, Q8WV28, Q13315, P63279, P24522, Q8NHW4, P09341, P19875, Q06643, Q9NQC7 | BCL2, BIRC3, IRAK1, TRAF5, RIPK1, IL1R1, IL1B, TNF, PLCG1, PRKCQ, MALT1, TRAF1, BCL2A1, LYN, LCK, BLNK, ATM, UBE2I, GADD45A, CCL4L2, CXCL1, CXCL2, LTB, CYLD | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P42681 | TXK | Tyrosine-protein kinase TXK | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.716 | | Q07912 | TNK2 | Activated CDC42 kinase 1 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.7 | | P22894 | MMP8 | Neutrophil collagenase | P10415 | BCL2 | Apoptosis regulator Bcl-2 | -0.959 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.744 | | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.807 | | P22894 | MMP8 | Neutrophil collagenase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.765 | | P22894 | MMP8 | Neutrophil collagenase | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | -0.744 | | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | 1 | | P42681 | TXK | Tyrosine-protein kinase TXK | O00463 | TRAF5 | TNF receptor-associated factor 5 | 0.827 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.932 | | P22894 | MMP8 | Neutrophil collagenase | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.867 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.837 | | P06239 | LCK | Tyrosine-protein kinase Lck | O00463 | TRAF5 | TNF receptor-associated factor 5 | 0.718 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | O00463 | TRAF5 | TNF receptor-associated factor 5 | 0.945 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.735 | | Q07912 | TNK2 | Activated CDC42 kinase 1 | Q13546 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | 0.702 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.782 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.854 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P01584 | IL1B | Interleukin-1 beta | 0.799 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | | P22894 | MMP8 | Neutrophil collagenase | P01375 | TNF | Tumor necrosis factor | 0.728 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P01375 | TNF | Tumor necrosis factor | -0.79 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P42681 | TXK | Tyrosine-protein kinase TXK | Q04759 | PRKCQ | Protein kinase C theta type | 0.876 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | | P22894 | MMP8 | Neutrophil collagenase | Q04759 | PRKCQ | Protein kinase C theta type | -0.756 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q04759 | PRKCQ | Protein kinase C theta type | 0.803 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | Q04759 | PRKCQ | Protein kinase C theta type | -0.737 | | Q07912 | TNK2 | Activated CDC42 kinase 1 | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | -0.801 | | P22894 | MMP8 | Neutrophil collagenase | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | -0.891 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 0.721 | | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 0.741 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.796 | | P22894 | MMP8 | Neutrophil collagenase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.806 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.73 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q13077 | TRAF1 | TNF receptor-associated factor 1 | 0.83 | | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | 0.801 | | P42681 | TXK | Tyrosine-protein kinase TXK | Q16548 | BCL2A1 | Bcl-2-related protein A1 | -0.756 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.958 | | P22894 | MMP8 | Neutrophil collagenase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.843 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.875 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q16548 | BCL2A1 | Bcl-2-related protein A1 | -0.877 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.742 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.701 | | P42681 | TXK | Tyrosine-protein kinase TXK | P06239 | LCK | Tyrosine-protein kinase Lck | 0.734 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P06239 | LCK | Tyrosine-protein kinase Lck | 0.774 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P06239 | LCK | Tyrosine-protein kinase Lck | -0.791 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q8WV28 | BLNK | B-cell linker protein | -0.704 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q8WV28 | BLNK | B-cell linker protein | -0.816 | | Q07912 | TNK2 | Activated CDC42 kinase 1 | Q13315 | ATM | Serine-protein kinase ATM | -0.755 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q13315 | ATM | Serine-protein kinase ATM | 0.752 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P63279 | UBE2I | SUMO-conjugating enzyme UBC9 | 0.756 | | P42681 | TXK | Tyrosine-protein kinase TXK | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.79 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.819 | | P22894 | MMP8 | Neutrophil collagenase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.766 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.796 | | P06239 | LCK | Tyrosine-protein kinase Lck | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.724 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.75 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.758 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | | P42681 | TXK | Tyrosine-protein kinase TXK | P09341 | CXCL1 | Growth-regulated alpha protein | -0.881 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09341 | CXCL1 | Growth-regulated alpha protein | 0.788 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.7 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09341 | CXCL1 | Growth-regulated alpha protein | -0.805 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P09341 | CXCL1 | Growth-regulated alpha protein | -0.802 | | Q13547 | HDAC1 | Histone deacetylase 1 | P09341 | CXCL1 | Growth-regulated alpha protein | -0.736 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P09341 | CXCL1 | Growth-regulated alpha protein | 0.78 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.862 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q06643 | LTB | Lymphotoxin-beta | 0.846 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q06643 | LTB | Lymphotoxin-beta | 0.74 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.799 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q9NQC7 | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD | 0.825 |
| | Acalabrutinib | hsa04066 | HIF-1 signaling pathway | 1.49E-02 | 5 | P08069, P17252, Q15389, Q02750, P46527 | IGF1R, PRKCA, ANGPT1, MAP2K1, CDKN1B | More | | | Acalabrutinib | hsa04068 | FoxO signaling pathway | 3.80E-04 | 2 | P04049, P08069 | RAF1, IGF1R | More | | | Acalabrutinib | hsa04070 | Phosphatidylinositol signaling system | 3.94E-04 | 8 | P0DP23, Q14643, P42338, P23743, Q86XP1, P27987, Q96DU7, P17252 | CALM1, ITPR1, PIK3CB, DGKA, DGKH, ITPKB, ITPKC, PRKCA | More | | | Acalabrutinib | hsa04071 | Sphingolipid signaling pathway | 3.50E-05 | 8 | P04049, P17252, P21453, Q9H228, P01375, Q13362, Q9BX95, P10415 | RAF1, PRKCA, S1PR1, EDG8, TNF, PPP2R5C, SGPP1, BCL2 | More | | | Acalabrutinib | hsa04072 | Phospholipase D signaling pathway | 2.31E-02 | 6 | P04049, P42338, P43657, P25024, P25025, P19174 | RAF1, PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1 | More | | | Acalabrutinib | hsa04080 | Neuroactive ligand-receptor interaction | 1.15E-03 | 11 | P08311, Q15722, P21453, Q9H228, O00398, P25116, Q01726, P41968, P21462, P21730, Q16581 | CTSG, LTB4R, S1PR1, EDG8, P2RY10, F2R, MC1R, MC3R, FPR1, C5AR1, C3AR1 | More | | | Acalabrutinib | hsa04110 | Cell cycle | 3.67E-06 | 9 | Q9UBD5, P06493, O60566, P78527, Q14683, P30304, P33981, P42773, P01106 | ORC3, CDK1, BUB1B, PRKDC, SMC1A, CDC25A, TTK, CDKN2C, MYC | More | | | Acalabrutinib | hsa04114 | Oocyte meiosis | 7.01E-06 | 6 | Q9Y6D9, P51812, Q02750, P16298, Q17RY0, P08069 | MAD1L1, RPS6KA3, MAP2K1, PPP3CB, CPEB4, IGF1R | More | | | Acalabrutinib | hsa04115 | p53 signaling pathway | 2.54E-02 | 3 | O15151, Q13315, P10415 | MDM4, ATM, BCL2 | More | | | Acalabrutinib | hsa04120 | Ubiquitin mediated proteolysis | 4.82E-03 | 2 | Q9UBT2, Q14669 | SAE2, TRIP12 | More | | | Acalabrutinib | hsa04136 | Autophagy - other | 4.46E-05 | 2 | O94817, Q9H1Y0 | ATG12, ATG5 | More | | | Acalabrutinib | hsa04137 | Mitophagy - animal | 1.41E-03 | 3 | P67870, P19532, P18848 | CSNK2B, TFE3, ATF4 | More | | | Acalabrutinib | hsa04140 | Autophagy - animal | 3.24E-04 | 7 | P08069, P04049, P22694, Q14643, P10415, Q9H1Y0, Q04759 | IGF1R, RAF1, PRKACB, ITPR1, BCL2, ATG5, PRKCQ | More | | | Acalabrutinib | hsa04141 | Protein processing in endoplasmic reticulum | 5.27E-04 | 8 | P18848, Q15437, Q15436, Q99941, P11142, Q9H3Z4, P07900, Q9NR31 | ATF4, SEC23B, SEC23A, CREBL1, HSPA8, DNAJC5, HSP90AA1, SAR1A | More | | | Acalabrutinib | hsa04142 | Lysosome | 2.45E-03 | 9 | Q99437, P25774, P06865, P22304, P38571, Q13510, P07602, Q9NRA2, P61916 | ATP6V0B, CTSS, HEXA, IDS, LIPA, ASAH1, PSAP, SLC17A5, NPC2 | More | | | Acalabrutinib | hsa04144 | Endocytosis | 1.13E-03 | 14 | Q13191, P0DMV8, P11142, Q9H444, O75351, P62491, P25024, Q96B97, P43250, Q15438, Q14161, P14784, Q9UMY4, Q9Y5X3 | CBLB, HSPA1A, HSPA8, CHMP4B, VPS4B, RAB11A, CXCR1, SH3KBP1, GRK6, PSCD1, GIT2, IL2RB, SNX12, SNX5 | More | | | Acalabrutinib | hsa04145 | Phagosome | 8.19E-06 | 13 | O75015, Q15080, P14598, Q13509, P68371, Q13488, Q99437, P05164, P78380, O60603, P35443, P13765, P25774 | FCGR3B, NCF4, NCF1, TUBB3, TUBB2C, TCIRG1, ATP6V0B, MPO, OLR1, TLR2, THBS4, HLA-DOB, CTSS | More | | | Acalabrutinib | hsa04150 | mTOR signaling pathway | 5.20E-04 | 2 | P08069, P04049 | IGF1R, RAF1 | More | | | Acalabrutinib | hsa04151 | PI3K-Akt signaling pathway | 1.01E-04 | 23 | P62753, P42338, P21860, P43657, P27348, P20827, P49767, P07900, P08238, Q8WYR1, P62873, P63218, P50151, P61952, O15335, Q16363, Q13751, P22105, P14784, Q99941, P18848, O00141, P30281 | RPS6, PIK3CB, ERBB3, P2RY5, YWHAQ, EFNA1, VEGFC, HSP90AA1, HSP90AB1, PIK3R5, GNB1, GNG5, GNG10, GNG11, CHAD, LAMA4, LAMB3, TNXB, IL2RB, CREBL1, ATF4, SGK, CCND3 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P62753 | RPS6 | 40S ribosomal protein S6 | 0.722 | | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | P62753 | RPS6 | 40S ribosomal protein S6 | 0.709 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | P21860 | ERBB3 | Receptor tyrosine-protein kinase erbB-3 | -0.85 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | -0.735 | | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P27348 | YWHAQ | 14-3-3 protein theta | 0.833 | | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | P27348 | YWHAQ | 14-3-3 protein theta | 0.76 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P20827 | EFNA1 | Ephrin-A1 | 0.715 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P49767 | VEGFC | Vascular endothelial growth factor C | 0.743 | | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | 1 | | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | 0.763 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q8WYR1 | PIK3R5 | Phosphoinositide 3-kinase regulatory subunit 5 | 0.752 | | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.789 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | P61952 | GNG11 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 | -0.756 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O15335 | CHAD | Chondroadherin | 0.795 | | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | Q16363 | LAMA4 | Laminin subunit alpha-4 | 0.773 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13751 | LAMB3 | Laminin subunit beta-3 | 0.844 | | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P22105 | TNXB | Tenascin-X | 0.777 | | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | P22105 | TNXB | Tenascin-X | 0.801 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | Q99941 | CREBL1 | Cyclic AMP-dependent transcription factor ATF-6 beta | 0.777 | | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | Q99941 | CREBL1 | Cyclic AMP-dependent transcription factor ATF-6 beta | 0.801 | | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.783 | | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.844 | | P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | O00141 | SGK | Serine/threonine-protein kinase Sgk1 | 0.709 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P30281 | CCND3 | G1/S-specific cyclin-D3 | 0.743 |
