PharmaCoNets of Abacavir (SPCN: 30.52 )
Drug NamePathway IDPathway nameP-valueNo. of gene membersUniProt ACGene nameDetail of Coexpression
Abacavirhsa00052Galactose metabolism1.06E-032P06280, O43451GLA, MGAMMore
Abacavirhsa00053Ascorbate and aldarate metabolism6.45E-051P14550AKR1A1More
Abacavirhsa00270Cysteine and methionine metabolism2.06E-022P26358, P48506DNMT1, GCLCMore
Abacavirhsa00440Phosphonate and phosphinate metabolism3.98E-021Q9Y6K0CEPT1More
Abacavirhsa00500Starch and sucrose metabolism2.32E-043O43451, P46976, P06737MGAM, GYG1, PYGLMore
Abacavirhsa00561Glycerolipid metabolism1.41E-022P14550, Q86XP1AKR1A1, DGKHMore
Abacavirhsa00564Glycerophospholipid metabolism4.61E-022Q9Y6K0, Q86XP1CEPT1, DGKHMore
Abacavirhsa00565Ether lipid metabolism1.52E-032Q9Y6K0, Q8N661CEPT1, TMEM86BMore
Abacavirhsa00670One carbon pool by folate3.15E-022O95954, Q99707FTCD, MTRMore
Abacavirhsa00730Thiamine metabolism2.53E-042P05186, P24666ALPL, ACP1More
Abacavirhsa00860Porphyrin and chlorophyll metabolism3.15E-022P36551, P30043CPOX, BLVRBMore
Abacavirhsa00983Drug metabolism - other enzymes4.76E-044P20839, P32320, P05164, Q16772IMPDH1, CDA, MPO, GSTA3More
Abacavirhsa01100Metabolic pathways5.92E-0310Q9Y234, Q16772, P20839, O94777, Q9Y6K0, Q86XP1, P14550, Q9UHK6, Q86VZ5, Q9NVH6LIPT1, GSTA3, IMPDH1, DPM2, CEPT1, DGKH, AKR1A1, AMACR, SGMS1, TMLHEMore
Abacavirhsa01524Platinum drug resistance2.82E-022Q16772, P07992GSTA3, ERCC1More
Abacavirhsa03010Ribosome1.88E-026P62753, P25398, P32969, P62829, P18077, P36578RPS6, RPS12, RPL9, RPL23, RPL35A, RPL4More
Abacavirhsa03013RNA transport7.52E-0511O14980, Q09161, P61326, Q9H307, Q7Z3B4, P35658, Q14152, O75822, Q14240, Q06787, P51114XPO1, NCBP1, MAGOH, PNN, NUP54, NUP214, EIF3A, EIF3J, EIF4A2, FMR1, FXR1More
Abacavirhsa03020RNA polymerase3.59E-022P30876, P62487POLR2B, POLR2GMore
Abacavirhsa03460Fanconi anemia pathway2.07E-022Q9BXW9, P07992FANCD2, ERCC1More
Abacavirhsa04071Sphingolipid signaling pathway1.94E-023Q9H228, P01375, Q9UQC2EDG8, TNF, GAB2More
Abacavirhsa04120Ubiquitin mediated proteolysis7.13E-034Q14145, Q13042, P61088, Q15751KEAP1, CDC16, UBE2N, HERC1More
Abacavirhsa04141Protein processing in endoplasmic reticulum4.88E-024P18848, O60337, P11142, P07900ATF4, MARH6, HSPA8, HSP90AA1More
Abacavirhsa04210Apoptosis3.58E-024O76075, P01375, Q9NR28, Q16548DFFB, TNF, DIABLO, BCL2A1More
Abacavirhsa04217Necroptosis4.42E-046P07900, P15104, P05141, P01584, P0C0S5, Q13557HSP90AA1, GLUL, SLC25A5, IL1B, H2AFZ, CAMK2DMore
Abacavirhsa04310Wnt signaling pathway1.79E-022P17612, P67870PRKACA, CSNK2BMore
Abacavirhsa04340Hedgehog signaling pathway2.36E-033P49841, P17612, P22694GSK3B, PRKACA, PRKACBMore
Abacavirhsa04380Osteoclast differentiation1.02E-026Q9UQC2, Q16539, P14778, O75015, P01375, Q8N149GAB2, MAPK14, IL1R1, FCGR3B, TNF, LILRA2More
Abacavirhsa04611Platelet activation2.12E-022Q9Y490, P17612TLN1, PRKACAMore
Abacavirhsa04612Antigen processing and presentation3.74E-054P61769, P01889, P10321, Q06323B2M, HLA-B, HLA-C, PSME1More
Abacavirhsa04625C-type lectin receptor signaling pathway3.87E-024Q9ULY5, P20749, P01375, Q16539CLEC4E, BCL3, TNF, MAPK14More
Abacavirhsa04650Natural killer cell mediated cytotoxicity4.37E-043Q29983, P10321, P01889MICA, HLA-C, HLA-BMore
Abacavirhsa04657IL-17 signaling pathway1.42E-047P07900, O00463, Q16539, P49841, P14780, P01375, P01584HSP90AA1, TRAF5, MAPK14, GSK3B, MMP9, TNF, IL1BMore
Abacavirhsa04664Fc epsilon RI signaling pathway3.98E-023P01375, Q16539, Q9UQC2TNF, MAPK14, GAB2More
Abacavirhsa04668TNF signaling pathway2.21E-025P01375, O00463, Q16539, P20749, P14780TNF, TRAF5, MAPK14, BCL3, MMP9More
Abacavirhsa04742Taste transduction3.91E-021P17612PRKACAMore
Abacavirhsa04910Insulin signaling pathway2.35E-023P22694, P06737, P49841PRKACB, PYGL, GSK3BMore
