PharmaCoNets of Abiraterone (SPCN: 48.89 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Abirateronehsa00030Pentose phosphate pathway1.69E-022P60891, P37837PRPS1, TALDO1More
Abirateronehsa00240Pyrimidine metabolism4.29E-022P21589, P04183NT5E, TK1More
Abirateronehsa00513Various types of N-glycan biosynthesis4.96E-021Q9NR34MAN1C1More
Abirateronehsa00564Glycerophospholipid metabolism4.29E-022Q6P1A2, P23743MBOAT5, DGKAMore
Abirateronehsa00590Arachidonic acid metabolism3.85E-022P11712, P09960CYP2C9, LTA4HMore
Abirateronehsa00591Linoleic acid metabolism4.07E-021P11712CYP2C9More
Abirateronehsa00670One carbon pool by folate3.15E-022O95954, Q99707FTCD, MTRMore
Abirateronehsa00860Porphyrin and chlorophyll metabolism8.96E-042P36551, P30043CPOX, BLVRBMore
Abirateronehsa00980Metabolism of xenobiotics by cytochrome P4509.14E-032P78417, P11712GSTO1, CYP2C9More
Abirateronehsa00982Drug metabolism - cytochrome P4509.14E-032P11712, P78417CYP2C9, GSTO1More
Abirateronehsa01230Biosynthesis of amino acids3.59E-023P60891, Q99707, P37837PRPS1, MTR, TALDO1More
Abirateronehsa03008Ribosome biogenesis in eukaryotes1.88E-023O14980, O60832, Q9BVP2XPO1, DKC1, GNL3More
Abirateronehsa03013RNA transport7.74E-0915O14980, P52298, Q09161, O14893, P61326, Q9H307, Q7Z3B4, P35658, Q14152, O75822, Q14240, P23588, Q9Y6A5, Q06787, P51114XPO1, NCBP2, NCBP1, GEMIN2, MAGOH, PNN, NUP54, NUP214, EIF3A, EIF3J, EIF4A2, EIF4B, TACC3, FMR1, FXR1More
Abirateronehsa03015mRNA surveillance pathway4.42E-024O60942, O43148, P52298, Q53GS7RNGTT, RNMT, NCBP2, GLE1More
Abirateronehsa04015Rap1 signaling pathway3.07E-024P25116, Q8TEU7, P08514, P17252F2R, RAPGEF6, ITGA2B, PRKCAMore
Abirateronehsa04061Viral protein interaction with cytokine and cytokine receptor4.48E-025P09341, P19875, P25024, P25025, P14784CXCL1, CXCL2, CXCR1, CXCR2, IL2RBMore
Abirateronehsa04062Chemokine signaling pathway1.83E-028P25024, P25025, P09341, P19875, P42338, P19174, P63218, P50151CXCR1, CXCR2, CXCL1, CXCL2, PIK3CB, PLCG1, GNG5, GNG10More
Abirateronehsa04064NF-kappa B signaling pathway2.98E-0413P10415, O00463, P14778, P19174, Q04759, Q9UDY8, Q16548, P06239, Q13315, P24522, P09341, P19875, Q06643BCL2, TRAF5, IL1R1, PLCG1, PRKCQ, MALT1, BCL2A1, LCK, ATM, GADD45A, CXCL1, CXCL2, LTBMore
Abirateronehsa04070Phosphatidylinositol signaling system1.53E-022Q86XP1, Q96DU7DGKH, ITPKCMore
Abirateronehsa04071Sphingolipid signaling pathway1.19E-025P21453, Q9H228, Q13362, Q9BX95, P10415S1PR1, EDG8, PPP2R5C, SGPP1, BCL2More
Abirateronehsa04072Phospholipase D signaling pathway4.48E-025P42338, P43657, P25024, P25025, P19174PIK3CB, P2RY5, CXCR1, CXCR2, PLCG1More
Abirateronehsa04080Neuroactive ligand-receptor interaction1.00E-027P08311, Q15722, P21453, Q9H228, O00398, P21730, P07550CTSG, LTB4R, S1PR1, EDG8, P2RY10, C5AR1, ADRB2More