| | Acalabrutinib | hsa04152 | AMPK signaling pathway | 1.99E-02 | 1 | P08069 | IGF1R | More | | | Acalabrutinib | hsa04210 | Apoptosis | 2.16E-02 | 1 | P04049 | RAF1 | More | | | Acalabrutinib | hsa04211 | Longevity regulating pathway | 5.33E-03 | 4 | P08069, P51828, Q99941, P18848 | IGF1R, ADCY7, CREBL1, ATF4 | More | | | Acalabrutinib | hsa04213 | Longevity regulating pathway - multiple species | 9.82E-04 | 8 | P42338, P08069, Q9Y4H2, Q08828, P51828, P0DMV8, P11142, Q13547 | PIK3CB, IGF1R, IRS2, ADCY1, ADCY7, HSPA1A, HSPA8, HDAC1 | More | | | Acalabrutinib | hsa04217 | Necroptosis | 3.44E-06 | 16 | P01568, Q13489, Q13546, P42224, P07900, P08238, P15104, P05141, P01584, P0C0S5, Q6FI13, Q93077, P10415, Q13557, O43633, Q08752 | IFNA21, BIRC3, RIPK1, STAT1, HSP90AA1, HSP90AB1, GLUL, SLC25A5, IL1B, H2AFZ, H2AC18; H2AC19, HIST1H2AC, BCL2, CAMK2D, CHMP2A, PPID | More | | | Acalabrutinib | hsa04218 | Cellular senescence | 2.49E-02 | 1 | P04049 | RAF1 | More | | | Acalabrutinib | hsa04261 | Adrenergic signaling in cardiomyocytes | 1.46E-02 | 4 | P51828, Q99941, P18848, Q13557 | ADCY7, CREBL1, ATF4, CAMK2D | More | | | Acalabrutinib | hsa04270 | Vascular smooth muscle contraction | 2.48E-04 | 7 | P0DP23, P04049, Q08828, P51828, P35579, P35749, P35318 | CALM1, RAF1, ADCY1, ADCY7, MYH9, MYH11, ADM | More | | | Acalabrutinib | hsa04310 | Wnt signaling pathway | 5.60E-03 | 3 | P30279, Q13485, O43318 | CCND2, SMAD4, MAP3K7 | More | | | Acalabrutinib | hsa04340 | Hedgehog signaling pathway | 3.93E-02 | 3 | P22694, Q13635, P10415 | PRKACB, PTCH1, BCL2 | More | | | Acalabrutinib | hsa04360 | Axon guidance | 9.70E-04 | 8 | P16333, P20827, O95631, P42338, P07332, P23528, P04049, P19174 | NCK1, EFNA1, NTN1, PIK3CB, FES, CFL1, RAF1, PLCG1 | More | | | Acalabrutinib | hsa04370 | VEGF signaling pathway | 2.99E-07 | 4 | P16298, Q05397, Q02750, P04049 | PPP3CB, PTK2, MAP2K1, RAF1 | More | | | Acalabrutinib | hsa04371 | Apelin signaling pathway | 5.09E-04 | 13 | P62873, P63218, P50151, P61952, Q8WYR1, P04049, Q08828, Q14814, Q14344, Q13485, P84022, P62753, P0DP24 | GNB1, GNG5, GNG10, GNG11, PIK3R5, RAF1, ADCY1, MEF2D, GNA13, SMAD4, SMAD3, RPS6, CALM2 | More | | | Acalabrutinib | hsa04380 | Osteoclast differentiation | 9.58E-05 | 13 | Q9NQC7, Q9UQC2, Q16539, P23458, P06239, P01584, P14778, O75015, Q8WV28, P01375, Q15080, Q8N149, P78324 | CYLD, GAB2, MAPK14, JAK1, LCK, IL1B, IL1R1, FCGR3B, BLNK, TNF, NCF4, LILRA2, SIRPA | More | | | Acalabrutinib | hsa04390 | Hippo signaling pathway | 5.79E-03 | 4 | P04628, Q9UJU2, O43623, Q13489 | WNT1, LEF1, SNAI2, BIRC3 | More | | | Acalabrutinib | hsa04392 | Hippo signaling pathway - multiple species | 3.01E-02 | 1 | Q6V0I7 | FAT4 | More | | | Acalabrutinib | hsa04510 | Focal adhesion | 1.63E-03 | 5 | Q15942, P51636, P30281, P04049, P08069 | ZYX, CAV2, CCND3, RAF1, IGF1R | More | | | Acalabrutinib | hsa04512 | ECM-receptor interaction | 1.90E-02 | 2 | P26012, P16070 | ITGB8, CD44 | More | | | Acalabrutinib | hsa04520 | Adherens junction | 1.81E-03 | 3 | Q13485, O43318, P08069 | SMAD4, MAP3K7, IGF1R | More | | | Acalabrutinib | hsa04530 | Tight junction | 3.29E-02 | 3 | P16989, P56750, Q14247 | CSDA, CLDN17, CTTN | More | | | Acalabrutinib | hsa04540 | Gap junction | 5.13E-06 | 8 | P17252, P22694, Q13509, P68371, Q02750, P04049, Q9NRA1, Q14643 | PRKCA, PRKACB, TUBB3, TUBB2C, MAP2K1, RAF1, PDGFC, ITPR1 | More | | | Acalabrutinib | hsa04550 | Signaling pathways regulating pluripotency of stem cells | 1.61E-03 | 5 | Q13873, P04049, Q02750, P08069, Q86SE9 | BMPR2, RAF1, MAP2K1, IGF1R, PCGF5 | More | | | Acalabrutinib | hsa04610 | Complement and coagulation cascades | 1.19E-06 | 2 | P00734, P0C0L4 | F2, C4A | More | | | Acalabrutinib | hsa04612 | Antigen processing and presentation | 1.82E-04 | 8 | P13765, P48382, P01730, P26715, P26717, Q13241, P01732, P01375 | HLA-DOB, RFX5, CD4, KLRC1, KLRC2, KLRD1, CD8A, TNF | More | | | Acalabrutinib | hsa04613 | Neutrophil extracellular trap formation | 3.67E-08 | 25 | P17252, P04049, O60603, P05164, P08246, Q9UM07, Q13547, Q92769, P04908, P0C0S5, Q6FI13, Q93077, P62807, O60814, P68431, P14598, Q15080, P20160, P08311, P49913, O75015, P21730, P21462, O43315, Q16539 | PRKCA, RAF1, TLR2, MPO, ELA2, PADI4, HDAC1, HDAC2, H2AC4; H2AC8, H2AFZ, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF1, NCF4, AZU1, CTSG, CAMP, FCGR3B, C5AR1, FPR1, AQP9, MAPK14 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P22894 | MMP8 | Neutrophil collagenase | P17252 | PRKCA | Protein kinase C alpha type | -0.759 | | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | P17252 | PRKCA | Protein kinase C alpha type | 0.849 | | P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | 1 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | O60603 | TLR2 | Toll-like receptor 2 | 0.772 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.842 | | P22894 | MMP8 | Neutrophil collagenase | O60603 | TLR2 | Toll-like receptor 2 | 0.89 | | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | O60603 | TLR2 | Toll-like receptor 2 | -0.729 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P05164 | MPO | Myeloperoxidase | 0.909 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P05164 | MPO | Myeloperoxidase | 0.719 | | P22894 | MMP8 | Neutrophil collagenase | P05164 | MPO | Myeloperoxidase | 0.905 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P08246 | ELA2 | Neutrophil elastase | 0.889 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P08246 | ELA2 | Neutrophil elastase | 0.702 | | P22894 | MMP8 | Neutrophil collagenase | P08246 | ELA2 | Neutrophil elastase | 0.985 | | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | P08246 | ELA2 | Neutrophil elastase | -0.716 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 1 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.813 | | P22894 | MMP8 | Neutrophil collagenase | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | 0.877 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.7 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q92769 | HDAC2 | Histone deacetylase 2 | -0.7 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | P04908 | H2AC4; H2AC8 | Histone H2A type 1-B/E | 0.734 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P0C0S5 | H2AFZ | Histone H2A.Z | 0.785 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.707 | | P22894 | MMP8 | Neutrophil collagenase | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | 0.909 | | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | Q6FI13 | H2AC18; H2AC19 | Histone H2A type 2-A | -0.843 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | Q93077 | HIST1H2AC | Histone H2A type 1-C | 0.737 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | Q93077 | HIST1H2AC | Histone H2A type 1-C | 0.754 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P62807 | HIST1H2BC | Histone H2B type 1-C/E/F/G/I | 0.717 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | O60814 | H2BC12 | Histone H2B type 1-K | 0.728 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.913 | | P11712 | CYP2C9 | Cytochrome P450 2C9 | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.845 | | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | P68431 | H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | Histone H3.1 | 0.703 | | P22894 | MMP8 | Neutrophil collagenase | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.74 | | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | P14598 | NCF1 | Neutrophil cytosol factor 1 | -0.816 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.795 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.762 | | P22894 | MMP8 | Neutrophil collagenase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.963 | | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | -0.813 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P20160 | AZU1 | Azurocidin | 0.884 | | P22894 | MMP8 | Neutrophil collagenase | P20160 | AZU1 | Azurocidin | 0.824 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P08311 | CTSG | Cathepsin G | 0.884 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P08311 | CTSG | Cathepsin G | 0.744 | | P22894 | MMP8 | Neutrophil collagenase | P08311 | CTSG | Cathepsin G | 0.8 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P49913 | CAMP | Cathelicidin antimicrobial peptide | 0.737 | | P22894 | MMP8 | Neutrophil collagenase | P49913 | CAMP | Cathelicidin antimicrobial peptide | 0.7 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.92 | | P22894 | MMP8 | Neutrophil collagenase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.734 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.825 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.983 | | P22894 | MMP8 | Neutrophil collagenase | P21730 | C5AR1 | C5a anaphylatoxin chemotactic receptor 1 | 0.756 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.733 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.839 | | P22894 | MMP8 | Neutrophil collagenase | P21462 | FPR1 | fMet-Leu-Phe receptor | 0.88 | | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | P21462 | FPR1 | fMet-Leu-Phe receptor | -0.726 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | O43315 | AQP9 | Aquaporin-9 | -0.764 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O43315 | AQP9 | Aquaporin-9 | 0.934 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | -0.744 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 |
| | Acalabrutinib | hsa04614 | Renin-angiotensin system | 2.74E-02 | 3 | P15144, P08311, O75787 | ANPEP, CTSG, ATP6AP2 | More | | | Acalabrutinib | hsa04623 | Cytosolic DNA-sensing pathway | 6.28E-07 | 5 | P01584, P01568, Q13546, P25963, Q8NHW4 | IL1B, IFNA21, RIPK1, NFKBIA, CCL4L2 | More | | | Acalabrutinib | hsa04625 | C-type lectin receptor signaling pathway | 2.21E-04 | 10 | Q9ULY5, P04049, P01584, Q9NQC7, P20749, Q14643, P01375, Q13191, P0DP24, Q16539 | CLEC4E, RAF1, IL1B, CYLD, BCL3, ITPR1, TNF, CBLB, CALM2, MAPK14 | More | | | Acalabrutinib | hsa04630 | JAK-STAT signaling pathway | 1.49E-02 | 1 | P04049 | RAF1 | More | | | Acalabrutinib | hsa04640 | Hematopoietic cell lineage | 3.96E-08 | 16 | P13612, P14778, P27930, P11215, P15144, P11836, P25063, P07766, P09693, P01732, P01730, P06127, P09564, P13765, P01375, P01584 | ITGA4, IL1R1, IL1R2, ITGAM, ANPEP, MS4A1, CD24, CD3E, CD3G, CD8A, CD4, CD5, CD7, HLA-DOB, TNF, IL1B | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P13612 | ITGA4 | Integrin alpha-4 | -0.74 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13612 | ITGA4 | Integrin alpha-4 | -0.797 | | P06239 | LCK | Tyrosine-protein kinase Lck | P13612 | ITGA4 | Integrin alpha-4 | 0.732 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P13612 | ITGA4 | Integrin alpha-4 | 0.774 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.782 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.721 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.926 | | P06239 | LCK | Tyrosine-protein kinase Lck | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.779 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.727 | | Q13547 | HDAC1 | Histone deacetylase 1 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.837 | | Q13547 | HDAC1 | Histone deacetylase 1 | P11215 | ITGAM | Integrin alpha-M | -0.751 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P15144 | ANPEP | Aminopeptidase N | 0.76 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P15144 | ANPEP | Aminopeptidase N | 0.851 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P15144 | ANPEP | Aminopeptidase N | -0.757 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P11836 | MS4A1 | B-lymphocyte antigen CD20 | -0.71 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P25063 | CD24 | Signal transducer CD24 | 0.866 | | P06239 | LCK | Tyrosine-protein kinase Lck | P25063 | CD24 | Signal transducer CD24 | -0.779 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P25063 | CD24 | Signal transducer CD24 | -0.839 | | Q13547 | HDAC1 | Histone deacetylase 1 | P25063 | CD24 | Signal transducer CD24 | -0.706 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.793 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.813 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.839 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.781 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.841 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.803 | | Q13547 | HDAC1 | Histone deacetylase 1 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.816 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | | P06493 | CDK1 | Cyclin-dependent kinase 1 | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.732 | | P06493 | CDK1 | Cyclin-dependent kinase 1 | P06127 | CD5 | T-cell surface glycoprotein CD5 | -0.739 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09564 | CD7 | T-cell antigen CD7 | 0.84 | | Q13547 | HDAC1 | Histone deacetylase 1 | P09564 | CD7 | T-cell antigen CD7 | 0.738 | | P06493 | CDK1 | Cyclin-dependent kinase 1 | P09564 | CD7 | T-cell antigen CD7 | -0.735 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.757 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.785 | | P06239 | LCK | Tyrosine-protein kinase Lck | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.777 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.85 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P01375 | TNF | Tumor necrosis factor | 0.788 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P01375 | TNF | Tumor necrosis factor | -0.79 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 |