Abacavirhsa04919Thyroid hormone signaling pathway7.11E-034P49841, P22694, O60244, Q9NVC6GSK3B, PRKACB, MED14, MED17More
Abacavirhsa04931Insulin resistance1.94E-023P01375, P49841, P06737TNF, GSK3B, PYGLMore
Abacavirhsa04932Non-alcoholic fatty liver disease9.70E-034P18848, P01584, P13073, O15239ATF4, IL1B, COX4I1, NDUFA1More
Abacavirhsa04940Type I diabetes mellitus5.03E-032P01889, P10321HLA-B, HLA-CMore
Abacavirhsa04976Bile secretion2.44E-022P22694, P08183PRKACB, ABCB1More
Abacavirhsa05012Parkinson disease2.53E-025O15239, P13073, P05141, P18848, Q13557NDUFA1, COX4I1, SLC25A5, ATF4, CAMK2DMore
Abacavirhsa05016Huntington disease3.21E-025O15239, P13073, P30876, P62487, P05141NDUFA1, COX4I1, POLR2B, POLR2G, SLC25A5More
Abacavirhsa05020Prion disease3.37E-037P13591, P01584, P11142, O15239, P13073, P18848, P05141NCAM1, IL1B, HSPA8, NDUFA1, COX4I1, ATF4, SLC25A5More
Abacavirhsa05022Pathways of neurodegeneration - multiple diseases3.80E-026O15239, P13073, P18848, P05141, P01584, Q13557NDUFA1, COX4I1, ATF4, SLC25A5, IL1B, CAMK2DMore
Abacavirhsa05110Vibrio cholerae infection2.11E-032Q99437, P17612ATP6V0B, PRKACAMore
Abacavirhsa05134Legionellosis1.28E-023P01584, P68104, P11142IL1B, EEF1A1, HSPA8More
Abacavirhsa05160Hepatitis C2.06E-023P52630, P60033, Q9NZJ5STAT2, CD81, EIF2AK3More
Abacavirhsa05162Measles4.02E-023P11142, P01584, Q9NP90HSPA8, IL1B, RAB9BMore
Abacavirhsa05163Human cytomegalovirus infection2.80E-026P01375, P49841, P14778, P25025, Q16539, O00463TNF, GSK3B, IL1R1, CXCR2, MAPK14, TRAF5More
Abacavirhsa05167Kaposi sarcoma-associated herpesvirus infection4.67E-033P01889, P10321, Q29983HLA-B, HLA-C, MICAMore
Abacavirhsa05168Herpes simplex virus 1 infection2.40E-027P01568, Q07955, Q13243, Q13489, P30101, Q13398, O75820IFNA21, SFRS1, SFRS5, BIRC3, PDIA3, ZNF211, ZNF189More
Abacavirhsa05170Human immunodeficiency virus 1 infection3.66E-044P01889, P10321, P61769, Q9NQU5HLA-B, HLA-C, B2M, PAK6More
Abacavirhsa05171Coronavirus disease - COVID-199.72E-037P01584, P62753, P25398, P36578, P32969, P18077, P62829IL1B, RPS6, RPS12, RPL4, RPL9, RPL35A, RPL23More
Abacavirhsa05203Viral carcinogenesis3.58E-033P06396, P01889, P10321GSN, HLA-B, HLA-CMore
Abacavirhsa05222Small cell lung cancer1.29E-024P10826, Q13751, Q13489, O75293RARB, LAMB3, BIRC3, GADD45BMore
Abacavirhsa05320Autoimmune thyroid disease3.18E-032P01889, P10321HLA-B, HLA-CMore
Abacavirhsa05330Allograft rejection3.18E-032P01889, P10321HLA-B, HLA-CMore
Abacavirhsa05332Graft-versus-host disease5.03E-032P01889, P10321HLA-B, HLA-CMore
Abacavirhsa05415Diabetic cardiomyopathy2.87E-024P05141, O15239, P13073, Q13557SLC25A5, NDUFA1, COX4I1, CAMK2DMore
Abacavirhsa05418Fluid shear stress and atherosclerosis1.08E-037Q16539, Q14145, P10599, P14780, P01375, P14778, P27930MAPK14, KEAP1, TXN, MMP9, TNF, IL1R1, IL1R2More

Community members of Abacavir (SDC: 3.71)

UniProtACGene NameProtein NameReported/
Predicted		DisGeNETSPVSdrugabilitySHiSBiNSDisG
P01889HLANoneBHLA class I histocompatibility antigen, B alpha chainReported10.25430.00670.97991.1203
P02768ALBAlbuminPredicted10.28480.91110.08572.0502
P08183ABCB1ATPNonedependent translocase ABCB1Predicted10.078810.20522.2446
P17612PRKACAcAMPNonedependent protein kinase catalytic subunit alphaPredicted00.69370.525712.3982
P49841GSK3BGlycogen synthase kinaseNone3 betaPredicted10.1678113.0839
Q9UBU7DBF4Protein DBF4 homolog APredicted00.00750.19610.2590.655
P10321HLANoneCHLA class I histocompatibility antigen, C alpha chainPredicted10.28410.00570.97991.1334
P30511HLANoneFHLA class I histocompatibility antigen, alpha chain FPredicted00.03710.00530.95250.9817
Q95460MR1Major histocompatibility complex class INonerelated gene proteinPredicted00.01110.002700.011
Q30201HFEHereditary hemochromatosis proteinPredicted00.33360.002500.1718
This pair is Reported in Drugbank.
Gene nameUniProt_IDBioactivityValue (nM)