Abirateronehsa04114Oocyte meiosis1.33E-024P51812, Q02750, P16298, Q17RY0RPS6KA3, MAP2K1, PPP3CB, CPEB4More
Abirateronehsa04136Autophagy - other5.92E-032O94817, Q9H1Y0ATG12, ATG5More
Abirateronehsa04140Autophagy - animal3.19E-024P22694, Q14643, P10415, Q04759PRKACB, ITPR1, BCL2, PRKCQMore
Abirateronehsa04145Phagosome3.23E-039P63261, Q15080, P14598, Q13509, P68371, P05164, O60603, P35443, P13765ACTG1, NCF4, NCF1, TUBB3, TUBB2C, MPO, TLR2, THBS4, HLA-DOBMore
Abirateronehsa04150mTOR signaling pathway3.60E-023Q02750, Q9NQL2, P51812MAP2K1, RRAGD, RPS6KA3More
Abirateronehsa04210Apoptosis3.44E-027Q13315, P10415, O76075, P24522, Q16548, P43234, Q14643ATM, BCL2, DFFB, GADD45A, BCL2A1, CTSO, ITPR1More
Abirateronehsa04213Longevity regulating pathway - multiple species3.85E-024P42338, Q9Y4H2, P11142, Q13547PIK3CB, IRS2, HSPA8, HDAC1More
Abirateronehsa04217Necroptosis5.89E-037P01568, Q13489, Q13546, P07384, Q6FI13, P10415, O43633IFNA21, BIRC3, RIPK1, CAPN1, H2AC18; H2AC19, BCL2, CHMP2AMore
Abirateronehsa04340Hedgehog signaling pathway3.09E-023P22694, Q13635, P10415PRKACB, PTCH1, BCL2More
Abirateronehsa04370VEGF signaling pathway2.68E-033P16298, Q05397, Q02750PPP3CB, PTK2, MAP2K1More
Abirateronehsa04510Focal adhesion4.64E-026O75369, Q15942, Q13489, P10415, P49767, P63261FLNB, ZYX, BIRC3, BCL2, VEGFC, ACTG1More
Abirateronehsa04530Tight junction3.29E-023P16989, P56750, Q14247CSDA, CLDN17, CTTNMore
Abirateronehsa04611Platelet activation3.39E-023P25116, P08514, P07359F2R, ITGA2B, GP1BAMore
Abirateronehsa04612Antigen processing and presentation4.48E-025P13765, P26715, P26717, Q13241, P01732HLA-DOB, KLRC1, KLRC2, KLRD1, CD8AMore
Abirateronehsa04613Neutrophil extracellular trap formation3.77E-0312O60603, P05164, P08246, Q9UM07, Q93077, P62807, O60814, P68431, Q15080, P20160, P08311, P21730TLR2, MPO, ELA2, PADI4, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12, NCF4, AZU1, CTSG, C5AR1More
Abirateronehsa04623Cytosolic DNA-sensing pathway2.46E-022P01568, Q13546IFNA21, RIPK1More
Abirateronehsa04640Hematopoietic cell lineage1.37E-027P14778, P27930, P11215, P25063, P07766, P01732, P09564IL1R1, IL1R2, ITGAM, CD24, CD3E, CD8A, CD7More
Abirateronehsa04650Natural killer cell mediated cytotoxicity1.54E-0513P16298, P50591, P19174, P06239, O60880, P20963, P42338, Q02750, Q13241, P26718, O14931, P26717, P26715PPP3CB, TNFSF10, PLCG1, LCK, SH2D1A, CD247, PIK3CB, MAP2K1, KLRD1, KLRK1, NCR3, KLRC2, KLRC1More
Abirateronehsa04658Th1 and Th2 cell differentiation7.66E-0712Q04759, P07766, P20963, P09693, P19174, P06239, Q14765, P23771, Q9UL17, P14784, P13765, Q13761PRKCQ, CD3E, CD247, CD3G, PLCG1, LCK, STAT4, GATA3, TBX21, IL2RB, HLA-DOB, RUNX3More