| | Acalabrutinib | hsa04650 | Natural killer cell mediated cytotoxicity | 1.63E-10 | 17 | P16298, P50591, P19174, P01375, P78314, P06239, O60880, P20963, P42338, Q02750, P04049, Q13241, P26718, O14931, O75015, P26717, P26715 | PPP3CB, TNFSF10, PLCG1, TNF, SH3BP2, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, RAF1, KLRD1, KLRK1, NCR3, FCGR3B, KLRC2, KLRC1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q05397 | PTK2 | Focal adhesion kinase 1 | P16298 | PPP3CB | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform | 0.919 | | Q05397 | PTK2 | Focal adhesion kinase 1 | P50591 | TNFSF10 | Tumor necrosis factor ligand superfamily member 10 | 0.849 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P01375 | TNF | Tumor necrosis factor | -0.79 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P78314 | SH3BP2 | SH3 domain-binding protein 2 | 0.761 | | P42681 | TXK | Tyrosine-protein kinase TXK | P06239 | LCK | Tyrosine-protein kinase Lck | 0.734 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P06239 | LCK | Tyrosine-protein kinase Lck | 0.774 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P42681 | TXK | Tyrosine-protein kinase TXK | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.881 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O60880 | SH2D1A | SH2 domain-containing protein 1A | -0.823 | | P06239 | LCK | Tyrosine-protein kinase Lck | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.906 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.862 | | Q13547 | HDAC1 | Histone deacetylase 1 | O60880 | SH2D1A | SH2 domain-containing protein 1A | 0.786 | | P42681 | TXK | Tyrosine-protein kinase TXK | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.811 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.839 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | | Q05397 | PTK2 | Focal adhesion kinase 1 | Q02750 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | 0.898 | | P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | 1 | | P42681 | TXK | Tyrosine-protein kinase TXK | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.888 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13241 | KLRD1 | Natural killer cells antigen CD94 | -0.82 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.758 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.852 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q13241 | KLRD1 | Natural killer cells antigen CD94 | 0.807 | | P42681 | TXK | Tyrosine-protein kinase TXK | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.869 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P26718 | KLRK1 | NKG2-D type II integral membrane protein | -0.91 | | P06239 | LCK | Tyrosine-protein kinase Lck | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.886 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.922 | | Q13547 | HDAC1 | Histone deacetylase 1 | P26718 | KLRK1 | NKG2-D type II integral membrane protein | 0.772 | | P06239 | LCK | Tyrosine-protein kinase Lck | O14931 | NCR3 | Natural cytotoxicity triggering receptor 3 | 0.732 | | Q13547 | HDAC1 | Histone deacetylase 1 | O14931 | NCR3 | Natural cytotoxicity triggering receptor 3 | 0.735 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.92 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | -0.778 | | P42681 | TXK | Tyrosine-protein kinase TXK | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.901 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P26717 | KLRC2 | NKG2-C type II integral membrane protein | -0.846 | | P06239 | LCK | Tyrosine-protein kinase Lck | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.756 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P26717 | KLRC2 | NKG2-C type II integral membrane protein | 0.943 | | P42681 | TXK | Tyrosine-protein kinase TXK | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.901 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | -0.846 | | P06239 | LCK | Tyrosine-protein kinase Lck | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.756 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P26715 | KLRC1 | NKG2-A/NKG2-B type II integral membrane protein | 0.943 |
| | Acalabrutinib | hsa04657 | IL-17 signaling pathway | 1.41E-04 | 8 | O00463, Q16539, P49841, P09341, P14780, P80188, P01375, P01584 | TRAF5, MAPK14, GSK3B, CXCL1, MMP9, LCN2, TNF, IL1B | More | | | Acalabrutinib | hsa04658 | Th1 and Th2 cell differentiation | 2.12E-18 | 15 | Q04759, P07766, P20963, P09693, Q16539, P19174, P01730, P06239, Q14765, P23771, Q9UL17, P14784, P13765, P23458, Q13761 | PRKCQ, CD3E, CD247, CD3G, MAPK14, PLCG1, CD4, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, JAK1, RUNX3 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P42681 | TXK | Tyrosine-protein kinase TXK | Q04759 | PRKCQ | Protein kinase C theta type | 0.876 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | Q04759 | PRKCQ | Protein kinase C theta type | -0.91 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q04759 | PRKCQ | Protein kinase C theta type | 0.803 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | Q04759 | PRKCQ | Protein kinase C theta type | -0.737 | | P07948 | LYN | Tyrosine-protein kinase Lyn | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.824 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.755 | | P42681 | TXK | Tyrosine-protein kinase TXK | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.811 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.828 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.839 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.778 | | P42681 | TXK | Tyrosine-protein kinase TXK | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.838 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.793 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.813 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.802 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.857 | | P42681 | TXK | Tyrosine-protein kinase TXK | P06239 | LCK | Tyrosine-protein kinase Lck | 0.734 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | | P07948 | LYN | Tyrosine-protein kinase Lyn | P06239 | LCK | Tyrosine-protein kinase Lck | -0.701 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P06239 | LCK | Tyrosine-protein kinase Lck | 0.774 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P06239 | LCK | Tyrosine-protein kinase Lck | -0.791 | | P42681 | TXK | Tyrosine-protein kinase TXK | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | 0.771 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | -0.815 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | -0.777 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | 0.904 | | P42681 | TXK | Tyrosine-protein kinase TXK | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.856 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.905 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.763 | | P06239 | LCK | Tyrosine-protein kinase Lck | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.77 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.784 | | P42681 | TXK | Tyrosine-protein kinase TXK | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.849 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.788 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.872 | | P07948 | LYN | Tyrosine-protein kinase Lyn | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.719 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.866 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.884 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.817 | | P07948 | LYN | Tyrosine-protein kinase Lyn | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.771 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.727 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.816 | | P42681 | TXK | Tyrosine-protein kinase TXK | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.89 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.757 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.785 | | P06239 | LCK | Tyrosine-protein kinase Lck | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.777 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.85 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.757 | | P07948 | LYN | Tyrosine-protein kinase Lyn | Q13761 | RUNX3 | Runt-related transcription factor 3 | -0.855 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.85 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.884 |
| | Acalabrutinib | hsa04659 | Th17 cell differentiation | 1.60E-16 | 21 | Q04759, Q16539, P19174, P01730, P06239, P42224, P14784, P13765, P14778, Q9HBE5, P40189, Q9UL17, P23771, P84022, Q13485, P01584, P08238, P07766, P09693, P20963, P23458 | PRKCQ, MAPK14, PLCG1, CD4, LCK, STAT1, IL2RB, HLA-DOB, IL1R1, IL21R, IL6ST, TBX21, GATA3, SMAD3, SMAD4, IL1B, HSP90AB1, CD3E, CD3G, CD247, JAK1 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P42681 | TXK | Tyrosine-protein kinase TXK | Q04759 | PRKCQ | Protein kinase C theta type | 0.876 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q04759 | PRKCQ | Protein kinase C theta type | 0.803 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | Q04759 | PRKCQ | Protein kinase C theta type | -0.737 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.802 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.857 | | P42681 | TXK | Tyrosine-protein kinase TXK | P06239 | LCK | Tyrosine-protein kinase Lck | 0.734 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | | P07948 | LYN | Tyrosine-protein kinase Lyn | P06239 | LCK | Tyrosine-protein kinase Lck | -0.701 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P06239 | LCK | Tyrosine-protein kinase Lck | 0.774 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P06239 | LCK | Tyrosine-protein kinase Lck | -0.791 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.764 | | P07948 | LYN | Tyrosine-protein kinase Lyn | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.771 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.727 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.768 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.816 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | | P42681 | TXK | Tyrosine-protein kinase TXK | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.89 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.785 | | P06239 | LCK | Tyrosine-protein kinase Lck | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.777 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.85 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | | P07948 | LYN | Tyrosine-protein kinase Lyn | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.714 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.782 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.854 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.764 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q9HBE5 | IL21R | Interleukin-21 receptor | 0.713 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P40189 | IL6ST | Interleukin-6 receptor subunit beta | 0.83 | | P42681 | TXK | Tyrosine-protein kinase TXK | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.849 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.872 | | P07948 | LYN | Tyrosine-protein kinase Lyn | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.719 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.866 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.884 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.817 | | P42681 | TXK | Tyrosine-protein kinase TXK | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.856 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.763 | | P06239 | LCK | Tyrosine-protein kinase Lck | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.77 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.784 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.725 | | P07948 | LYN | Tyrosine-protein kinase Lyn | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.729 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.746 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | | P07948 | LYN | Tyrosine-protein kinase Lyn | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.782 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.711 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | | P07948 | LYN | Tyrosine-protein kinase Lyn | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.824 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.755 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.838 | | P42681 | TXK | Tyrosine-protein kinase TXK | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.838 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.813 | | P42681 | TXK | Tyrosine-protein kinase TXK | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.811 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.839 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.778 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.757 |
| | Acalabrutinib | hsa04660 | T cell receptor signaling pathway | 2.57E-15 | 18 | P01375, Q9UDY8, Q04759, P42338, P10747, O95267, Q08881, P19174, P07766, P20963, P09693, P01730, P01732, Q13191, P06239, P04049, Q16539, P49841 | TNF, MALT1, PRKCQ, PIK3CB, CD28, RASGRP1, ITK, PLCG1, CD3E, CD247, CD3G, CD4, CD8A, CBLB, LCK, RAF1, MAPK14, GSK3B | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P01375 | TNF | Tumor necrosis factor | 0.788 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P01375 | TNF | Tumor necrosis factor | -0.79 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | -0.779 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q9UDY8 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 0.721 | | P42681 | TXK | Tyrosine-protein kinase TXK | Q04759 | PRKCQ | Protein kinase C theta type | 0.876 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | Q04759 | PRKCQ | Protein kinase C theta type | -0.91 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q04759 | PRKCQ | Protein kinase C theta type | 0.803 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | Q04759 | PRKCQ | Protein kinase C theta type | -0.737 | | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | | P42681 | TXK | Tyrosine-protein kinase TXK | P10747 | CD28 | T-cell-specific surface glycoprotein CD28 | 0.776 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P10747 | CD28 | T-cell-specific surface glycoprotein CD28 | -0.735 | | P42681 | TXK | Tyrosine-protein kinase TXK | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | 0.857 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.799 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.852 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | 0.925 | | P42681 | TXK | Tyrosine-protein kinase TXK | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.847 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.855 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | -0.866 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 0.774 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | 1 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.755 | | P42681 | TXK | Tyrosine-protein kinase TXK | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.811 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.828 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.839 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.778 | | P42681 | TXK | Tyrosine-protein kinase TXK | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.838 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.793 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.813 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.857 | | P42681 | TXK | Tyrosine-protein kinase TXK | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.9 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.839 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | -0.781 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.841 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.803 | | Q13547 | HDAC1 | Histone deacetylase 1 | P01732 | CD8A | T-cell surface glycoprotein CD8 alpha chain | 0.816 | | P42681 | TXK | Tyrosine-protein kinase TXK | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.716 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | -0.796 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | -0.803 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.714 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.811 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q13191 | CBLB | E3 ubiquitin-protein ligase CBL-B | 0.806 | | P42681 | TXK | Tyrosine-protein kinase TXK | P06239 | LCK | Tyrosine-protein kinase Lck | 0.734 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P06239 | LCK | Tyrosine-protein kinase Lck | 0.774 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P06239 | LCK | Tyrosine-protein kinase Lck | -0.791 | | P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | 1 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.802 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.812 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.733 |
| | Acalabrutinib | hsa04662 | B cell receptor signaling pathway | 1.64E-06 | 6 | P42338, P60033, P07948, P21854, Q8N149, P04049 | PIK3CB, CD81, LYN, CD72, LILRA2, RAF1 | More | | | Acalabrutinib | hsa04664 | Fc epsilon RI signaling pathway | 2.24E-06 | 9 | P01375, Q16539, P42338, Q9UQC2, P07948, P19174, P04049, P09917, P20292 | TNF, MAPK14, PIK3CB, GAB2, LYN, PLCG1, RAF1, ALOX5, ALOX5AP | More | | | Acalabrutinib | hsa04666 | Fc gamma R-mediated phagocytosis | 2.06E-04 | 8 | O75015, P42338, P04049, P23528, P06396, O14494, P14598, P17252 | FCGR3B, PIK3CB, RAF1, CFL1, GSN, PLPP1, NCF1, PRKCA | More | | | Acalabrutinib | hsa04668 | TNF signaling pathway | 8.17E-04 | 10 | P01375, O00463, Q16539, Q99941, P18848, P01584, P20749, P14780, P20333, O95429 | TNF, TRAF5, MAPK14, CREBL1, ATF4, IL1B, BCL3, MMP9, TNFRSF1B, BAG4 | More | | | Acalabrutinib | hsa04672 | Intestinal immune network for IgA production | 1.66E-02 | 3 | P10747, P13765, P13612 | CD28, HLA-DOB, ITGA4 | More | | | Acalabrutinib | hsa04713 | Circadian entrainment | 4.66E-05 | 9 | P0DP24, P0DP23, Q13557, Q02153, P17252, P62873, P61952, Q14643, Q08828 | CALM2, CALM1, CAMK2D, GUCY1B3, PRKCA, GNB1, GNG11, ITPR1, ADCY1 | More | | | Acalabrutinib | hsa04714 | Thermogenesis | 6.01E-04 | 8 | Q16539, P51828, P62753, P33121, P12074, O15239, Q16718, O14521 | MAPK14, ADCY7, RPS6, ACSL1, COX6A1, NDUFA1, NDUFA5, SDHD | More | | | Acalabrutinib | hsa04720 | Long-term potentiation | 8.72E-09 | 14 | P17252, Q16566, Q13557, P16298, P0DP24, P0DP23, Q15418, P51812, P18848, P22694, Q08828, Q02750, P04049, Q14643 | PRKCA, CAMK4, CAMK2D, PPP3CB, CALM2, CALM1, RPS6KA1, RPS6KA3, ATF4, PRKACB, ADCY1, MAP2K1, RAF1, ITPR1 | More | | | Acalabrutinib | hsa04721 | Synaptic vesicle cycle | 9.45E-04 | 2 | Q13488, P31645 | TCIRG1, SLC6A4 | More | | | Acalabrutinib | hsa04722 | Neurotrophin signaling pathway | 8.58E-03 | 4 | P04049, P51617, P10415, P0DP23 | RAF1, IRAK1, BCL2, CALM1 | More | | | Acalabrutinib | hsa04723 | Retrograde endocannabinoid signaling | 3.71E-02 | 4 | P62873, P61952, Q08828, O15239 | GNB1, GNG11, ADCY1, NDUFA1 | More | | | Acalabrutinib | hsa04724 | Glutamatergic synapse | 2.84E-05 | 7 | O15399, Q08828, P62873, P63218, P50151, P61952, P15104 | GRIN2D, ADCY1, GNB1, GNG5, GNG10, GNG11, GLUL | More | | | Acalabrutinib | hsa04725 | Cholinergic synapse | 6.32E-08 | 16 | Q08828, P51828, P22694, Q14643, P17252, P62873, P62879, P63218, P50151, P61952, P18848, Q16566, Q13557, P42338, P10415, Q02750 | ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, GNB1, GNB2, GNG5, GNG10, GNG11, ATF4, CAMK4, CAMK2D, PIK3CB, BCL2, MAP2K1 | More | | | Acalabrutinib | hsa04726 | Serotonergic synapse | 4.99E-04 | 8 | P22694, Q14643, P17252, P62873, P62879, P33260, P04049, Q02750 | PRKACB, ITPR1, PRKCA, GNB1, GNB2, CYP2C18, RAF1, MAP2K1 | More | | | Acalabrutinib | hsa04727 | GABAergic synapse | 4.52E-06 | 11 | Q08828, P62873, P62879, P63218, P50151, P61952, P15104, P22694, O60296, Q15111, P17252 | ADCY1, GNB1, GNB2, GNG5, GNG10, GNG11, GLUL, PRKACB, TRAK2, PLCL1, PRKCA | More | | | Acalabrutinib | hsa04728 | Dopaminergic synapse | 3.77E-05 | 12 | P62873, P50151, P61952, P49841, Q99941, P18848, Q16539, Q13557, P49407, P0DP24, O15516, P48058 | GNB1, GNG10, GNG11, GSK3B, CREBL1, ATF4, MAPK14, CAMK2D, ARRB1, CALM2, CLOCK, GRIA4 | More | | | Acalabrutinib | hsa04730 | Long-term depression | 1.25E-04 | 2 | P08069, P04049 | IGF1R, RAF1 | More | | | Acalabrutinib | hsa04740 | Olfactory transduction | 3.49E-04 | 4 | P62873, Q13557, P0DP23, P0DP24 | GNB1, CAMK2D, CALM1, CALM2 | More | | | Acalabrutinib | hsa04744 | Phototransduction | 3.12E-06 | 3 | P62873, P0DP23, P0DP24 | GNB1, CALM1, CALM2 | More | | | Acalabrutinib | hsa04750 | Inflammatory mediator regulation of TRP channels | 4.07E-06 | 14 | P14778, P01584, Q08828, P51828, P22694, Q13557, Q16539, P19174, P42338, Q14643, P24723, Q04759, P0DP24, P0DP23 | IL1R1, IL1B, ADCY1, ADCY7, PRKACB, CAMK2D, MAPK14, PLCG1, PIK3CB, ITPR1, PRKCH, PRKCQ, CALM2, CALM1 | More | | | Acalabrutinib | hsa04810 | Regulation of actin cytoskeleton | 3.81E-02 | 1 | P04049 | RAF1 | More | | | Acalabrutinib | hsa04910 | Insulin signaling pathway | 1.49E-02 | 1 | P04049 | RAF1 | More | | | Acalabrutinib | hsa04911 | Insulin secretion | 2.15E-05 | 5 | Q08828, P51828, Q99941, P18848, Q13557 | ADCY1, ADCY7, CREBL1, ATF4, CAMK2D | More | | | Acalabrutinib | hsa04912 | GnRH signaling pathway | 4.30E-04 | 11 | P17252, P51828, P18848, Q13557, Q16539, Q9Y6R4, Q14643, P0DP24, P0DP23, P22694, P04049 | PRKCA, ADCY7, ATF4, CAMK2D, MAPK14, MAP3K4, ITPR1, CALM2, CALM1, PRKACB, RAF1 | More | | | Acalabrutinib | hsa04913 | Ovarian steroidogenesis | 8.40E-04 | 2 | P06213, P08069 | INSR, IGF1R | More | | | Acalabrutinib | hsa04914 | Progesterone-mediated oocyte maturation | 5.21E-07 | 9 | P08069, Q17RY0, P42338, Q13370, Q9Y6D9, P08238, P51812, Q02750, P04049 | IGF1R, CPEB4, PIK3CB, PDE3B, MAD1L1, HSP90AB1, RPS6KA3, MAP2K1, RAF1 | More | | | Acalabrutinib | hsa04915 | Estrogen signaling pathway | 1.81E-05 | 11 | P04049, Q99941, P18848, Q08828, P51828, P07900, P0DMV8, P11142, P0DP23, P0DP24, Q15788 | RAF1, CREBL1, ATF4, ADCY1, ADCY7, HSP90AA1, HSPA1A, HSPA8, CALM1, CALM2, NCOA1 | More | | | Acalabrutinib | hsa04916 | Melanogenesis | 2.03E-03 | 3 | P49841, Q01726, P04049 | GSK3B, MC1R, RAF1 | More | | | Acalabrutinib | hsa04917 | Prolactin signaling pathway | 6.63E-03 | 1 | P04049 | RAF1 | More | | | Acalabrutinib | hsa04918 | Thyroid hormone synthesis | 4.59E-05 | 6 | Q08828, P51828, Q99941, P18848, P02768, P05543 | ADCY1, ADCY7, CREBL1, ATF4, ALB, SERPINA7 | More | | | Acalabrutinib | hsa04919 | Thyroid hormone signaling pathway | 4.56E-03 | 6 | P17252, P04049, Q02750, P22694, Q12778, Q9UM47 | PRKCA, RAF1, MAP2K1, PRKACB, FOXO1, NOTCH3 | More | | | Acalabrutinib | hsa04921 | Oxytocin signaling pathway | 2.32E-02 | 1 | P04049 | RAF1 | More | | | Acalabrutinib | hsa04922 | Glucagon signaling pathway | 4.18E-02 | 2 | P14618, P06737 | PKM2, PYGL | More | | | Acalabrutinib | hsa04923 | Regulation of lipolysis in adipocytes | 4.24E-03 | 4 | P07550, P06213, P42338, Q9Y4H2 | ADRB2, INSR, PIK3CB, IRS2 | More | | | Acalabrutinib | hsa04924 | Renin secretion | 3.27E-03 | 5 | P22694, P07550, Q14643, Q13370, P0DP23 | PRKACB, ADRB2, ITPR1, PDE3B, CALM1 | More | | | Acalabrutinib | hsa04925 | Aldosterone synthesis and secretion | 2.01E-06 | 10 | Q14643, Q99941, P18848, Q08828, P51828, P0DP24, P0DP23, P17252, Q16566, Q13557 | ITPR1, CREBL1, ATF4, ADCY1, ADCY7, CALM2, CALM1, PRKCA, CAMK4, CAMK2D | More | | | Acalabrutinib | hsa04926 | Relaxin signaling pathway | 2.31E-06 | 13 | P42338, P62873, P63218, P50151, P61952, Q99941, P18848, P49767, Q08828, P51828, P04049, P30679, P49407 | PIK3CB, GNB1, GNG5, GNG10, GNG11, CREBL1, ATF4, VEGFC, ADCY1, ADCY7, RAF1, GNA15, ARRB1 | More | | | Acalabrutinib | hsa04927 | Cortisol synthesis and secretion | 7.54E-05 | 6 | Q14643, Q99941, P18848, Q08828, P51828, P22694 | ITPR1, CREBL1, ATF4, ADCY1, ADCY7, PRKACB | More | | | Acalabrutinib | hsa04928 | Parathyroid hormone synthesis, secretion and action | 8.88E-04 | 8 | P51828, P22694, P04049, Q02750, P17252, Q99941, P18848, Q9Y5Q3 | ADCY7, PRKACB, RAF1, MAP2K1, PRKCA, CREBL1, ATF4, MAFB | More | | | Acalabrutinib | hsa04929 | GnRH secretion | 3.50E-03 | 3 | P42338, P49407, P04049 | PIK3CB, ARRB1, RAF1 | More | | | Acalabrutinib | hsa04930 | Type II diabetes mellitus | 3.14E-02 | 1 | P06213 | INSR | More | | | Acalabrutinib | hsa04932 | Non-alcoholic fatty liver disease | 1.44E-04 | 11 | P49841, O43521, P18848, O75460, P01584, P13073, P12074, O15239, Q16718, O95298, O14521 | GSK3B, BCL2L11, ATF4, ERN1, IL1B, COX4I1, COX6A1, NDUFA1, NDUFA5, NDUFC2, SDHD | More | | | Acalabrutinib | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 3.21E-02 | 5 | P84022, Q13485, P42338, P49767, P19174 | SMAD3, SMAD4, PIK3CB, VEGFC, PLCG1 | More | | | Acalabrutinib | hsa04934 | Cushing syndrome | 1.55E-04 | 5 | Q99941, P18848, Q08828, P51828, Q13557 | CREBL1, ATF4, ADCY1, ADCY7, CAMK2D | More | | | Acalabrutinib | hsa04935 | Growth hormone synthesis, secretion and action | 5.33E-03 | 4 | P51828, P04049, Q99941, P18848 | ADCY7, RAF1, CREBL1, ATF4 | More | | | Acalabrutinib | hsa04940 | Type I diabetes mellitus | 2.91E-03 | 3 | P10747, P13765, P01375 | CD28, HLA-DOB, TNF | More | | | Acalabrutinib | hsa04960 | Aldosterone-regulated sodium reabsorption | 3.14E-02 | 1 | P06213 | INSR | More | | | Acalabrutinib | hsa04962 | Vasopressin-regulated water reabsorption | 7.22E-03 | 2 | P52566, P62491 | ARHGDIB, RAB11A | More | | | Acalabrutinib | hsa04964 | Proximal tubule bicarbonate reclamation | 4.48E-02 | 1 | P00918 | CA2 | More | | | Acalabrutinib | hsa04966 | Collecting duct acid secretion | 1.95E-03 | 3 | Q13488, P00918, Q9Y666 | TCIRG1, CA2, SLC12A7 | More | | | Acalabrutinib | hsa04970 | Salivary secretion | 7.66E-05 | 10 | P07550, Q08828, P51828, P22694, Q14643, P17252, P0DP23, P0DP24, Q02153, P49913 | ADRB2, ADCY1, ADCY7, PRKACB, ITPR1, PRKCA, CALM1, CALM2, GUCY1B3, CAMP | More | | | Acalabrutinib | hsa04973 | Carbohydrate digestion and absorption | 1.29E-02 | 2 | O43451, P42338 | MGAM, PIK3CB | More | | | Acalabrutinib | hsa04975 | Fat digestion and absorption | 4.83E-02 | 1 | O14494 | PLPP1 | More | | | Acalabrutinib | hsa04976 | Bile secretion | 3.14E-03 | 5 | O43315, Q08828, P51828, P08183, Q14032 | AQP9, ADCY1, ADCY7, ABCB1, BAAT | More | | | Acalabrutinib | hsa05010 | Alzheimer disease | 3.57E-02 | 4 | P13073, P18848, P67870, P05141 | COX4I1, ATF4, CSNK2B, SLC25A5 | More | | | Acalabrutinib | hsa05012 | Parkinson disease | 4.13E-02 | 8 | O15239, P13073, P12074, P05496, P05141, P18848, P0DP24, Q13557 | NDUFA1, COX4I1, COX6A1, ATP5G1, SLC25A5, ATF4, CALM2, CAMK2D | More | | | Acalabrutinib | hsa05016 | Huntington disease | 6.61E-04 | 12 | O95298, P13073, P12074, Q9GZM3, P24928, P30876, P62487, P52435, O75460, P28070, P55036, O00232 | NDUFC2, COX4I1, COX6A1, POLR2J2, POLR2A, POLR2B, POLR2G, POLR2J, ERN1, PSMB4, PSMD4, PSMD12 | More | | | Acalabrutinib | hsa05017 | Spinocerebellar ataxia | 1.93E-03 | 5 | Q92915, Q8TB72, O15399, P42338, P21796 | FGF14, PUM2, GRIN2D, PIK3CB, VDAC1 | More | | | Acalabrutinib | hsa05020 | Prion disease | 4.37E-05 | 20 | P01584, P46531, P11142, O15239, Q16718, O14521, P05496, P13073, P12074, Q14643, P18848, P05141, Q13509, P68371, P49841, P67870, Q99941, P14598, Q15080, Q16539 | IL1B, NOTCH1, HSPA8, NDUFA1, NDUFA5, SDHD, ATP5G1, COX4I1, COX6A1, ITPR1, ATF4, SLC25A5, TUBB3, TUBB2C, GSK3B, CSNK2B, CREBL1, NCF1, NCF4, MAPK14 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | P01584 | IL1B | Interleukin-1 beta | 0.725 | | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | P46531 | NOTCH1 | Neurogenic locus notch homolog protein 1 | 0.784 | | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 0.745 | | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | O15239 | NDUFA1 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | 0.885 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | Q16718 | NDUFA5 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | 0.757 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | O14521 | SDHD | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial | 0.732 | | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | O14521 | SDHD | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial | 0.728 | | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | P05496 | ATP5G1 | ATP synthase F(0) complex subunit C1, mitochondrial | 0.818 | | Q15418 | RPS6KA1 | Ribosomal protein S6 kinase alpha-1 | P13073 | COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 0.758 | | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | P13073 | COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | 0.712 | | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | P12074 | COX6A1 | Cytochrome c oxidase subunit 6A1, mitochondrial | 0.763 | | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | 0.701 | | Q15418 | RPS6KA1 | Ribosomal protein S6 kinase alpha-1 | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.722 | | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.844 | | Q15418 | RPS6KA1 | Ribosomal protein S6 kinase alpha-1 | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.715 | | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | P05141 | SLC25A5 | ADP/ATP translocase 2 | 0.779 | | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | Q13509 | TUBB3 | Tubulin beta-3 chain | -0.716 | | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | P68371 | TUBB2C | Tubulin beta-4B chain | -0.892 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | P49841 | GSK3B | Glycogen synthase kinase-3 beta | -0.714 | | Q15418 | RPS6KA1 | Ribosomal protein S6 kinase alpha-1 | P67870 | CSNK2B | Casein kinase II subunit beta | 0.768 | | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | Q99941 | CREBL1 | Cyclic AMP-dependent transcription factor ATF-6 beta | 0.801 | | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | P14598 | NCF1 | Neutrophil cytosol factor 1 | -0.816 | | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | -0.813 | | P31645 | SLC6A4 | Sodium-dependent serotonin transporter | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | -0.744 |
| | Acalabrutinib | hsa05022 | Pathways of neurodegeneration - multiple diseases | 1.56E-03 | 14 | Q14643, Q13509, P68371, P49841, P10415, Q16718, O14521, Q06055, Q13561, P17252, Q16539, Q08752, O15020, P0DP23 | ITPR1, TUBB3, TUBB2C, GSK3B, BCL2, NDUFA5, SDHD, ATP5G2, DCTN2, PRKCA, MAPK14, PPID, SPTBN2, CALM1 | More | | | Acalabrutinib | hsa05030 | Cocaine addiction | 4.87E-02 | 2 | Q99941, P18848 | CREBL1, ATF4 | More | | | Acalabrutinib | hsa05031 | Amphetamine addiction | 2.12E-04 | 4 | P0DP24, Q13557, Q99941, P18848 | CALM2, CAMK2D, CREBL1, ATF4 | More | | | Acalabrutinib | hsa05034 | Alcoholism | 3.82E-06 | 13 | Q99941, P18848, P0DP24, Q96RR4, P62873, P61952, P04049, P0C0S5, Q93077, P62807, O60814, P84243, P68431 | CREBL1, ATF4, CALM2, CAMKK2, GNB1, GNG11, RAF1, H2AFZ, HIST1H2AC, HIST1H2BC, H2BC12, H3F3A, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 | More | | | Acalabrutinib | hsa05100 | Bacterial invasion of epithelial cells | 3.14E-03 | 3 | Q14141, Q05397, Q96JJ3 | SEPT6, PTK2, ELMO2 | More | | | Acalabrutinib | hsa05110 | Vibrio cholerae infection | 4.78E-02 | 1 | Q99437 | ATP6V0B | More | | | Acalabrutinib | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 1.40E-08 | 8 | Q16539, Q99437, P09341, P19875, P19174, P25024, P25025, P41240 | MAPK14, ATP6V0B, CXCL1, CXCL2, PLCG1, CXCR1, CXCR2, CSK | More | | | Acalabrutinib | hsa05130 | Pathogenic Escherichia coli infection | 4.08E-02 | 3 | Q15438, P35579, P55061 | PSCD1, MYH9, TEGT | More | | | Acalabrutinib | hsa05131 | Shigellosis | 1.76E-03 | 10 | Q13546, Q9UDY8, Q9NQL2, P0CG47, Q14141, Q96JJ3, Q05397, Q12778, Q13315, P10415 | RIPK1, MALT1, RRAGD, UBB, SEPT6, ELMO2, PTK2, FOXO1, ATM, BCL2 | More | | | Acalabrutinib | hsa05132 | Salmonella infection | 1.59E-07 | 12 | P51617, P04049, Q9UJU2, Q13546, Q13489, P10415, O75369, O60603, Q9BQS8, Q13561, Q13509, P68371 | IRAK1, RAF1, LEF1, RIPK1, BIRC3, BCL2, FLNB, TLR2, FYCO1, DCTN2, TUBB3, TUBB2C | More | | | Acalabrutinib | hsa05133 | Pertussis | 2.84E-04 | 4 | P0DP23, P23528, P09871, P0C0L4 | CALM1, CFL1, C1S, C4A | More | | | Acalabrutinib | hsa05134 | Legionellosis | 6.26E-05 | 8 | P01584, Q9NR31, P11215, P68104, P0DMV8, P11142, P09341, P19875 | IL1B, SAR1A, ITGAM, EEF1A1, HSPA1A, HSPA8, CXCL1, CXCL2 | More | | | Acalabrutinib | hsa05135 | Yersinia infection | 3.29E-02 | 4 | Q05397, P51812, Q02750, Q96JJ3 | PTK2, RPS6KA3, MAP2K1, ELMO2 | More | | | Acalabrutinib | hsa05140 | Leishmaniasis | 1.30E-08 | 15 | P13612, O75015, P14598, P23458, P42224, P13765, O60603, P25963, P01375, P01584, P29350, P49006, Q16539, P51617, Q15080 | ITGA4, FCGR3B, NCF1, JAK1, STAT1, HLA-DOB, TLR2, NFKBIA, TNF, IL1B, PTPN6, MARCKSL1, MAPK14, IRAK1, NCF4 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
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| P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13612 | ITGA4 | Integrin alpha-4 | -0.797 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P13612 | ITGA4 | Integrin alpha-4 | 0.774 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.92 | | P22894 | MMP8 | Neutrophil collagenase | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.734 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | 0.814 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | O75015 | FCGR3B | Low affinity immunoglobulin gamma Fc region receptor III-B | -0.778 | | P22894 | MMP8 | Neutrophil collagenase | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.74 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P14598 | NCF1 | Neutrophil cytosol factor 1 | 0.798 | | P49336 | CDK8 | Cyclin-dependent kinase 8 | P14598 | NCF1 | Neutrophil cytosol factor 1 | -0.721 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.757 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.787 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.785 | | P22894 | MMP8 | Neutrophil collagenase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.797 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.754 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.85 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.842 | | P22894 | MMP8 | Neutrophil collagenase | O60603 | TLR2 | Toll-like receptor 2 | 0.89 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O60603 | TLR2 | Toll-like receptor 2 | 0.73 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | O60603 | TLR2 | Toll-like receptor 2 | -0.714 | | P49336 | CDK8 | Cyclin-dependent kinase 8 | O60603 | TLR2 | Toll-like receptor 2 | -0.734 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | 0.768 | | P49336 | CDK8 | Cyclin-dependent kinase 8 | P25963 | NFKBIA | NF-kappa-B inhibitor alpha | -0.728 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | | P22894 | MMP8 | Neutrophil collagenase | P01375 | TNF | Tumor necrosis factor | 0.728 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P01375 | TNF | Tumor necrosis factor | -0.79 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | P29350 | PTPN6 | Tyrosine-protein phosphatase non-receptor type 6 | 0.808 | | P49336 | CDK8 | Cyclin-dependent kinase 8 | P29350 | PTPN6 | Tyrosine-protein phosphatase non-receptor type 6 | -0.726 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P49006 | MARCKSL1 | MARCKS-related protein | -0.852 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | | P22894 | MMP8 | Neutrophil collagenase | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | -0.744 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.762 | | P22894 | MMP8 | Neutrophil collagenase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.963 | | P09960 | LTA4H | Leukotriene A-4 hydrolase | Q15080 | NCF4 | Neutrophil cytosol factor 4 | 0.758 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q15080 | NCF4 | Neutrophil cytosol factor 4 | -0.74 | | P49336 | CDK8 | Cyclin-dependent kinase 8 | Q15080 | NCF4 | Neutrophil cytosol factor 4 | -0.754 |