Abirateronehsa04659Th17 cell differentiation8.48E-0511Q04759, P19174, P06239, P14784, P13765, P14778, Q9UL17, P23771, P07766, P09693, P20963PRKCQ, PLCG1, LCK, IL2RB, HLA-DOB, IL1R1, TBX21, GATA3, CD3E, CD3G, CD247More
Abirateronehsa04660T cell receptor signaling pathway1.09E-0412Q9UDY8, Q04759, P42338, P10747, Q08881, P19174, P07766, P20963, P09693, P01732, Q13191, P06239MALT1, PRKCQ, PIK3CB, CD28, ITK, PLCG1, CD3E, CD247, CD3G, CD8A, CBLB, LCKMore
Abirateronehsa04672Intestinal immune network for IgA production1.35E-022P29965, P13765CD40LG, HLA-DOBMore
Abirateronehsa04720Long-term potentiation1.38E-023P16298, P51812, Q02750PPP3CB, RPS6KA3, MAP2K1More
Abirateronehsa04750Inflammatory mediator regulation of TRP channels7.24E-035P14778, P19174, P42338, P24723, Q04759IL1R1, PLCG1, PIK3CB, PRKCH, PRKCQMore
Abirateronehsa04914Progesterone-mediated oocyte maturation2.94E-023Q17RY0, P51812, Q02750CPEB4, RPS6KA3, MAP2K1More
Abirateronehsa04918Thyroid hormone synthesis3.16E-022P17252, P27824PRKCA, CANXMore
Abirateronehsa04922Glucagon signaling pathway4.23E-024P22694, P06737, Q12778, Q14643PRKACB, PYGL, FOXO1, ITPR1More
Abirateronehsa04923Regulation of lipolysis in adipocytes2.24E-023P07550, P42338, Q9Y4H2ADRB2, PIK3CB, IRS2More
Abirateronehsa04924Renin secretion1.04E-023P22694, P07550, Q14643PRKACB, ADRB2, ITPR1More
Abirateronehsa04928Parathyroid hormone synthesis, secretion and action4.23E-024Q14643, P22694, P23771, P10415ITPR1, PRKACB, GATA3, BCL2More
Abirateronehsa04973Carbohydrate digestion and absorption1.29E-022O43451, P42338MGAM, PIK3CBMore
Abirateronehsa05022Pathways of neurodegeneration - multiple diseases2.69E-028O15399, Q13509, P68371, P10415, Q13561, P07384, P04628, P0DP23GRIN2D, TUBB3, TUBB2C, BCL2, DCTN2, CAPN1, WNT1, CALM1More
Abirateronehsa05034Alcoholism2.89E-034Q93077, P62807, O60814, P68431HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Abirateronehsa05120Epithelial cell signaling in Helicobacter pylori infection2.78E-035P09341, P19875, P19174, P25024, P25025CXCL1, CXCL2, PLCG1, CXCR1, CXCR2More
Abirateronehsa05132Salmonella infection6.88E-038P63261, Q13546, Q13489, P10415, O75369, Q13561, Q13509, P68371ACTG1, RIPK1, BIRC3, BCL2, FLNB, DCTN2, TUBB3, TUBB2CMore
Abirateronehsa05134Legionellosis1.29E-024P11215, P11142, P09341, P19875ITGAM, HSPA8, CXCL1, CXCL2More
Abirateronehsa05146Amoebiasis2.21E-048P09341, P19875, P14778, P27930, P42338, P11215, P05089, P12814CXCL1, CXCL2, IL1R1, IL1R2, PIK3CB, ITGAM, ARG1, ACTN1More
Abirateronehsa05167Kaposi sarcoma-associated herpesvirus infection1.94E-024P62879, P16298, Q02750, P0CG47GNB2, PPP3CB, MAP2K1, UBBMore
Abirateronehsa05168Herpes simplex virus 1 infection1.17E-0210Q9UKJ0, Q06124, P01568, Q01130, Q13489, Q13398, Q9NR11, Q03923, Q9UDV6, P10415PILRB, PTPN11, IFNA21, SFRS2, BIRC3, ZNF211, ZNF302, ZNF85, ZNF212, BCL2More