| | Acalabrutinib | hsa05143 | African trypanosomiasis | 2.81E-03 | 2 | P69905, P68871 | HBA2, HBB | More | | | Acalabrutinib | hsa05144 | Malaria | 1.16E-04 | 6 | P60033, O60603, P01375, P35443, P01584, P26718 | CD81, TLR2, TNF, THBS4, IL1B, KLRK1 | More | | | Acalabrutinib | hsa05146 | Amoebiasis | 1.08E-11 | 13 | P01584, P09341, P19875, P14778, P27930, P01375, O60603, P42338, P11215, P05089, P22694, P12814, P08311 | IL1B, CXCL1, CXCL2, IL1R1, IL1R2, TNF, TLR2, PIK3CB, ITGAM, ARG1, PRKACB, ACTN1, CTSG | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | | P42681 | TXK | Tyrosine-protein kinase TXK | P09341 | CXCL1 | Growth-regulated alpha protein | -0.881 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.868 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09341 | CXCL1 | Growth-regulated alpha protein | 0.788 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09341 | CXCL1 | Growth-regulated alpha protein | 0.7 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09341 | CXCL1 | Growth-regulated alpha protein | -0.805 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P09341 | CXCL1 | Growth-regulated alpha protein | -0.802 | | Q13547 | HDAC1 | Histone deacetylase 1 | P09341 | CXCL1 | Growth-regulated alpha protein | -0.736 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P09341 | CXCL1 | Growth-regulated alpha protein | 0.78 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19875 | CXCL2 | C-X-C motif chemokine 2 | -0.862 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.766 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | | P06239 | LCK | Tyrosine-protein kinase Lck | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.782 | | Q13547 | HDAC1 | Histone deacetylase 1 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | -0.854 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.854 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.721 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.926 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.811 | | P06239 | LCK | Tyrosine-protein kinase Lck | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.779 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.727 | | Q13547 | HDAC1 | Histone deacetylase 1 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.837 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.824 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P01375 | TNF | Tumor necrosis factor | 0.788 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P01375 | TNF | Tumor necrosis factor | -0.79 | | P42681 | TXK | Tyrosine-protein kinase TXK | O60603 | TLR2 | Toll-like receptor 2 | -0.714 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | O60603 | TLR2 | Toll-like receptor 2 | 0.772 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.842 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O60603 | TLR2 | Toll-like receptor 2 | 0.73 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | O60603 | TLR2 | Toll-like receptor 2 | -0.714 | | Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | | Q13547 | HDAC1 | Histone deacetylase 1 | P11215 | ITGAM | Integrin alpha-M | -0.751 | | P42681 | TXK | Tyrosine-protein kinase TXK | P05089 | ARG1 | Arginase-1 | -0.739 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P05089 | ARG1 | Arginase-1 | 0.897 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P05089 | ARG1 | Arginase-1 | 0.848 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P05089 | ARG1 | Arginase-1 | 0.702 | | P06239 | LCK | Tyrosine-protein kinase Lck | P05089 | ARG1 | Arginase-1 | -0.803 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P05089 | ARG1 | Arginase-1 | -0.868 | | Q13547 | HDAC1 | Histone deacetylase 1 | P05089 | ARG1 | Arginase-1 | -0.769 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P05089 | ARG1 | Arginase-1 | 0.875 | | P42681 | TXK | Tyrosine-protein kinase TXK | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | 0.878 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | -0.809 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | -0.772 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P22694 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | 0.873 | | P06239 | LCK | Tyrosine-protein kinase Lck | P12814 | ACTN1 | Alpha-actinin-1 | -0.867 | | Q13547 | HDAC1 | Histone deacetylase 1 | P12814 | ACTN1 | Alpha-actinin-1 | -0.887 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P12814 | ACTN1 | Alpha-actinin-1 | 0.794 | | P42681 | TXK | Tyrosine-protein kinase TXK | P08311 | CTSG | Cathepsin G | -0.83 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P08311 | CTSG | Cathepsin G | 0.884 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P08311 | CTSG | Cathepsin G | 0.744 | | P06239 | LCK | Tyrosine-protein kinase Lck | P08311 | CTSG | Cathepsin G | -0.816 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P08311 | CTSG | Cathepsin G | -0.866 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P08311 | CTSG | Cathepsin G | 0.768 |
| | Acalabrutinib | hsa05150 | Staphylococcus aureus infection | 2.68E-03 | 8 | P0C0L4, P21730, P21462, O75015, P13765, Q16581, P13646, P49913 | C4A, C5AR1, FPR1, FCGR3B, HLA-DOB, C3AR1, KRT13, CAMP | More | | | Acalabrutinib | hsa05152 | Tuberculosis | 3.00E-06 | 15 | P04049, Q13488, Q99437, P0DP23, O75015, P48382, O60603, P01375, P10415, P13765, P25774, P01568, P49913, Q9UDY8, P51617 | RAF1, TCIRG1, ATP6V0B, CALM1, FCGR3B, RFX5, TLR2, TNF, BCL2, HLA-DOB, CTSS, IFNA21, CAMP, MALT1, IRAK1 | More | | | Acalabrutinib | hsa05160 | Hepatitis C | 4.55E-03 | 5 | P52630, P60033, Q9NZJ5, P04049, P49841 | STAT2, CD81, EIF2AK3, RAF1, GSK3B | More | | | Acalabrutinib | hsa05161 | Hepatitis B | 5.33E-03 | 4 | P04049, Q99941, P18848, P27348 | RAF1, CREBL1, ATF4, YWHAQ | More | | | Acalabrutinib | hsa05162 | Measles | 3.18E-02 | 4 | P23458, P0DMV8, P01584, Q9NP90 | JAK1, HSPA1A, IL1B, RAB9B | More | | | Acalabrutinib | hsa05163 | Human cytomegalovirus infection | 3.55E-07 | 26 | P04049, P01375, P62873, P50151, P61952, Q14643, P0DP23, P0DP24, Q8NHW4, Q08828, P51828, P23458, P49841, P14778, P01584, P17252, Q13651, P25025, Q16539, Q99941, P18848, P04637, Q13546, O00463, P61769, P01568 | RAF1, TNF, GNB1, GNG10, GNG11, ITPR1, CALM1, CALM2, CCL4L2, ADCY1, ADCY7, JAK1, GSK3B, IL1R1, IL1B, PRKCA, IL10RA, CXCR2, MAPK14, CREBL1, ATF4, TP53, RIPK1, TRAF5, B2M, IFNA21 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | 1 | | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P01375 | TNF | Tumor necrosis factor | 0.732 | | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | 0.789 | | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.795 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.766 | | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | P61952 | GNG11 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 | -0.756 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | -0.728 | | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | Q14643 | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 | 0.701 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P0DP23 | CALM1 | Calmodulin-1 | 0.822 | | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | P0DP24 | CALM2 | Calmodulin-2 | 0.786 | | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | P0DP23 | CALM1 | Calmodulin-1 | -0.8 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q8NHW4 | CCL4L2 | C-C motif chemokine 4-like | 0.802 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.84 | | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | Q08828 | ADCY1 | Adenylate cyclase type 1 | 0.75 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P51828 | ADCY7 | Adenylate cyclase type 7 | 0.834 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 1 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.78 | | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 1 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P49841 | GSK3B | Glycogen synthase kinase-3 beta | 0.733 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.76 | | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.778 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P14778 | IL1R1 | Interleukin-1 receptor type 1 | 0.854 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | P01584 | IL1B | Interleukin-1 beta | 0.799 | | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | P01584 | IL1B | Interleukin-1 beta | 0.725 | | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | P17252 | PRKCA | Protein kinase C alpha type | 0.849 | | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | Q13651 | IL10RA | Interleukin-10 receptor subunit alpha | 0.799 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | Q13651 | IL10RA | Interleukin-10 receptor subunit alpha | -0.797 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | 0.889 | | P49841 | GSK3B | Glycogen synthase kinase-3 beta | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | 0.861 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P25025 | CXCR2 | C-X-C chemokine receptor type 2 | 0.774 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | | P49841 | GSK3B | Glycogen synthase kinase-3 beta | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.78 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.802 | | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | Q99941 | CREBL1 | Cyclic AMP-dependent transcription factor ATF-6 beta | 0.801 | | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | P18848 | ATF4 | Cyclic AMP-dependent transcription factor ATF-4 | 0.844 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P04637 | TP53 | Cellular tumor antigen p53 | -0.823 | | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | Q13546 | RIPK1 | Receptor-interacting serine/threonine-protein kinase 1 | -0.788 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.837 | | P49841 | GSK3B | Glycogen synthase kinase-3 beta | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.734 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | O00463 | TRAF5 | TNF receptor-associated factor 5 | -0.735 | | Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | P61769 | B2M | Beta-2-microglobulin | 0.753 | | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | P01568 | IFNA21 | Interferon alpha-21 | 0.898 |
| | Acalabrutinib | hsa05164 | Influenza A | 3.65E-02 | 1 | P04049 | RAF1 | More | | | Acalabrutinib | hsa05165 | Human papillomavirus infection | 4.71E-03 | 10 | P46527, Q02750, P35443, Q92796, Q05086, Q9UM47, P22694, Q13362, Q12778, Q13315 | CDKN1B, MAP2K1, THBS4, DLG3, UBE3A, NOTCH3, PRKACB, PPP2R5C, FOXO1, ATM | More | | | Acalabrutinib | hsa05167 | Kaposi sarcoma-associated herpesvirus infection | 3.15E-02 | 1 | P04049 | RAF1 | More | | | Acalabrutinib | hsa05168 | Herpes simplex virus 1 infection | 1.38E-04 | 15 | P25963, P01568, Q05823, P42224, Q07955, Q01130, Q13243, Q13489, P42338, Q13398, Q9HCX3, Q03923, P52738, O75820, Q9UDV6 | NFKBIA, IFNA21, RNASEL, STAT1, SFRS1, SFRS2, SFRS5, BIRC3, PIK3CB, ZNF211, ZNF304, ZNF85, ZNF140, ZNF189, ZNF212 | More | | | Acalabrutinib | hsa05169 | Epstein-Barr virus infection | 1.01E-04 | 15 | P13765, P01106, Q13547, O00463, P10415, P42338, P07948, Q13761, P24522, O75293, O60603, P29728, P07766, P09693, P20963 | HLA-DOB, MYC, HDAC1, TRAF5, BCL2, PIK3CB, LYN, RUNX3, GADD45A, GADD45B, TLR2, OAS2, CD3E, CD3G, CD247 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P42681 | TXK | Tyrosine-protein kinase TXK | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.89 | | P06239 | LCK | Tyrosine-protein kinase Lck | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.777 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01106 | MYC | Myc proto-oncogene protein | 0.719 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | Q13547 | HDAC1 | Histone deacetylase 1 | -0.774 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q13547 | HDAC1 | Histone deacetylase 1 | 0.811 | | P42681 | TXK | Tyrosine-protein kinase TXK | O00463 | TRAF5 | TNF receptor-associated factor 5 | 0.827 | | P06239 | LCK | Tyrosine-protein kinase Lck | O00463 | TRAF5 | TNF receptor-associated factor 5 | 0.718 | | P42681 | TXK | Tyrosine-protein kinase TXK | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.716 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 1 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | P07948 | LYN | Tyrosine-protein kinase Lyn | 0.735 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07948 | LYN | Tyrosine-protein kinase Lyn | -0.701 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | Q13761 | RUNX3 | Runt-related transcription factor 3 | -0.708 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q13761 | RUNX3 | Runt-related transcription factor 3 | 0.85 | | P42681 | TXK | Tyrosine-protein kinase TXK | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.79 | | P06239 | LCK | Tyrosine-protein kinase Lck | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.724 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | 0.768 | | P42681 | TXK | Tyrosine-protein kinase TXK | O60603 | TLR2 | Toll-like receptor 2 | -0.714 | | P42681 | TXK | Tyrosine-protein kinase TXK | P29728 | OAS2 | 2'-5'-oligoadenylate synthase 2 | 0.831 | | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.77 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | P42681 | TXK | Tyrosine-protein kinase TXK | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.838 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | P42681 | TXK | Tyrosine-protein kinase TXK | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.811 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 |