Abirateronehsa05170Human immunodeficiency virus 1 infection6.02E-035Q02750, P62879, P16298, Q05397, P20333MAP2K1, GNB2, PPP3CB, PTK2, TNFRSF1BMore
Abirateronehsa05202Transcriptional misregulation in cancer2.90E-029Q12778, Q13315, P14780, Q16548, O15550, P05164, P08246, Q9C0K0, P24522FOXO1, ATM, MMP9, BCL2A1, UTX, MPO, ELA2, BCL11B, GADD45AMore
Abirateronehsa05203Viral carcinogenesis4.85E-023Q15283, P62807, O60814RASA2, HIST1H2BC, H2BC12More
Abirateronehsa05204Chemical carcinogenesis1.48E-022P78417, P11712GSTO1, CYP2C9More
Abirateronehsa05205Proteoglycans in cancer4.46E-024Q12955, Q14247, P17252, P08962ANK3, CTTN, PRKCA, CD63More
Abirateronehsa05213Endometrial cancer3.79E-022O15169, Q02750AXIN1, MAP2K1More
Abirateronehsa05226Gastric cancer3.79E-022Q02750, O15169MAP2K1, AXIN1More
Abirateronehsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer6.79E-049P42338, P19174, P07766, P20963, P09693, P06239, O60603, P10747, Q04759PIK3CB, PLCG1, CD3E, CD247, CD3G, LCK, TLR2, CD28, PRKCQMore
Abirateronehsa05310Asthma1.35E-022P13765, P29965HLA-DOB, CD40LGMore
Abirateronehsa05320Autoimmune thyroid disease3.16E-022P13765, P29965HLA-DOB, CD40LGMore
Abirateronehsa05321Inflammatory bowel disease1.17E-035O60603, P13765, Q14765, Q9UL17, P23771TLR2, HLA-DOB, STAT4, TBX21, GATA3More
Abirateronehsa05322Systemic lupus erythematosus1.31E-045P09871, Q93077, P62807, O60814, P68431C1S, HIST1H2AC, HIST1H2BC, H2BC12, H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12More
Abirateronehsa05323Rheumatoid arthritis1.60E-024P13765, P10747, P09341, O60603HLA-DOB, CD28, CXCL1, TLR2More
Abirateronehsa05330Allograft rejection3.16E-022P13765, P29965HLA-DOB, CD40LGMore
Abirateronehsa05332Graft-versus-host disease3.45E-034P13765, P10747, P26715, Q13241HLA-DOB, CD28, KLRC1, KLRD1More
Abirateronehsa05412Arrhythmogenic right ventricular cardiomyopathy1.82E-023P14923, P08514, Q9UJU2JUP, ITGA2B, LEF1More
Abirateronehsa05416Viral myocarditis4.29E-022P13765, P29965HLA-DOB, CD40LGMore

Community members of Abiraterone (SDC: 4.67)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P11511CYP19A1AromatasePredicted00.815610.15882.5666
Q9P1W9PIM2Serine/threonineNoneprotein kinase pimNone2Predicted00.12670.76740.26381.8619
Q9UBU7DBF4Protein DBF4 homolog APredicted00.00750.19610.2590.655
P25116F2RProteinaseNoneactivated receptor 1Predicted10.20380.31960.51361.2547
Q13547HDAC1Histone deacetylase 1Predicted00.044710.9863.0084
Q92769HDAC2Histone deacetylase 2Predicted10.047310.9863.0097
P42330AKR1C3AldoNoneketo reductase family 1 member C3Predicted00.40170.83480.17482.0453
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
P33260CYP2C18Cytochrome P450 2C18Predicted10.02390.07560.15280.316
P11712CYP2C9Cytochrome P450 2C9Predicted10.010610.15242.1577
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)