| | Acalabrutinib | hsa05170 | Human immunodeficiency virus 1 infection | 2.53E-06 | 17 | P04049, Q02750, P62873, P62879, P16298, P0DP23, Q05397, P17252, Q13546, Q14643, P01568, P51617, O60603, Q13315, P23528, P10415, Q9Y6Q5 | RAF1, MAP2K1, GNB1, GNB2, PPP3CB, CALM1, PTK2, PRKCA, RIPK1, ITPR1, IFNA21, IRAK1, TLR2, ATM, CFL1, BCL2, AP1M2 | More | | | Acalabrutinib | hsa05171 | Coronavirus disease - COVID-19 | 3.87E-04 | 5 | P62249, P40429, P27635, Q07020, P05386 | RPS16, RPL13A, RPL10, RPL18, RPLP1 | More | | | Acalabrutinib | hsa05200 | Pathways in cancer | 2.72E-05 | 29 | Q13751, P42338, P08238, P42224, P19174, Q9UJU2, P43246, P84022, Q13485, P52701, Q13547, P14923, P30279, P30281, P10415, Q13077, P49767, P43657, P62873, P63218, P50151, Q14344, Q7LDG7, Q9UM47, P78417, O75293, P0DP23, P14784, P40189 | LAMB3, PIK3CB, HSP90AB1, STAT1, PLCG1, LEF1, MSH2, SMAD3, SMAD4, MSH6, HDAC1, JUP, CCND2, CCND3, BCL2, TRAF1, VEGFC, P2RY5, GNB1, GNG5, GNG10, GNA13, RASGRP2, NOTCH3, GSTO1, GADD45B, CALM1, IL2RB, IL6ST | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13751 | LAMB3 | Laminin subunit beta-3 | 0.844 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.79 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.777 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | 0.711 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | -0.823 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P42224 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | 0.764 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | -0.766 | | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | Q9UJU2 | LEF1 | Lymphoid enhancer-binding factor 1 | 0.768 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P43246 | MSH2 | DNA mismatch repair protein Msh2 | 0.87 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43246 | MSH2 | DNA mismatch repair protein Msh2 | -0.811 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P84022 | SMAD3 | Mothers against decapentaplegic homolog 3 | 0.725 | | O43318 | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | 0.794 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13485 | SMAD4 | Mothers against decapentaplegic homolog 4 | -0.746 | | O43318 | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | P52701 | MSH6 | DNA mismatch repair protein Msh6 | 0.91 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.754 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P14923 | JUP | Junction plakoglobin | -0.735 | | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | P14923 | JUP | Junction plakoglobin | 0.766 | | O43318 | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | P30279 | CCND2 | G1/S-specific cyclin-D2 | 0.704 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P30281 | CCND3 | G1/S-specific cyclin-D3 | 0.743 | | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | P10415 | BCL2 | Apoptosis regulator Bcl-2 | 0.807 | | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | Q13077 | TRAF1 | TNF receptor-associated factor 1 | 0.801 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P49767 | VEGFC | Vascular endothelial growth factor C | 0.743 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P43657 | P2RY5 | Lysophosphatidic acid receptor 6 | -0.735 | | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | P62873 | GNB1 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | -0.759 | | O43318 | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | -0.707 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P63218 | GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | 0.941 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P50151 | GNG10 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | 0.948 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | 0.87 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | Q7LDG7 | RASGRP2 | RAS guanyl-releasing protein 2 | 0.704 | | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | Q9UM47 | NOTCH3 | Neurogenic locus notch homolog protein 3 | -0.71 | | O43318 | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | P78417 | GSTO1 | Glutathione S-transferase omega-1 | -0.849 | | P29375 | JARID1A | Lysine-specific demethylase 5A | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | -0.748 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | O75293 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | 0.731 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P0DP23 | CALM1 | Calmodulin-1 | 0.755 | | P51617 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | P0DP23 | CALM1 | Calmodulin-1 | -0.703 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P14784 | IL2RB | Interleukin-2 receptor subunit beta | 0.768 | | P09917 | ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | P14784 | IL2RB | Interleukin-2 receptor subunit beta | -0.835 | | P29375 | JARID1A | Lysine-specific demethylase 5A | P40189 | IL6ST | Interleukin-6 receptor subunit beta | 0.83 |
| | Acalabrutinib | hsa05202 | Transcriptional misregulation in cancer | 8.82E-09 | 25 | Q12778, Q15532, Q13315, P41732, P17844, P14780, P27930, P14923, Q15744, Q16548, Q13489, Q13077, O15550, P08069, P46527, P35226, P05164, P12838, P08246, Q9C0K0, P41182, Q13547, Q92769, P12980, P24522 | FOXO1, SS18, ATM, TSPAN7, DDX5, MMP9, IL1R2, JUP, CEBPE, BCL2A1, BIRC3, TRAF1, UTX, IGF1R, CDKN1B, BMI1, MPO, DEFA4, ELA2, BCL11B, BCL6, HDAC1, HDAC2, LYL1, GADD45A | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P22894 | MMP8 | Neutrophil collagenase | Q12778 | FOXO1 | Forkhead box protein O1 | -0.72 | | Q13315 | ATM | Serine-protein kinase ATM | Q12778 | FOXO1 | Forkhead box protein O1 | 0.821 | | P22894 | MMP8 | Neutrophil collagenase | Q15532 | SS18 | Protein SSXT | -0.867 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q13315 | ATM | Serine-protein kinase ATM | 0.752 | | Q13315 | ATM | Serine-protein kinase ATM | Q13315 | ATM | Serine-protein kinase ATM | 1 | | P42681 | TXK | Tyrosine-protein kinase TXK | P41732 | TSPAN7 | Tetraspanin-7 | -0.719 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P17844 | DDX5 | Probable ATP-dependent RNA helicase DDX5 | 0.863 | | P42681 | TXK | Tyrosine-protein kinase TXK | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.762 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.9 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.94 | | P22894 | MMP8 | Neutrophil collagenase | P14780 | MMP9 | Matrix metalloproteinase-9 | 0.882 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P14780 | MMP9 | Matrix metalloproteinase-9 | -0.855 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.721 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P27930 | IL1R2 | Interleukin-1 receptor type 2 | 0.926 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P27930 | IL1R2 | Interleukin-1 receptor type 2 | -0.727 | | P22894 | MMP8 | Neutrophil collagenase | P14923 | JUP | Junction plakoglobin | -0.809 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | Q15744 | CEBPE | CCAAT/enhancer-binding protein epsilon | 0.772 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q15744 | CEBPE | CCAAT/enhancer-binding protein epsilon | -0.833 | | Q13315 | ATM | Serine-protein kinase ATM | Q15744 | CEBPE | CCAAT/enhancer-binding protein epsilon | -0.709 | | P42681 | TXK | Tyrosine-protein kinase TXK | Q16548 | BCL2A1 | Bcl-2-related protein A1 | -0.756 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.776 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.958 | | P22894 | MMP8 | Neutrophil collagenase | Q16548 | BCL2A1 | Bcl-2-related protein A1 | 0.843 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q16548 | BCL2A1 | Bcl-2-related protein A1 | -0.877 | | P22894 | MMP8 | Neutrophil collagenase | Q13489 | BIRC3 | Baculoviral IAP repeat-containing protein 3 | -0.765 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.796 | | P22894 | MMP8 | Neutrophil collagenase | Q13077 | TRAF1 | TNF receptor-associated factor 1 | -0.806 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q13077 | TRAF1 | TNF receptor-associated factor 1 | 0.83 | | P42681 | TXK | Tyrosine-protein kinase TXK | O15550 | UTX | Lysine-specific demethylase 6A | -0.731 | | P08069 | IGF1R | Insulin-like growth factor 1 receptor | P08069 | IGF1R | Insulin-like growth factor 1 receptor | 1 | | Q13315 | ATM | Serine-protein kinase ATM | P46527 | CDKN1B | Cyclin-dependent kinase inhibitor 1B | 0.708 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.716 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.778 | | P22894 | MMP8 | Neutrophil collagenase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.821 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P35226 | BMI1 | Polycomb complex protein BMI-1 | 0.76 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.716 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.778 | | P22894 | MMP8 | Neutrophil collagenase | P35226 | BMI1 | Polycomb complex protein BMI-1 | -0.821 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P35226 | BMI1 | Polycomb complex protein BMI-1 | 0.76 | | P42681 | TXK | Tyrosine-protein kinase TXK | P05164 | MPO | Myeloperoxidase | -0.829 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P05164 | MPO | Myeloperoxidase | 0.909 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P05164 | MPO | Myeloperoxidase | 0.719 | | P22894 | MMP8 | Neutrophil collagenase | P05164 | MPO | Myeloperoxidase | 0.905 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P05164 | MPO | Myeloperoxidase | -0.811 | | Q13315 | ATM | Serine-protein kinase ATM | P05164 | MPO | Myeloperoxidase | -0.725 | | P42681 | TXK | Tyrosine-protein kinase TXK | P12838 | DEFA4 | Neutrophil defensin 4 | -0.707 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P12838 | DEFA4 | Neutrophil defensin 4 | 0.882 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P12838 | DEFA4 | Neutrophil defensin 4 | 0.784 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P12838 | DEFA4 | Neutrophil defensin 4 | -0.86 | | P42681 | TXK | Tyrosine-protein kinase TXK | P08246 | ELA2 | Neutrophil elastase | -0.756 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P08246 | ELA2 | Neutrophil elastase | 0.889 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P08246 | ELA2 | Neutrophil elastase | 0.702 | | P22894 | MMP8 | Neutrophil collagenase | P08246 | ELA2 | Neutrophil elastase | 0.985 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P08246 | ELA2 | Neutrophil elastase | -0.782 | | Q13315 | ATM | Serine-protein kinase ATM | P08246 | ELA2 | Neutrophil elastase | -0.742 | | P42681 | TXK | Tyrosine-protein kinase TXK | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | 0.874 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.85 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.783 | | P22894 | MMP8 | Neutrophil collagenase | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | -0.778 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | 0.9 | | Q13315 | ATM | Serine-protein kinase ATM | Q9C0K0 | BCL11B | B-cell lymphoma/leukemia 11B | 0.741 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P41182 | BCL6 | B-cell lymphoma 6 protein | 0.919 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q13547 | HDAC1 | Histone deacetylase 1 | -0.7 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q92769 | HDAC2 | Histone deacetylase 2 | -0.7 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P12980 | LYL1 | Protein lyl-1 | 0.702 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P12980 | LYL1 | Protein lyl-1 | 0.784 | | P42681 | TXK | Tyrosine-protein kinase TXK | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.79 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.859 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.819 | | P22894 | MMP8 | Neutrophil collagenase | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | 0.766 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P24522 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | -0.75 |
| | Acalabrutinib | hsa05203 | Viral carcinogenesis | 2.63E-03 | 7 | Q99941, P18848, P27348, Q15283, P61978, P62807, O60814 | CREBL1, ATF4, YWHAQ, RASA2, HNRPK, HIST1H2BC, H2BC12 | More | | | Acalabrutinib | hsa05204 | Chemical carcinogenesis | 1.09E-03 | 3 | P09211, P78417, P11712 | GSTP1, GSTO1, CYP2C9 | More | | | Acalabrutinib | hsa05205 | Proteoglycans in cancer | 2.26E-03 | 6 | Q13009, Q12955, O75369, P04049, P08069, P08962 | TIAM1, ANK3, FLNB, RAF1, IGF1R, CD63 | More | | | Acalabrutinib | hsa05206 | MicroRNAs in cancer | 1.19E-02 | 7 | P46527, Q9UM47, P16070, Q13315, P17252, P04049, Q02750 | CDKN1B, NOTCH3, CD44, ATM, PRKCA, RAF1, MAP2K1 | More | | | Acalabrutinib | hsa05210 | Colorectal cancer | 4.39E-03 | 3 | Q13485, P04049, P52701 | SMAD4, RAF1, MSH6 | More | | | Acalabrutinib | hsa05211 | Renal cell carcinoma | 1.16E-02 | 1 | P04049 | RAF1 | More | | | Acalabrutinib | hsa05212 | Pancreatic cancer | 4.56E-04 | 6 | P42338, P04049, P42224, P84022, Q13485, O75293 | PIK3CB, RAF1, STAT1, SMAD3, SMAD4, GADD45B | More | | | Acalabrutinib | hsa05213 | Endometrial cancer | 9.95E-03 | 1 | P04049 | RAF1 | More | | | Acalabrutinib | hsa05214 | Glioma | 1.77E-04 | 5 | P08069, P0DP23, P04049, P42338, O75293 | IGF1R, CALM1, RAF1, PIK3CB, GADD45B | More | | | Acalabrutinib | hsa05215 | Prostate cancer | 2.34E-04 | 5 | P10415, Q12778, P08069, Q9NRA1, P04049 | BCL2, FOXO1, IGF1R, PDGFC, RAF1 | More | | | Acalabrutinib | hsa05217 | Basal cell carcinoma | 7.91E-03 | 5 | Q13635, P04628, P49841, Q9UJU2, P24522 | PTCH1, WNT1, GSK3B, LEF1, GADD45A | More | | | Acalabrutinib | hsa05218 | Melanoma | 3.85E-05 | 2 | P08069, P04049 | IGF1R, RAF1 | More | | | Acalabrutinib | hsa05219 | Bladder cancer | 5.65E-03 | 3 | P14780, P04637, P04049 | MMP9, TP53, RAF1 | More | | | Acalabrutinib | hsa05220 | Chronic myeloid leukemia | 3.00E-03 | 6 | Q13547, Q13485, P84022, P42338, P04049, O75293 | HDAC1, SMAD4, SMAD3, PIK3CB, RAF1, GADD45B | More | | | Acalabrutinib | hsa05221 | Acute myeloid leukemia | 8.29E-03 | 1 | P04049 | RAF1 | More | | | Acalabrutinib | hsa05223 | Non-small cell lung cancer | 6.63E-03 | 1 | P04049 | RAF1 | More | | | Acalabrutinib | hsa05224 | Breast cancer | 2.75E-03 | 6 | P04049, P08069, P49841, Q92837, P04637, P24522 | RAF1, IGF1R, GSK3B, FRAT1, TP53, GADD45A | More | | | Acalabrutinib | hsa05225 | Hepatocellular carcinoma | 1.65E-04 | 2 | P04049, P08069 | RAF1, IGF1R | More | | | Acalabrutinib | hsa05226 | Gastric cancer | 8.29E-03 | 1 | P04049 | RAF1 | More | | | Acalabrutinib | hsa05230 | Central carbon metabolism in cancer | 9.95E-03 | 1 | P04049 | RAF1 | More | | | Acalabrutinib | hsa05231 | Choline metabolism in cancer | 4.44E-03 | 4 | P04049, Q9Y259, P19174, P49619 | RAF1, CHKB, PLCG1, DGKG | More | | | Acalabrutinib | hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 4.32E-10 | 14 | P42338, O95267, P19174, P07766, P20963, P09693, P06239, P04049, P23458, O60603, P10747, Q04759, Q16539, P01730 | PIK3CB, RASGRP1, PLCG1, CD3E, CD247, CD3G, LCK, RAF1, JAK1, TLR2, CD28, PRKCQ, MAPK14, CD4 | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| Q13547 | HDAC1 | Histone deacetylase 1 | P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | -0.774 | | P42681 | TXK | Tyrosine-protein kinase TXK | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | 0.857 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.852 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O95267 | RASGRP1 | RAS guanyl-releasing protein 1 | -0.716 | | Q13547 | HDAC1 | Histone deacetylase 1 | P19174 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 0.7 | | P06239 | LCK | Tyrosine-protein kinase Lck | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.928 | | Q13547 | HDAC1 | Histone deacetylase 1 | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | 0.802 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P07766 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | -0.755 | | P42681 | TXK | Tyrosine-protein kinase TXK | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.811 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.786 | | P06239 | LCK | Tyrosine-protein kinase Lck | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.927 | | Q13547 | HDAC1 | Histone deacetylase 1 | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | 0.87 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P20963 | CD247 | T-cell surface glycoprotein CD3 zeta chain | -0.778 | | P42681 | TXK | Tyrosine-protein kinase TXK | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.838 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.835 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | -0.744 | | P06239 | LCK | Tyrosine-protein kinase Lck | P09693 | CD3G | T-cell surface glycoprotein CD3 gamma chain | 0.752 | | P42681 | TXK | Tyrosine-protein kinase TXK | P06239 | LCK | Tyrosine-protein kinase Lck | 0.734 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P06239 | LCK | Tyrosine-protein kinase Lck | -0.726 | | P06239 | LCK | Tyrosine-protein kinase Lck | P06239 | LCK | Tyrosine-protein kinase Lck | 1 | | Q13547 | HDAC1 | Histone deacetylase 1 | P06239 | LCK | Tyrosine-protein kinase Lck | 0.811 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P06239 | LCK | Tyrosine-protein kinase Lck | -0.791 | | P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | P04049 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | 1 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 0.757 | | P42681 | TXK | Tyrosine-protein kinase TXK | O60603 | TLR2 | Toll-like receptor 2 | -0.714 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.842 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | O60603 | TLR2 | Toll-like receptor 2 | 0.73 | | P42681 | TXK | Tyrosine-protein kinase TXK | P10747 | CD28 | T-cell-specific surface glycoprotein CD28 | 0.776 | | P42681 | TXK | Tyrosine-protein kinase TXK | Q04759 | PRKCQ | Protein kinase C theta type | 0.876 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q04759 | PRKCQ | Protein kinase C theta type | -0.767 | | P06239 | LCK | Tyrosine-protein kinase Lck | Q04759 | PRKCQ | Protein kinase C theta type | 0.779 | | Q13547 | HDAC1 | Histone deacetylase 1 | Q04759 | PRKCQ | Protein kinase C theta type | 0.723 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | Q04759 | PRKCQ | Protein kinase C theta type | -0.737 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.883 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 1 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 0.802 | | Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.707 | | P06239 | LCK | Tyrosine-protein kinase Lck | P01730 | CD4 | T-cell surface glycoprotein CD4 | 0.746 | | P51813 | BMX | Cytoplasmic tyrosine-protein kinase BMX | P01730 | CD4 | T-cell surface glycoprotein CD4 | -0.857 |
| | Acalabrutinib | hsa05310 | Asthma | 1.90E-05 | 3 | P13765, P12724, P01375 | HLA-DOB, RNASE3, TNF | More | | | Acalabrutinib | hsa05321 | Inflammatory bowel disease | 1.68E-11 | 8 | O60603, P01375, P13765, Q14765, Q9UL17, P23771, P01584, Q9HBE5 | TLR2, TNF, HLA-DOB, STAT4, TBX21, GATA3, IL1B, IL21R | More | | Genes in community(ComG) | Gene name of ComG | Protein name of ComG | Co-expressed genes in pathway (PathG) | Gene name of PathG | Protein name of PathG | Coexpression |
|---|
| P42681 | TXK | Tyrosine-protein kinase TXK | O60603 | TLR2 | Toll-like receptor 2 | -0.714 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | O60603 | TLR2 | Toll-like receptor 2 | 0.772 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | O60603 | TLR2 | Toll-like receptor 2 | 0.842 | | P22894 | MMP8 | Neutrophil collagenase | O60603 | TLR2 | Toll-like receptor 2 | 0.89 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | O60603 | TLR2 | Toll-like receptor 2 | -0.714 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P01375 | TNF | Tumor necrosis factor | 0.788 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01375 | TNF | Tumor necrosis factor | 0.78 | | P22894 | MMP8 | Neutrophil collagenase | P01375 | TNF | Tumor necrosis factor | 0.728 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P01375 | TNF | Tumor necrosis factor | -0.79 | | P42681 | TXK | Tyrosine-protein kinase TXK | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.89 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.757 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.785 | | P22894 | MMP8 | Neutrophil collagenase | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | -0.797 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P13765 | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain | 0.85 | | P42681 | TXK | Tyrosine-protein kinase TXK | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | 0.771 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | -0.815 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | -0.777 | | P22894 | MMP8 | Neutrophil collagenase | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | -0.757 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q14765 | STAT4 | Signal transducer and activator of transcription 4 | 0.904 | | P42681 | TXK | Tyrosine-protein kinase TXK | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.849 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.788 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | Q9UL17 | TBX21 | T-box transcription factor TBX21 | -0.872 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q9UL17 | TBX21 | T-box transcription factor TBX21 | 0.884 | | P42681 | TXK | Tyrosine-protein kinase TXK | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.856 | | Q9UM07 | PADI4 | Protein-arginine deiminase type-4 | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.905 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.763 | | P22894 | MMP8 | Neutrophil collagenase | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | -0.751 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | P23771 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | 0.784 | | P43490 | PBEF1 | Nicotinamide phosphoribosyltransferase | P01584 | IL1B | Interleukin-1 beta | 0.807 | | Q08881 | ITK | Tyrosine-protein kinase ITK/TSK | Q9HBE5 | IL21R | Interleukin-21 receptor | 0.713 |
| | Acalabrutinib | hsa05322 | Systemic lupus erythematosus | 1.24E-04 | 13 | O75015, P08246, P08311, P09871, P01375, P10747, P13765, Q6FI13, Q93077, P62807, O60814, P68431, P05455 | FCGR3B, ELA2, CTSG, C1S, TNF, CD28, HLA-DOB, H2AC18; H2AC19, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, SSB | More | | | Acalabrutinib | hsa05323 | Rheumatoid arthritis | 8.82E-04 | 5 | P01375, P13765, P10747, P09341, O60603 | TNF, HLA-DOB, CD28, CXCL1, TLR2 | More | | | Acalabrutinib | hsa05332 | Graft-versus-host disease | 1.14E-08 | 5 | P13765, P10747, P01375, P26715, Q13241 | HLA-DOB, CD28, TNF, KLRC1, KLRD1 | More | | | Acalabrutinib | hsa05340 | Primary immunodeficiency | 2.19E-02 | 4 | P01730, P01732, P07766, P06239 | CD4, CD8A, CD3E, LCK | More | | | Acalabrutinib | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy | 4.48E-02 | 1 | P54284 | CACNB3 | More | | | Acalabrutinib | hsa05414 | Dilated cardiomyopathy | 4.55E-02 | 2 | P54284, P26678 | CACNB3, PLN | More | | | Acalabrutinib | hsa05415 | Diabetic cardiomyopathy | 4.54E-04 | 8 | P17252, P14598, Q15080, Q16718, O14521, Q16539, P49841, P04406 | PRKCA, NCF1, NCF4, NDUFA5, SDHD, MAPK14, GSK3B, GAPDH | More | | | Acalabrutinib | hsa05418 | Fluid shear stress and atherosclerosis | 1.56E-05 | 12 | Q16539, P42338, Q14145, P14598, P10599, P14780, P01375, P04637, P14778, P27930, P0DP23, P08238 | MAPK14, PIK3CB, KEAP1, NCF1, TXN, MMP9, TNF, TP53, IL1R1, IL1R2, CALM1, HSP90AB1 | More | |
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